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| 1 | Acute syndesmotic injuries in ankle fractures:From diagnosis to treatment and current concepts显示文摘A stable and precise articulation of the distal tibiofibular syndesmosis maintains the tibiofibular relationship,and it is essential for normal motion of the ankle joint.The disruption of this joint is frequently accompanied by rotational ankle fracture,such as pronation-external rotation,and rarely occurs without ankle fracture.The diagnosis is not simple,and ideal management of the various presentations of syndesmotic injury remains controversial to this day.Anatomical restoration and stabilization of the disrupted tibiofibular syndesmosis is essential to improve functional outcomes.In such an injury,including inadequately treated,misdiagnosed and correctly diagnosed cases,a chronic pattern characterized by persistent ankle pain,function disability and early osteoarthritis can result.This paper reviews anatomical and biomechanical characteristics of this syndesmosis,the mechanism of its acute injury associated to fractures,radiological and arthroscopic diagnosis and surgical treatment. | Francesco Pogliacomi Massimo De Filippo Daniele Casalini Alberto Longhi Fabrizio Tacci Rocco Perotta Francesco Pagnini Silvio Tocco Francesco Ceccarelli | 2021 | World Journal of Orthopedics2021，12，5： | 3 |
| 2 | Mucosal adhesion and anti-inflammatory effects of Lactobacillus rhamnosus GG in the human colonic mucosa: A proof-of-concept study显示文摘AIM To investigate the adhesion and anti-inflammatory effects of Lactobacil us rhamnosus GG (LGG) in the colonic mucosa of healthy and ulcerative colitis (UC) patients, both in vivo and ex vivo in an organ culture model.METHODS For the ex vivo experiment, a total of 98 patients (68 UC patients and 30 normal subjects) were included. Endoscopic biopsies were collected and incubated with and without LGG or LGG-conditioned media to evaluate the mucosal adhesion and anti-inflammatory effects [reduction of tumor necrosis factor alpha (TNFα) and interleukin (IL)-17 expression] of the bacteria, and extraction of DNA and RNA for quantification by real-time (RT)-PCR occurred after the incubation. A dose-response study was performed by incubating biopsies at 'regular', double and 5 times higher doses of LGG. For the in vivo experiment, a total of 42 patients (20 UC patients and 22 normal controls) were included. Biopsies were taken from the colons of normal subjects who consumed a commercial formulation of LGG for 7 d prior to the colonoscopy,and the adhesion of the bacteria to the colonic mucosa was evaluated by RT-PCR and compared with that of control biopsies from patients who did not consume the formulation. LGG adhesion and TNFα and IL-17 expression were compared between UC patients who consumed a regular or double dose of LGG supplementation prior to colonoscopy.RESULTS In the ex vivo experiment, LGG showed consistent adhesion to the distal and proximal colon in normal subjects and UC patients, with a trend towards higher concentrations in the distal colon, and in UC patients, adhesion was similar in biopsies with active and quiescent inflammation. In addition, bioptic samples from UC patients incubated with LGG conditioned media (CM) showed reduced expression of TNFα and IL-17 compared with the corresponding expression in controls (P < 0.05). Incubation with a double dose of LGG increased mucosal adhesion and the anti-inflammatory effects (P < 0.05). In the in vivo experiment, LGG was detectable only in the colon of patients who consumed the LGG formulation, and bowel cleansing did not affect LGG adhesion. UC patients who consumed the double LGG dose had increased mucosal concentrations of the bacteria and reduced TNFα and IL-17 expression compared with patients who consumed the regular dose (48% and 40% reduction, respectively, P < 0.05).CONCLUSION In an ex vivo organ culture model, LGG showed consistent adhesion and anti-inflammatory effects. Colonization by LGG after consumption for a week was demonstrated in vivo in the human colon. Increasing the administered dose increased the adhesion and effectiveness of the bacteria. For the first time, we demonstrated that LGG effectively adheres to the colonic mucosa and exerts antiinflammatory effects, both ex vivo and in vivo. | Cristiano Pagnini Vito Domenico Corleto Michela Martorelli Claudio Lanini Giancarlo D'Ambra Emilio Di Giulio Gianfranco Delle Fave | 2018 | World Journal of Gastroenterology2018，24，41： | 2 |
| 3 | A comparative evaluation of methicillin-resistant staphylococci isolated from harness racing-horses,breeding mares and riding-horses in Italy显示文摘Objective:To investigate the prevalence of methicillin-resistant staphylococci(MRS)which is a potencial risk factor of transmission between animals and humans in different types of horses(harness racing-horses,breeding mares and riding-horses)and to compare the antimicrobial resistance of the isolates.Methods:A total of 191 healthy horses,housed at different locations of the Campania Region(Italy),were included in the study.Nasal swab samples were collected from each nostril of the horses.The mecA gene was detected by a nested PCR technique.Antibiotic susceptibility was tested for each isolate.Results:MRS was isolated from nasal samples of 68/191(35.6%;95%CI:28.9%-42.9%)healthy horses.All isolates were coagulase-negative with the exception of two coagulase-positive MRS strains,identified as Staphylococcus aureus and Staphylococcus pseudintermedius.2/83(2.4%;95%,CI:0.4%-9.2%).Interestingly,both coagulase-positive MRS isolates were from harness racing-horses.These horses also presented a significantly higher positivity for MRS(53.3%;95%CI:40.1%-66.1%)than the breeding mares and riding-horses groups.Antibiotic susceptibility testing showed difference between isolates due to different origins except for an almost common high resistance to aminopenicillins,such as ampicillin and amoxicillin.Conclusions:It can be concluded that harness racing-horses may act as a significant reservoir of MRS as compared to breeding mares and riding-horses. | Karina Mallardo Sandra Nizza Filomena Fiorito Ugo Pagnini Luisa De Martino | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，3： | 2 |
