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| 1 | Electroporative interleukin-10 gene transfer ameliorates carbon tetrachlo-ride-induced murine liver fibrosis by MMP and TIMP modulation显示文摘瞄准:肝纤维变性代表响应长期的肝损伤愈合并且结疤的一个过程。为肝纤维变性的有效治疗正在缺乏。Interleukin-10 (IL-10 ) 是 cytokine 下面调整支持 inflammatory 回答并且在肝的纤维发生上有调节效果。这研究的目的是调查 electroporative IL-10 基因治疗是否在老鼠上有肝的 fibrolytic 效果。方法:肝的纤维变性被在老鼠管理四氯化碳(CCl4 ) 10 个星期导致。在肝的纤维变性被建立以后,人的 IL-10 表示原生质标志经由 electroporation 被交付。组织病理学说,反向的抄写聚合酶链反应(RT-PCR ) ,弄污的免疫,和明胶 zymography 被用来调查 IL-10 的行动的可能的机制。结果:人的 IL-10 基因治疗在老鼠颠倒了导致 CCl4 的肝纤维变性。RT-PCR 表明那 IL-10 基因治疗稀释了肝 TGF-beta1,骨胶原 alpha1, fibronectin,和房间粘附分子在规定上面的 mRNA。后面的基因转移,两个都, alpha 光滑的肌肉肌动朊和 cyclooxygenase-2 的激活显著地被稀释。而且, IL-10 显著地禁止了矩阵 metalloproteinase-2 (MMP-2 ) 和矩阵 metalloproteinase (TIMP ) 的织物禁止者在 CCl4 沉醉以后的激活。结论:我们证明那 IL-10 基因治疗在老鼠稀释了导致 CCl4 的肝纤维变性。在调整 fibrogenic 和支持 inflammatory 基因回答上面阻止的 IL-10。它的溶胶原效果可以被归因于 MMP 和 TIMP 调整。IL-10 基因治疗可以是对有潜在的临床的使用的肝纤维变性的一种有效治疗学的形式。 | Wen-ying CHOU Cheng-nan LU Tsung-hsing LEE Chia-ling WU Kung-sheng HUNG Allan M CONCEJERO Bruno JAWAN Cheng-haung WANG | 2006 | Acta Pharmacologica Sinica2006，27，4： | 25 |
| 2 | Left-sided gallbladder:Its clinical significance and imaging presentations显示文摘AIM: To assess the importance of preoperative diagnosis and presentation of left-sided gallbladder using ultrasound (US),CT and angiography. METHODS: Retrospective review of 1482 patients who underwent enhanced CT scanning was performed. Left-sided gallbladder was diagnosed if a right-sided ligamentum teres was present. The image presentations on US,CT and angiography were also reviewed. RESULTS: Left-sided gallbladder was diagnosed in nine patients. The associated abnormalities on CT imaging included portal vein anomalies,absence of umbilical portion of the portal vein in the left lobe of the liver,club-shaped portal vein in the right lobe of the liver,and difficulty in identifying segment Ⅳ. Angiography in six of nine patients demonstrated abnormal portal venous system (trifurcation type in four of six patients). The main hepatic arteries followed the portal veins in all six patients. The segment Ⅳ artery was identified in four of six patients using angiography,although segment Ⅳ was difficult to define on CT imaging. Hepatectomy was performed in three patients with concomitant liver tumor and the diagnosis of left-sided gallbladder was confirmed intraoperatively. CONCLUSION: Left-sided gallbladder is an important clinical entity in hepatectomy due to its associated portal venous and biliary anomalies. It should be considered in US,CT and angiography images that demonstrate no definite segment Ⅳ,absence of umbilical portion of the portal vein in the left lobe,and club-shaped right anterior portal vein. | Sheng-Lung Hsu Tai-Yi Chen Tung-Liang Huang Cheuk-Kwan Sun Allan M Concejero Leo Leung-Chit Tsang Yu-Fan Cheng | 2007 | World Journal of Gastroenterology2007，13，47： | 6 |
| 3 | Macro-regenerative nodules in biliary atresia:CT/MRI findings and their pathological relations显示文摘AIM: To describe the radiological findings of a macro-regenerative nodule (MRN) in the liver of pre-transplantation biliary atresia (BA) patients and to correlate it with histological findings. METHODS: Between August 1990 and November 2007, 144 BA patients underwent liver transplantation (LT) at our institution. The pre-transplantation computer tomograghy (CT) and magnetic resonance imaging (MRI) findings were reviewed and correlated with the post-transplantation pathological findings. RESULTS: Nine tumor lesions in 7 patients were diagnosed in explanted livers. The post-transplantation pathological findings showed that all the lesions were MRNs without malignant features. No small nodule was detected by either MRI or CT. Of the 8 detectable lesions, 6 (75%) were in the central part of the liver, 5 (63%) were larger than 5 cm, 5 (63%) had intra- tumor tubular structures, 3 (38%) showed enhancing fibrous septa, 3 (38%) had arterial enhancement in CT, one (13%) showed enhancement in MRI, and one (13%) had internal calcifications. CONCLUSION: Although varied in radiological appearance, MRN can be differentiated from hepatocellular carcinoma (HCC) in most of BA patients awaiting LT. The presence of an arterial-enhancingnodule does not imply that LT is withheld solely on the basis of presumed malignancy by imaging studies. Liver biopsy may be required in aid of diagnostic imaging to exclude malignancy. | Jiun-Lung Liang Yu-Fan Cheng Allan M Concejero Tung-Liang Huang Tai-Yi Chen Leo Leung-Chit Tsang Hsin-You Ou | 2008 | World Journal of Gastroenterology2008，14，28： | 4 |
