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| 1 | Clopidogrel plus as-pirin versus aspirin alone for reducing embolisation in patients with a-cute symptomatic cerebral or carotid artery stenosis(CLAIR study):arandomised,open-label,blinded-endpoint trial显示文摘 | Ka Sing Lawrence Wong Christopher Chen | 2010 | Lancet Neural2010，9，： | 1 |
| 2 | Case study method and problem-based learning:utilizing the pedagogical model of progressive complexity in nursing education显示文摘 | McMahon MA Christopher KA | 2011 | Int J Nurs Educ Scholarsh2011，8，1： | 1 |
| 3 | Low-molecu-lar-weight heparin compared with aspirin for the treatment ofacute ischaemic stroke in Asian patients with large artery occlu-sive disease:a randomised study显示文摘 | Ka S W Christopher C Ping Wing Ng | 2007 | 6(5):4072007，6，5： | 1 |
| 4 | Duret hemorrhage: demonstration of ruptured paramedian pontine branches of the basilar artery on minimally invasive, whole body postmortem CT angiography显示文摘 | Ka Lip Chew Yeliena Baber Linda Iles Christopher O’Donnell | 2012 | Forensic Science, Medicine, and Pathology2012，，4： | 1 |
| 5 | Low-molecular-weight heparin compared with aspirin for the treatment of acute ischaemic stroke in asian patients with large artery occlusive disease:a randomised study显示文摘 | Ka SW Christopher C Ping WN | 2007 | The Lancet Neurology2007，6，5： | 1 |
| 6 | Spontaneous fetalloss demonstration of a live fetus in the first trimester显示文摘 | Cashner KA Christopher CR Dysert GA | 1987 | Obstet Gyneeol1987，70，6： | 1 |
| 7 | Case study method and problem-based learning: utilizing the pedagogical model of progressive complexity in nursing education 显示文摘 | McMahon MA Christopher KA | 2011 | Int J Nurs Educ Scholarsh2011，19，8： | 1 |
| 8 | Older than 60 years: a study of the East German Hematology and Oncology Study Group ( OSHO ) 显示文摘 | Christoph K Rainer K Haifa KA | 2014 | Blood ( ASH annual meeting abstracts )2014，124，21： | 1 |
| 9 | Spontaneous fetal loss demonstrationof a live fetus in the first trimester显示文摘 | Cashner KA Christopher CR Dysert GA | 2011 | Obstet Gyne col2011，70，6： | 1 |
| 10 | Eagle, Aortic Dissection: New Frontiers in Diagnosis and Management:Part I:From Eti- ology to Diagnostic Strategies 显示文摘 | Christoph A Nienabe KA | 2003 | Circulation2003，108，5： | 1 |
| 11 | Spontaneous fetal loss dem- onstration of a live fetus in the first trimester 显示文摘 | Cashner KA Christopher CR Dysert GA | 1997 | Obstet Gynecol1997，70，6： | 1 |
| 12 | Clopidogrel plus aspirin versus aspirin alone for reducing embolisation in patients with acute symptomatic cerebral or carotid artery stenosis (CLAIR study): a randomised, open-label, blinded-endpoint trial显示文摘 | Ka Sing Lawrence Wong Christopher Chen Jianhui Fu Hui Meng Chang Nijasri C Suwanwela Yining N Huang Zhao Han Kay Sin Tan Disya Ratanakorn Pavithra Chollate Yudong Zhao Angeline Koh Qing Hao Hugh S Markus | 2010 | Lancet Neurology2010，，5： | 1 |
| 13 | Toward a mid-range theory of nursing presence显示文摘 | McMahon MA Christopher KA | | 0，，02： | 1 |
| 14 | Retiming the failing heart:Principles and current clinical status of cardiac resynchronization显示文摘 | Christophe L David KA | 2002 | J Am Coll Cardiol2002，39，： | 1 |
| 15 | Lowmolecular-weight heparin compared with aspirin for the treatment of acute ischaemic stroke in Asian patients with large artery occlusive disease:a randomised study显示文摘 | Ka Sing Wong Christopher Chen Ping Wing Ng | | 0，，05： | 1 |
| 16 | Low-molecular-weight heparin compared with aspirin for the treatment of acute ischaemic stroke in Asian patients with large artery occlusive disease: a randomised study显示文摘 | Ka Sing Wong Christopher Chen Ping Wing Ng Tak Hong Tsoi Ho Lun Li Wing Chi Fong Jonas Yeung Chi Keung Wong Kin Keung Yip Hong Gao Hwee Bee Wong | 2007 | Lancet Neurology2007，，5： | 1 |
| 17 | HM30181A,a potent P-glycoprotein inhibitor,potentiates the absorption and in vivo antitumor efficacy of paclitaxel in an orthotopic brain tumor model显示文摘Objective:Delivery of chemotherapeutic drugs to the brain has remained a major obstacle in the treatment of glioma,owing to the presence of the blood-brain barrier and the activity of P-gp,which pumps its substrate back into the systemic circulation.The aim of the present study was to develop an intravenous formulation of HM30181 A(HM)to inhibit P-gp in the brain to effectively deliver paclitaxel(PTX)for the treatment of malignant glioma.Methods:Two formulations of solubilized HM were designed on the basis of different solid dispersion strategies:i)spray-drying[polyvinlypyrrolidone(PVP)-HM]and ii)solvent evaporation[HP-β-cyclodextrin(cyclodextrin)-HM].The P-gp inhibition of these 2 formulations was assessed on the basis of rhodamine 123 uptake in cancer cells.Blood and brain pharmacokinetic parameters were also determined,and the antitumor effect of cyclodextrin-HM with PTX was evaluated in an orthotopic glioma xenograft mouse model.Results:Although both PVP-HM and cyclodextrin-HM formulations showed promising P-gp inhibition activity in vitro,cyclodextrin-HM had a higher maximum tolerated dose in mice than did PVP-HM.Pharmacokinetic study of cyclodextrin-HM revealed a plasma concentration plateau at 20 mg/kg,and the mice began to lose weight at doses above this level.Cyclodextrin-HM(10 mg/kg)administered with PTX at 10 mg/kg showed optimal antitumor activity in a mouse model,according to both tumor volume measurement and survival time(P<0.05).Conclusions:In a mouse orthotopic brain tumor model,the intravenous co-administration of cyclodextrin-HM with PTX showed potent antitumor effects and therefore may have potential for glioma therapy in humans. | Wu Zeng Betty Yuen Kwan Law Vincent Kam Wai Wong Denise So Bik Chan Simon Wing Fai Mok Joyce Jia Ying Gao Rebecca Ka Yan Ho Xu Liang Jia Hao Li Ming Tsung Lee Weng Li Yoon Michael P Smolinski Johnson Yiu Nam Lau Christopher Wai Kei Lam Manson Fok | 2020 | Cancer Biology & Medicine2020，17，4： | 0 |
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