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您的检索式：作者名="DAVID D.EISENSTAT"
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| 1 | PathVisio Analysis:An Application Targeting the miRNA Network Associated with the p53 Signaling Pathway in Osteosarcoma显示文摘MicroRNAs(miRNAs)are small single-stranded,non-coding RNA molecules involved in the pathogenesis and progression of cancer,including osteosarcoma.We aimed to clarify the pathways involving miRNAs using new bioinformatics tools.We applied WikiPathways and PathVisio,two open-source platforms,to analyze miRNAs in osteosarcoma using miRTar and ONCO.IO as integration tools.We found 1298 records of osteosarcoma papers associated with the word“miRNA”.In osteosarcoma patients with good response to chemotherapy,miR-92a,miR-99b,miR-193a-5p,and miR-422a expression is increased,while miR-132 is decreased.All identified miRNAs seem to be centered on the TP53 network.This is the first application of PathVisio to determine miRNA pathways in osteosarcoma.MiRNAs have the potential to become a useful diagnostic and prognostic tool in the management of osteosarcoma.PathVisio is a full pathway editor with the potentiality to illustrate the biological events,augment graphical elements,and elucidate all the physical structures and interactions with standard external database identifiers. | MERVIN BURNETT VITO RODOLICO FAN SHEN ROGER LENG MINGYONG ZHANG DAVID D.EISENSTAT CONSOLATO SERGI | 2021 | BIOCELL2021，45，1： | 0 |
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