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| 1 | 北京石景山工业区附近一个污染土壤剖面的磁学研究显示文摘对北京西郊石景山工业区附近的土壤剖面进行环境磁学研究,结合粒度、金属元素分析、磁学指标测试和多元统计分析,发现磁参数(χ,ARM,SIRM)与重金属元素(Mn,Cu,Fe,Pb,Zn,Al,Sr)含量呈同步垂向变化趋势.来源于工业区附近工业生产排放(钢铁厂、发电厂、水泥厂)的污染物是土壤剖面上部(0-3cm)磁性和金属含量增强的主要原因,由富集在细粉砂和中粉砂的多畴磁铁矿主导了样品的磁性特征.3—10cm重金属含量逐渐下降,土壤的磁性特征与上层相似,但磁性矿物含量降低,属于剖面中的迁移过渡阶段.10cm以下,土壤基本未受到污染,磁性矿物和重金属含量都低,磁性颗粒大小变化稳定,基本代表了该地区土壤的自然背景.指标聚类和相关分析表明,土壤磁参数与重金属元素含量显著相关.结合模糊聚类分析,磁参数可用于追踪、识别工业污染物质在土壤剖面中的富集、迁移状态,揭示不同深度土壤的污染程度. | 沈明洁 胡守云 U. Blaha 闫海涛 W. Rsler V. Hoffmann | 2006 | 地球物理学报2006，49，6： | 44 |
| 2 | 南京某钢铁公司周边耕作土壤的磁学性质与重金属污染的相关性研究显示文摘对取自于南京西南郊某钢铁公司附近水稻田土壤NJ008样芯进行了磁性测量和重金属含量分析,探讨了利用农业耕作土壤的磁参数指示工业区周围重金属污染的可行性.环境磁学测试结果表明:磁化率(χ)、非磁滞剩磁(ARM)及饱和等温剩磁(SIRM)在土壤剖面上部20cm显著增强,磁化率平均值达到112.5×10?8m3·kg?1;20cm以下呈现为较低磁背景特征,磁化率平均值为27.8×10?8m3·kg?1.进一步的磁学实验证明低矫顽力的亚铁磁矿物主导了NJ008样芯的磁性特征,不完整反铁磁性矿物在20cm以下土壤中含量相对较高.Ni,Cu,Fe,Pb,V和Zn等重金属与磁化率呈现相同的变化特征.主成分分析表明亚铁磁性矿物和重金属受同一主成分控制,且磁指标(χ,ARM和SIRM)与重金属(Ni,Cu,Fe,Pb,V和Zn)呈显著相关关系(0.69≤R≤0.98).对远离钢铁公司的同种耕作土壤剖面NJ013测试表明:其磁化率随深度变化不大,绝对值与NJ008在20cm以下磁背景值基本一致.表明耕作过程中的化肥和农药对土壤磁化率影响不大,钢铁公司释放的工业污染是NJ008土壤剖面中磁化率显著增强的主要原因.耕作土壤由于反复翻种,虽然不能用于污染历史及污染物迁移过程研究,但基于磁指标与部分重金属之间的显著相关性,耕作土壤仍然可以用于重金属污染分布范围的圈定和相对污染程度评价. | 段雪梅 胡守云 闫海涛 Blaha U. Rǒsler W. Appel E. 孙伟华 | 2009 | 中国科学(D辑)2009，39，9： | 26 |
| 3 | 北京首钢工业区大气重金属污染树叶的磁学响应显示文摘在北京西郊首钢工业区及附近混杂的居民区、公园绿地和农村耕作区采集了55个一年生的树叶样品,并对其进行岩石磁学和元素含量分析.结果表明:磁性矿物的含量和粒径由污染源区向周边递减.研究区域树叶的磁性由低矫顽力的磁铁矿主导.进一步研究表明样品的主要磁性参数(磁化率、非磁滞剩磁以及饱和等温剩磁)与元素Fe,Pb,Cr,V和Zn呈显著相关关系(0.73≤R≤0.88).因此树叶的磁参数可以作为大气重金属污染研究的理想替代指标. | 胡守云 段雪梅 沈明洁 Blaha U Rosler W 闫海涛 Appel E Hoffmann V | 2008 | 科学通报2008，53，4： | 19 |
| 4 | Relationship between magnetic parameters and heavy element contents of arable soil around a steel company,Nanjing显示文摘Magnetic parameters and element contents were determined in core NJ008 collected from the uppermost ca. 40 cm in a steel company in southwest Nanjing. The results showed that magnetic susceptibility (χ), saturation isothermal remanent magnetization (SIRM) and anhysteretic remanent magnetization (ARM) were enhanced in the uppermost 20 cm, with a mean magnetic susceptibility value of 112.5×10-8 m3 kg-1. Below 20 cm, χ decreased sharply with a mean value of 27.8×10-8m3 kg-1. Low-coercivity minerals such as magnetite dominate in arable soils, while the relative content of antiferromagnetic minerals increases below 20 cm. Heavy metals (Ni, Cu, Fe, Pb, V, and Zn) have similar vertical trends as χ. Principal component analysis reveals common high loadings of the same factor for magnetic concentration parameters (χ, ARM, and SIRM) and elements (Ni, Cu, Fe, Pb, V, and Zn) with an excellent linear correlation (0.69≤R≤0.98) between them. Magnetic susceptibility of paddy soil core NJ013, which had the same parent material as NJ008 but was far from pollution sources, showed stable values of magnetic concentration parameters along the whole core. Absolute values correspond to the so-called magnetic background value (below 20 cm) of NJ008. This indicates that pesticide and fertilizer had little effect on magnetic signals of the upper part of core NJ008 and the extremely enhanced magnetic concentration parameters originate from the steel company emission. Although, the arable soil does not reveal the pollution history and transportation due to annual ploughing, the significant linear relationship between magnetic concentration parameters and heavy metal contents suggests that magnetic parameters can serve as a proxy for quickly detecting soil metallic pollution and estimating the extent of contamination. | BLAHA U ROESLER W APPEL E | 2010 | Science China Earth Sciences2010，53，3： | 10 |
