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| 1 | Comparison between endoscopic sphincterotomy vs endoscopic sphincterotomy associated with balloon dilation for removal of bile duct stones:A systematic review and meta-analysis based on randomized controlled trials显示文摘AIM To compare gallstones removal rate and incidence of bleeding, pancreatitis, use of mechanical lithotripsy, cholangitis and perforation between isolated sphincterotomy vs sphincterotomy associated with balloon dilation of papilla in choledocholithiasis through the meta-analysis of randomized clinical trials. METHODS We conducted a systematic review according to the PRISMA guidelines. Literature search was restricted to randomized controlled trials(RCTs) on Med Line, Cochrane Library, LILACS, and EMBASE database platforms in July 2017. The manual search included references of retrieved articles. We extracted data focusing on outcomes: The primary endpoint was the stones removal rate; Secondary endpoints were rates of pancreatitis, bleeding, use of mechanical lithotripsy(ML), perforation and cholangitis. RESULTS Eleven RCTs with 1824 patients were included. EST was associated with more post-endoscopic retrograde cholangiopancreatography(ERCP) bleeding [FE RD-0.02, CI(-0.03,-0.00), I2 = 33%, P = 0.05] and more need of mechanical lithotripsy in general [RE RD-0.16, CI(-0.25,-0.06), I2 = 90%, P = 0.002] and in subgroup analysis of stones greater than 15 mm [RE RD-0.20, CI(-0.38,-0.02), I2 = 82%, P = 0.003]. Incidence of pancreatitis [FE RD-0.01, CI(-0.03, 0.01), I2 = 0, P = 0.36], cholangitis [FE RD-0.00, CI(-0.01, 0.01), I2 =0, P = 0.97] and perforation [FE RD-0.01, CI(-0.01, 0.00), I2 = 0, P = 0.23] was similar between the groups as well as similar stone removal rates in general [FE RD-0.01, CI(-0.01, 0.04), I2 = 0, P = 0.23] and pooled analysis of stones greater than 15 mm [FE RD-0.02, CI(-0.02, 0.07), I2 = 11%, P = 0.31]. CONCLUSION Through meta-analysis of randomized clinical trials we found that isolated sphincterotomy was associated with more post-ERCP bleeding and more need for mechanical lithotripsy. However, there was no statistical difference in the stone removal rate between isolated sphincterotomy and sphincterotomy associated with balloon dilation in the approach to remove gallstones. | Cesar Capel de Clemente Junior Wanderley Marques Bernardo Tomazo Prince Franzini Gustavo Oliveira Luz Marcos Eduardo Lera dos Santos Jonah Maxwell Cohen Diogo Turiani Hourneaux de Moura Fábio Ramalho Tavares Marinho Martin Coronel Paulo Sakai Eduardo Guimaraes Hourneaux de Moura | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，8： | 8 |
| 2 | 对明串珠菌及其他细菌的抑制效果显示文摘在从压榨间直到蔗汁澄清的蔗糖生产过程中,蔗汁中微生物活动是破坏蔗糖品质的一个重要因素。蔗糖损失和葡聚糖的形成通常与蔗汁中微生物引起的变质有关。多年来,这一直成为糖厂试图改善蔗糖品质时所面临的问题。本文以直接影响得糖率的微生物减少和相对纯度为指标,研究了不同杀菌方法在蔗汁中的效果。浓度为0.007%的S抑制剂显示了对某糖厂初压汁和混合汁中的微生物菌群的抗菌效应。在对照组中,12h后观察到4.8单位的纯度降低。加入S抑制剂后,只降低2个单位。且蔗汁的稳定性在3个样品中几乎完全一致。以S抑制剂处理的蔗汁保持深褐色和清新的气味,且pH与初始相比无显著变化,而未处理的蔗汁变浅褐色,产生很强的酒味,pH和纯度显著降低。这种稳定效应尚未被其他常用的糖用杀菌剂所报导。同样,本文证明了有可能通过使用S抑制剂来稳定混合汁。经S抑制剂处理后,游离的还原物质和多聚糖比不经处理的样品低6倍。这些结果表明,形成的葡聚糖以及随之形成的游离果糖减少。 | Georgina Michelena Aidin Martinez Graciela Cerutti Monica Coronel Antonio Bell Emilia Carrera Agustin Lopez-Murguia Roberto Portuondo Lazaro Mergarejo Frost M Steele 李宜海 | 2006 | 广西轻工业2006，22，4： | 3 |
| 3 | Physiological effects of amyloid precursor protein and its derivatives on neural stem cell biology and signaling pathways involved显示文摘The pathological implication of amyloid precursor protein(APP)in Alzheimer’s disease has been widely documented due to its involvement in the generation of amyloid-β peptide.However,the physiological functions of APP are still poorly understood.APP is considered a multimodal protein due to its role in a wide variety of processes,both in the embryo and in the adult brain.Specifically,APP seems to play a key role in the proliferation,differentiation and maturation of neural stem cells.In addition,APP can be processed through two canonical processing pathways,generating different functionally active fragments:soluble APP-α,soluble APP-β,amyloid-β peptide and the APP