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| 1 | 载脂蛋白E、5-羟色胺转运体基因多态性与阿尔茨海默病的关联分析显示文摘目的 探索载脂蛋白E (apoE)基因及 5 羟色胺 (5 HT)转运体基因多态性在阿尔茨海默病 (AD)发病中的作用。方法 应用聚合酶链反应 (PCR)和限制性片段长度多态性方法 ,观察 10 2例AD和 10 5名正常对照者 (对照组 )的apoE基因多态性及 2个 5 HT转运体基因多态性的分布。结果中、重度AD患者含apoEε4 基因型频率 (2 4% )高于对照组 (12 % ) ,但差异无显著性 (χ2 =3 17,P >0 0 5 ) ;携带apoEε4 等位基因频率 (16 % )高于正常对照 [(7% ) ,χ2 =6 43,P <0 0 5 ,RR =2 6 0 ,95 %CI =1 14~ 5 95 ]和轻度AD[(6 % ) ,χ2 =5 0 9,P <0 0 5 ;RR =2 98,95 %CI=1 0 3~ 8 96 ]。AD患者中携带的apoEε4 等位基因数多者的发病年龄低 ,不含ε4 、含 1个ε4 、含 2个ε4 等位基因者发病年龄分别为 (78± 8)岁、(75± 8)岁、(71± 8)岁 (F =1 85 ,P >0 0 5 )。AD患者 5 HT转运体基因启动子区缺失 /插入多态性 (χ2 =1 0 3,P >0 0 5 )及可变数重复序列多态性 (χ2 =0 0 3,P >0 0 5 )与对照组的差异无显著性。结论 apoEε4 等位基因与中、重度AD相关联 ,是中、重度AD的易感因素 ;不支持 5 | 唐牟尼 李涛 刘协和 韩海英 唐铭民 David A Collier | 2000 | 中华精神科杂志2000，33，3： | 14 |
| 2 | Repeat endoscopic retrograde cholangiopancreaticography after failed initial precut sphincterotomy for biliary cannulation显示文摘AIM: To investigate the outcome of repeating endoscopic retrograde cholangiopancreaticography(ERCP) after initially failed precut sphincterotomy to achieve biliary cannulation.METHODS: In this retrospective study, consecutive ERCPs performed between January 2009 and September 2012 were included. Data from our endoscopy and radiology reporting databases were analysed for use of precut sphincterotomy, biliary access rate, repeat ERCP rate and complications. Patients with initially failed precut sphincterotomy were identified.RESULTS: From 1839 consecutive ERCPs, 187(10%) patients underwent a precut sphincterotomy during the initial ERCP in attempts to cannulate a native papilla. The initial precut was successful in 79/187(42%). ERCP was repeated in 89/108(82%) of patients with failed initial precut sphincterotomy after a median interval of 4 d, leading to successful biliary cannulation in 69/89(78%). In 5 patients a third ERCP was attempted(successful in 4 cases). Overall, repeat ERCP after failed precut at the index ERCP was successful in 73/89 patients(82%). Complications after precut-sphincterotomy were observed in 32/187(17%) patients including pancreatitis(13%), retroperitoneal perforations(1%), biliary sepsis(0.5%) and haemorrhage(3%).CONCLUSION: The high success rate of biliary cannulation in a second attempt ERCP justifies repeating ERCP within 2-7 d after unsuccessful precut sphincterotomy before more invasive approaches should be considered. | Michael Pavlides Ashley Barnabas Nilesh Fernandopulle Adam A Bailey Jane Collier Jane Phillips-Hughes Anthony Ellis Roger Chapman Barbara Braden | 2014 | World Journal of Gastroenterology2014，20，36： | 3 |
| 3 | Safety of and immunological response to a recombinant vaccinia virus vaccine expressing HIV envelope glycoprotein 显示文摘 | Cooney E L Collier A C Greenberg P D | 1991 | Lancet1991，337，： | 1 |
| 4 | Effect of regular consumption of oily fish compared with white fish on chronic plaque psoriasis 显示文摘 | Collier PM Ursell A Zaremba K | 1993 | Eur J Clin Nutr1993，47，4： | 1 |
