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| 1 | Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy显示文摘AIM: To study the prognostic value of adjuvant chemo-therapy in patients with pancreatic, ductal adenocar-cinoma.METHODS: Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three (41%) of the 106 patients were staged as pT1/2, 63 (59%) as pT3/4, 51 (48%) as pN0, and 55 (52%) as pN1. The study population included 59 (56%) patients exhibiting G1/2, and 47 (44%) patients with G3 tumors. Patients received no adjuvant chemo- or radiation therapy and were followed up for a median of 12 (range: 3.5 to 139) mo.RESULTS: Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as “tumor free” by conventional histopathology in 73 (69%) out of the 106 patients. Twenty-nine (57%)of 51 patients staged histopathologically as pN0 had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free (relative risk 2.92, P = 0.005) and overall (relative risk 2.49, P = 0.009) survival.CONCLUSION: The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports may help to improve risk stratification of patients with pancreatic cancer. | Emre F Yekebas Dean Bogoevski Michael Bubenheim Bjrn-Christian Link Jussuf T Kaifi Robin Wachowiak Oliver Mann Asad Kutup Guellue Cataldegirmen Lars Wolfram Andreas Erbersdobler Christoph Klein Klaus Pantel Jakob R Izbicki | 2006 | World Journal of Gastroenterology2006，12，40： | 3 |
| 2 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 3 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 4 | A processing, characterization and marine biodegradation study of melt-extruded polyhydroxyalkanoate (pha) films显示文摘 | Christopher T Megan C Danielle F | 2008 | Journal of Polymers and Environment2008，16，1： | 1 |
| 5 | The effect of body contact series resistance on SOI CMOS amplifier stages显示文摘 | CHRISTOPHER F E WILLIAM R W BERNARD M T | 1997 | IEEE Trans Electron Devices1997，44，12： | 1 |
| 6 | Analysis of the innate and adaptive phases of allograft rejection by cluster analysis of transcriptional profiles显示文摘 | Christopher K Mueller T F Ma C Y | 2002 | J Immunol2002，169，： | 1 |
| 7 | The use of a pretherapeutic,predictive score to determine inclusion xriteria for the non-surgical treatment of ectopix pregnancy显示文摘 | Herve F Christophe L Viviane T | 1991 | Hum Reprod1991，6，7： | 1 |
| 8 | Synthesis of Highly Ordered,Three-Dimensional,Macroporous Structures of Amorphous or Crystalline Inorganic Oxides,Phosphates,and Hybrid Composites显示文摘 | Brian T H Christopher F B Thang D | 2004 | Chem Mater2004，16，11： | 1 |
| 9 | The neural basis of loss aversion in decision-making under risk显示文摘 | SABRINA M T GRAIG R F CHRISTOPHER T | 2007 | Science2007，315，： | 1 |
| 10 | Leptin and reproduction 显示文摘 | Denis AM Huang M Christopher T F | 1998 | Endocrinologist1998，8，： | 1 |
| 11 | Callous-unemotional traits and conduct problems in the prediction of conduct problem severity, aggression, and self-report of delinquency显示文摘 | Paul J F Amy HC Christopher T | 2003 | Abnormal Child Psychology2003，3，1： | 1 |
| 12 | General synthesis of periodic macroporous solids by templated salt precipitation and chemical conversion显示文摘 | HONGWEI Y CHRISTOPHER F B BRIAN T H | 2000 | Chem Mater2000，12，： | 1 |
| 13 | A chemical synthesis of periodic macroporous NiO and metallic Ni 显示文摘 | Yan Hongwei Blanford Christopher F Holland Brian T | 1999 | Adv Mater1999，11，12： | 1 |
| 14 | The morphology of built-up landscapes in Wallonia (Belgium):A classification using fractal indices显示文摘 | Isabelle T Pierre F Christophe B | 2008 | Landscape and Urban Planning2008，84，2： | 1 |
| 15 | General synthesis of periodic macroporous solids by templated salt precipitation and chemical conversion显示文摘 | Yah Hongwei Blanford Christopher F Holland Brian T | 2000 | Chem Mater2000，12，4： | 1 |
| 16 | Influence of thrombolytic therapy, with or without intra-aortic balloon counterpulsation, on 12-month survival in the SHOCK trial显示文摘 | John K French Henry A Feldman Susan F Assmann Timothy Sanborn Sebastian T Palmeri David Miller Jean Boland Christopher E Buller Richard Steingart Lynn A Sleeper Judith S Hochman | 2003 | American Heart Journal2003，，： | 1 |
| 17 | Multipleresistance to dissimilar herbicide chemistries in a biotype of Loliumrigidum due to enhanced activity of several herbicide degrading en-zymes 显示文摘 | PRESTON C TARDIF F J CHRISTOPHER J T | 1996 | Pesticide Biochemistry and Physiology1996，54，2： | 1 |
| 18 | High content imaging of Mycobacterium tuberculosis-infected macrophages anin vitro model for tuberculosis drug discovery显示文摘 | Christophe T Ewann F Jeon HK | | Future Med Chem0，2，8： | 1 |
| 19 | Multiple resistance to dissimilar herbicide chemistries in a biotype of Lolium rigidum due to enhanced activity of several herbicide degrading enzymes显示文摘 | Preston C Tardif F J Christopher J T | 1996 | Pesticide Biochemistry and Physiology1996，54，2： | 1 |
| 20 | Antibiotics for emerging pathogens显示文摘 | Michael A F Christopher T W | 2009 | Science2009，325，1089： | 1 |
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