| 5 | Magnetic response to atmospheric heavy metal pollution recorded by dust-loaded leaves in Shougang industrial area, western Beijing显示文摘Fifty-five evergreen tree's leaves growing less than one year were collected from Shougang industrial area in western suburb of Beijing, including steel plants and its ambient residential areas, recreational parks and farmlands. Rock magnetic properties and heavy metal contents were studied. The results show that the magnetic properties of leaf samples are predominated by low-coercivity magnetite, and both the concentration and grain size of magnetite particles gradually decreased with the distance from the main pollution source increases. Moreover, there is a significant linear relationship between magnetic parameters (the low-field magnetic susceptibility, saturation isothermal remanent magnetization and anhysteretic remanent magnetization) and heavy metals contents (Fe, Pb, V, Cr and Zn) (0.73≤R≤ 0.88). Hence, the magnetic parameters of leaves can serve as a proxy for quick detecting of the recent atmospheric metallic pollution. | HU ShouYun DUAN XueMei SHEN MingJie U BLAHA W ROESLER YAN HaiTao E APPEL V HOFFMANN | 2008 | Chinese Science Bulletin2008，53，10： | 10 |
| 6 | Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA显示文摘BACKGROUND One of the most notable applications for circulating tumor DNA(ctDNA)detection in peripheral blood of patients with metastatic colorectal cancer(mCRC)is a long-term postoperative follow-up.Sometimes referred to as a“liquid(re)biopsy”it is a minimally invasive procedure and can be performed repeatedly at relatively short intervals(months or even weeks).The presence of the disease and the actual extent of the tumor burden(tumor mass)within the patient’s body can be monitored.This is of particular importance,especially when evaluating radicality of surgical treatment as well as for early detection of disease progression or recurrence.AIM To confirm the radicality of surgery using ctDNA and compare available methods for detection of recurrence in metastatic colorectal cancer.METHODSA total of 47 patients with detected ctDNA and indications for resection of mCRC were enrolled in the multicenter study involving three surgical centers.Standard postoperative follow-ups using imaging techniques and the determination of tumor markers were supplemented by ctDNA sampling.In addition to the baseline ctDNA testing prior to surgery,a postoperative observation was conducted by evaluating ctDNA presence up to a week after surgery and subsequently at approximately three-month intervals.The presence of ctDNA was correlated with radicality of surgical treatment and the actual clinical status of the patient.RESULTS Among the monitored patients,the R0(curative)resection correlated with postoperative ctDNA negativity in 26 out of 28 cases of surgical procedures(26/28,93%).In the remaining cases of R0 surgeries that displayed ctDNA,both patients were diagnosed with a recurrence of the disease after 6 months.In 7 patients who underwent an R1 resection,4 ctDNA positivities(4/7,57%)were detected after surgery and associated with the confirmation of early disease recurrence(after 3 to 7 months).All 15 patients(15/15,100%)undergoing R2 resection remained constantly ctDNA positive during the entire follow-up period.In 22 cases of recurrence,ctDNA positivity was detected 22 times(22/22,100%)compared to 16 positives(16/22,73%)by imaging methods and 15 cases(15/22,68%)of elevated tumor markers.CONCLUSION ctDNA detection in patients with mCRC is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment. | Lucie Benešová Tereza Hálková Renata Ptáčková Anastasiya Semyakina Kateřina Menclová JiříPudil Miroslav Ryska Miroslav Levý JaromírŠimša Filip Pazdírek JiříHoch Milan Blaha Marek Minárik | 2019 | World Journal of Gastroenterology2019，25，48： | 3 |