| 5 | Health risk assessment of dioxin emissions from municipal waste incinerators: the Neerlandquarter (Wilrijk, Belgium)显示文摘 | J Nouwen C Cornelis R De Fré M Wevers P Viaene C Mensink J Patyn L Verschaeve R Hooghe A Maes M Collier G Schoeters R Van Cleuvenbergen P Geuzens | 2001 | Chemosphere2001，，4： | 1 |
| 6 | Sources of sedimentary lipids deduced from stable carbon isotope analyses of individual compounds 显示文摘 | Gareth Rieley Robert J Collier David M Jones Geoffrey Eglinton Paul A Eakin Anthony E Fallick | 1991 | Nature1991，352，： | 1 |
| 7 | Stability and function of screen printed electrodes based on cholinesterase stabilited by a copoly2 mer sugar alcoholmixture显示文摘 | A L Hart W A Collier | 1998 | Sensors and A ctuators B1998，53，： | 1 |
| 8 | Factors affecting insulin-like growth factor I concentration in Bovine colostrum 显示文摘 | COLLIER R J MILLER M A HIDEBRANT J R | 1991 | J Dairy Sci1991，74，： | 1 |
| 9 | Mechanism of forma- tion of chloropropanols present in protein hydrolysates 显示文摘 | Collier P D Cromie D D O Davies A P | 1991 | Journal of American Oil Chemists Society1991，68，10： | 1 |
| 10 | Free radical activity in Type 2 Diabetes 显示文摘 | Collier A Wilson R Bradley H | 1990 | Diabet Med1990，7，1： | 1 |
| 11 | On the chemical mass-balance in estuaries 显示文摘 | Boyle E Collier R Dengler A T | 1974 | Geochim Cosmochim Acta1974，38，11： | 1 |
| 12 | A Multilingual ontology for infectious disease surveillance rationale,design and challenges显示文摘 | Collier N Kawazoe A Jin L Shigematsu M Dien D Barrero R Takeuehi K Kawtrakul A | | 0，，： | 1 |
| 13 | LIDAR- 3ased hazard avoidance for landing on Mars 显示文摘 | JOHNSON A E KLUMPP A COLLIER J | 2002 | Journal of uidance Control and Dynamies2002，25，6： | 1 |
| 14 | Potent sex attractant of the gypsy moth: its isolation, identification, and synthesis 显示文摘 | Bierl B A Beroza M Collier C W | 1970 | Science1970，170，3953： | 1 |
| 15 | Effect of co-ingestion of fat on the metabolic responses to slowly and rapidly absorbed carbohydrates 显示文摘 | Collier G Mclean A O'Dea K | 1984 | Diabetologia1984，26，1： | 1 |
| 16 | A procedure for combining vertical and horizontal seismic action effects 显示文摘 | Collier C Elnashai A S | 2001 | Journal of Earthquake Engineering2001，5，4： | 1 |
| 17 | Mechanisms of resistance to the cytotoxic effects of oxysterols in human leukemic cells显示文摘 | Claudia C Gregorio-King Tamara Gough Gavin J Van Der Meer Jane B Hosking Caryll M Waugh Janet L McLeod Fiona Mc Collier Mark A Kirkland | 2004 | Journal of Steroid Biochemistry and Molecular Biology2004，，3： | 1 |
| 18 | Direct synthesis of hydrogen peroxide from H2 and O2 using Pd and Au catalysts 显示文摘 | Landon P Collier P J Carley A F | 2003 | Physical Chemistry Chemical Physics2003，34，32： | 1 |
| 19 | Estimation of Multi-output production functions in commercial fisheries显示文摘 | Collier T C Mamula A Ruggiero J | 2013 | Omega2013，，： | 1 |
| 20 | NF-kappaB protects neurons from ischemic injury after middle cerebral artery occlusion in mice显示文摘 | Duckworth E A Butler T Collier L | 2006 | Brain Res2006，1088，1： | 1 |
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