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| 1 | Total thyroidectomy is safer with identification of recurrent laryngeal nerve显示文摘Objective:To investigate the effect of recurrent laryngeal nerve(RLN)identification on the complications after total thyroidectomy and lobectomy.Methods:Total 134 consecutive patients undergoing total thyroidectomy or thyroid lobectomy from January 2003 to November 2004 were investigated retrospectively.Patients were divided into two groups:RLN identified (Group A)or not(Group B).The two groups were compared for RLN injury and hypocalcaemia.Results:The numbers of patients and nerves at risk were 71 and 129 in Group A,and 63 and 121 in Group B,respectively.RLN injury in Group A(0)was sig- nificantly lower than that in Group B(57.9%)patients,75.8%nerves)for the numbers of patients(P=0.016)and nerves at risk (P=0.006).Temporary hypocalcaemia was significantly higher in Group A than in Group B(1424.1%vs 610.3%,P=0.049). Permanent complications in Group B were significantly higher than those in Group A(1320.6%vs 45.6%,P=0.009).Con- clusion:RLN injury was prevented and permanent complications were decreased by identifying the whole course and branches of the recurrent laryngeal nerve during total thyroidectomy. | Hakan CANBAZ Musa DIRLIK Tahsin COLAK Koray OCAL Tamer AKCA Oner BILGIN Bahar TASDELEN Suha AYDIN | 2008 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2008，9，6： | 20 |
| 2 | Drainage after total thyroidectomy or lobectomy for benign thyroidal disorders显示文摘Objective: This prospective randomized clinical trial was conducted to evaluate the necessity of drainage after total thyroidectomy or lobectomy for benign thyroidal disorders. Methods: A total of 116 patients who underwent total thyroidectomy or lobectomy for benign thyroidal disorders were randomly allocated to be drained or not. Operative and postoperative outcomes including operating time, postoperative pain assessed by visual analogue scale (VAS), total amount of intramuscular analgesic administration, hospital stay, complications, necessity for re-operation and satisfaction of patients were all assessed. Results: The mean operating time was similar between two groups (the drained and non-drained groups). The mean VAS score was found to be significantly low in the non-drained group patients in postoperative day (POD) 0 and POD 1. The mean amount of intramuscular analgesic requirement was significantly less in the non-drained group. One case of hematoma, two cases of seroma and three cases of transient hypoparathyroidism occurred in the non-drained group, whereas one case of hematoma, two cases of seroma, two cases of wound infections and two cases of transient hypoparathyroidism occurred in the drained group. No patient needed re-operation for any complication. The mean hospital stay was significantly shorter and the satisfaction of patients was superior in the non-drained group. Conclusion: These findings suggest that postoperative complications cannot be prevented by using drains after total thyroidectomy or lobectomy for benign thyroid disorders. Furthermore, the use of drains may increase postoperative pain and the analgesic requirement, and prolong the hospital stay. In the light of these findings, the routine use of drains might not be necessary after thyroid surgery for benign disorders. | Tahsin COLAK Tamer AKCA Ozgur TURKMENOGLU Hakan CANBAZ Bora USTUNSOY Arzu KANIK Suha AYDIN1 | 2008 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2008，9，4： | 12 |
