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| 1 | Clinical characteristics and outcome of a cohort of 101 patients with hepatocellular carcinoma显示文摘AIM To conduct a cohort study of 101 patients with hepatocellular carcinoma (HCC) presenting to a tertiary care medical referral center in Germany between 1997 and 1999.METHODS AND RESULTS Data were retrospectively analyzed by chart review. In 95cases (72 males and 23 females) sufficient data were available for analysis. Twenty-five (29%)of 8.5 patients were HBsAg or anti-HBc positive,21/85 (25%) were anti-HCV positive, and 6/85(7%) were positive for both HBV and HCV-markers. Age was significantly lower in HBV-positive patients than in the other two groups.Thirty-one (34%) of 90 patients had histories of alcohol abuse, In 79/ 94 (84%) patients,cirrhosis was diagnosed. Of these cirrhotic patients, 29/79 (37%) belonged to Child-Pugh's group (CHILD) A, 32/79 (40%) to CHILD B, and 18/79 (23%) to CHILD C. AFP was elevated in 61/91 (67%) patients. A single tumor nodule was found in 38/94 (40%), more than one nodule in 31/94 (34%), and 25/94 (26%) had a diffusely infiltrating tumor, i.e. the tumor margins could not be seen on imaging procedures. Portal vein thrombosis was present in 19/ 94 (20%).Imaging data consistent with lymph node metastases were found in 10/92 (11%), while distant metastases were found in 8/93 (9%).According to Okuda 28/94 (30%) were grouped to stage Ⅰ, 53/94 (56%) were grouped to stage Ⅱ, and 13/94 (14%) were grouped to stage Ⅲ.Survival data were available for 83 patients. The Kaplan-Meier estimate for median survival was 8.4 months. Factors influencing survival were the Okuda score, the presence of portal vein thrombosis, and the presence of ascites. The presence of non-complicated liver cirrhosis by itself, distant metastases, or infection with hepatitis viruses did not influence survival. AFP positivity by itself did not influence survival,though patients with an AFP value greater than 100μg/L did experience shortened survival.Treatment besides tamoxifen or supportive care was associated with prolonged survival. The influence of therapy on survival was most pronounced in Okuda stage Ⅱ patients. There was longer survival in those Okuda stage Ⅱpatients who were treated with percutaneous ethanol injection.CONCLUSION Even in a Iow incidence area such as Germany, the majority of HCC is caused by viral hepatitis and therefore potentially preventable. Reflecting the high proportion of advanced stage tumors in our patients, the median survival was poor. Patients who received active therapy had a longer survival. | Christian Rabe Tillmann Pilz Christoph Klostermann Marc Berna Hans H.Schild Tilman Sauerbruch Wolfgang H.Caselmann | 2001 | World Journal of Gastroenterology2001，7，2： | 60 |
| 2 | 'Micro-deletions' of the human Y chromosome and their relationship with male infertility显示文摘The Y chromosome evolves from an autochromosome and accumulates male-related genes including sex-determining region of Y-chromosome (SRY) and several spermatogenesis-related genes. The human Y chromosome (60 Mb long) is largely composed of repeti-tive sequences that give it a heterochromatic appearance, and it consists of pseudoautosomal, euchromatic, and heterochromatic regions. Located on the two extremities of the Y chromosome, pseudoautosomal regions 1 and 2 (PAR1 and PAR2, 2.6 Mb and 320 bp long, re-spectively) are homologs with the termini of the X chromosome. The euchromatic region and some of the repeat-rich heterochromatic parts of the Y chromosome are called 'male-specific Y' (MSY), which occupy more than 95% of the whole Y chromosome. After evolu-tion, the Y chromosome becomes the smallest in size with the least number of genes but with the most number of copies of genes that are mostly spermatogenesis-related. The Y chromosome is characterized by highly repetitive sequences (including direct repeats, inverted