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| 1 | Physiological effects of amyloid precursor protein and its derivatives on neural stem cell biology and signaling pathways involved显示文摘The pathological implication of amyloid precursor protein(APP)in Alzheimer’s disease has been widely documented due to its involvement in the generation of amyloid-β peptide.However,the physiological functions of APP are still poorly understood.APP is considered a multimodal protein due to its role in a wide variety of processes,both in the embryo and in the adult brain.Specifically,APP seems to play a key role in the proliferation,differentiation and maturation of neural stem cells.In addition,APP can be processed through two canonical processing pathways,generating different functionally active fragments:soluble APP-α,soluble APP-β,amyloid-β peptide and the APP intracellular C-terminal domain.These fragments also appear to modulate various functions in neural stem cells,including the processes of proliferation,neurogenesis,gliogenesis or cell death.However,the molecular mechanisms involved in these effects are still unclear.In this review,we summarize the physiological functions of APP and its main proteolytic derivatives in neural stem cells,as well as the possible signaling pathways that could be implicated in these effects.The knowledge of these functions and signaling pathways involved in the onset or during the development of Alzheimer’s disease is essential to advance the understanding of the pathogenesis of Alzheimer’s disease,and in the search for potential therapeutic targets. | Raquel Coronel Charlotte Palmer Adela Bernabeu-Zornoza María Monteagudo Andreea Rosca Alberto Zambrano Isabel Liste | 2019 | Neural Regeneration Research2019，14，10： | 2 |
| 2 | Energy-dependent transport of calcium to the extracelluar space during acute ischemia of the rat heart显示文摘 | Schumacher C A Baartscheer A Coronel R | 1998 | J Mol Cardiol1998，30，： | 1 |
| 3 | Antologia显示文摘 | Ocana Sierra J Alcala Romero F Coronel A | 1974 | Dermatologica1974，4，： | 1 |
| 4 | Repolarization gradients in the canine left ventricle before and after induction of short - term cardiac memory 显示文摘 | JANSE M I SOSUNOV E A CORONEL R | 2005 | Circulation2005，112，12： | 1 |
| 5 | Long -term cardiac memory in canine heat is associated with the evolution of a transmural repolarization gradient 显示文摘 | CORONEL R OPTHOF T PLOTNIKOV A N | 2007 | Cardiovasc Res2007，74，3： | 1 |
| 6 | Relationship between extracellular potassium accumulation and local QT-segment potential during acute myocardial ischemia in the porcine显示文摘 | JOHNSON T A CORONEL R GRAEBNER C A | 1987 | J Mol Cell Cardiol1987，19，： | 1 |
| 7 | Ochratoxin A in adult population of Lleida,Spain: Presence in blood plasma and consumption in different regions and seasons显示文摘 | Coronel M B Sanchis V Ramos A J Marin S | 2011 | Food and Chemical Toxicology2011，49，10： | 1 |
| 8 | Ochratoxin A and its metabolite ochratoxin alpha in urine and assessment of the exposure of inhabitants of Lleida,Spain显示文摘 | Coronel M B Marin S Tarragó M Cano-Sancho G Ramos A J Sanchis V | 2011 | Food and Chemical Toxicology2011，49，6： | 1 |
| 9 | Influence of Admission Glucose Level on Long-Term Prognosis in Patients With Acute Coronary Syndrome显示文摘 | Stella M. Macín Eduardo R. Perna María L. Coronel Jorge O. Kriskovich Pablo A. Bayol Valeria A. Franciosi Jorge L. Riera-Stival Bilda González-Arjol Jorge R. Badaracco | 2006 | 2006，，： | 1 |
| 10 | Electrophysiological changes in heart failure and their implications for arrhythmogenesis 显示文摘 | CORONEL R WILDERS R VERKERK A O | 2013 | Biochim Bio- phys Aeta2013，1832，： | 1 |
| 11 | Assessment of the ex-posure to ochratoxin A in the province of Lleida,Spain显示文摘 | Coronel M B Sanchis V Ramos A J | | 0，，11： | 1 |
| 12 | Injury of peripheral muscles in smokers with chronic obstructive pulmonary disease显示文摘 | Orozco-Levi M Coronell C Ramirez-Sarmiento A | 2012 | Ultrastruct Pathol2012，36，4： | 1 |
| 13 | Global muscle dysfunction as a risk factor of readmission to hospital due to COPD exacerbations显示文摘 | Jordi Vilaró Alba Ramirez-Sarmiento Juana M a Martínez-Llorens Teresa Mendoza Miguel Alvarez Natalia Sánchez-Cayado ángeles Vega Elena Gimeno Carlos Coronell Joaquim Gea Josep Roca Mauricio Orozco-Levi | 2010 | Respiratory Medicine2010，，12： | 1 |
| 14 | Microscopic-Observation Drug-Susceptibility Assay for the Diagnosis of TB显示文摘 | Moore DAJ Evans CAW Gilman RH Caviedes L Coronel J Vivar A Sanchez E PifiedoY Saravia JC Salazar C Oberhelman R Hollm-Delgado MG LaChira D Escombe R Friedland JS | 2006 | N Engl J Med2006，355，15： | 1 |
| 15 | Infrequent MODS TB culture cross-contamination in a high-burden resource poor setting显示文摘 | Moore DAJ Caviedes L Gilman RH Coronel J Arenas F LaChira D Salazar C Saravia JC Oberhelman R Hollm-Delgado MG Escombe R Evans C A W Friedland J S | 2006 | Diagnostic Microbiology and Infectious Disease2006，56，： | 1 |
| 16 | Oral protein -energy supplements in peritoneal dialysis :a multicenter study 显示文摘 | TEIXIDO-PLANAS J ORTIZ A CORONEL F | 2005 | Peritoneal Dialysis Int2005，25，2： | 1 |
| 17 | Intraspecific Response of 188 Rice Cultivars to Enhanced UV-B Radition显示文摘 | Dai Q J Peng S Coronel A Q | 1994 | Enviromental and Experimental Botany1994，34，： | 1 |
| 18 | Republic of Kazakhstan:Selected Issues显示文摘 | CORONEL A L ROZHKOV D RAMAN N | 2011 | IMF Country Report2011，，11： | 1 |
| 19 | Microscopic-observation drug-susceptibility assay for the diagnosis of TB 显示文摘 | Moore DA Evans CA Gilman RH Caviedes L Coronel J Vivar A Sanchez E Pifiedo Y Saravia JC Salazar C Oberhelman R Hollm-Delgado MG LaChira D Escombe AR Friedland JS | 2006 | N Engl J Med2006，355，15： | 1 |
| 20 | Intraspecific responses of 188 rice cultivars to enhanced UV-B radiation 显示文摘 | Dai Q J Peng S Coronel A Q | 1994 | Environmental and Experimental Botany1994，34，： | 1 |
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