| 7 | 冠状动脉钙化在高血压患者心血管病风险分层中的作用显示文摘研究者研究了冠状动脉钙化(coronary artery calcium,CAC)在成人高血压心血管病风险分层中的作用,包括符合收缩压干预试验(systolic blood pressure intervention trial,SPRINT)标准的患者。此外,研究者使用CAC来确定心血管病死亡率与SPRINT中标准降压组心血管病死亡率('SPRINT水平')相当的高血压成年患者,其可能受益于强化降压治疗。研究人群包括来自CAC研究联盟的高血压患者16 167例,其中6375例患者构成'SPRINT类似人群'。研究者按CAC分类(0,1~99,100~399,≥400)比较了多因素校正后的冠状动脉粥样硬化性心脏病(冠心病)和心血管病死亡风险比。 | 刘青(译) 叶鹏(摘、审校) Uddin SMI Mirbolouk M Kianoush S Orimoloye OA Dardari Z Whelton SP Miedema MD Nasir K Rumberger JA Shaw LJ Berman DS Budoff MJ McEvoy JW Matsushita K Blaha MJ Graham G | 2019 | 中华高血压杂志2019，27，5： | 3 |
| 8 | Nonalcoholic fatty liver disease and serum lipoproteins: The Multi-Ethnic Study of Atherosclerosis显示文摘 | Andrew Paul DeFilippis Michael J. Blaha Seth S. Martin Robert M. Reed Steven R. Jones Khurram Nasir Roger S. Blumenthal Matthew J. Budoff | 2013 | Atherosclerosis2013，，： | 2 |
| 9 | 冠状动脉钙化用于指导个性化阿司匹林治疗以预防心血管病:基于多民族动脉粥样硬化研究显示文摘最近美国心脏病学会/美国心脏协会(American College of Cardiology/American Heart Association,ACC/AHA)的一级预防指南建议,低剂量阿司匹林治疗仅适用于年龄40~70岁、患动脉粥样硬化性心血管病(atherosclerotic cardiovascular disease,ASCVD)风险较高,但出血风险不高的成年人。然而,尚不清楚如何更准确地识别出这些患者。根据2019年降低心血管病相对危险度和出血风险的阿司匹林荟萃分析研究数据,本研究旨在评估冠状动脉钙化(coronary artery calcium,CAC)在指导阿司匹林在一级预防中如何使用的价值。 | 周卫(译) 叶鹏(摘/审校) Achirica MC Miedema MD McEvoy JW Rifai MA Greenland P Dardari Z Budoff M Blumenthal RS Yeboah J Duprez DA Mortensen MB Dzaye O Hong J Nasir K Blaha MJ | 2020 | 中华高血压杂志2020，28，4： | 2 |
| 10 | Clinical and research applications of carotid intimamedia thickness显示文摘 | SHARMA K BLAHA M J BLUMENTHAL R S et a1 | 2009 | Am J Cardiol2009，103，： | 1 |
| 11 | U2504 determines the species specificity of the A- site cleft antibiotics: the structures of tiamulin, homoharringtonine, and bruceantin bound to the ribosome显示文摘 | Gurel G Blaha G Moore PB | 2009 | J Mol Bioi2009，7，： | 1 |
| 12 | Time course of cytokine,corticosterone,and tissue injury responses in mice during heat strain recovery显示文摘 | LEON L R BLAHA M D DUBOSE D A | 2006 | J Appl Physiol2006，100，4： | 1 |
| 13 | Statin therapy in the prevention and treatment of atrial fibrillation显示文摘 | LEE Y L BLAHA M J JONES S R | 2011 | J Clin Lipi- dol2011，5，1： | 1 |
| 14 | Molecular signature of mice T lymphocytes following tolerance induction by allogeneic BMT and CD40-CD40L costimulation blockade显示文摘 | Perco P Blaha P Kainz A | | 0，，02： | 1 |
| 15 | Geochronol- ogy and Geochemistry of a Dyke-host Rock Associa- tion and Implications for the Formation of the Bavari- an Pfahl Shear Zone, Bohemian Massif显示文摘 | SIEBEL W BLAHA U CHEN F K | 2005 | Interna- tional Journal of Earth Sciences2005，94，1： | 1 |
| 16 | Full scale moving bed biofilm reactor results from refinery and slaughter house treatment facilities显示文摘 | M W Page L Blaha | 2000 | Wat Sci & Tch2000，41，45： | 1 |
| 17 | Changes of central haemodynamic parameters during mental stress and acute bouts of static and dynamic exercise显示文摘 | LYDAKIS C MOMEN A BLAHA C et a l | 2008 | J Hum Hypertens2008，22，5： | 1 |
| 18 | Effects and induction of glutathione S- transferase by short chain chlorinated paraffins (SCCPs) and C-12 alkane (dodecane) in Xenopus Laevis frog embryos显示文摘 | Buryskova B Blaha L | 2006 | Acta Vet Brno2006，75，： | 1 |
| 19 | Blood pressure is associated with the presence and severity of nonalcoholic fatty liver disease across the spectrum of cardiometabolic risk显示文摘 | Ehimen C. Aneni Ebenezer T. Oni Seth S. Martin Michael J. Blaha Arthur S. Agatston Theodore Feldman Emir Veledar Raquel D. Con?eicao Jose A.M. Carvalho Raul D. Santos Khurram Nasir | 2015 | Journal of Hypertension2015，，6： | 1 |
| 20 | Data warehouses and decision support systems显示文摘 | Michael Blaha | 2001 | M Computer2001，34，12： | 1 |
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