repeats, and palindromes) and high polymorphism. Several gene rearrangements on the Y chromosome occur during evolution owing to its specific gene structure. The consequences of such rearrangements are not only loss but also gain of specific genes. One hundred and fifty three haplotypes have been discovered in the human Y chromosome. The structure of the Y chromosome in the GenBank belongs to haplotype R1. There are 220 genes (104 coding genes, 111 pseudogenes, and 5 other uncategorized genes) according to the most recent count. The 104 coding genes encode a total of about 48 proteins/protein families (including putative proteins/protein families). Among them, 16 gene products have been discovered in the azoospermia factor region (AZF) and are related to spermatogenesis. It has been dis-covered that one subset of gene rearrangements on the Y chromosome, 'micro-deletions', is a major cause of male infertility in some populations. However, controversies exist about different Y chromosome haplotypes. Six AZFs of the Y chromosome have been discov-ered including AZFa, AZFb, AZFc, and their combinations AZFbc, AZFabc, and partial AZFc called AZFc/gr/gr. Different deletions in AZF lead to different content spermatogenesis loss from teratozoospermia to infertility in different populations depending on their Y hap-lotypes. This article describes the structure of the human Y chromosome and investigates the causes of micro-deletions and their relation-ship with male infertility from the view of chromosome evolution. After analysis of the relationship between AZFc and male infertility, we concluded that spermatogenesis is controlled by a network of genes, which may locate on the Y chromosome, the autochromosomes, or even on the X chromosome. Further investigation of the molecular mechanisms underlying male fertility/infertility will facilitate our knowledge of functional genomics. | Zheng Li Christopher J Haines Yibing Han | 2008 | Journal of Genetics and Genomics2008，35，4： | 25 |
| 3 | Three-dimensional human facial morphologies as robust aging markers显示文摘老化与许多复杂疾病被联系。变老的过程的可靠预言为估计联系老化的疾病的风险是重要的。然而尽管有强烈研究,到目前为止没有可靠老化标记。这里,我们由检验人的 3D 美容成像特征是否能被用作可靠老化标记处理了这个问题。我们收集了 >300 幅 3D 人美容图象和越过 17 ~ 77 年的年龄散布得好的血侧面。由分析词法侧面,我们产生了变老的人的面部 phenome 的第一张全面地图。我们鉴别量的面部特征例如眼睛斜坡,高度与年龄联系了。我们构造了一个柔韧的年龄预言者并且发现平均,一样的按年代先后的年龄的人由 ± 不同;在美容的 6 年变老,与在年龄 40 以后增加的偏差。用这个预言者,我们识别了被健康指示物的层次显著地支持的慢、快的蒸化机。尽管有在在血的面部词法特征和健康指示物之间的一种靠近的关系,面部特征比血侧面是更可靠的老化 biomarkers 并且能更好比按年代先后的年龄反映一般健康地位。 | Weiyang Chen Wei Qian Gang Wu Weizhong Chen Bo Xian Xingwei Chen Yaqiang Cao Christopher D Green Fanghong Zhao Kun Tang Jing-Dong J Han | 2015 | Cell Research2015，25，5： | 17 |
| 4 | Clinically detected gastroenteropancreatic neuroendocrine tumors are on the rise: Epidemiological changes in Germany显示文摘AIM:To study the epidemiologic changes of gastroenteropancreatic neuroendocrine tumors(GEP-NET)in Germany,we analyzed two time periods 1976-1988 and1998-2006.METHODS:We evaluated epidemiological data of GEP-NET from the former East German National Cancer Registry(DDR Krebsregister,1976-1988)and its successor,the Joint Cancer Registry(GKR,1998-2006),which was founded after German reunification.Due to a particularly substantial database the epidemiological data from the federal states of Mecklenburg-Western Pomerania,Saxony,Brandenburg and Thuringia,covering a population of more than 10.8 million people,were analyzed.Survival probabilities were calculated using life table analysis.In addition,GEP-NET patients were evaluated for one or more second(non-GEP-NET)primary malignancies.RESULTS:A total of 2821 GEP neuroendocrine neoplasms were identified in the two registries.The overall incidence increased significantly between 1976 and2006 from 0.31(per 100.000 inhabitants per year)to2.27 for men and from 0.57 to 2.38 for women.In the later period studied(2004-2006),the small intestine was the most common site.Neuroendocrine(NE)neoplasms