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| 1 | New challenges in perioperative management of pancreatic cancer显示文摘Pancreatic ductal adenocarcinoma(PDAC)is the fourth leading cause of cancer-related death in the industrialized world.Despite progress in the understanding of the molecular and genetic basis of this disease,the5-year survival rate has remained low and usually does not exceed 5%.Only 20%-25%of patients present with potentially resectable disease and surgery represents the only chance for a cure.After decades of gemcitabine hegemony and limited therapeutic options,more active chemotherapies are emerging in advanced PDAC,like 5-Fluorouracil,folinic acid,irinotecan and oxaliplatin and nab-paclitaxel plus gemcitabine,that have profoundly impacted therapeutic possibilities.PDAC is considered a systemic disease because of the high rate of relapse after curative surgery in patients with resectable disease at diagnosis.Neoadjuvant strategies in resectable,borderline resectable,or locally advanced pancreatic cancer may improve outcomes.Incorporation of tissue biomarker testing and imaging techniques into preoperative strategies should allow clinicians to identify patients who may ultimately achieve curative benefit from surgery.This review summarizes current knowledge of adjuvant and neoadjuvant treatment for PDAC and discusses the rationale for moving from adjuvant to preoperative and perioperative therapeutic strategies in the current era of more active chemotherapies and personalized medicine.We also discuss the integration of good specimen collection,tissue biomarkers,and imaging tools into newly designed preoperative and perioperative strategies. | Francesco Puleo Raphaёl Maréchal Pieter Demetter Maria-Antonietta Bali Annabelle Calomme Jean Closset Jean-Baptiste Bachet Jacques Deviere Jean-Luc Van Laethem | 2015 | World Journal of Gastroenterology2015，21，8： | 4 |
| 2 | Pancreaticojejunostomy versus pancreaticogastrostomy reconstruction after pancreaticoduodenectomy for pancreatic or periampullary tumours: a multicentre randomised trial显示文摘 | Baki Topal Steffen Fieuws Raymond Aerts Joseph Weerts Tom Feryn Geert Roeyen Claude Bertrand Catherine Hubert Marc Janssens Jean Closset | 2013 | Lancet Oncology2013，，7： | 2 |
| 3 | TTF-1 positive small cell cancers:Don't think they're always primary pulmonary!显示文摘Thyroid transcription factor 1 (TTF-1) plays a key role in morphogenesis of the lungs and is expressed in up to 90% of pulmonary small cell carcinomas.This explains why this marker is frequently used in the search for the primary origin of metastatic endocrine tumours.Here we report on a TTF-1 expressing mixed endocrine-exocrine carcinoma of the common bile duct in a patient with pulmonary nodules that did not appear to be neoplastic.TTF-1 positivity in pulmonary and extrapulmonary neuroendocrine tumours is reviewed,and we conclude that TTF-1 expression in neuroendocrine tumours of the small-cell type are not uncommon at extrapulmonary locations.Therefore,immunohistochem-istry for TTF-1 in such tumours should be interpreted with caution. | Laurine Verset Marianna Arvanitakis Patricia Loi Jean Closset Myriam Delhaye Myriam Remmelink Pieter Demetter | 2011 | World Journal of Gastrointestinal Oncology2011，3，10： | 2 |
| 4 | Study of the effect of a silver nanoparticle seeding layer on the crystallisation temperature,photoinduced hydrophylic and catalytic properties of TiOz thin films deposited on glass by magnetron sputtering显示文摘 | Limage H Tichelaar F D Closset R | | 0，，13： | 1 |
| 5 | Clusterin activates survival through the phosphatidylinositol 3-kinase/Akt pathway显示文摘 | Ammar H Closset JL | | 0，，19： | 1 |
| 6 | Pancreaticojejunostomy versus pancreaticogastrostomy reconstruction after pancreaticoduodenectomy for pancreatic or periampullary tumours: a multicentre randomised trial显示文摘 | Baki Topal Steffen Fieuws Raymond Aerts Joseph Weerts Tom Feryn Geert Roeyen Claude Bertrand Catherine Hubert Marc Janssens Jean Closset | 2013 | Lancet Oncology2013，，7： | 1 |
| 7 | Transoral gastroplasty is safe, feasible, and induces significant weight loss in morbidly obese patients: results of the second human pilot study显示文摘 | Moreno C Closset J Dugardeyn S | 2008 | Endoscopy2008，40，5： | 1 |
| 8 | Advances in the refining and alloying oflow-bismuth lead 显示文摘 | HIBBINS S G CLOSSET B BRAY M | 1995 | Journal of Power Sources1995，53，： | 1 |
| 9 | Contribution of computed tomography to decision making in the manage ment of adhesive small bowel obstruction 显示文摘 | Donckier V Closset J Van Gansbekd D | 1998 | Br J Surg1998，85，8： | 1 |
| 10 | Outpatient cervical ripening by nitric oxide donors for prolonged pregnancy: arandomized controlled trial显示文摘 | Schmitz T Fuchs F Closset E | | 1089-10970，，： | 1 |
| 11 | Preconditioning of donors with interleukin-10 reduces hepatic ischemic reperfusion injury after liver transplantation in piss 显示文摘 | Donckier V Loi P Closset J | 2003 | Transplantation2003，75，6： | 1 |
| 12 | Enteryx显示文摘 | Louis H Closset J Deviere J | 2004 | Best Pract Res Clin Gastroenterol2004，18，1： | 1 |
| 13 | The aluminum-strontium phase diagram显示文摘 | B. Closset H. Dugas M. Pekguleryuz J. E. Gruzleski | 1986 | Metallurgical Transactions A1986，，7： | 1 |
| 14 | Laparoscopic Nissen fundoplication after failure of Enteryx injection into the lower esophageal sphincter显示文摘 | ElNakadi I Closset J De Moor V | 2004 | Surg Endosc2004，18，5： | 1 |
| 15 | Clusterin activates survival through the phos- phatidylinositol 3-kinase/Akt pathway显示文摘 | Ammar H Closset JL | 2008 | J Biol Chem2008，283，12： | 1 |
| 16 | Purification and characterization of a bovine pregnancy-associated glycoprotein显示文摘 | Zoli AP Beckers JF Wouters-Bailman P Closset J Falmagne P Ectors F | | 0，，： | 1 |
| 17 | Preconditioning of donors with interleukin-10 reduce hepatic ischemia-reperfusion injury after liver transplantation in pigs 显示文摘 | Donckier V Loi P Closset J | 2003 | Transplantation2003，75，6： | 1 |
| 18 | Structure and Properities of Hypoeutectic Al-Si-Mg Alloys Modified with Pure Strontium显示文摘 | B Closset J EGruzleski | 1982 | Chemistry and Materials Science1982，13，： | 1 |
| 19 | The quantitative control of modification in A1-Si foundry alloys using a thermal analysis technique显示文摘 | Argyropoulos S Closset B Oger H | 1983 | AFS Transaction1983，90，： | 1 |
| 20 | Results of surgical resection for hepatocellular carcinoma 显示文摘 | Closset J Gelin M Nakadi I | 1993 | Aeta Chir Belg1993，93，3： | 1 |
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