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| 1 | The Mesocolon: A Histological and Electron Microscopic Characterization of the Mesenteric Attachment of the Colon Prior to and After Surgical Mobilization显示文摘 | Kevin Culligan Stewart Walsh Colum Dunne Michael Walsh Siobhan Ryan Fabio Quondamatteo Peter Dockery J. Calvin Coffey | 2014 | Annals of Surgery2014，，6： | 2 |
| 2 | A detailed appraisal of mesocolic lymphangiology – an immunohistochemical and stereological analysis显示文摘 | Kevin Culligan Rishabh Sehgal Daniel Mulligan Colum Dunne Stewart Walsh Fabio Quondamatteo Peter Dockery J. Calvin Coffey | 2014 | J. Anat2014，，： | 1 |
| 3 | Comparison of novel tools with traditional cognitive tests in detecting delirium in elderly medical patients显示文摘BACKGROUND Efficient detection of delirium and comorbid delirium-dementia is a key diagnostic challenge.Development of new,efficient delirium-focused methods of cognitive assessment is a key challenge for improved detection of neurocognitive disorders in everyday clinical practice.AIM To compare the accuracy of two novel bedside tests of attention,vigilance and visuospatial function with conventional bedside cognitive tests in identifying delirium in older hospitalized patients.METHODS 180 consecutive elderly medical inpatients(mean age 79.6±7.2;51%female)referred to a psychiatry for later life consultation-liaison service with delirium,dementia,comorbid delirium-dementia and cognitively intact controls.Participants were assessed cross-sectionally with conventional bedside cognitive tests[WORLD,Months Backward test(MBT),Spatial span,Vigilance A and B,Clock Drawing test and Interlocking Pentagons test]and two novel cognitive tests[Lighthouse test,Letter and Shape Drawing test(LSD)-4].RESULTS Neurocognitive diagnoses were delirium(n=44),dementia(n=30),comorbid delirium-dementia(n=60)and no neurocognitive disorder(n=46).All conventional tests had sensitivity of>70%for delirium,with best overall accuracy for the Vigilance-B(78.3%),Vigilance-A(77.8%)and MBT(76.7%)tests.The sustained attention component of the Lighthouse test was the most distinguishing of delirium(sensitivity 84.6%;overall accuracy 75.6%).The LSD-4 had sensitivity of 74.0%and overall accuracy 74.4%for delirium identification.Combining tests allowed for enhanced sensitivity(>90%)and overall accuracy(≥75%)with the highest overall accuracy for the combination of MBT-Vigilance A and the combined Vigilance A and B tests(both 78.3%).When analyses were repeated for those with dementia,there were similar findings with the MBTVigilance A the most accurate overall combination(80.0%).Combining the Lighthouse-SA with the LSD-4,a fail in either test had sensitivity for delirium of 91.4 with overall accuracy of 74.4%.CONCLUSION Bedside tests of attention,vigilance and visuospatial ability can help to distinguish neurocognitive disorders,including delirium,from other presentations.The Lighthouse test and the LSD-4 are novel tests with high accuracy for detecting delirium. | David J Meagher Henry O’Connell Maeve Leonard Olugbenga Williams Fahad Awan Chris Exton Michael Tenorio Margaret O’Connor Colum P Dunne Walter Cullen John McFarland Dimitrios Adamis | 2020 | World Journal of Psychiatry2020，10，4： | 1 |
| 4 | Probiotics: from myth to reality. Demonstration of functionality in animal models of disease and in human clinical trials显示文摘 | Colum Dunne Lisa Murphy Sarah Flynn Liam O’Mahony Sile O’Halloran Maria Feeney Darrin Morrissey Gerardine Thornton Gerald Fitzgerald Charles Daly Barry Kiely Eamonn M. M. Quigley Gerald C. O’Sullivan Fergus Shanahan J. Kevin Collins | 1999 | Antonie van Leeuwenhoek1999，，1： | 1 |
| 5 | Overproduction of an inducible extracellular serine protease improves biological control of Pythium ultimum by Stenotrophomonas maltophilia strain W81显示文摘 | Colum Dunne Yvan Monne-Loccoz de Bruijn F J | 2000 | Microbiology2000，146，： | 1 |
| 6 | 碳水化合物——蛋白质饮料对运动耐力的影响显示文摘人在长时间运动后的疲劳和体内存储的肌糖原的消耗密切相关,因此运动后糖原合成的速度是短时间内运动恢复的关键因素。接下来的实验有效地研究了运动后补充的营养成分对于再次运动时耐力表现的影响。 | Antonia Rossiter Philip Jakeman Aaron J. O'Sullivan colum Dunne | 2007 | 食品工业科技2007，28，8： | 0 |
| 7 | Benefits of post-operative oral protein supplementation in gastrointestinal surgery patients: A systematic review of clinical trials显示文摘AIM: To evaluate published trials examining oral postoperative protein supplementation in patients having undergone gastrointestinal surgery and assessment of reported results.METHODS: Database searches(MEDLINE, BIOSIS, EMBASE, Cochrane Trials, Cinahl, and CAB), searches of reference lists of relevant papers, and expert referral were used to identify prospective randomized controlled clinical trials. The following terms were used to locate articles: 'oral'' or 'enteral'' and 'postoperative care'' or 'post-surgical'' and 'proteins' ' or 'milk proteins' ' or 'dietary proteins' ' or 'dietary supplements' ' or 'nutritional supplements' '. In databases that allowed added limitations, results