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| 1 | 血液透析患者血压水平的地域和季节性差异显示文摘季节和气候对一般人群以及血液透析患者的血压调节有影响。目前这个现象在世界各地是否有所不同尚不清楚。研究者对来自7个欧洲国家(西班牙、意大利、法国、比利时、德国、英国和瑞典)2005-2011年间参加国际透析预后与实践模式研究(dialysis outcomes and practice patterns study,DOPPS)的患者进行了研究,目的是探究来自不同地理位置的血液透析患者的血压季节差异。 | 刘青 叶鹏 Duranton F Kramer A Szwarc I Bieber B Gayrard N Jover B Vetromile F Massy ZA Combe C Tentori F Jager KJ Servel MF Argilés | 2018 | 中华高血压杂志2018，26，1： | 5 |
| 2 | Positron emission tomography scanning in the evaluation of hepatocellular carcinoma显示文摘 | M.Akram Khan Connie S Combs Elizabeth M Brunt Val J Lowe Michael K Wolverson Harvey Solomon Brian T Collins Adrian M.Di Bisceglie | 2000 | Journal of Hepatology2000，，5： | 2 |
| 3 | Smoothelin,a new marker to determine the origin of liver fibrogenic cells显示文摘AIM:To explore this hypothesis that smooth muscle cells may be capable of acquiring a myofibroblastic phenotype,we have studied the expression of smoothelin in fibrotic conditions.METHODS:Normal liver tissue(n=3)was obtained from macroscopically normal parts of hepatectomy,taken at a distance from hemangiomas.Pathological specimens included post-burn cutaneous hypertrophic scars(n=3),fibrotic liver tissue(n=5),cirrhotic tissue(viral and alcoholic hepatitis)(n=5),and hepatocellular carcinomas(n=5).Tissue samples were fixed in 10%formalin and embedded in paraffin for immunohistochemistry or were immediately frozen in liquid nitrogen-cooled isopentane for confocal microscopy analysis.Sections were stained with antibodies against smoothelin,which is expressed exclusively by smooth muscle cells,andα-smooth muscle actin,which is expressed by both smooth muscle cells and myofibroblasts.RESULTS:In hypertrophic scars,α-smooth muscle actin was detected in vascular smooth muscle cells and in numerous myofibroblasts present in and around nodules,whereas smoothelin was exclusively expressed in vascular smooth muscle cells.In the normal liver,vascular smooth muscle cells were the only cells that expressα-smooth muscle actin and smoothelin.In fibrotic areas of the liver,myofibroblasts expressingα-smooth muscle actin were detected.Myofibroblasts co-expressingα-smooth muscle actin and smoothelin were observed,and their number was slightly increased in parallel with the degree of fibrosis(absent in liver with mild or moderate fibrosis;5%to 10%positive in liver showing severe fibrosis).In cirrhotic septa,numerous myofibroblasts co-expressedα-smooth muscle actin and smoothelin(more than 50%).In hepatocellular carcinomas,the same pattern of expression forα-smooth muscle actin and smoothelin was observed in the stroma reaction surrounding the tumor and around tumoral cell plates.In all pathological liver samples,α-smooth muscle actin and smoothelin were co-expressed in vascular smooth muscle cells.CONCLUSION:During development of advanced liver fibrosis,a subpopulation of myofibroblasts expressing smoothelin may be derived from vascular smooth muscle cells,illustrating the different cellular origins of myofibroblasts. | Sébastien Lepreux Christelle Guyot Fabrice Billet Chantal Combe Charles Balabaud Paulette Bioulac-Sage Alexis Desmoulière | 2013 | World Journal of Gastroenterology2013，19，48： | 2 |
| 4 | Single-column purification of free recombinant proteins using a self-cleavable affinity tag derived from a protein splicing element显示文摘 | Chong S Mersha F B Comb D G | 1997 | Gene1997，192，2： | 1 |