intracellular C-terminal domain.These fragments also appear to modulate various functions in neural stem cells,including the processes of proliferation,neurogenesis,gliogenesis or cell death.However,the molecular mechanisms involved in these effects are still unclear.In this review,we summarize the physiological functions of APP and its main proteolytic derivatives in neural stem cells,as well as the possible signaling pathways that could be implicated in these effects.The knowledge of these functions and signaling pathways involved in the onset or during the development of Alzheimer’s disease is essential to advance the understanding of the pathogenesis of Alzheimer’s disease,and in the search for potential therapeutic targets. | Raquel Coronel Charlotte Palmer Adela Bernabeu-Zornoza María Monteagudo Andreea Rosca Alberto Zambrano Isabel Liste | 2019 | Neural Regeneration Research2019，14，10： | 2 |
| 4 | Dielectric properties of pumpable food materials at 915 MHz显示文摘 | Coronel P J Simunovic K P Sandeep P | 2008 | International Journal of Food Properties2008，，11： | 1 |
| 5 | Incorporatedfish oil fatty acids prevent action potential shorteninginduced by circulating fish oil fatty acids显示文摘 | Den Ruijter HM Verkerk AO Coronel R | 2010 | FrontPhysiol2010，1，： | 1 |
| 6 | Energy-dependent transport of calcium to the extracelluar space during acute ischemia of the rat heart显示文摘 | Schumacher C A Baartscheer A Coronel R | 1998 | J Mol Cardiol1998，30，： | 1 |
| 7 | Cardiac expression of skeletalmuscle sodium channels increases longitudinal conduction velocity inthe canine 1 -week myocardial infarction 显示文摘 | Coronel R Lau DH Sosunov EA | 2010 | Heart Rhythm2010，7，： | 1 |
| 8 | The response to fish oil inpatients with heart disease depends on the predominantarrhythmia mechanism显示文摘 | Den Ruijter HM Coronel R | 2009 | Cardiovasc Drugs Ther2009，23，4： | 1 |
| 9 | Dispersion of re- polarization in canine ventricle and the electrocardiographic T wave: Tp-e interval does not reflect transmural dispersion 显示文摘 | Opthof T Coronel R Wilms-Schopman FJ | 2007 | Heart Rhythm2007，4，3： | 1 |
| 10 | L-arginine and antioxidant diet supplementation partially restores nitric oxide-dependent regulation of phenylephrine renal vasoconstriction in diabetics rats显示文摘 | Coronel I Arellano-Mendoza M G del-Valle-Mondragon L | 2010 | J Ren Nutr2010，20，3： | 1 |
| 11 | A wedge is not a heart显示文摘 | Opthof T Coronel R Janse MJ | 2007 | Heart Rhythm2007，4，8： | 1 |
| 12 | Long-term cardiac memory in canine heart is associated with the evolution of a transmural repolarization gradient 显示文摘 | Coronel Opthof T Plotnikov AV | 2007 | Cardiovasc Res2007，74，3： | 1 |
| 13 | Wear induced material modifica- tions of cemented carbide rocked rill buttons显示文摘 | Beste U Coronel E Jacobson S | 2006 | International Journal of Refractory Metals and Hard Materials2006，，24： | 1 |
| 14 | Antologia显示文摘 | Ocana Sierra J Alcala Romero F Coronel A | 1974 | Dermatologica1974，4，： | 1 |
| 15 | Application of the phase Transfer Catalysis in Rare Earth Solvent Extraction显示文摘 | Talavera Coronel F | 1982 | Talata1982，29，： | 1 |
| 16 | Dispersion of repolarization in canine ventricle and the electrocardiographie T wave : Tp-e interval does not reflect transmural dispersion 显示文摘 | Opthof T Coronel R Wilms-Schopman FJ | 2007 | Heart Rhythm2007，4，3： | 1 |
| 17 | Intercellular couplingthrough gap junctions masks M cells in the human heart显示文摘 | Conrath CE Wilders R Coronel R | 2004 | Card-iovasc Res2004，62，2： | 1 |
| 18 | Dispersion of repolarization in canine ventricle and theelectrocardiographic T wave : Tp-e interval does not reflecttransmural dispersion显示文摘 | OPTHOF T CORONEL R WILMS-SCHOPMAN F J etal | 2007 | Heart Rhythm2007，4，3： | 1 |
| 19 | Nucleocapsid incorporation into parainfluenza virus is regulated by specific interaction with matrixprotein显示文摘 | Coronel E C Takimoto T Murti K G | 2001 | JVirol2001，75，3： | 1 |
| 20 | Ionic re-modeling of sinoatrial node cells by heart failure显示文摘 | VERKERK AO WILDERS R CORONEL R | 2003 | Circula-tion2003，108，6： | 1 |
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