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| 1 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 2 | Determination of quinolones and fluoroquinolones in fish tissue and seafood by high-performance liquid chromatography with electrospray ionization tandem mass spectrometric detection显示文摘 | Johnston L Mackay L Croft M | 2002 | J Chromatogra A2002，982，1： | 2 |
| 3 | Saddle shape of the mi- tral annulus reduees systolic strains on the P2 segment of the posteri- or mitral leaflet显示文摘 | Padala M Hutehison RA Croft LR | 2009 | Ann Thorae Surg2009，88，5： | 1 |
| 4 | The role of TNF superfamily members in T-cell function and diseases显示文摘 | Croft M | 2009 | Nat Rev Immunol2009，9，4： | 1 |
| 5 | Differences in the localization and morphology of chromosomes in the human nucleus显示文摘 | Croft J A Bridger J M Boyle S | 1999 | J Cell Biol1999，145，： | 1 |
| 6 | The evolving crosstalk between co-stimulatory and co-inhibitory receptors:HVEM-BTLA显示文摘 | Croft M | 2005 | Trends Immunol2005，26，6： | 1 |
| 7 | The role of TNF superfamily members in T-cell function and diseases显示文摘 | Croft M | 2009 | Nat Rev Immunol2009，9，4： | 1 |
| 8 | Action of insecticides to leafhopper on tea tree,toxicity,resistance and synergistic combinations显示文摘 | CROFT B A ALINIAZEE M T | 1990 | Journal of economic entomology1990，83，4： | 1 |
| 9 | The applicability of empiri- cal vegetation indices for determining leaf chlorophyU con- tent over different leaf and canopy structures显示文摘 | Croft H Chen J M Zhang Y | 2014 | Ecologi- cal Complexity2014，17，1： | 1 |
| 10 | Modified Japanese medaka embryo-larval bioassay for rapid determination of developmental abnormalities 显示文摘 | Farwell A Nero V Croft M | 2006 | Environmental Contamination and Toxicity2006，51，4： | 1 |
| 11 | The significance of OX4o and OX40 L to T-cell biology and immune disease显示文摘 | Croft M So T Duan W | 2009 | Immunol Rev2009，229，1： | 1 |
| 12 | Control of immunity by the TNFR-related molecule OX40 (CD134) 显示文摘 | Croft M | 2010 | Annu Rev Immunol2010，28，： | 1 |
| 13 | The Protein-sparing effect of carbohydrate 显示文摘 | Fuller M F Crofts R M J | 1977 | British J Nutr1977，38，03： | 1 |
| 14 | Co - stimulatory members of the TNFR family: keys to effective T -cell immunity? 显示文摘 | Croft M | 2003 | Nat Rev Immunol2003，3，2： | 1 |
| 15 | Systematic Mn d-Configuration Change in the La1-xCaxMnO3 System: a kin K-edge XAS Study显示文摘 | Croft M Sills D Greenblatt M | 1997 | Physical Review B1997，55，14： | 1 |
| 16 | Vitamin E in human health and disease显示文摘 | Clarke M W Burnett J R Croft K D | 2008 | Critical Reviews in Clinical Laboratory Sciences2008，45，5： | 1 |
| 17 | Peptide dose,affinity,and time of differentiation can contribute tothe Th1/Th2 cytokine balance显示文摘 | Rogers PR Croft M | 1999 | J Immunol1999，163，3： | 1 |
| 18 | Primaquine-loaded poly (lactide) nanoparticules: physicochemical study and acutetolerancein mice显示文摘 | Rodrigues J M Croft S L Fessi H | 1995 | Int J Pharm1995，126，： | 1 |
| 19 | Soybean isotlavonoids and their metabolic products inhibit in vitro lipoprotein oxidation in serum 显示文摘 | HODGSON J M CROFT K D PUDDEY I B | 1996 | The Journal of Nutritional Biochemistry1996，，7： | 1 |
| 20 | Regulation of PI-3-Kinase and Akt Signaling in T Lymphocytes and Other Cells by TN FR Family Molecules显示文摘 | So T Croft M | 2013 | Front Immunol2013，4，7： | 1 |
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