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| 1 | Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction显示文摘Zika 病毒(ZIKV ) 的最近的爆发为治疗学加亮迫切需要。朊酶建筑群 NS2B-NS3 在 flaviviral polyprotein 处理期间起必要作用,并且因此代表一个吸引人的药目标。这里,我们开发了裂口酶识别直接指向 flavivirus NS2B-NS3 相互作用的 orthosteric 禁止者的基于互补的高产量的屏蔽试金。由屏蔽一个总数 2 816 同意了并且 investigational 药,我们识别了三个有势力候选人, temoporfin, niclosamide,和 nitazoxanide,,有 nanomolar 力量的 flavivirus NS2B-NS3 相互作用禁止者。显著地,在老鼠的在人的胎盘、神经的祖先房间的大多数有势力化合物, temoporfin,不是仅仅禁止的 ZIKV 复制,而且阻止的导致 ZIKV 的 viremia 和死亡当模特儿。结构的停靠建议 temoporfin 潜在地绑保持批评 NS2B 残余的 NS3 衣袋,因此禁止以一种非竞争的方式处理的 flaviviral polyprotein。当这些药已经在 USA 或另外的国家在另外的指示任何一个为临床的使用被同意了,他们由 ZIKV 和另外的 flaviviruses 为感染的管理代表有希望、容易开发的治疗。 | Zhong Li Matthew Brecher Yong-Qiang Deng Jing Zhang Srilatha Sakamuru Binbin Liu Ruili Huang Cheri A Koetzner Christina A Allen Susan A Jones Haiying Chen Na-Na Zhang Min Tian Fengshan Gao Qishan Lin Nilesh Banavali Jia Zhou Nathan Boles Menghang Xia Laura D Kramer Cheng-Feng Qin Hongmin Li | 2017 | Cell Research2017，27，8： | 11 |
| 2 | Efficacy of SpyGlass^(TM)-directed biopsy compared to brush cytology in obtaining adequate tissue for diagnosis in patients with biliary strictures显示文摘AIM: To evaluate the diagnostic yield(inflammatory activity) and efficiency(size of the biopsy specimen) of SpyGlassTM-guided biopsy vs standard brush cytology in patients with and without primary sclerosing cholangitis(PSC).METHODS: At the University Medical Center Mainz, Germany, 35 consecutive patients with unclear biliarylesions(16 patients) or long-standing PSC(19 patients) were screened for the study. All patients underwent a physical examination, lab analyses, and abdominal ultrasound. Thirty-one patients with non-PSC strictures or with PSC were scheduled to undergo endoscopic retrograde cholangiography(ERC) and subsequent per-oral cholangioscopy(POC). Standard ERC was initially performed, and any lesions or strictures were localized. POC was performed later during the same session. The Boston Scientific SpyGlass SystemTM(Natick, MA, United States) was used for choledochoscopy. The biliary tree was visualized, and suspected lesions or strictures were biopsied, followed by brush cytology of the same area. The study endpoints(for both techniques) were the degree of inflammation, tissue specimen size, and the patient populations(PSC vs non-PSC). Inflammatory changes were divided into three categories: none, low activity, and high activity. The specimen quantity was rated as low, moderate, or sufficient.RESULTS: SpyGlassTM imaging and brush cytology with material retrieval were performed in 29 of 31(93.5%) patients(23 of the 29 patients were male). The median patient age was 45 years(min, 20 years; max, 76 years). Nineteen patients had known PSC, and 10 showed non-PSC strictures. No procedure-related complications were encountered. However, for both methods, tissues could only be retrieved from 29 pa-tients. In cases of inflammation of the biliary tract, the diagnostic yield of the SpyGlassTM-directed biopsies was greater than that using brush cytology. More tissue material was obtained for the biopsy method than for the brush cytology method(P = 0.021). The biopsies showed significantly more inflammatory characteristics and greater inflammatory activity compared to the cy-tological investigation(P = 0.014). The greater quantity of tissue samples proved useful for both PSC and non-PSC patients.CONCLUSION: SpyGlassTM imaging can be recom-mended for proper inflammatory diagnosis in PSC pa-tients. However, its value in diagnosing dysplasia wasnot addressed in this study and requires further investi-gation. | Johannes Wilhelm Rey Torsten Hansen Sebastian Dümcke Achim Tresch Katja Kramer Peter Robert Galle Martin Goetz Marcus Schuchmann Ralf Kiesslich Arthur Hoffman | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，4： | 2 |
