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| 1 | The modulation of co-stimulatory molecules by circulating exosomes in primary biliary cirrhosis显示文摘Exosomes 是 endocytic 起源的 nanoparticles,由由他们调制 cell-to-cell 通讯的能力的优点正在吸引增加的注意的无数房间人口藏匿了。他们也在许多免疫学的问题正在吸引注意,包括 autoimmunity 和,特别地调整 cytokine 和 chemokine 激活的他们的能力。主要胆汁的肝硬化(PBC ) 被认为一个模型自体免疫疾病,它对胆汁的上皮的房间有高度集中的细胞毒素的回答。我们与 PBC 和 30 健康控制(HC ) 从 29 个病人从血浆孤立 exosomes,并且用一个前 vivo 系统在 mononuclear 房间人口在 co-stimulatory 分子表示和 cytokine 生产上学习了这些 exosomes 的效果。我们也与 HC exosomes 相比在 PBC 识别了 microRNA (miRNA ) 人口。我们此处报导尽管 exosomes 不改变 cytokine 生产,他们显著地确实在介绍抗原的人口上改变 co-stimulatory 分子表示。进一步,我们在 CD14 + 单核白血球上表明了那 CD86 起来调整的表情,而在 CD11c + 上起来调整的 CD40 由从有 PBC 的病人的 exosomes 的树枝状的房间。另外,有在有 PBC 的病人的传播 exosomes 的 miRNA 表示的差别。这些数据基于 co-stimulatory 分子玩的观察有重要重要性在 T 房间激活的规定的一个微分角色。我们的观察显示从 PBC 的异常 exosomes 有选择地在介绍抗原的房间的不同子集导致 co-stimulatory 分子的表示。这些改变可以在自体免疫的肝疾病的致病包含。 | Takashi Tomiyama Guo-Xiang Yang Ming Zhao Weici Zhang Hajime Tanaka Jing Wang Patrick SC Leung Kazuiclli Okazaki Xiao-Song He Qianjin Lu Ross L Coppel Christopher L Bowlus M Eric Gershwin | 2017 | Cellular & Molecular Immunology2017，14，3： | 18 |
| 2 | Prevalence of vulvarlichen sclerosus in a general gynecology practice 显示文摘 | Goldstein AT Marinoff SC Christopher K | 2005 | J Reprod Med2005，50，7： | 1 |
| 3 | Prevalence of vul- varlichen sclerosus in a general gynecologypractiee 显示文摘 | Goldstein AT Marinoff SC Christopher K | 2005 | J Reprod Meal2005，50，7： | 1 |
| 4 | Prevalence of vulvar lichen sclerosus in a general gynecology practice 显示文摘 | Goldstein AT Marinoff SC Christopher K | 2005 | J Reprod Med2005，50，7： | 1 |
| 5 | Cluster analysis for identifying sub-groups and selecting potential discriminatory variables in human encephalitis显示文摘 | Jemila SH Christopher M Natasha SC | 2010 | BMC Infectious Diseases2010，10，1： | 1 |
| 6 | George Cystatin C paradigm of evidence based laboratory medicine 显示文摘 | Janice SC Chew Mohammed Saleem Christopher M | 2008 | Clin Biochem Rev2008，1，： | 1 |
| 7 | High-resolution mapping of quantitative trait loci in outbred mice显示文摘 | Christopher JT Alison N Stacey SC | 1999 | Nature Genetic1999，21，： | 1 |
| 8 | Molecular biomarkers in non-small-cell lung cancer: a retrospective analysis of data from the phase 3 FLEX study显示文摘 | Kenneth J O’Byrne Ulrich Gatzemeier Igor Bondarenko Carlos Barrios Corinna Eschbach Uwe M Martens Yevhen Hotko Cornelius Kortsik Luis Paz-Ares Jose R Pereira Joachim von Pawel Rodryg Ramlau Jae-Kyung Roh Chih-Teng Yu Christopher Stroh Ilhan Celik Armin Sc | 2011 | Lancet Oncology2011，，8： | 1 |
| 9 | Function, expression and localization of annexin A7 in platelets and red blood ceils: Insights derived from an annexin A7 mutant mouse 显示文摘 | CLAUDIA H CHRISTOPH SC GISELA L | 2003 | BMC Biochemistry2003，4，： | 1 |
| 10 | Prevalence of vulva lichen sclerosus in a general gynecology practice显示文摘 | Goldstein AT Marinoff SC Christopher K | 2005 | Reprod Med2005，50，： | 1 |
| 11 | Cystatin C-A paradigm of evidence based laboratory medicine显示文摘 | JANICE SC CHEW MOHAMMED SALEEM CHRISTOPHER M FLORKOWSKI | 2008 | Clin Biochem Rev2008，29，： | 1 |
| 12 | Pimeerolimus for the treatment of vulva lichen selerosus: a report of 4 cases显示文摘 | Goldstein AT Marinoff SC Christopher K | 2004 | J Reprod Med2004，49，10： | 1 |
| 13 | Pimeerolimus for the treatment of vulvar liehen selerosus in a premenarehal girl显示文摘 | Goldstein AT Marinoff SC Christopher K | 2004 | J Pediatr Adolese Gyneeol2004，17，1： | 1 |
| 14 | Cystatin C-A para- digm of evidence based laboratory medicine 显示文摘 | Janice SC Saleem M Christopher CM | 2008 | Clin Biochem Rev2008，29，2： | 1 |
| 15 | Prevalence of vulvar lichen sclerosus in a general gynecology practice显示文摘 | Goldstein AT Marinoff SC Christopher K | 2005 | Reprod Med2005，50，7： | 1 |
| 16 | Cluster analysis for identifying sub-groups and selecting potential discriminatory variables in human encephalitis显示文摘 | Jemila SH Christopher M Natasha SC | 2010 | BMC Infectious Diseases2010，10，： | 1 |
| 17 | Cardiopulmonary bypass,myocardial management and support techniques显示文摘 | Chris KR Christopher SC Takashi N | 1995 | J Thorac Card iovasc Surg1995，110，1： | 1 |
| 18 | Sex with Older Partners Is Associated with Primary HIV Infection among Men Who Have Sex with Men in North Carolina显示文摘 | Christopher BH Derrick DM Molly SC | 2010 | J Acquit Im- mune Defic Syndr2010，54，2： | 1 |
| 19 | Prevalence of vulvar lichen sclerosus in a general gynecology practice 显示文摘 | Goldstein AT Marinoff SC Christopher K | 2005 | J Reprod Med2005，50，7： | 1 |
| 20 | Cystatin C-A Paradigm of Evidence Based Laboratory Medicine 显示文摘 | Janice SC Chew Mohammed Saleem Christopher M Florkowski | 2008 | Clin Biochem Rev2008，29，： | 1 |
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