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| 1 | Changing face of hepatic encephalopathy:Role of inflammation and oxidative stress显示文摘The face of hepatic encephalopathy(HE) is changing.This review explores how this neurocognitive disorder,which is associated with both acute and chronic liver injury,has grown to become a dynamic syndrome that spans a spectrum of neuropsychological impairment,from normal performance to coma.The central role of ammonia in the pathogenesis of HE remains incontrovertible.However,over the past 10 years,the HE community has begun to characterise the key roles of inflammation,infection,and oxidative/nitrosative stress in modulating the pathophysiological effects of ammonia on the astrocyte.This review explores the current thoughts and evidence base in this area and discusses the potential role of existing and novel therapies that might abrogate the oxidative and nitrosative stresses inflicted on the brain in patients with,or at risk of developing,HE. | Amit S Seyan Robin D Hughes Debbie L Shawcross | 2010 | World Journal of Gastroenterology2010，16，27： | 23 |
| 2 | Pathophysiology of cerebral oedema in acute liver failure显示文摘Cerebral oedema is a devastating consequence of acute liver failure(ALF)and may be associated with the development of intracranial hypertension and death.In ALF,some patients may develop cerebral oedema and increased intracranial pressure but progression to lifethreatening intracranial hypertension is less frequent than previously described,complicating less than one third of cases who have proceeded to coma since the advent of improved clinical care.The rapid onset of encephalopathy may be dramatic with the development of asterixis,delirium,seizures and coma.Cytotoxic and vasogenic oedema mechanisms have been implicated with a preponderance of experimental data favouring a cytotoxic mechanism.Astrocyte swelling is the most consistent neuropathological finding in humans with ALF and ammonia plays a definitive role in the development of cytotoxic brain oedema.The mechanism(s)by which ammonia induces astrocyte swelling remains unclear but glutamine accumulation within astrocytes has led to the osmolyte hypothesis.Current evidence also supports an alternate‘Trojan horse’hypothesis,with glutamine as a carrier of ammonia into mitochondria,where its accumulation results in oxidative stress,energy failure and ultimately astrocyte swelling.Although a complete breakdown of the blood-brain barrier is not evident in human ALF,increased permeation to water and other small molecules such as ammonia has been demonstrated resulting from subtle alterations in the protein composition of paracellular tight junctions.At present,there is no fully efficacious therapy for cerebral oedema other than liver transplantation and this reflects our incomplete knowledge of the precise mechanisms underlying this process which remain largely unknown. | Teresa R Scott Victoria T Kronsten Robin D Hughes Debbie L Shawcross | 2013 | World Journal of Gastroenterology2013，19，48： | 8 |
| 3 | Preparation and properties of the succinic ester of porous starch显示文摘 | Peter R C Qian D Y Debbie P A | 2012 | Carbohydrate Polymers2012，88，2： | 1 |
| 4 | Immune Responses to ISCOM Formulations in Animal and Primate Models显示文摘 | S Anders D Debbie M Eugene | 2001 | Vaccine2001，19，： | 1 |
| 5 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 6 | The effects of changes in salinity on osmoregulation and chloride cell morphology of juvenile Australian snapper显示文摘 | FIELDERr D S GEOFF L A DEBBIE P | 2007 | Aquacuhure2007，272，14： | 1 |
| 7 | ESTs, cDNA microarray, and gene expression profiling : tools for dissecting plant physiology and development显示文摘 | AIBA R FEI Z J PAYTON P LIU Y MOORE S L DEBBIE P COHN J D'ASCENZO M GORDON J S JOCELYN K C ROSE MARTIN G TANKSLEY S D BOUZAYEN M JAHN M M GIOVANNONI J | 2004 | Plant Journal2004，39，5： | 1 |
| 8 | Online monitoring of voltage stability margin using an artificial neural network显示文摘 | DEBBIE Q Z ANNAKKAGE U D ATHULA D R | 2010 | IEEE Transactions on Power Systems2010，25，3： | 1 |
| 9 | An extreme value analysis of advanced age mortality data 显示文摘 | Kathryn A W Debbie J D Bruce L J | 2006 | North A- merican Actuarial Journal2006，10，4： | 1 |
| 10 | American Cancer So- ciety guideline for the early detection of cervical neoplasia and cancer显示文摘 | Debbie S Carolyn D R Diane S | 2002 | Cancer J Clin2002，52，： | 1 |
| 11 | American cancer society guideline for the early detectionof cervical neopJasia and cancer显示文摘 | DEBBIE S CAROLYN D R DIANE S | 2003 | J Lower Genital Tract Dis2003，7，2： | 1 |
| 12 | Systemic responsiveness to lipopolysaccharide and polymorphisms in the toll-like receptor 4 gene in human beings显示文摘 | Olivier Michel Tricia D LeVan Debbie Stern | 2003 | American Academy of Allergy Asthma and Immunology2003，，： | 1 |
| 13 | TSLC1 gene silencing in cervical cancer cell lines and cervical neoplasia显示文摘 | Kramer D Steenbergen R D Debbie Kramer | 2004 | J Nat Cancer Inst2004，96，4： | 1 |
| 14 | Cytotoxic T cell polyepitope vaccines delivered by ISCOMs显示文摘 | Thuy TTL Debbie D Jim M | 2001 | Vaccine2001，19，： | 1 |
| 15 | Cytotoxic T cell polyepitope vaccines delivered by ISCOMs 显示文摘 | Thuy T T L Debbie D Jim M | 2001 | Vaccine2001，19，： | 1 |
| 16 | Insulin preincubation enhances insulin like growth factor 2 (IGF 2 ) action on steroidogrnesis in human granulosa cells显示文摘 | Helen D Mason Debbie S | 1994 | Clin Endocrinol Metab1994，79，5： | 1 |
| 17 | ESTs, cDNA microarrays, and gene expression profiling: tools for dissecting plant physiology and development显示文摘 | ALBA R FEI Z PAYTON P LIU Y MOORE S L DEBBIE P COHN J ASCENZO M D GORDON J S ROSE J K C MARTIN G TANKSLEY S D BOUZAYEN M JAHN M M GIOVANNONI J J | 2004 | The Plant Journal2004，39，5： | 1 |
| 18 | Total pancreatectomy and autologous Islet cell transplantation as a means to treat severe chronic pancreatitis显示文摘 | Horacio L Rodriguez Rilo Syed A Ahmad David D’Alessio Yasuhiro Iwanaga Joseph Kim Kyuran A Choe Jonathan S Moulton Jill Martin Linda J Pennington Debbie A Soldano Jamie Biliter Steve P Martin Charles D Ulrich Lehel Somogyi Jeffrey Welge Jeffrey B Matthews | 2003 | Journal of Gastrointestinal Surgery2003，，8： | 1 |
| 19 | American cancer society guideline for the early detection of cervical neoplasia and cancer显示文摘 | Debbie Saslow Carolyn D Runowicz | 2002 | CA Cancer J Clin2002，52，： | 1 |
| 20 | Intracranially administered anti-Aβ antibodies reduce β-amyloid deposition by mechanisms both independent of and associated with microglial activation显示文摘 | Giovanni D Debbi H | 2003 | J Neurosci2003，23，9： | 1 |
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