| 4 | Comparison of Postoperative Morphine Requirements in Healthy Living Liver Donors, Patients With Hepatocellular Carcinoma Undergoing Partial Hepatectomy, and Liver Transplant Recipients显示文摘 | J.-P. Chen B. Jawan C.-L. Chen C.-H. Wang K.-W. Cheng C.-C. Wang A.M. Concejero E. Villagomeza C.-J. Huang | 2010 | Transplantation Proceedings2010，，3： | 2 |
| 5 | Early post-operative complications in living donor liver transplantation:prevention,detection and management显示文摘Living donor liver transplantation (LDLT) is now performed with high rates of success due to judicious recipient and donor selection,careful preoperative planning, excellent anesthesia management, and prompt detection and treatment of complications. The indications for LDLT for adult and pediatric recipients should be the same as for deceased donor liver transplantation. Early postoperative complications are often defined as complications occurring within the first 3 | Allan M. Concejero | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，4： | 2 |
| 6 | Resection of Large Hepatocellular Carcinoma Using the Combination of Liver Hanging Maneuver and Anterior Approach显示文摘 | Chih-Chi Wang Kailash Jawade Anthony Q. Yap Allan M. Concejero Chi-Yin Lin Chao-Long Chen | 2010 | World Journal of Surgery2010，，8： | 2 |
| 7 | Living donor liver trans plantation for biliary at resia: a single center experience with first 100 cases显示文摘 | Chen C L Concejero A Wang C C | 2006 | Am J Transplant2006，，： | 1 |
| 8 | Living donor liver transplantation for biliary atresia:a single-centre experience with first 100 cases显示文摘 | Chen CL Concejero A Wang CC | 2006 | Am J Transpl2006，6，11： | 1 |
| 9 | Living donor liver trans- plantation for biliary atresia: a single-center experience with first 100 cases显示文摘 | Chen CL Concejero A Wrang CC | 2006 | Am J Transplant2006，6，11： | 1 |
| 10 | Comparison of three techniques of anterior fusion in single-level cervical disc herniation显示文摘 | Garcia de las HB Concejero LV | 1998 | Eur Spine J1998，7，： | 1 |
| 11 | Intraoperative Portal Vein Stent Placement in Pediatric Living Donor Liver Transplantation显示文摘 | Chao-Long Chen Allan M. Concejero Hsin-You Ou Yu-Fan Cheng Chun-Yen Yu Tung-Liang Huang | 2012 | Journal of Vascular and Interventional Radiology2012，，5： | 1 |
| 12 | Routine microsmgical biliary reconstruction decreases early anastomotic complications in living donor liver transplantation 显示文摘 | Lin TS Concejero AM Chen CL | 2009 | Liver Transpl2009，15，12： | 1 |
| 13 | Routine microsurgical biliary reconstruction decreases early anastomotic complications in living donor liver transplantation显示文摘 | Lin TS Concejero AM Chen CL | 2009 | Liver Transplantation2009，，12： | 1 |
| 14 | Outcome of routine use of microsurgical biliary reconstruction in pediatric living donor liver transplantation显示文摘 | Chen CL Concejero AM Lin TS | 2013 | J Hepatobiliary Pancreat Sci2013，，05： | 1 |
| 15 | Living donor liver transplantation for biliary atresia: a single-center experience with first 100 cases 显示文摘 | Chen CL Concejero A Wang CC | 2006 | Am J Transplant2006，6，11： | 1 |
| 16 | Outcome of routine use of microsurgical biliary reconstruction in pediatric living donor liver transplantation显示文摘 | Chao-Long Chen Allan M. Concejero Tsan-Shiun Lin Yu-Hung Lin Yuan-Cheng Chiang Chih-Chi Wang Shih-Ho Wang Chih-Che Lin Yueh-Wei Liu Chee-Chien Yong | 2013 | Journal of Hepato-Biliary-Pancreatic Sciences2013，，5： | 1 |
| 17 | Doppler Ultrasound Evaluation of Postoperative Portal Vein Stenosis in Adult Living Donor Liver Transplantation显示文摘 | T.L. Huang Y.F. Cheng T.Y. Chen L.L. Tsang H.Y. Ou C.Y. Yu C.C. Wang S.H. Wang C.L. Lin H.K. Cheung H.L. Eng B. Jawan A.M. Concejero C.L. Chen | 2010 | Transplantation Proceedings2010，，3： | 1 |
| 18 | Living donor liver transplantation for biliary atresia:a single-center experience with first 100 cases显示文摘 | Chen CL Concejero A Wang CC | 2006 | Am J Transplant2006，6，： | 1 |
| 19 | Active immunization to prevent de novo hepatitis B virus infection in pediatric live donor liver recipients显示文摘 | Lin CC Chen CL Concejero A | | 0，，01： | 1 |
| 20 | Intraoperative Portal Vein Stent Placement in Pediatric Living Donor Liver Transplantation显示文摘 | Chao-Long Chen Allan M. Concejero Hsin-You Ou Yu-Fan Cheng Chun-Yen Yu Tung-Liang Huang | 2012 | Journal of Vascular and Interventional Radiology2012，，5： | 1 |
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