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| 1 | Bicuspid aortic valve hemodynamics does not promote remodeling in porcine aortic wall concavity显示文摘AIM: To investigate the role of type-I left-right bicuspid aortic valve(LR-BAV) hemodynamic stresses in the remodeling of the thoracic ascending aorta(AA) concavity, in the absence of underlying genetic or structural defects.METHODS: Transient wall shear stress(WSS) profiles in the concavity of tricuspid aortic valve(TAV) and LR-BAV AAs were obtained computationally. Tissue specimens excised from the concavity of normal(nondilated) porcine AAs were subjected for 48 h to those stress environments using a shear stress bioreactor. Tissue remodeling was characterized in terms of matrix metalloproteinase(MMP) expression and activity via immunostaining and gelatin zymography.RESULTS: Immunostaining semi-quantification results indicated no significant difference in MMP-2 and MMP-9 expression between the tissue groups exposed to TAV and LR-BAV AA WSS(P = 0.80 and P = 0.19, respectively). Zymography densitometry revealed no difference in MMP-2 activity(total activity, active form and latent form) between the groups subjected to TAV AA and LR-BAV AA WSS(P = 0.08, P = 0.15 and P = 0.59, respectively).CONCLUSION: The hemodynamic stress environment present in the concavity of type-I LR-BAV AA does not cause any significant change in proteolytic enzyme expression and activity as compared to that present in the TAV AA. | Samantha K Atkins Alison N Moore Philippe Sucosky | 2016 | World Journal of Cardiology2016，8，1： | 3 |
| 2 | Reproducibility of thrombus volume quantification in multicenter computed tomography pulmonary angiography studies显示文摘AIM To evaluate reproducibility of pulmonary embolism(PE) clot volume quantification using computed tomography pulmonary angiogram(CTPA) in a multicenter setting.METHODS This study was performed using anonymized data in conformance with HIPAA and IRB Regulations(March 2015-November 2016). Anonymized CTPA data was acquired from 23 scanners from 18 imaging centers using each site's standard PE protocol. Two independent analysts measured PE volumes using a semi-automated region-growing algorithm on an FDA-approved image analysis platform. Total thrombus volume(TTV) was calculated per patient as the primary endpoint. Secondary endpoints were individual thrombus volume(ITV), Qanadli score and modified Qanadli score per patient. Inter-and intra-observer reproducibility were assessed using intra-class correlation coefficient(ICC) and BlandAltman analysis. RESULTS Analyst 1 found 72 emboli in the 23 patients with a mean number of emboli of 3.13 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.0041-47.34 cm3(mean +/-SD, 5.93 +/-10.15 cm3). On the second read, analyst 1 found the same number and distribution of emboli with a range of volumes for read 2 from 0.0041 – 45.52 cm3(mean +/-SD, 5.42 +/-9.53 cm3). Analyst 2 found 73 emboli in the 23 patients with a mean number of emboli of 3.17 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.00459-46.29 cm3(mean +/-SD, 5.91 +/-10.06 cm3). Inter-and intraobserver variability measurements indicated excellent reproducibility of the semi-automated method for quantifying PE volume burden. ICC for all endpoints was greater than 0.95 for inter-and intra-observer analysis. Bland-Altman analysis indicated no significant biases.CONCLUSION Semi-automated region growing algorithm for quantifying PE is reproducible using data from multiple scanners and is a suitable method for image analysis in multicenter clinical trials. | Audrey E Kaufman Alison N Pruzan Ching Hsu Sarayu Ramachandran Adam Jacobi Indravadan Patel Lee Schwocho Michele F Mercuri Zahi A Fayad Venkatesh Mani | 2018 | World Journal of Radiology2018，10，10： | 3 |
| 3 | Effect of varying computed tomography acquisition and reconstruction parameters on semi-automated clot volume quantification显示文摘AIM To examine effects of computed tomography(CT)image acquisition/reconstruction parameters on clot volume quantification in vitro for research method validation purposes.METHODS This study was performed in conformance with HIPAA and IRB Regulations(March 2015-November 2016).A ten blood clot phantom was designed and scanned on a dual-energy CT scanner(SOMATOM Force,Siemens Healthcare Gm BH,Erlangen,Germany)with varying pitch,iterative reconstruction,energy level and slicethickness.A range of clot and tube sizes were used in an attempt to replicate in vivo emboli found within central and segmental branches of the pulmonary arteries in patients with pulmonary emboli.Clot volume was the