| 3 | Diagnosis and treatment of gallbladder perforation显示文摘AIM: To present our clinical experience with gallbladder perforation cases. METHODS: Records of 332 patients who received medical and/or surgical treatment with the diagnosis of acute cholecystitis in our clinic between 1997 and 2006 were reviewed retrospectively. Sixteen (4.8%) of those patients had gallbladder perforation. The parameters including age, gender, time from the onset of symptoms to the time of surgery, diagnostic procedures, surgical treatment, morbidity, and mortality were evaluated. RESULTS: Seven patients had typeⅠgallbladder perforation, 7 type Ⅱ gallbladder perforation, and 2 type Ⅲ gallbladder perforation according to Niemeier’ s classification. The patients underwent surgery after administration of intravenous electrolyte solutions, and were treated with analgesics and antibiotics within the first 36 h (mean 9 h) after admission. Two patients died of sepsis and multiple organ failure in the early postoperative period. Subhepatic abscess, pelvic abscess, pneumonia, pancreatitis, and acute renal failure were found in 6 patients. CONCLUSION: Early diagnosis and emergency surgical treatment of gallbladder perforation are of crucial importance. Upper abdominal computerized tomography for acute cholecystitis patients may contribute to the preoperative diagnosis of gallbladder perforation. | Hayrullah Derici Cemal Kara Ali Dogan Bozdag Okay Nazli Tugrul Tansug Esra Akca | 2006 | World Journal of Gastroenterology2006，12，48： | 9 |
| 4 | Assessment of the correlation between serum prolidase and alpha-fetoprotein levels in patients with hepatocellular carcinoma显示文摘AIM: To determine the predictive value of increased prolidase activity that reflects increased collagen turnover in patients with hepatocellular carcinoma(HCC).METHODS: Sixty-eight patients with HCC(mean age of 69.1 ± 10.1), 31 cirrhosis patients(mean age of59.3 ± 6.3) and 33 healthy volunteers(mean age of51.4 ± 12.6) were enrolled in this study. Univariate and multivariate analysis were used to evaluate the association of serum α-fetoprotein(AFP) values with HCC clinicopathological features, such as tumor size,number and presence of vascular and macrovascular invasion. The patients with HCC were divided into groups according to tumor size, number and presence of vascular invasion(diameters; ≤ 3 cm, 3-5 cmand ≥ 5 cm, number; 1, 2 and ≥ 3, macrovascular invasion; yes/no). Barcelona-clinic liver cancer(BCLC)criteria were used to stage HCC patients. Serum samples for measurement of prolidase and alphafetoprotein levels were kept at-80 ℃ until use.Prolidase levels were measured spectrophotometrically and AFP concentrations were determined by a chemiluminescence immunometric commercial diagnostic assay.RESULTS: In patients with HCC, prolidase and AFP values were evaluated according to tumor size, number,presence of macrovascular invasion and BCLC staging classification. Prolidase values were significantly higher in patients with HCC compared with controls(P <0.001). Prolidase levels were significantly associated with tumor size and number(P < 0.001, P = 0.002,respectively). Prolidase levels also differed in patients in terms of BCLC staging classification(P < 0.001).Furthermore the prolidase levels in HCC patients showed a significant difference compared with patients with cirrhosis(P < 0.001). In HCC patients grouped according to tumor size, number and BCLC staging classification, AFP values differed separately(P = 0.032,P = 0.038, P = 0.015, respectively). In patients with HCC, there was a significant correlation(r = 0.616; P< 0.001) between prolidase and AFP values in terms of tumor size, number and BCLC staging classification,whereas the presence of macrovascular invasion did not show a positive association with serum prolidase and AFP levels.CONCLUSION: Considering the levels of both serum prolidase and AFP could contribute to the early diagnosing of hepatocellular carcinoma. | Sevil Uygun Ilikhan Muammer Bilici Hatice Sahin Ayse Semra Demir Akca Murat Can Ibrahim Ilker Oz Berrak Guven M Cagatay Buyukuysal Yucel Ustundag | 2015 | World Journal of Gastroenterology2015，21，22： | 8 |