of the small intestine showed the largest absolute increase in incidence,while rectal NE neoplasms exhibited the greatest relative increase.Only the incidence of appendiceal NET in women showed little change between 1976 and 2006.Overall survival of patients varied for sex,tumor site and the two periods studied but improved significantly over time.Interestingly,about 20%of the GEP-NET patients developed one or more second malignancies.Their most common location was the gastrointestinal tract.GEP-NET patients without second malignancies fared better than those with one or more of them.CONCLUSION:The number of detected GEP-NET increased about 5-fold in Germany between 1976 and2006.At the same time,their anatomic distribution changed,and the survival of GEP-NET patients improved significantly.Second malignancies are common and influence the overall survival of GEP-NET patients.Thus,GEP-NET warrant our attention as well as intensive research on their tumorigenesis. | Hans Scherübl Brigitte Streller Roland Stabenow Hermann Herbst Michael Hopfner Christoph Schwertner Joachim Steinberg Jan Eick Wanda Ring Krishna Tiwari Soren M Zappe | 2013 | World Journal of Gastroenterology2013，19，47： | 16 |
| 5 | P2RX7 sensitizes Mac-1/ICAM-1-dependent leukocyte- endothelial adhesion and promotes neurovascular injury during septic encephalopathy显示文摘 | Huan Wang Ling-Juan Hong Ji-Yun Huang Quan Jiang Rong-Rong Tao Chao Tan Nan-Nan Lu Cheng-Kun Wang Muhammad M Ahmed Ying-Mei Lu Zhi-Rong Liu Wei-Xing Shi En-Yin Lai Christopher S Wilcox Feng Han | 2015 | Cell Research2015，25，6： | 16 |
| 6 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 7 | Risk Factors for Survival after Lung Metastasectomy in Colorectal Cancer Patients: A Systematic Review and Meta-Analysis显示文摘 | Michel Gonzalez Antoine Poncet Christophe Combescure John Robert Hans Beat Ris Pascal Gervaz | 2013 | Annals of Surgical Oncology2013，，2： | 9 |
| 8 | Testicular expression of survivin and human telomerase reverse transcriptase(hTERT)associated with spermatogenic function in infertile patients显示文摘瞄准:与改变精子发生的功能在人的睾丸描绘 survivin, apoptosis (国际星际航空联合会) 的一个禁止者,和人的 telomerase 颠倒 transcriptase (hTERT ) 的 coexpression。方法:survivin mRNA 和 hTERT mRNA 的抄本层次用即时反向抄写的聚合酶链反应(RT-PCR ) 与有缺点的精子发生(n=28 ) 在正常睾丸(n=11 ) 和睾丸被决定。组织学的病情的检查根据一个修改 Johnsen 分数被执行。结果:survivin 和 hTERT 的表情在正常精子发生在 96.8 和 709 的中部的层次是最高的并且随减数分裂后精子发生的拘捕(n=10 ) 在睾丸落下到 53.3 和 534。在严重精子发生的失败( n=18 ), survivin 表示缺乏大多数标本( n=16 ),而阴囊的 hTERT 表示的至少底层在 premeiotic 精子发生的拘捕( n=7 )与 73 的规范的表情大部分是可检测的并且 45 在有 Sertoli 房间唯一的症候群( SCOS )( n=3 )的病人。survivin 和 hTERT 表情与一个进行的 Johnsen 分数(为 trend=0.001 的 P ) 增加了。结论:尽管 survivin 和 hTERT 与精子发生的功能被相关,他们在不肥沃的病人的睾丸显示出不同表示模式。这些调查结果在在 meiotically 划分生殖细胞建议 survivin 的占优势的表情的啮齿类动物睾丸从研究证实结果。 | Steffen Weikert Frank Christoph Wolfgang Schulze Hans Krause Carsten Kempkensteffen Martin Schostak Kurt Miller Mark Schrader | 2006 | Asian Journal of Andrology2006，8，1： | 8 |
| 9 | Effects of grazing intensity on seed production of Caragana stenophylla along a climatic aridity gradient in the Inner Mongolia Steppe,China显示文摘As the increases of climatic aridity and grazing intensity,shrubs play an increasingly important role in grassland ecosystem in arid and semi-arid regions,and its abundance also generally increases.However,the effects of climatic aridity and grazing intensity on sexual reproduction of shrubs in grassland remain largely unclear.In order to understand the effects of grazing intensity and climatic drought stress,and their interaction on seed production of shrub species,we examined the seed number,seed weight and seed yield of Caragana stenophylla under three grazing intensities(fenced,mild grazing and severe grazing) across a climatic aridity gradient(semi-arid,arid,very arid and intensively arid zones) in the Inner Mongolia Steppe,northern China during 2012–2013.The seed number,seed weight and seed yield gradually increased from the semi-arid