measured parameter and was analyzed by a single image analyst using a semi-automated region growing algorithm implemented in the FDA-approved Siemens syngo.via image analysis platform.Mixed model analysis was performed on the data.RESULTS On the acquisition side,the continuous factor of energy showed no statistically significant effect on absolute clot volume quantification(P=0.9898).On the other hand,when considering the fixed factor of pitch,there were statistically significant differences in clot volume quantification(P<0.0001).On the reconstruction side,with the continuous factor of reconstruction slice thickness no statistically significant effect on absolute clot volume quantification was demonstrated(P=0.4500).Also on the reconstruction side,with the fixed factor of using iterative reconstructions there was also no statistically significant effect on absolute clot volume quantification(P=0.3011).In addition,there was excellent R^2 correlation between the scale-measured mass of the clots both with respect to the CT measured volumes and with respect to volumes measure by the water displacement method.CONCLUSION Aside from varying pitch,changing CT acquisition parameters and using iterative reconstructions had no significant impact on clot volume quantification with a semi-automated region growing algorithm. | Audrey E Kaufman Alison N Pruzan Ching Hsu Sarayu Ramachandran Adam Jacobi Zahi A Fayad Venkatesh Mani | 2018 | World Journal of Radiology2018，10，3： | 3 |
| 4 | Monitoring a high cell density recombinant Pichia pastoris fed-batch bioprocess using transmission and reflectance near infrared spectroscopy 显示文摘 | Crowley J Alison Arnold S Wood N | 2005 | Enzyme and Microbial Technology2005，36，56： | 1 |
| 5 | Ultrasound image segmentation:a survey 显示文摘 | Alison N J Djamal B | 2006 | IEEE Transactions on Medical Imaging2006，25，8： | 1 |
| 6 | Androgen receptor expression is greater with implications for atherosclerosis 显示文摘 | McCrohon JA Alison KD Shirly N | 2000 | Circulation2000，101，2： | 1 |
| 7 | The effect of morphological filters on texture boundary localization显示文摘 | ALISON N J | 1996 | IEEE Trans on Pattern Analysis and Machine Intelligence1996，18，5： | 1 |
| 8 | What is so special about aerosol-OT 显示文摘 | SANDRINE N ALISON P JULIAN E | 2005 | Langmuir2005，21，10： | 1 |
| 9 | Finding cancer stem cells: are aldehyde dehydrogenases fit for purpose? 显示文摘 | ALISON M R GUPPY N J LIM S M | 2010 | J Pathol2010，222，4： | 1 |
| 10 | High-resolution mapping of quantitative trait loci in outbred mice显示文摘 | Christopher JT Alison N Stacey SC | 1999 | Nature Genetic1999，21，： | 1 |
| 11 | A mathematical modelof a high sulphate waste water ananerobic treatment system显示文摘 | Anthony N Knobel Alison E Lewis | 2002 | Water Research2002，36，： | 1 |
| 12 | Environmental tobacco smoke exposure and lung cancer:A systematic review显示文摘AIM:To review evidence relating passive smoking to lung cancer risk in never smokers,considering various major sources of bias.METHODS:Epidemiological prospective or case-control studies were identified which provide estimates of relative risk(RR) and 95% CI for never smokers for one or more of seven different indices of exposure to environmental tobacco smoke(ETS):The spouse; household; workplace; childhood; travel; social and other; and total.A wide range of study details were entered into a database,and the RRs for each study,including descriptions of the comparisons made,were entered into a linked database.RRs were derived where necessary.Results were entered,where available,for all lung cancer,and for squamous cell cancer and adenocarcinoma.'Most adjusted' results were entered based on results available,adjusted for the greatest number of potential confounding variables.'Least adjusted' results were also entered,with a preference for results adjusted at least for age for prospective studies.A pre-planned series of fixed-effects and random-effects meta-analyses were conducted.Overall analyses and analyses by continent were run for each exposure index,with results for spousal smoking given by sex,and results for childhood exposure given by source of ETS exposure.For spousal exposure,more extensive analyses provide results by various aspects of study design and definition of the RR.For smoking by the husband(or nearest equivalent),additional analyses were carried out both for overall risk,and for risk per 10 cigarettes per day smoked by the husband.These adjusted for uncontrolled confounding by four factors(fruit,vegetable and dietary fat consumption,and education),and corrected for misclassification of smoking status of the wife.For the