| 5 | MR imaging of neoplas tie central nervous system lesions: review and recommendations for current practice显示文摘 | Essig M Anzalone N Combs S E | 2012 | AJNR2012，33，5： | 1 |
| 6 | Antecedents to strategic flexibility: Management cognition, firm resources and strategic options 显示文摘 | Combe I A Rudd J M Leeflang P S H | 2012 | European Journal of Marketing2012，46，10： | 1 |
| 7 | Predicting favourable outcomes in the set- ting of radiofrequency catheter ablation of long-standing persistent atrial fibrilla- tion:a pilot study assessing the value of left atrial appendage peak flow velocity 显示文摘 | Combes S Jacob S Combes N | 2013 | Arch Cardiovasc Dis2013，106，1： | 1 |
| 8 | DETERMINATION OF SELENIUM AND ARSENIC IN PLANT AND ANIMAL TISSUES BY HYDRIDE GENERATION INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY显示文摘 | L S Zhang S M Combs | | 0，，： | 1 |
| 9 | Identifi-cation of microglial signal transduction pathways me-diating a neurotoxic response to amyloidogenic frag-ments of beta-amyloid and prion proteins显示文摘 | Combs C K Johnson D E?Cannady S B | 1999 | J Neu-rosci1999，19，： | 1 |
| 10 | Risk factors for venous thromboembolism in hospitalized patients with acute medical ill- ness:analysis of the MEDENOX study显示文摘 | Alikhan R Cohen AT Combe S | 2004 | Arch Intern Meal2004，164，9： | 1 |
| 11 | Formation of poly submicron fibers and particles from supercritical carbon dioxide solutions 显示文摘 | Mawson S Johnston K P Combes J R | 1995 | Macromolecules1995，28，9： | 1 |
| 12 | Endogenous glucose production is inhibited by the adipose-derived protein Acrp30显示文摘 | Combs TP Berg AH Obici S | 2001 | J Clin Invest2001，108，： | 1 |
| 13 | Esterification by immobilized lipase in solvent-free media:Kinetic and thermodynamic arguments显示文摘 | Combes D Condoret J S | 2002 | Biotech Bioeng2002，78，3： | 1 |
| 14 | Effects of ascorbic acid on proliferation of and collagen synthesis in relation to the donor age of human topical fibroblasts显示文摘 | Philips C L Combs S B Pinnel S R | 1994 | Journal of Investigative Dermatology1994，103，： | 1 |
| 15 | An overall strategy for the testing of chemicals for human hazard and risk assessment under the EU REACH system 显示文摘 | COMBES R BARRATr M BALLM S | 2003 | Altern Lab Anim2003，31，1： | 1 |
| 16 | The selenium requirement of the puppy显示文摘 | Wedekind K J S Yu G F Combs | 2003 | Journal of Animal Physiology and Animal Nutrition2003，88，： | 1 |
| 17 | Variations of ^18O/^16O in plants from temperate peat bogs(Switzerland) :implications for paleoclimatic studies显示文摘 | MENOT COMBES G BURNS S J MARKUS L | 2002 | Earth and Planetary Science Letters2002，202，： | 1 |
| 18 | Effect of Lactobacillus inoculants and forage dry matter on the fermentation and aerobic stability of ensiled mixed- crop tall fescue and meadow fescue 显示文摘 | Guo X S Undersander D J Combs D K | 2013 | Journal of Dairy Science2013，，96： | 1 |
| 19 | Risk factors for venous thromboembolism in hospitalized patients with acute medical illness:analysis of the MEDENOX Study显示文摘 | Alikhan R Cohen AT Combe S | 2004 | Arch Intern Med2004，164，： | 1 |
| 20 | Hepatic fibrosis and cirrhosis: The (myo) fibroblastic cell subpopulations involved显示文摘 | Guyot C Lepreux S Combe C | 2006 | The International Journal of Biochemistry Cell Biology2006，38，1： | 1 |
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