| 5 | Diagnosis and phylogenetic analysis of orf virus in Aleppo and Saanen goats from an outbreak in Turkey显示文摘Dear Editor,The Poxviridae family is divided into Chordopoxvirinae and Entomopoxvirinae genera.Parapoxvirus is one of 11genera in the Chordopoxvirinae genus,including orf virus(ORFV),bovine papular stomatitis virus(BPSV),pseudocowpox virus(PCPV)and parapoxvirus of red deer in New Zealand(PVNZ)(Skinner et al.,2012).This virus,also known as contagious ecthyma or contagious pustular dermatitis,is a viral skin disease causing edematous proliferative lesions,most often in hairless | Zeynep Akkutay-Yoldar Tuba Cigdem Oguzoglu Yilmaz Akca | 2016 | Virologica Sinica2016，31，3： | 2 |
| 6 | Levels of soluble intercellular adhesion molecule-land total sialic acid in serum of patients with laryngeal cancer 显示文摘 | Akca YF Taysi S Uslu C | 2001 | Jpn J Clin Oncol2001，31，12： | 1 |
| 7 | Effects of different retraction medicaments on gingival tissue显示文摘 | Akca EA Yildirim E Dalkiz M | 2006 | Quintessence lnt2006，37，1： | 1 |
| 8 | Molecular and serological evidence of Anaplasma phagocytophilum infection of farm animals in the Black Sea Region of Turkey 显示文摘 | Gokce HI Genc O Akca A | 2008 | Aeta Vet Hung2008，56，3： | 1 |
| 9 | Supplemental perioperative oxygen to reduce the incidence of surgical-wound infection 显示文摘 | Greif R Akca O Horn EP | 2000 | N Engl J Med2000，342，3： | 1 |
| 10 | Catheter ablation of ventricular tachycardias using remote magnetic navigation:a consecutive case-control study显示文摘 | Szili-Torok T Schwagten B Akca F | 2012 | Cardiovasc Electrophysiol2012，23，9： | 1 |
| 11 | Evaluation of the Effect of the Residual Bone Angulation on Implant-Supported Fixed Prosihesis in Mandibular Posterior Edentulism Part JI: 3-D Finite ElementStress Analysis 显示文摘 | Akca K Iplikqioglu H | 2001 | Implant Dentistry2001，10，4： | 1 |
| 12 | A morphological and micro-tensile bond strength evalu -ation of a single-bottle adhesive to caries-affected human dentine after four different caries removal techniques显示文摘 | Cehreli ZC Yazici AR Akca T | 2003 | J Dent2003，31，6： | 1 |
| 13 | A Randomized Clinical Study Evaluating the Need for Drainage After Limberg Flap for Pilonidal Sinus显示文摘 | Tahsin Colak Ozgur Turkmenoglu Ahmet Dag Tamer Akca Suha Aydin | 2010 | Journal of Surgical Research2010，，1： | 1 |
| 14 | Psoriasis treatment via doctor fishes as part of health tourism : A case study of Kangal Fish Spring, Turkey显示文摘 | Murat Sayili Hasan Akca Teoman Dmnan | 2007 | Tourism Management2007，28，： | 1 |
| 15 | Aggressive warming reduces blood loss during hip arthroplasty 显示文摘 | Winkler M Akca O Birkenberg B | 2000 | Anesth Analg2000，91，4： | 1 |
| 16 | Continuous-time additive Hopfield-type neural networks with impulses显示文摘 | AKCA H ALASSAR R COVACHEV V | 2004 | Journal of Mathematical Analysis and Applications2004，290，： | 1 |
| 17 | Temperature monitoring and management during neuraxial anesthesia:an observational study显示文摘 | Arkilic CF Akca O Taguchi A | 2000 | Anesth Analg2000，91，： | 1 |
| 18 | Supplemental perioperative oxygen to reduce the incidence of surgical - wound infection 显示文摘 | Greif R Akca O Hom E | 2000 | N Engl J Med2000，342，3： | 1 |
| 19 | Tumour suppressor PTEN enhanced enzyme activity of GPx, SOD and catalase by suppression of PI3K/AKT pathway in non-small cell lung cancer cell lines 显示文摘 | Akca H Demiray A Aslan M | 2013 | J Enzyme Inhib Med Chem2013，28，3： | 1 |
| 20 | Sevoflurane induced preconditioning protects against cerebral ischemic neuronal damage in rats显示文摘 | Payne RS Akca O Roewer N | 2005 | Brain Res2005，1034，12： | 1 |
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