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| 1 | Role of bacterial and genetic factors in gastric cancer in Costa Rica显示文摘AIM: To evaluate several risk factors for gastric cancer (GC) in Costa Rican regions with contrasting GC incidence rate (GCIR). METHODS: According to GCIR, 191 Helicobacter pylori (H pylori)-positive patients were classified into groups A (high GCIR, n = 101) and B (low GCIR, n = 90). Human DNA obtained from biopsy specimens was used in the determination of polymorphisms of the genes coding for interleukin (IL)-1β and IL-10 by PCR-RFLP, and IL-1RN by PCR. H pylori DNA extractions obtained from clinical isolates of 83 patients were used for PCR-based genotyping of H pylori cagA, vacA and babA2. Human DNA from gastric biopsies of 52 GC patients was utilized for comparative purposes. RESULTS: Cytokine polymorphisms showed no association with GCIR variability. However, gastric atrophy, intestinal metaplasia and strains with different vacA genotypes in the same stomach (mixed strain infection) were more frequently found in group A than in group B, and cagA and vacA s1b were signif icantly associated with high GCIR (P = 0.026 and 0.041, respectively). IL- 1β+3954_T/C (OR 2.1, 1.0-4.3), IL-1RN*2/L (OR 3.5, 1.7-7.3) and IL-10-592_C/A (OR 3.2, 1.5-6.8) were individually associated with GC, and a combination of these cytokine polymorphisms with H pylori vacA s1b and m1 further increased the risk (OR 7.2, 1.4-36.4). CONCLUSION: Although a proinflammatory cytokine genetic profile showed an increased risk for developing GC, the characteristics of H pylori infection, in particular the status of cagA and vacA genotype distribution seemed to play a major role in GCIR variability in Costa Rica. | Sergio A Con Hiroaki Takeuchi Gil R Con-Chin Vicky G Con-Chin Nobufumi Yasuda Reinaldo Con-Wong | 2009 | World Journal of Gastroenterology2009，15，2： | 9 |
| 2 | Clinical relevance of Helicobacter pylori babA2 and babA2/B in Costa Rica and Japan显示文摘AIM:To evaluate the prevalence of Helicobacter pylori(H.pylori ) babA2 ,babB and a recombinant gene between babA2 and babB(babA2/B ),and their role in the development of atrophic gastritis in Costa Rican and Japanese clinical isolates.METHODS:A total of 95 continuous H.pylori-positive Costa Rican(41 males and 54 females;mean age,50.65 years;SD,± 13.04 years) and 95 continuous H.pylori-positive Japanese(50 males and 45 females;mean age,63.43;SD,± 13.21 years) patients underwent upper endoscopy from October 2005 to July 2006.They were enrolled for the polymerase chain reaction(PCR)-based genotyping of the H.pylori babA2 ,babB and babA2/B genes.Statistical analysis was performed using the χ2 test and the Fisher's exact probability test and multivariate analysis was performed by logistic regression adjusting for gender and age.P < 0.05 was regarded as statistically significant.RESULTS:The PCR-based genotyping of 95 Costa Rican and 95 Japanese isolates showed a higher prevalence of babA2 in Japan(96.8%) than in Costa Rica(73.7%),while that of babA2/B was higher in Costa Rica(11.6%) than in Japan(1.1%).In Costa Rican isolates only,babA2 was significantly associated with atrophic gastritis(P = 0.01).CONCLUSION:These results suggest that the status of babA2 and babA2/B shows geographic differences,and that babA2 has clinical relevance in Costa Rica. | Sergio A Con Hiroaki Takeuchi Mitsuaki Nishioka Norihito Morimoto Tetsuro Sugiura Nobufumi Yasuda Reinaldo Con-Wong | 2010 | World Journal of Gastroenterology2010，16，4： | 4 |
| 3 | Deep learning vs conventional learning algorithms for clinical prediction in Crohn's disease: A proof-of-concept study显示文摘BACKGROUND Traditional methods of developing predictive models in inflammatory bowel diseases(IBD)rely on using statistical regression approaches to deriving clinical scores such as the Crohn's disease(CD)activity index.However,traditional approaches are unable to take advantage of more complex data structures such as repeated measurements.Deep learning methods have the potential ability to automatically find and learn complex,hidden relationships between predictive markers and outcomes,but their application to clinical prediction