confounding adjustment,estimates for never smoking women were derived from publications on the relationship of the four factors to both lung cancer risk and at home ETS exposure,and on the correlations between the factors.The bias due to misclassification was calculated on the basis that the proportion of ever smokers denying smoking is 10% in Asian studies and 2.5% elsewhere,and that those who deny smoking have the same risk as those who admit it.This approach,justified in previous work,balances higher true denial rates and lower risk in deniers compared to non-deniers.RESULTS:One hundred and two studies were identified for inclusion,published in 1981 onwards,45 in Asia,31 in North America,21 in Europe,and five elsewhere.Eightyfive were of case-control design and 17 were prospective.Significant(P < 0.05) associations were noted,with random-effects of(RR=1.22,95%CI:1.14-1.31,n=93) for smoking by the husband(RR=1.14,95%CI:1.01-1.29,n=45) for smoking by the wife(RR=1.22,95%CI:1.15-1.30,n=47) for workplace exposure(RR=1.15,95%CI:1.02-1.29,n=41) for childhood exposure,and(RR=1.31,95%CI:1.19-1.45,n=48) for total exposure.No significant association was seen for ETS exposure in travel(RR=1.34,95%CI:0.94-1.93,n=8) or in social situations(RR=1.01,95%CI:0.82-1.24,n=15).A significant negative association(RR=0.78,95%CI:0.64-0.94,n=8) was seen for ETS exposure in childhood,specifically from the parents.Significant associations were also seen for spousal smoking for both squamous cell carcinoma(RR=1.44,95%CI:1.15-1.80,n=24) and adenocarcinoma(RR=1.33,95%CI:1.17-1.51,n=30).Results generally showed marked heterogeneity between studies.For smoking by either the husband or wife,where 119 RR estimates gave an overall estimate of(RR=1.21,95%CI:1.14-1.29),the heterogeneity was highly significant(P < 0.001),with evidence that the largest RRs were seen in studies published in 1981-89,in small studies(1-49 cases),and for estimates unadjusted by age.For smoking by the husband,the additional analyses showed that adjustment for the four factors reduced the overall(RR=1.22,95%CI:1.14-1.31) based on 93 estimates to(RR=1.14,95%CI:1.06-1.22),implying bias due to uncontrolled confounding of 7%.Further correction for misclassification reduced the estimate to a marginally non-significant(RR=1.08,95%CI:0.999-1.16).In the fully adjusted and corrected analyses,there was evidence of an increase in Asia(RR=1.18,95%CI:1.07-1.30,n=44),but not in other regions(RR=0.96,95%CI:0.86-1.07,n=49).Studies published in the 1980's,studies providing dose-response data,and studies only providing results unadjusted for age showed elevated RRs,but later published studies,studies not providing dose-response data,and studies adjusting for age did not.The pattern of results for RRs per 10 cigs/d was similar,with no significant association in the adjusted and corrected results(RR=1.03,95%CI:0.994-1.07).CONCLUSION:Most,if not all,of the ETS/lung cancer association can be explained by confounding adjustment and misclassification correction.Any causal relationship is not convincingly demonstrated. | Peter N Lee John S Fry Barbara A Forey Jan S Hamling Alison J Thornton | 2016 | World Journal of Meta-Analysis2016，4，2： | 1 |
| 13 | Early Response to Platinum based first-line chemotherapy in non-small cell lung cancer may predict survival显示文摘 | Bhawna S Sue A Alison N | 2007 | J Thorae Oncol2007，2，8： | 1 |
| 14 | Sleeping characteristics of children undergoing outpatient elective surgery显示文摘 | Zeev N Kain Linda C Mayes Alison A | | 0，，： | 1 |
| 15 | The timing of pronuclear formation, DNA synthesis and cleavage in the human 1 -cell embryo 显示文摘 | Gemma Capmany Alison Taylor Peter R Braude and Virginia N Bohon | 1996 | Molecular Hum Reprod1996，2，5： | 1 |
| 16 | Quinapril Review of its Pharmacological Properties,and Therapeutic Efficacy in Cardiovascular Disorders显示文摘 | Alison N Wadworth Rex N | | 0，，： | 1 |
| 17 | Flavonol glycosides from the seeds of Agrimonia eupatoria(Rosaceae) 显示文摘 | Craig TM Lutfun N Alison C | 2003 | Biochem System Ecol2003，31，4： | 1 |
| 18 | A mathematical model of a high sulphate waste water ananerobic treatment system 显示文摘 | Anthony N K Alison E L | 2002 | Wa- ter Reserch2002，36，： | 1 |
| 19 | A mathematical model of a high sulphate wastewater ananerobic treatment system显示文摘 | Anthony N Knobel Alison E Lewis | 2002 | Water Research2002，36，： | 1 |
| 20 | Nucleation control in solution mediated polymorphic phase transformations:the case of 2,6-dihydroxybenzoic acid显示文摘 | Davey R J Blagden N Righini S Alison H Ferrari E S | | 0，，： | 1 |
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