| 3 | Development of a selective enzyme- linked immunosorbent assay for 1- naphthol- the major metabolite of carbaryl(1- naphthyl n- methylcarbamate)显示文摘 | Marco M P Hammock B D | 1994 | J Agric Food Chem1994，42，4： | 1 |
| 4 | Aerosol insulin induces regulatory CD8 gamma delta T cells that prevent murine insulin dependent diabetes显示文摘 | DEMPSEY C M KRAMER D R | 1996 | J Exp Med1996，184，6： | 1 |
| 5 | Effects of photodynamic therapy using verteporfin on experimental choroidal neovascularization and normal retina and choroid up to 7 w eeks after treatment显示文摘 | Husain D Kramer M Kenny AG | 1999 | Invest Ophthalmol Vis Sci1999，40，： | 1 |
| 6 | Indocyanine green angiograph-ic findings in nonproliferative diabetic retinopathy显示文摘 | Weinberger D Kramer M Priel E | 1998 | Am J Ophthalmol1998，126，2： | 1 |
| 7 | Free histidine as a metal chelator in plants that accumulate nickel 显示文摘 | KRAMER U COTTER-HOWELLS J D CHARNOCK J M | 1996 | Nature1996，379，： | 1 |
| 8 | TSLC1 gene silencing in cervical cancer cell lines and cervical ne- oplasia显示文摘 | Steenbergen RD Kramer D Braakhuis BJ | 2004 | J Natl Cancer Inst2004，96，4： | 1 |
| 9 | Field-scale nitrogen balances associated with long-term continuous corn production显示文摘 | Karlen D L Kramer L A Logsdon S D | 1998 | Agronomy Journal1998，9，5： | 1 |
| 10 | The pan-HDAC inhibitor vorinostat potentiates the activity of the proteasome inhibitor carfilzomib in human DLBCL cells in vitro and in vivo显示文摘 | Dasmahapatra G Lembersky D Kramer L | | 0，，22： | 1 |
| 11 | Renal insufficiency in the absence of albuminuria and retinopathy among adults with type 2 diabetes mellitus显示文摘 | Kramer H J Nguyen Q D Curhan G | 2003 | JAMA2003，289，7： | 1 |
| 12 | Ultra Sensitive, Specific Method for Cyanide Using p-Nitrobenzaldehyde and o-Dinitrobenzene显示文摘 | Guilbault G G Kramer D N | 1966 | Analytical Chemistry1966，38，7： | 1 |
| 13 | Renal replacement therapy in Europe:a summary of the 2011 ERA-EDTA Registry Annual Report显示文摘 | Noordzij M Kramer A Abad Diez JM et d | 2014 | Clin Kidney J2014，7，2： | 1 |
| 14 | Blood lead levels in the US population 显示文摘 | Brody D J Pirkle JL Kramer RA | 1994 | JAMA1994，272，4： | 1 |
| 15 | Stress-corosion cracking susceptibility of various product forms of aluminum alloy 2519显示文摘 | KRAMER L S BLAIR T BLOUGH S D | 2002 | Journal of Materials Engineering and Performance2002，11，6： | 1 |
| 16 | Executive dysfunction in subcortical ischaemic vascular disease显示文摘 | Kramer JH Reed BR Mungas D | 2002 | J Neurol Neurosurg Psychiatry2002，72，2： | 1 |
| 17 | New fluorescence parameters for the determination of QA redox state and excitation energy fluxes 显示文摘 | Kramer D M Johnson G Kiirats O Edwards G E | 2004 | Photosynthesis Research2004，79，2： | 1 |
| 18 | Nanocelluloses as innovative polymers in research and application显示文摘 | Klemm D Schumann D Kramer F He(B)ler N Hornung M Schmauder H P Marsch S | | 0，，09： | 1 |
| 19 | Swift trust and temporary groups显示文摘 | Meyerson D Weick K E Kramer R M | 1996 | Trust in Organizations: Frontiers of Theory and Research1996，166，： | 1 |
| 20 | In situdiagnostic oftwo-phase flow phenomena in polymer electrocly fuel cells by neu-tron imaging part a experimental, data treatment, and quantification显示文摘 | KRAMER D ZHANG J SHIMOI R | 2005 | Electrochimica Acta2005，50，13： | 1 |
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