to the very arid zones,but decreased from the very arid to the intensively arid zones in fenced plots.The seed number and seed yield decreased from the semi-arid to the intensively arid zones in mild and severe grazing treatment plots,therefore,grazing enhanced the suppression effect of climatic aridity on seed production of C.stenophylla.The seed number and seed yield gradually decreased as grazing intensity increased.The seed weight was highest in severe grazing plots,followed by the mild grazing plots and then the fenced plots.Precipitation varied interannually during the study period.We observed that the seed number,seed weight and seed yield were lower in the low precipitation year(2013) than in the high precipitation year(2012).As climatic drought stress increased,the negative effects of grazing on seed production of C.stenophylla also gradually increased.Our results indicated that climatic drought stress may contribute to the encroachment of C.stenophylla shrub in arid zones by promoting its seed production.However,grazing had negative effects on sexual reproduction of C.stenophylla,and the combined effects of drought stress and grazing seriously suppressed sexual reproduction of C.stenophylla in the intensively arid zone. | XIE Lina CHEN Weizhong Christopher A GABLER HAN Lei GUO Hongyu CHEN Qing MA Chengcang GU Song | 2016 | Journal of Arid Land2016，8，6： | 5 |
| 10 | Risk of Melanoma and Nonmelanoma Skin Cancer Among Patients With Inflammatory Bowel Disease显示文摘 | Millie D. Long Christopher F. Martin Clare A. Pipkin Hans H. Herfarth Robert S. Sandler Michael D. Kappelman | 2012 | Gastroenterology2012，，2： | 4 |
| 11 | Tyrosine metabolic enzymes from insects and mammals:A comparative perspective显示文摘在在昆虫和哺乳动物之间的酷氨酸的新陈代谢的差别举分子的进化的一个有趣的例子。昆虫和哺乳动物拥有酶的调整系统为酷氨酸代谢物遇见他们的特定的要求;然而,涉及酷氨酸新陈代谢的更相应的酶出现在许多昆虫种类。没有现代 genomics 的知识,一个人可能假定哺乳动物,通常比昆虫更复杂并且为重要 catecholamine neurotransmitters 并且为黑素作为一位先锋要求酷氨酸,应该拥有更多的酶控制酷氨酸新陈代谢。因此,昆虫为什么实际上拥有更多的酷氨酸的问题新陈代谢的酶相当有趣。昆虫为表皮变硬并且为天生的有免疫力的回答重重地依靠酷氨酸新陈代谢,这长被知道了,并且这些进化限制是可能的这个问题的关键答案。以 melanogenesis,哺乳动物也拥有规定的高水平;而昆虫加速象 melanogenesis 一样的小径必须因此忍受增加的氧化压力,然而哺乳动物的系统为 detoxification 拥有更多的机制。我们的研究组有机会描绘从昆虫和哺乳动物涉及酷氨酸新陈代谢的许多关键蛋白质的结构和功能。在这微型评论,我们将与昆虫相比在哺乳动物的一个进化观点的范围给我们关于酷氨酸的研究的简短概述新陈代谢的酶。 | Christopher John Vavricka Qian Han Prajwalini Mehere Haizhen Ding Bruce M. Christensen and Jianyong Li | 2014 | Insect Science2014，21，1： | 4 |
| 12 | Tyrosine aminotransferase: biochemical and structural properties and molecular dynamics simulations显示文摘Tyrosine aminotransferase(TAT)catalyzes the transamination of tyrosine and other aromatic amino acids.The enzyme is thought to play a role in tyrosinemia type II,hepatitis and hepatic carcinoma recovery.The objective of this study is to investigate its biochemical and structural characteristics and substrate specificity in order to provide insight regarding its involvement in these diseases.Mouse TAT(mTAT)was cloned from a mouse cDNA library,and its recombinant protein was produced using Escherichia coli cells and purified using various chromatographic techniques.The recombinant mTAT is able to catalyze the transamination of tyrosine usingα-ketoglutaric acid as an amino group acceptor at neutral pH.The enzyme also can use glutamate and phenylalanine as amino group donors and p-hydroxyphenylpyruvate,phenylpyruvate and alpha-ketocaproic acid as amino group acceptors.Through macromolecular crystallography we have determined the mTAT crystal structure at 2.9Åresolution.The crystal structure revealed the interaction between the pyridoxal-5′-phosphate cofactor and the enzyme,as well as the formation of a disulphide bond.The detection of disulphide bond provides some rational explanation regarding previously observed TAT inactivation under oxidative conditions and reactivation of the inactive TAT in the presence of a reducing agent.Molecular dynamics simulations using the crystal structures of Trypanosoma cruzi TAT and human TAT provided further insight regarding the substrate-enzyme interactions and substrate specificity.The biochemical and structural properties of TAT and the binding of its cofactor and the substrate may help in elucidation of the mechanism of TAT inhibition and activation. | Prajwalini Mehere Qian Han Justin A.Lemkul Christopher J.Vavricka Howard Robinson David R.Bevan Jianyong Li | 2010 | Protein & Cell2010，1，11： | 4 |