in CD and IBD has not been explored previously.AIM To determine and compare the utility of deep learning with conventional algorithms in predicting response to anti-tumor necrosis factor(anti-TNF)therapy in CD.METHODS This was a retrospective single-center cohort study of all CD patients who commenced anti-TNF therapy(either adalimumab or infliximab)from January 1,2010 to December 31,2015.Remission was defined as a C-reactive protein(CRP)<5 mg/L at 12 mo after anti-TNF commencement.Three supervised learning algorithms were compared:(1)A conventional statistical learning algorithm using multivariable logistic regression on baseline data only;(2)A deep learning algorithm using a feed-forward artificial neural network on baseline data only;and(3)A deep learning algorithm using a recurrent neural network on repeated data.Predictive performance was assessed using area under the receiver operator characteristic curve(AUC)after 10×repeated 5-fold cross-validation.RESULTS A total of 146 patients were included(median age 36 years,48%male).Concomitant therapy at anti-TNF commencement included thiopurines(68%),methotrexate(18%),corticosteroids(44%)and aminosalicylates(33%).After 12 mo,64%had CRP<5 mg/L.The conventional learning algorithm selected the following baseline variables for the predictive model:Complex disease behavior,albumin,monocytes,lymphocytes,mean corpuscular hemoglobin concentration and gamma-glutamyl transferase,and had a cross-validated AUC of 0.659,95%confidence interval(CI):0.562-0.756.A feed-forward artificial neural network using only baseline data demonstrated an AUC of 0.710(95%CI:0.622-0.799;P=0.25 vs conventional).A recurrent neural network using repeated biomarker measurements demonstrated significantly higher AUC compared to the conventional algorithm(0.754,95%CI:0.674-0.834;P=0.036).CONCLUSION Deep learning methods are feasible and have the potential for stronger predictive performance compared to conventional model building methods when applied to predicting remission after anti-TNF therapy in CD. | Danny Con Daniel R van Langenberg Abhinav Vasudevan | 2021 | World Journal of Gastroenterology2021，27，38： | 2 |
| 4 | Current management of chemotherapy-induced neutropenia in adults:key points and new challenges显示文摘Chemotherapy-induced neutropenia(CIN)is a potentially fatal and common complication in myelosuppressive chemotherapy.The timing and grade of CIN may play prognostic and predictive roles in cancer therapy.CIN is associated with older age,poor functional and nutritional status,the presence of significant comorbidities,the type of cancer,previous chemotherapy cycles,the stage of the disease,specific chemotherapy regimens,and combined therapies.There are many key points and new challenges in the management of CIN in adults including:(1)Genetic risk factors to evaluate the patient’s risk for CIN remain unclear.However,these risk factors urgently need to be identified.(2)Febrile neutropenia(FN)remains one of the most common reasons for oncological emergency.No consensus nomogram for FN risk assessment has been established.(3)Different assessment tools[e.g.,Multinational Association for Supportive Care in Cancer(MASCC),the Clinical Index of Stable Febrile Neutropenia(CISNE)score model,and other tools]have been suggested to help stratify the risk of complications in patients with FN.However,current tools have limitations.The CISNE score model is useful to support decision-making,especially for patients with stable FN.(4)There are still some challenges,including the benefits of granulocyte colony stimulating factor treatment and the optimal antibiotic regimen in emergency management of FN.In view of the current reports,our group discusses the key points,new challenges,and management of CIN. | Committee of Neoplastic Supportive-Care(CONS),China Anti-Cancer Association Committee of Clinical Chemotherapy,China Anti-Cancer Association Yi Ba Yuankai Shi Wenqi Jiang Jifeng Feng Ying Cheng Li Xiao Qingyuan Zhang Wensheng Qiu Binghe Xu Ruihua Xu Bo Shen Zhiguo Luo Xiaodong Xie Jianhua Chang Mengzhao Wang Yufu Li Yuerong Shuang Zuoxing Niu Bo Liu Jun Zhang Li Zhang Herui Yao Conghua Xie Huiqiang Huang Wangjun Liao Gongyan Chen Xiaotian Zhang Hanxiang An Yanhong Deng Ping Gong Jianping Xiong Qinghua Yao Xin An Cheng Chen Yanxia Shi Jialei Wang Xiaohua Wang Zhiqiang Wang Puyuan Xing Sheng Yang Chenfei Zhou | 2020 | Cancer Biology & Medicine2020，17，4： | 2 |
