|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Long-term stability of gentamicin sulfate-ethylenediaminetetraacetic acid disodium salt (EDTA-Na_2) solution for catheter locks显示文摘A lock solution composed of gentamicin sulfate(5 mg/mL) and ethylenediaminetetraacetic acid disodium salt(EDTA-Na2, 30 mg/mL) could fully eradicate in vivo bacterial biofilms in totally implantable venous access ports(TIVAP). In this study, fabrication, conditioning and sterilization processes of antimicrobial lock solution(ALS) were detailed and completed by a stability study. Stability of ALS was conducted for12 months in vial(25 °C 7 2 °C, 60% 7 5% relative humidity(RH), and at 40 °C 7 2 °C, RH 75% 7 5%)and for 24 h and 72 h in TIVAP(40 °C 7 2 °C, RH 75% 7 5%). A stability indicating HPLC assay with UV detection for simultaneous quantification of gentamicin sulfate and EDTA-Na2 was developed. ALS was assayed by ion-pairing high performance liquid chromatography(HPLC) needing gentamicin derivatization, EDTA-Na2 metallocomplexation of samples and gradient mobile phase. HPLC methods to separate four gentamicin components and EDTA-Na2 were validated. Efficiency of sterility procedure and conditioning of ALS was confirmed by bacterial endotoxins and sterility tests. Physicochemical stability of ALS was determined by visual inspection, osmolality, pH, and sub-visible particle counting. Results confirmed that the stability of ALS in vials was maintained for 12 months and 24 h and 72 h in TIVAP. | Anne-Sophie Fiolet Elise Jandot Pauline Doucey Coralie Crétet Célia Brunel Christine Pivot Jean-Marc Ghigo Christophe Beloin David Lebeaux Fabrice Pirot | 2018 | Journal of Pharmaceutical Analysis2018，8，6： | 2 |
| 2 | Halovirs A-E, New Antiviral Agents from a Marine- Derived Fungus of the Genus Scytalidium 显示文摘 | David CR Sara K Christopher AK | 2003 | Bioorganic & Medicinal Chemistry2003，11，： | 1 |
| 3 | Management of patients with aortic dissection 显示文摘 | Ernst W Christoph AN Tim CR | 2008 | Dtsch arztebl2008，105，38： | 1 |
| 4 | Spontaneous fetalloss demonstration of a live fetus in the first trimester显示文摘 | Cashner KA Christopher CR Dysert GA | 1987 | Obstet Gyneeol1987，70，6： | 1 |
| 5 | Spontaneous fetal loss demonstrationof a live fetus in the first trimester显示文摘 | Cashner KA Christopher CR Dysert GA | 2011 | Obstet Gyne col2011，70，6： | 1 |
| 6 | Sex,gender and pain: A review of recent clinical and experimental findings显示文摘 | Roger BF Christopher DK Margarete CR | 2009 | J Pain2009，10，44： | 1 |
| 7 | Numerical instabilities in bone remodeling simulations: the advantages of anodebased finite element approach 显示文摘 | Christopher R Jacobs CR | 1995 | J Biomech1995，28，4： | 1 |
| 8 | Axillary lymph node metastases in patients with breast carcinomas:assessment with nonenhanced versus USPIO-enhanced MR imaging 显示文摘 | Mazda M Christopher CR Andreas K | 2006 | Radiology2006，241，2： | 1 |
| 9 | Per ceptions of the organizational context and psychological con tract breach:Assessing competing perspectives 显示文摘 | Christopher CR Chu Hsiang Chang Russell EJ | 2009 | Behavior and Human Decision Processes2009，2，108： | 1 |
| 10 | Spontaneous fetal loss dem- onstration of a live fetus in the first trimester 显示文摘 | Cashner KA Christopher CR Dysert GA | 1997 | Obstet Gynecol1997，70，6： | 1 |
| 11 | Axillary lymph node metastases in patients with breast carcinomas: assessment with nonenhanced versus USPIO-enhanced MR imaging 显示文摘 | Mazda M Christopher CR Andreas K | 2006 | Radiology2006，241，2： | 1 |
| 12 | Inactivation of the NCAM gene in the mice results in size reduction of the olfactory bulb and deficits in spatial learning显示文摘 | Lange R Christoph A | 1994 | Nature1994，367，： | 1 |
| 13 | Head-to-Head Com- parison of^ 11C-PiB and ^18F-AZD4694 (NAV4694) for b-Amyloid Imaging in Aging and Dementia显示文摘 | Christopher CR Svetlana P | 2013 | The Journal of Nuclear Medcine2013，54，6： | 1 |
| 14 | Histopathological evaluation of liver fibrosis: quantitative image analysis vs semi-quantitative scores显示文摘 | Christophe P Marie CR Pierre B | 1998 | Hepatol1998，28，3： | 1 |
| 15 | Barriers to nonviral gene delivery显示文摘 | Christopher MW Middaugh CR | 2003 | J Pharm Sci2003，92，2： | 1 |
| 16 | Histopthological evaluation of liver fibrosis: quantitative image analysis vs semi - quantitative scores显示文摘 | Christophe P Marie CR Pierre B | 1998 | Hepatol1998，28，6： | 1 |
| 17 | Adult human hematopoietic cells provide functional hemangioblast activity显示文摘 | Christopher CR Wainman DA Jorgensen ML | 2004 | Blood2004，103，1： | 1 |
| 18 | Barriers to nonviral gene delivery显示文摘 | Christopher M Wiethoff Middaugh CR | 2003 | J Pharmaceut Sci2003，92，： | 1 |
| 19 | Management of patients with aortic dissection显示文摘 | Emst W Christoph AN Tim CR | 2008 | Dtsch Arztebl2008，105，38： | 1 |
| 20 | Management of Patients With Aortic Dissection显示文摘 | Emst WG Christoph AN Tim CR | 2008 | Dtsch Arztebl2008，105，38： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员