| 4 | Alteration of Local Microflora and α-defensins Hyper-production in Colonic Adenoma Mucosa显示文摘 | Cristiano Pagnini Vito D. Corleto Maria Luisa Mangoni Emanuela Pilozzi Maria Simona Torre Rodolfo Marchese Antonella Carnuccio Emilio Di Giulio Gianfranco Delle Fave | 2011 | Journal of Clinical Gastroenterology2011，，7： | 2 |
| 5 | Probiotics in inflammatory bowel disease: Pathophysiological background and clinical applications显示文摘Ulcerative colitis and Crohn's disease, collectively termed the inflammatory bowel diseases(IBD), are chronic inflammatory disorders of the gastrointestinal tract. A 'dysbiotic' relationship between the commensal gut flora and the intestinal mucosa-associated immune system has been at the core of the pathogenesis of these conditions. Probiotics are 'good bacteria' with the ability to benefit the health of the host and their therapeutic application has been studied in IBD. The theoretical basis for such utilization relies upon the ability of probiotic microorganisms to interfere with the dysregulated homeostasis that takes place in IBD and restore the immune-bacterial interaction at the intestinal mucosa. Proposed mechanisms of action include the reconstitution of altered flora composition, enhancement of the integrity of the epithelial barrier, promotion of tolerogenic action by dendritic cells, strengthening of the defensive mechanisms of the innate immunity, and the suppression of pro-inflammatory adaptive immune responses. Despite this abundance of supporting experimental evidence, clinical application of probiotics in IBD has been disappointing. Possible explanations for such discrepancy include the great diversity of microorganisms that fall under the definition of probiotics, the lack of standardization of dosages and administration schemes, the heterogeneity between clinical trials, and the inclusion in the treatment arms of patients with a large variety of clinical phenotypes. Addressing these important issues will be critical for the optimal usage of probiotic-based therapies for patients with IBD. | Cristiano Pagnini Gianfranco Delle Fave Giorgos Bamias | 2013 | World Journal of Immunology2013，3，3： | 2 |
| 6 | Discrete random walk models for space-time fractional diffusion显示文摘 | GORENFLOR MAINARDI F MORETTI D PAGNINI G PARADISI P | 2002 | Chemical Physics2002，284，： | 1 |
| 7 | The Fundamental Solution of the Space-time Fractional Diffusion Equation显示文摘 | Mainardi F Luchko Y Pagnini G | 2001 | Fractional Calculus and Applied Analysis2001，4，2： | 1 |
| 8 | The fundamental solution of the space-time fractional diffusion equation显示文摘 | Mainardi F Luchko Y Pagnini G | 2001 | Fractional Calculus and Applied Analysis2001，4，2： | 1 |
| 9 | Serviceability criteria for wind-induced accderation and damping uncertainties显示文摘 | PAGNINI L C SOLARI G | 1998 | J Wind Eng Ind Aerodyn1998，，76： | 1 |
| 10 | Fractional diffusion: probability distributions and random walk models显示文摘 | GORENFLO R MAINARDI F MORETTI D PAGNINI G PARADISI P | 2002 | Physica A2002，305，： | 1 |
| 11 | Immunological activity of photodynamic therapy for genital warts 显示文摘 | Giomi B Pagnini F Cappuccini A | 2011 | Br J Dermatol2011，164，2： | 1 |
| 12 | Proposal of a new clinical index predictive of endoscopic severity in ulcerative colitis显示文摘 | Azzolini F Pagnini C Camellini L | 2005 | Dig Dis Sci2005，50，2： | 1 |
| 13 | Transanal endoscopic Microsurgery VS tatal mesorectal laparoscopic resection of T2N0 Low rectal Cancer after neoadjuvant Treatment显示文摘 | Lezoche E Guerieri M Pagnini AM | 2005 | Surg Endose2005，19，： | 1 |
| 14 | Gust buffeting and aeroelastic behavior of poles and monotubular towers 显示文摘 | SOLARI G PAGNINI L C | 1999 | Journal of Fluids and Structures1999，13，7： | 1 |
| 15 | Stochastic analysis of the linear equivalent response of bridge piers with aseismic device显示文摘 | Pagnini L C Solari G | 1999 | Earthquake Engineering and Structural Dynamics1999，28，5： | 1 |
| 16 | The Fundamental Solution of the Space-time Fractional Diffusion Equation显示文摘 | Mainardi F Luchko Y Pagnini G | 2001 | Frac- tional Calculus and Applied Analysis2001，4，2： | 1 |
| 17 | Immunological activity of photody- namic therapy for genital warts 显示文摘 | Giomi B Pagnini F Cappuceini A | 2011 | British Journal of Dermatology2011，164，2： | 1 |
| 18 | What do cytokine profiles tell us about subsets of juvenile idiopathic arthritis显示文摘 | Cimaz R Moretti D Pagnini I | 2012 | Curr Rheumatol Rep2012，14，2： | 1 |
| 19 | Immunological adivity of photodynamic therapy for genital warts 显示文摘 | Giomi B Pagnini F Cappuccini A | | Br J Dermato10，164，2： | 1 |
| 20 | Delayed endolymphatic hydrops显示文摘 | Giannoni B Pagnini P Vannucchi P | 1998 | Acta Otorhinolaryngol Ital1998，18，： | 1 |
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