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| 1 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 2 | Recommendations for Comprehensive Stroke Centers: A Consensus Statement From the Brain Attack Coalition显示文摘 | Mark J. Alberts Richard E. Latchaw Warren R. Selman Timothy Shephard Mark N. Hadley Lawrence M. Brass Walter Koroshetz John R. Marler John Booss Richard D. Zorowitz Janet B. Croft Ellen Magnis Diane Mulligan Andrew Jagoda Robert O’Connor C Michael Cawley | 2005 | Stroke2005，，7： | 2 |
| 3 | Targetto Target Interval Versus Probability Effects on P300 in One and Two-Tone Tasks显示文摘 | Croft R J C J Gonsalvez C Gabriel | 2003 | Psychophysiology2003，40，3： | 1 |
| 4 | Estimating the prevalence of low back pain in the general population显示文摘 | Papageorgiou A C Croft P R Ferry S | | 0，，17： | 1 |
| 5 | Osteoarthritis as a public health problem: the impact of developing knee pain on physical function in adults living in the community: ( KNEST 3 )显示文摘 | JINKS C JORDAN K CROFT P | 2007 | Rheumatology ( Oxford )2007，46，5： | 1 |
| 6 | Is the P300 wave an en- dophenotype for schizophrenia? A meta-analysis and a family study 显示文摘 | Bramon E McDonald C Croft ILl | 2005 | Neuroimage2005，27，4： | 1 |
| 7 | Target-to-target inter- val versus probability effects on P300 in one-and two-tone tasks 显示文摘 | Croft RJ Gonsalvez C J Gabriel C | 2003 | Psychophysiology2003，40，3： | 1 |
| 8 | Test systems to determine the ecological risks posed by toxin release from Bacillus thuringiensis genes in crop plants显示文摘 | Jepson P C Croft B A Pratt G E | 1994 | Mol Ecol1994，3，： | 1 |
| 9 | Uses and complications of uvulopalatopharyngoplasty显示文摘 | CROFT C B GOLDING-WOOD D G | 1990 | J Laryngol Otol1990，104，11： | 1 |
| 10 | Comparison of several techniques to obtain multiple-look SAR imagery 显示文摘 | Li Fuk-Kwok Croft C Held D N | 1983 | IEEE Transactions on Geoscience and Remote Sensing1983，21，3： | 1 |
| 11 | Uptake, distribution, and effects of carbon tetrachloride in rainbow trout (Salmo gairdneri) 显示文摘 | Statham C N Croft W A Lech J J | 1978 | Toxicol Appl Pharmacol1978，45，1： | 1 |
| 12 | Clinical targeting of the TNF and TNFR superfamilies 显示文摘 | Croft M Benedict C A Ware C F | 2013 | Nat Rev Drug Discov2013，12，2： | 1 |
| 13 | Formulation and biopharmaceutical issues in the development of drug delivery systerns for antiparasitic drugs显示文摘 | Olbrich C Croft SL Kiderlen A F | 2003 | Parasitol Res2003，90，2： | 1 |
| 14 | The United Kingdom public health re- sponse to an imported laboratory confirmed case of a no- vel coronavirus in September 2012显示文摘 | Pebody R G Chand M A Thomas H L Green H K Boddington N L Carvalho C Brown C S Anderson S R Rooney C Crawley-Boevey E Irwin D J Aarons E Tong C Newsholme W Price N Langrish C Tucker D Zhao H Phin N Crofts J Bermingham A Gil- gunn-Jones E Brown K E Evans B Catchpole M Watson J M | 2012 | Euro Surveill2012，17，20： | 1 |
| 15 | Annual Consultation Prevalence of Regional Museuloskel- etal Problems in Primary Care : Anobservational Study 显示文摘 | Jordan KP Kadam UT Hayward R Porcheret M Young C Croft P | 2010 | BMC Musculoskelet Disord2010，11，： | 1 |
| 16 | Modeling and measurement approaches for electrostatic discharge in semiconductor devices and ICs: an o- verview显示文摘 | Lee J C Croft G D | 1999 | Microeleetronic Reliability1999，39，5： | 1 |
| 17 | A comparison of eomputerised tomography, laparoscopic ultrasound and endoscopic ultrasound in the preoperative staging of oesophago-gastric carcinoma 显示文摘 | Wakelin SJ Deans C Crofts TJ | 2002 | Eur J Radiol2002，41，2： | 1 |
| 18 | Individual risk factors for hip osteoarthritis: obesity, hip injury, and physical activity 显示文摘 | COOPER C INSKIP H CROFT P | 1998 | Am J Epidemiol1998，147，6： | 1 |
| 19 | Effect of volatile methyl Jasmonate on the oxylipin pathway in tobacco,cucumber and Arabidopsis 显示文摘 | Avdiushko S Croft K P C Brown G C | 1995 | Plant Physiol1995，109，： | 1 |
| 20 | A comparison of com- puted tomography, laparoscopic ultrasound and endoscopic ultrasound in the preoperative staging of esophago-gastric carcinoma显示文摘 | Wakelin S J Deans C Crofts T J | 2002 | Eur J Radiol2002，41，2： | 1 |
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