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| 1 | Hirschsprung's disease:Historical notes and pathological diagnosis on the occasion of the 100^(th) anniversary of Dr.Harald Hirschsprung's death显示文摘Hirschsprung's disease(HSCR) or congenital megacolon is one of the differential diagnoses of chronic constipation mostly in infancy and may indeed represent a challenge for pediatricians, pediatric surgeons, and pediatric pathologists. The diagnosis relies clearly on the identification of the absence of ganglion cells at the plexuses(submucosus and myentericus) of the bowel wall. HSCR is usually located at the terminal(distal) rectum with potential pre-terminal or proximal extension to the less distal large bowel(sigmoid colon). Astonishingly, there is some evidence that Hindu surgeons of prehistoric India may have been exposed and had considerable knowledge about HSCR, but this disease is notoriously and eponymously named to Dr. Harald Hirschsprung(1830-1916), who brilliantly presented two infants with fatal constipation at the Berlin conference of the German Society of Pediatrics more than one century ago. Historical milestones and diagnosis of HSCR(originally called 'Die Hirschsprungsche Krankheit') are reviewed. More than 100 years following his meticulous and broad description, HSCR is still a puzzling disease for both diagnosis and treatment. HSCR remains a critical area of clinical pediatrics and pediatric surgery and an intense area of investigation for both molecular and developmental biologists. | Consolato Sergi | 2015 | World Journal of Clinical Pediatrics2015，4，4： | 4 |
| 2 | Angiogenic Remodeling in Pediatric EoE Is Associated With Increased Levels of VEGF-A, Angiogenin, IL-8, and Activation of the TNF-α–NFκB Pathway显示文摘 | Rabindranath Persad Hien Q. Huynh Li Hao Jacqueline R. Ha Consolato Sergi Rahul Srivastava Sujata Persad | 2012 | Journal of Pediatric Gastroenterology and Nutrition2012，，3： | 2 |
| 3 | Medical management of motility disorders in patients with in- testinal failure: a focus on necrotizing enterocolitis, gastros- chisis, and intestinal atresia 显示文摘 | Bryan J Dicken Consolato Sergi Frederick J Rescorla | 2011 | Journal of Pediatric Surger-y2011，46，8： | 1 |
| 4 | Biliary-Type Cytokeratin Pattern in a Canine Isolated Perfused Liver Transplantation Model显示文摘 | Consolato Sergi Wolfgang Gross Martin Mory Michael Schaefer Martha-Maria Gebhard | 2008 | Journal of Surgical Research2008，，2： | 1 |
| 5 | Faecal elastase-1 is an independent predictor of survival in advanced pancreatic cancer显示文摘 | Stefano Partelli Luca Frulloni Consolato Minniti Claudio Bassi Giuliano Barugola Mirko D’Onofrio Stefano Crippa Massimo Falconi | 2012 | Digestive and Liver Disease2012，，11： | 1 |
| 6 | Promptly reporting of critical laboratory values in pediatrics:A work in progress显示文摘In the 21st century,the determination of alert thresholds remains the most challenging and controversial issue in clinical pediatrics.Pre-analytical,analytical,and postanalytical matters will consolidate or undermine the fate of any laboratory process.Pre-analytical issues need to be cleared off before the laboratory physician can dispatch the result to the pediatrician in charge.Once it is cleared off,the classification of essential laboratory results is paramount.It is more than an academic exercise and may be subdivided in the order of priority we handle it to inform promptly and safely the primary physicians.Currently,we are applying new modes of making sure relevant information is transmitted without interrupting the standard workflow of the primary physicians in charge for the child,who eventually need a fast line of action for results that may be lifethreatening. | Consolato Sergi | 2018 | World Journal of Clinical Pediatrics2018，7，5： | 0 |
| 7 | PathVisio Analysis:An Application Targeting the miRNA Network Associated with the p53 Signaling Pathway in Osteosarcoma显示文摘MicroRNAs(miRNAs)are small single-stranded,non-coding RNA molecules involved in the pathogenesis and progression of cancer,including osteosarcoma.We aimed to clarify the pathways involving miRNAs using new bioinformatics tools.We applied WikiPathways and PathVisio,two open-source platforms,to analyze miRNAs in osteosarcoma using miRTar and ONCO.IO as integration tools.We found 1298 records of osteosarcoma papers associated with the word“miRNA”.In osteosarcoma patients with good response to chemotherapy,miR-92a,miR-99b,miR-193a-5p,and miR-422a expression is increased,while miR-132 is decreased.All identified miRNAs seem to be centered on the TP53 network.This is the first application of PathVisio to determine miRNA pathways in osteosarcoma.MiRNAs have the potential to become a useful diagnostic and prognostic tool in the management of osteosarcoma.PathVisio is a full pathway editor with the potentiality to illustrate the biological events,augment graphical elements,and elucidate all the physical structures and interactions with standard external database identifiers. | MERVIN BURNETT VITO RODOLICO FAN SHEN ROGER LENG MINGYONG ZHANG DAVID D.EISENSTAT CONSOLATO SERGI | 2021 | BIOCELL2021，45，1： | 0 |
| 8 | Vitamin D supplementation for autoimmune hepatitis: A need for further investigation显示文摘Autoimmune hepatitis is a chronic liver disease harboring an autoimmune basis and progressive character.Despite still obscurity in etiology and pathogenesis,some evidence supports the importance of sustaining the immune system.Vitamin D is a lipo-soluble vitamin,which has been identified as decreased in our body.It is often due to the daily habit change and decrease of individual sun exposure due to the increase of the ultraviolet-induced potential melanocytic transformation.Here,we emphasize the importance of vitamin D supplementation in patients affected with liver disease. | Consolato M Sergi | 2022 | World Journal of Hepatology2022，14，1： | 0 |
| 9 | Intraepithelial lymphocytes, scores, mimickers and challenges in diagnosing gluten-sensitive enteropathy(celiac disease)显示文摘The upper digestive tract is routinely scoped for several causes of malabsorption, and the number of duodenal biopsy specimens has increased notably in the last 10 years. Gluten-sensitive enteropathy(GSE) is an autoimmune disease, which shows an increasing prevalence worldwide and requires a joint clinicopathological approach. The classical histopathology of GSE with partial or total villous blunting is well recognized, but the classification of GSE is not straightforward. Moreover, several mimickers of GSE with intraepithelial lymphocytosis have been identified in the last 20 years, with drug interactions and medical comorbidities adding to the conundrum. In this review, we report on the normal duodenal mucosa, the clinical presentation and laboratory diagnosis of GSE, the duodenal intraepithelial lymphocytes and immunophenotype of GSE-associated lymphocytes, the GSE mimickers, the differences 'across oceans' among guidelines in diagnosing GSE, and the use of a synoptic report for reporting duodenal biopsies in both children and adults in the 21^(st) century. | Consolato Sergi Fan Shen Gerd Bouma | 2017 | World Journal of Gastroenterology2017，23，4： | 0 |
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