were limited to clinical trials that studied humans, and publications between 1990 and 2014. Quality of collated studies was evaluated using a qualitative assessment tool and the collective results interpreted.RESULTS: Searches identified 629 papers of which, following review, 7 were deemed eligible for qualitative evaluation. Protein supplementation does not appear to affect mortality but does reduce weight loss, and improve nutritional status. Reduction in grip strength deterioration was observed in a majority of studies, and approximately half of the studies described reduced complication rates. No changes in duration of hospital stay or plasma protein levels were reported. There is evidence to suggest that protein supplementation should be routinely provided post-operatively to this population. However, despite comprehensive searches, clinical trials that varied only the amount of protein provided via oral nutritional supplements(discrete from other nutritionalcomponents) were not found. At present, there is some evidence to support routinely prescribed oral nutritional supplements that contain protein for gastrointestinal surgery patients in the immediate post-operative stage.CONCLUSION: The optimal level of protein supplementation required to maximise recovery in gastrointestinal surgery patients is effectively unknown, and may warrant further study. | Mike Crickmer Colum P Dunne Andrew O'Regan J Calvin Coffey Suzanne S Dunne | 2016 | World Journal of Gastrointestinal Surgery2016，8，7： | 0 |
| 8 | Months backward test:A review of its use in clinical studies显示文摘AIM: To review the use of the Months Backwards Test(MBT) in clinical and research contexts.METHODS: We conducted a systematic review of reports relating to the MBT based upon a search of Psych INFO and MEDLINE between January 1980 and December 2014. Only reports that specifically described findings pertaining to the MBT were included. Findings were considered in terms of rating procedures, testing performance, psychometric properties, neuropsychological studies and use in clinical populations.RESULTS: We identified 22 data reports. The MBT is administered and rated in a variety of ways with very little consistency across studies. It has been used to assess various cognitive functions including focused and sustained attention as well as central processingspeed. Performance can be assessed in terms of the ability to accurately complete the test without errors('MB accuracy'), and time taken to complete the test('MB duration'). Completion time in cognitively intact subjects is usually < 20 s with upper limits of 60-90 s typically applied in studies. The majority of cognitively intact adults can complete the test without error such that any errors of omission are strongly suggestive of cognitive dysfunction. Coverage of clinical populations, including those with significant cognitive difficulties is high with the majority of subjects able to engage with MBT procedures. Performance correlates highly with other cognitive tests, especially of attention, including the digit span backwards, trailmaking test B, serial threes and sevens, tests of simple and complex choice reaction time, delayed story recall and standardized list learning measures. Test-retest and inter-rater reliability are high(both > 0.90). Functional magnetic resonance imaging studies comparing the months forward test and MBT indicate greater involvement of more complex networks(bilateral middle and inferior frontal gyri, the posterior parietal cortex and the left anterior cingulate gyrus) for backwards cognitive processing. The MBT has been usefully applied to the study of a variety of clinical presentations, for both cognitive and functional assessment. In addition to the assessment of major neuropsychiatric conditions such as delirium, dementia and Mild Cognitive Impairment, the MBT has been used in the assessment of concussion, profiling of neurocognitive impairments in organic brain disorders and Parkinson's disease, prediction of delirium risk in surgical patients and medication compliance in diabetes. The reported sensitivity for acute neurocognitive disturbance/delirium in hospitalised patients is estimated at 83%-93%. Repeated testing can be used to identify deteriorating cognitive function over time.CONCLUSION: The MBT is a simple, versatile tool that is sensitive to significant cognitive impairment. Performance can be assessed according to accuracy and speed of performance. However, greater consistency in administration and rating is needed. We suggest two approaches to assessing performance- a simple(pass/fail) method as well as a ten point scale for rating test performance(467). | James Meagher Maeve Leonard Laura Donoghue Niamh O'Regan Suzanne Timmons Chris Exton Walter Cullen Colum Dunne Dimitrios Adamis Alasdair J Maclullich David Meagher | 2015 | World Journal of Psychiatry2015，5，3： | 0 |
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