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| 1 | A Spatio-Temporal Model for the Manipulation of Lineage Metadata显示文摘 | Laurent Spéry Christophe Claramunt Thérèse Libourel | 2001 | GeoInformatica2001，，1： | 1 |
| 2 | Surveillance for HIV-1 incidence using tests for recent infection in resource-constrained countries 显示文摘 | MeDougal JS Christopher DP Bharat SP | 2005 | AIDS2005，19，2： | 1 |
| 3 | Mucinous and Signet-Ring Cell Colorectal Cancers Differ from Classical Adenocarcinomas in Tumor Biology and Prognosis显示文摘 | Ulrich Nitsche Anina Zimmermann Christoph Sp?th Tara Müller Matthias Maak Tibor Schuster Julia Slotta-Huspenina Samuel A. K?ser Christoph W. Michalski Klaus-Peter Janssen Helmut Friess Robert Rosenberg Franz G. Bader | 2013 | Annals of Surgery2013，，5： | 1 |
| 4 | Aspirin inhibits cell viability and mTOR downstream signaling in gastroenteropancreatic and bronchopulmonary neuroendocrine tumor cells显示文摘AIM:To investigate the effect of aspirin on neuroendocrine tumor(NET)cell growth and signaling in vitro.METHODS:Human pancreatic BON1,bronchopulmonary NCI-H727 and midgut GOT1 neuroendocrine tumor cells were treated with different concentrations of aspirin(from 0.001 to 5 mmol/L),and the resulting effects on metabolic activity/cell proliferation were measured using cell proliferation assays and SYBR-DNAlabeling after 72,144 and 216 h of incubation.The effects of aspirin on the expression and phosphorylation of several critical proteins that are involved in the most common intracellular growth factor signaling pathways(especially Akt protein kinase B)and mammalian target of rapamycin(mTOR)were determined by Western blot analyses.Propidium iodide staining and flow cytometry were used to evaluate changes in cell cycle distribution and apoptosis.Statistical analysis was performed using a 2-tailed Student’s t-test to evaluate the proliferation assays and cell cycle analyses.The results are expressed as the mean±SD of 3 or 4 independently performed experiments.Statistical significance was set at P<0.05.RESULTS:Treatment with aspirin suppressed the viability/proliferation of BON1,NCI-H727 and GOT1 cells in a time-and dose-dependent manner.Significant effects were observed at starting doses of 0.5-1 mmol/L and peaked at 5 mmol/L.For instance,after treatment with 1 mmol/L aspirin for 144 h,the viability of pancreatic BON1 cells decreased to 66%±13%(P<0.05),the viability of bronchopulmonary NCI-H727 cells decreased to 53%±8%(P<0.01)and the viability of midgut GOT1 cells decreased to 89%±6%(P<0.01).These effects were associated with a decreased entry into the S phase,the induction of the cyclin-dependent kinase inhibitor p21 and reduced expression of cyclindependent kinase 4 and cyclin D3.Aspirin suppressed mTOR downstream signaling,evidenced by the reduced phosphorylation of the mTOR substrates 4E binding protein 1,serine/threonine kinase P70S6K and S6 ribosomal protein and inhibited glycogen synthase kinase3 activity.We observed the(compensatory)activation of tuberous sclerosis 2,the serine/threonine specific protein kinase AKT and extracellular signal-regulated kinases.CONCLUSION:Aspirin demonstrates promising anticancer properties for NETs in vitro.Further preclinical and clinical studies are needed. | Matilde Spampatti George Vlotides Gerald Spttl Julian Maurer Burkhard Gke Christoph J Auernhammer | 2014 | World Journal of Gastroenterology2014，20，29： | 1 |
| 5 | High-resolution CT and CT angiography of peripheral pulmonary vascular disorders 显示文摘 | Christoph E Cornelia SP Eckart S | 2002 | Radiographics2002，22，： | 1 |
| 6 | Hypoglycemia in patients with type 2 diabetes mellitus显示文摘 | Christopher DM Lawrence SP David CZ | 2001 | Arch Intern Med2001，161，： | 1 |
| 7 | Incorporation of flexdbility into rigid-body docking: applications in rounds 3-5 of CAPRI显示文摘 | Graham RS Paul WF Christopher SP etal | 2005 | Proteins2005，60，2： | 1 |
| 8 | Multidetector-CT angiog- raphy in pulmonary embolism-can image parameters predict clinical outcome? 显示文摘 | Christoph M Heyer CM Lemburg SP | 2011 | Eur Radiol2011，21，： | 1 |
| 9 | A randomized controlled trial of high-dose ursodesoxycholic acid for nonalcoholic steatohepatitis显示文摘 | Vlad Ratziu Victor de Ledinghen Fréderic Oberti Philippe Mathurin Claire Wartelle-Bladou Christophe Renou Philippe Sogni Marianne Maynard Dominique Larrey Lawrence Serfaty Dominique Bonnefont-Rousselot Jean-Philippe Bastard Marc Rivière Jean Spénard | 2011 | Journal of Hepatology2011，，5： | 1 |
| 10 | Differential expression of bcl-2 in intestinal epithelia: Correlation with attenuation of apoptosis in colonic crypts and the incidence of colonic neoplasia显示文摘 | Anita JM Christopher SP Alastair JMW | 1995 | Journal of Cell Science1995，108，6： | 1 |
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