| 5 | Mechanical thrombectomy with the S olitaire AB device in large intracerebral artery occlusions显示文摘 | John J McCabe Timothy J Phillips Con Phatouros Tejinder Singh David Blacker Graeme J Hankey William McAuliffe | 2012 | Journal of Medical Imaging and Radiation Oncology2012，，2： | 2 |
| 6 | The SNW Domain of SKIP Is Required for Its Integration into the Spliceosome and Its Interaction with the Pall Complex in Arabidopsis显示文摘翻斗车是从酵母的保存蛋白质到植物和人。在工厂房间,翻斗车是由由与 Paf1 建筑群交往集成到 spliceosome 并且作为 transcriptional 使活跃之物作为一个拼接的因素在原子核工作的一个 bifunctional 管理者。在这研究,我们在翻斗车识别了二个原子本地化信号并且证实那各对足够目标翻斗车到原子核。翻斗车的 SNW 域被由与 Paf1 建筑群控制它的相互作用参予 flowering 作为 transcriptional 使活跃之物响应应力,和它的函数支持集成进 spliceosome 作为一个拼接的因素为它的函数要求。包括了翻斗车的 SNW 领域和 N 终点或 C 终点的截断的蛋白质仍然能在基因在 Arabidopsis 拼接和 transcriptional 激活执行全身的蛋白质的功能。另外,我们发现那个翻斗车经历 26S 调停 proteasome 的降级,并且翻斗车的 C 终点被要求在工厂房间维持蛋白质的稳定性。一起,我们的调查结果表明翻斗车的结构的域组织并且在工厂揭示核心域和主题位于 \O 下面翻斗车功能。 | Yan Li Con qconcl Xia Jinlin Feng Dong Yang Fangming Wu Ying Cao Legong Li Ligeng Ma | 2016 | Molecular Plant2016，9，7： | 2 |
| 7 | Azithromycin for the secondary prevention of coronary heart disease events:The WIZARD study:a randomized controlled trial显示文摘 | O'Con nor CM Dun ne M W Pfeffer M A | | 0，，： | 1 |
| 8 | Production of bacteriocin-like metabolites by lactic acid cultures isolated from sucuk samples显示文摘 | Con A H Gokalp H Y | 2000 | Meat Science2000，55，1： | 1 |
| 9 | Revised 2003 consensus on diagnostic criteria and long-term health risks re lated to polycystic ovary syndrome显示文摘 | Rotterdam ESHRE /ASRM-Sponsored PCOS Con sensus Workshop Group | 2004 | Fertil Ster- il2004，81，1： | 1 |
| 10 | An observational, retrospective analysis of retreatment with Bortezomib for multiple myeloma 显示文摘 | CON N ER TM DONA QD WALTERS IB | 2008 | Clin Lymphoma Myeloma2008，8，3： | 1 |
| 11 | Solifenacin: as effective in mixed urinary incontinence as in urge urinary incontinence显示文摘 | Con Kelleher Linda Cardozo Kathleen Kobashi Vincent Lucente | 2006 | International Urogynecology Journal2006，，4： | 1 |
| 12 | Blood pressure is associated with the presence and severity of nonalcoholic fatty liver disease across the spectrum of cardiometabolic risk显示文摘 | Ehimen C. Aneni Ebenezer T. Oni Seth S. Martin Michael J. Blaha Arthur S. Agatston Theodore Feldman Emir Veledar Raquel D. Con?eicao Jose A.M. Carvalho Raul D. Santos Khurram Nasir | 2015 | Journal of Hypertension2015，，6： | 1 |
| 13 | Expression of survivin and its relationship to loss of apoptosis in breast carcinomas显示文摘 | Tanaka K Lwamoto S Con G | 2000 | Clin Cancer Res2000，6，： | 1 |
| 14 | The mechanical bind-ing strengths of Helicobacter pylori BabA and SabA adhesins u-sing an adhesion binding assay-ELISA,and its clinical relevancein Japan显示文摘 | Nishioka M Takeuchi H Con SA | 2010 | Microbiol Immunol2010，54，8： | 1 |
| 15 | Effica- cy and safety of second-generation antipsychotics in chil- dren and adolescents with psychotic and bipolar spectrum disorders: comprehensive review of prospective head-to- head and placebo-controlled comparisons显示文摘 | Fraguas D Con'ell CU Merchin-Naranjo J | 2011 | European Ne- uropsychopharmacology2011，21，8： | 1 |
| 16 | Expression of surviving and its relationship to loss of apoptosis in breast carcinomas显示文摘 | Tanaka K Iwamoto S Con G | 2000 | Clin Cancer Res2000，6，： | 1 |
| 17 | “Shifting From Cleanups to Greenup”Cheem 显示文摘 | Conning Kathie | 2001 | Proeesing2001，64，499： | 1 |
| 18 | Subcutaneours panni culitis-like T-cell lymphoma显示文摘 | Salhany KE Ma Con WR Choi JK | 1998 | Am J Surg pathol1998，22，7： | 1 |
| 19 | An update on the role of markers of inflammation in atherosclerosis 显示文摘 | Con'ado E Rizzo M Coppola G | 2010 | J Atheroscler Thromb2010，17，1： | 1 |
| 20 | Credit constrains and the impact of property rights on the quantity and composition of investment显示文摘 | Conning&Udry | 2005 | American journal of agricultural economics2005，，5： | 1 |
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