| 13 | Solid-pseudopapillary tumor of the pancreatic tail显示文摘We report a case of the rare solid-pseudopapillary tumor of the pancreas. In contrast to other pancreatic tumors,the solid-pseudopapillary tumor has a favorable prognosis.The 60-year-old female patient we report on here was treated by left pancreatic resection combined with splenectomy for a non-metastasizing tumor of the pancreas. A solid-pseudopapillary tumor was found on histology. The patient had no signs of metastases at present.Since a microscopically invasive tumor growth is assumed,oncologically curative resection should be preferred vs the less radical enucleation. The rare solid-pseudopapillary tumor of the pancreas has a good prognosis after successful oncological resection. | Frank Eder Hans-Ulrich Schulz Christoph R(o|¨)cken Hans Lippert | 2005 | World Journal of Gastroenterology2005，11，26： | 4 |
| 14 | A software-defined networking approach for handover management with real-time video in WLANs显示文摘To achieve high performance and reliability in video streaming over wireless local area networks (WLANs), one must jointly consider both optimized association to access points (APs) and handover management based on dynamic scanning of alternate APs. In this article, we propose a new architecture within the software-defined networking (SDN) framework, which allows stations to be connected to several APs simultaneously and to switch fast between them. We evaluate our system in a real-time testbed and demonstrate that our SDN-based handover mechanism significantly reduces the number and duration of video freeze events and allows for smaller playout buffers. | Peter Dely Andreas Kassler Lawrence Chow Nicholas Bambos Nico Bayer Hans Einsiedler Christoph Peylo Daniel Mellado Miguel Sanchez | 2013 | Journal of Modern Transportation2013，21，1： | 3 |
| 15 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 16 | Significance of scintigraphy for the localisation of obscure gastrointestinal bleedings显示文摘AIM: To determine the role of scintigraphy in patients with gastrointestinal (GI) bleeding of unknown localisation. METHODS: We performed retrospective analyses on 92 patients receiving scintigraphies from 1993 to 2000 in the University of Regensburg hospital, which were done for localisation of GI bleeding as a diagnostic step after an unsuccessful endoscopy. In addition to the scintigraphies, further diagnostic steps such as endoscopy, angiography or operations were performed. In some of the scintigraphies with negative results, a provocation test for bleeding with heparinisation was carried out. RESULTS: 73% of all scintigraphies showed a positive result. In 4.5% of the positive results, the source was located in the stomach, in 37% the source was the small bowel, in 25% the source was the right colon, in 4.5% the source was the left colon, and in 20% no clear localisation was possible. Only 4% of all scintigraphies were false positive. A reliablepositive scintigraphy was independent of the age of the examined patient. A provocation test for bleeding with heparin resulted in an additional 46% of positive scintigraphies with a reliable localisation in primary negative scintigraphies. CONCLUSION: Our results show that scintigraphy and scintigraphy with heparin provocation tests are reliable procedures. They enable a reliable localisation in about half of the obscure GI-bleeding cases. Scintigraphy is superior to angiography in locating a bleeding. It is shown that even in the age of video capsule endoscopy and double-balloon enteroscopy, scintigraphy provides a reliable and directed localization of GI bleeding and offers carefully targeted guidance for other procedures. | Tanja Brünnler Frank Klebl Sascha Mundorff Christoph Eilles Michael Reng Hans von Korn Jürgen Schlmerich Julia Langgartner Stefan Grüne | 2008 | World Journal of Gastroenterology2008，14，32： | 3 |
