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| 1 | Long-term outcome and prognostic factors of patients with hilar cholangiocarcinoma显示文摘AIM: To evaluate the long-term outcome and prognostic factors of patients with hilar cholangiocarinoma. METHODS: Ninety-six consecutive patients underwent treatment for malignant hilar bile duct tumors during 1995–2005. Of the 96 patients, 20 were initially treated with surgery (n = 2 R0 / n = 18 R1). In non-operated patients, data analysis was performed retrospectively. RESULTS: Among the 96 patients, 76 were treated with endoscopic transpapillary (ERC, n = 45) and/or percutaneous transhepatic biliary drainage (PTBD, n = 31). The mean survival time of these 76 patients undergoing palliative endoscopic and/or percutaneous drainage was 359 ± 296 d. The mean survival time of patients with initial bilirubin levels > 10 mg/dL was significantly lower (P < 0.001) than patients with bilirubin levels < 10 mg/dL. The mean survival time of patients with Bismuth stage Ⅱ (n = 8), Ⅲ (n = 28) and Ⅳ (n = 40) was 496 ± 300 d, 441 ± 385 d and 274 ± 218 d, respectively. Thus, patients with advanced Bismuth stage showed a reduced mean survival time, but the difference was not significant. The type of biliary drainage had no significant beneficial effect on the mean survival time (ERC vs PTBD, P = 0.806). CONCLUSION: Initial bilirubin level is a significant prognostic factor for survival of patients. In contrast, age, tumor stage according to the Bismuth-Corlette classification, and types of intervention are not significant prognostic parameters for survival. Palliative treatment with endoscopic or percutaneous biliary drainage is still suboptimal, new diagnostic and therapeutic tools need to be evaluated. | Andreas Weber Sonja Landrock Jochen Schneider Manfred Stangl Bruno Neu Peter Born Meinhard Classen Thomas Rsch Roland M Schmid Christian Prinz | 2007 | World Journal of Gastroenterology2007，13，9： | 23 |
| 2 | Daily meatal care for prevention of catheter-associated bacteriuria:results using frequent applications of polyantibiotic cream显示文摘 | Classen D C Larsen R A Burke J P | 1991 | Infect Control Hosp Epidemiol1991，12，3： | 1 |
| 3 | Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation显示文摘 | Chen R Classen J Gerloff C | 1997 | Neurology1997，48，： | 1 |
| 4 | In vitro hydrolysis of phytate in canola meal with purified and crude sources of phytase显示文摘 | NEWKIRK R W CLASSEN H L | 1998 | Journal of Animal and Feed Sciences1998，72，： | 1 |
| 5 | Endoscopic ultrasonographyin the evaluation of colon and rectal disease 显示文摘 | Rosch T Lorenz R Classen M | 1990 | Gastrointestinal Endoscopy1990，36，2： | 1 |
| 6 | Nutritional evaluation of low glucosinolate mustard meals (Brassica juncea) in broiler diets 显示文摘 | Newkirk R W Classen H L Tyler R T | 1997 | Poult Sci1997，76，： | 1 |
| 7 | Endosonography - What Are the Limits in Gastroenterological Diagnostics?显示文摘 | T. R?sch M. Classen | 1991 | Endoscopy1991，，03： | 1 |
| 8 | The effect of pelleting, salt, and pentosanase on the viscosity of intestinal contents and the performance of broilers fed rye显示文摘 | Bedford M R Classen H L | 1991 | Poultry Sci1991，70，： | 1 |
| 9 | Global trigger tool shows that adverse events in hospitals may be ten times greater than previously measured显示文摘 | Classen DC Resar R Griffin F | 2011 | Health Aff (Millwood)2011，30，： | 1 |
| 10 | Reduction of intestinal viscosity through manipulation of dietary rye and pentosanase concentration effeeted growth rate and food conversion efficiency of broiler chicken显示文摘 | Bedford M R Classen H L | 1992 | Nutr1992，122，： | 1 |
| 11 | ERCP or EUS for tissue diagnosis of biliary strictures? a prospective comparative study显示文摘 | Thomas R?sch Kim Hofrichter Eckart Frimberger Alexander Meining Peter Born Norbert Weigert Hans-Dieter Allescher Meinhard Classen Marius Barbur Ulrich Schenck Martin Werner | 2004 | Gastrointestinal Endoscopy2004，，3： | 1 |
| 12 | Laparoscopic versus\sopen appendectomy:which factors influence the decision between the\ssurgical techniques?显示文摘 | Horsemann R Tiwisina C Classen C | 2005 | Zentralbl Chir2005，130，1： | 1 |
| 13 | Complications of diagnostic gastrointestinal endoscopy显示文摘 | Hart R Classen M | 1990 | Endoscopy1990，22，22： | 1 |
| 14 | An in vitro assay for prediction of broiler intestinal viscosity and growth when fed rye-based diets in the presence of exogenous enzyme显示文摘 | Bedford M R and Classen H L | 1993 | Poultry Sci1993，72，： | 1 |
| 15 | Endoscopic ultrasonographyin the evaluation of colon and rectal disease 显示文摘 | RSsch T Lorenz R Classen M | 1990 | Gastrointest En- dosc1990，36，2： | 1 |
| 16 | Global trigger tool'showsthat adveree events in hospitals may be ten times greater than previ-ously measured显示文摘 | Classen DC Resar R Griffin F | 2011 | Health Aff (Millwood)2011，30，4： | 1 |
| 17 | A prospective comparison of the diagnostic accuracy of ERCP, MRCP, CT, and EUS in biliary strictures显示文摘 | Thomas R?sch Alexander Meining Silke Frühmorgen Christian Zillinger Volker Schusdziarra Karin Hellerhoff Meinhard Classen Hermann Helmberger | 2002 | Gastrointestinal Endoscopy2002，，7： | 1 |
| 18 | The non-mineral nutritional impact of phytate in canola meal fed to broiler chicks显示文摘 | Nekirk R W Classen H L | 2001 | Animal Feed Science and Technology2001，91，： | 1 |
| 19 | Complications of diagnostic gastrointestinal endoscopy显示文摘 | Hart R Classen M | 1990 | Endoscopy1990，22，5： | 1 |
| 20 | ln vitro hydrolysis of phytate in canola with purified and crude sources of phytase显示文摘 | Nekirk R W Classen H L | 1998 | Feed Science and Technology1998，72，： | 1 |
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