| 17 | Chinese Herbal Medicine for Systemic Lupus Erythematosus:A Systematic Review and Meta-Analysis of Randomized,Placebo-Controlled Trials显示文摘Objective:To provide evidence on the efficacy and safety of Chinese herbal medicine(CHM)as interventions for systemic lupus erythematosus(SLE).Methods:Seven electronic databases,including the Cochrane Library,Chinese National Knowledge Infrastructure(CNKI),Chinese Scientific Journal Database(VIP),Chinese Biomedical Literature Service System(SinoMed),Wanfang,Embase,and PubMed,were comprehensively searched,from their inception to August 16,2020,for all randomized controlled trials(RCTs)that focused on CHM used alone or in combination with conventional medicine for SLE.Outcomes were SLE activity index(SLEDAI),traditional Chinese medicine symptom/syndrome score(TCMSS),dosage of glucocorticoids,main serological testing,and incidence of adverse events.Data were extracted and pooled using Review Manager 5.3 software.Results:A total of 13 RCTs enrolling 856 participants met our inclusion criteria.Meta-analyses showed that,compared to placebo,CHM had statistically significant effect on reducing SLEDAI score(MD=-1.74,95%Cl:-2.29 to-1.18),diminishing TCMSS(SMD=-0.89,95%Cl:-1.16 to-0.62),decreasing dosage of glucocorticoids(MD=-2.41 mg/d,95%Cl:-3.34 to-1.48),lowering erythrocyte sedimentation rate(MD=-4.78 mm/h,95%Cl:-8.86 to-0.71),and increasing serum complement C4 level(MD=0.03 mg/dL,95%Cl:0.00 to 0.06).No significant difference was found between CHM and placebo on adverse events.Conclusions:CHM provided significant beneficial effect on controlling disease activity and reducing dose of glucocorticoids used among SLE patients.Future advanced designed RCTs for CHM treating moderate to severe SLE with multicenter and longer follow-up are urgently needed. | WANG Ying HAN Mei Christopher EPedigo XIE Zhi-min WANG Wei-jie LIU Jian-ping | 2021 | Chinese Journal of Integrative Medicine2021，27，10： | 3 |
| 18 | Comparative Effectiveness for Survival and Renal Function of Partial and Radical Nephrectomy for Localized Renal Tumors: A Systematic Review and Meta-Analysis显示文摘 | Simon P. Kim R. Houston Thompson Stephen A. Boorjian Christopher J. Weight Leona C. Han M. Hassan Murad Nathan D. Shippee Patricia J. Erwin Brian A. Costello George K. Chow Bradley C. Leibovich | 2012 | The Journal of Urology2012，，： | 2 |
| 19 | 第16章 温带气旋:气象学100年来的研究核心显示文摘1919年在气象学上是重要的一年,不仅因为美国气象学会成立于这一年,同时还有其他两个原因。其中之一是J.皮叶克尼斯关于温带气旋结构的论文于1919年发表,建立了著名的挪威气旋模型。也是在那一年,一系列会议的举办促进了温带气旋研究所需的国际合作和科学交流组织的形成,这必然包括跨越国界的空间尺度。本章主要描述针对温带气旋的形成、演变和动力过程,它们构成的锋,以及伴随而来的急流和风暴路径进行科学探究的历史。我们将这些现象统称为气象学的核心,因为在此期间,其在促进气象学研究方面发挥着核心作用。这个成果丰硕的世纪使得温带气旋研究成为可能,是因为1)解决不良预报的实际挑战具有巨大的社会经济影响,2)理论、观测和诊断(包括动力模式)的结合提供了改进的物理解释和概念模型,以及3)强有力的国际合作。气旋的概念框架产生于对气旋分类和理解的渴望;它们包括挪威气旋模型和Shapiro-Keyser气旋模型。理解气旋动力学的挑战引申出诸如准地转、斜压不稳定、半地转和锋生等理论框架。预测爆发性温带气旋的挑战尤其带来了新的理论发展,如位势涡度(PV)理论和上游效应。对可预报性的局限性的更深层次的认识源于混沌决定论的演变。最后,观测的洞察力成就了详细的气旋和锋面结构、风暴路径及雨带分类。 | 大卫·舒尔茨 LANCE F.BOSART BRIAN A.COLLE HUW C.DAVIES CHRISTOPHER DEARDEN DANIEL KEYSER OLIVIA MARTIUS PAUL J.ROEBBER W.JAMES STEENBURGH HANS VOLKERT ANDREW C.WINTERS 张萌(编译) 贾朋群(编译) | 2019 | 气象科技进展2019，9，S01： | 2 |
| 20 | Endometrial receptivity in an in vitro fertilization program as assessed by spiral artery blood flow, endometrial thickness, endometrial volume, and uterine artery blood flow显示文摘 | Ralf L Schild Christine Knobloch Christoph Dorn Rolf Fimmers Hans van der Ven Manfred Hansmann | 2001 | Fertility and Sterility2001，，2： | 2 |
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