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| 1 | Esophageal tissue engineering:A new approach for esophageal replacement显示文摘A number of congenital and acquired disorders require esophageal tissue replacement.Various surgical techniques,such as gastric and colonic interposition,are standards of treatment,but frequently complicated by stenosis and other problems.Regenerative medicine approaches facilitate the use of biological constructs to replace or regenerate normal tissue function.We review the literature of esophageal tissue engineering,discuss its implications,compare the methodologies that have been employed and suggest possible directions for the future.Medline,Embase,the Cochrane Library,National Research Register and ClinicalTrials.gov databases were searched with the following search terms:stem cell and esophagus,esophageal replacement,esophageal tissue engineering,esophageal substitution.Reference lists of papers identified were also examined and experts in this field contacted for further information.All full-text articles in English of all potentially relevant abstracts were reviewed.Tissue engineering has involved acellular scaffolds that were either transplanted with the aim of being repopulated by host cells or seeded prior to transplantation.When acellular scaffolds were used to replace patch and short tubular defects they allowed epithelial and partial muscular migration whereas when employed for long tubular defects the results were poor leading to an increased rate of stenosis and mortality.Stenting has been shown as an effective means to reduce stenotic changes and promote cell migration,whilst omental wrapping to induce vascularization of the construct has an uncertain benefit.Decellularized matrices have been recently suggested as the optimal choice for scaffolds,but smart polymers that will incorporate signalling to promote cell-scaffold interaction may provide a more reproducible and available solution.Results in animal models that have used seeded scaffolds strongly suggest that seeding of both muscle and epithelial cells on scaffolds prior to implantation is a prerequisite for complete esophageal replacement.Novel approaches need to be designed to allow for peristalsis and vascularization in the engineered esophagus.Although esophageal tissue engineering potentially offers a real alternative to conventional treatments for severe esophageal disease,important barriers remain that need to be addressed. | Giorgia Totonelli Panagiotis Maghsoudlou Jonathan M Fishman Giuseppe Orlando Tahera Ansari Paul Sibbons Martin A Birchall Agostino Pierro Simon Eaton Paolo De Coppi | 2012 | World Journal of Gastroenterology2012，18，47： | 5 |
| 2 | Low-level laser therapy enhances the number of osteocytes in calvaria bone defects of ovariectomized rats显示文摘Background : Osteoporosis can make bone repair difficult. Low-level laser therapy( LLLT) has been shown to be a promising tool for bone neoformation. This study aimed to analyze the effect of LLLT on calvaria bone defects of ovariectomized rats using stereology. Methods : Fifty-four Wistar rats were subjected to bilateral ovariectomy, and bone defects were created in calvaria after 150 days. The animals were divided into nine groups(n = ?6 per group), and 24 hours after the bone defects were created they received three, six or 12 sessions of LLLT at 0, 20 or 30 J/cm 2, using a 780-nm low-intensity GaAlAs laser. One-way ANOVA followed by Tukey ' s post hoc test was used for data processing. A difference of P < 0.05 was considered statistically significant. The parameters evaluated were osteocyte density( Nv_(ost)), total osteocyte number( Nto ost), trabecular surface density( Sv_t), and trabecular surface area( Sa_t). Results : Data obtained showed that Nto ost, Sv t, and Sa t in group G2 rats were significantly different from G1(0 J/cm^2)( P < 0.05). Compared to group G4, G5 presented higher values for the parameters Sv t and Sa t, and G6 presented significantly higher values for almost all the analyzed parameters( Nv _(ost), Nto_(ost), Sv_t, and Sa t)( P < 0.05). Compared to group G7, G8 showed a higher value only for the parameter Sa t, and G9 showed significantly higher values for parameters Nv ost, Nto ost, Sv_t, and Sa_t. Conclusion : We conclude that LLLT stimulated bone neoformation and contributed to an increase in the total number of osteocytes, especially with a laser energy density of 30 J/cm^2 given for six and 12 sessions. | Priscilla Hakime Scalize Luiz Gustavo de Sousa Lígia Maria Napolitano Goncalves Dimitrius Leonardo Pitol Marcelo Palinkas Antonio Augusto Coppi Mariah Acioli Righeti Vitória Ricardo Karina Fittipaldi Bombonato-Prado Simone Cecílio Hallak Regalo Selma Siessere | 2019 | Animal Models and Experimental Medicine2019，2，1： | 2 |
| 3 | Protein immobilization in crosslinked alginate microparticles 显示文摘 | Coppi C Iannuccelli V Leo E | 2002 | J Microencapsul2002，19，1： | 2 |
| 4 | Antimalarial activity of allicin,abiolo gically active compound from garlic cloves显示文摘 | Coppi A Abini A N M Mirelmand | 2006 | Antimicro Agents Chemoth2006，50，17： | 1 |
| 5 | Protective effects of pidotimod against experimental bacterial infections in mice显示文摘 | Coppi G Falcone A Manzardo S | 1994 | Arzneimittelforsch1994，44，： | 1 |
| 6 | Propagation,expansion,and multilineage differentiation of human somatic stem cells from dermal progenitors显示文摘 | Bartsch G Yoo JJ De Coppi P | 2005 | Stem Cells Dev2005，14，3： | 1 |
| 7 | Immumopharmacology of pidotimod effect on natural killer cell activity and thymocyte cell death 显示文摘 | Migliorati G Coppi G D'Adamio F | 1992 | Pharmaeol Res1992，26，2： | 1 |
| 8 | Protective effects of pidotimod against experimental bacterial infections in mice显示文摘 | Coppi G Falcone A Manzardo S | 1994 | Arzneimittel- forsch1994，44，12： | 1 |
| 9 | Alginate microparticles for enzyme peroral administration显示文摘 | COPPI G IANNUCCELLI V BERNABEI M T | 2002 | Int J of Pharm2002，242，： | 1 |
| 10 | Anticonvulsant effect of AMP by direct activation of adenosine A1 receptor 显示文摘 | Muzzi M Coppi E Pugliese AM | 2013 | Exp Neurol2013，250，： | 1 |
| 11 | Chitosan-alginate microparticles as a protein carrier显示文摘 | Coppi G Iannuccelli V Leo E | 2001 | Drug Devel Ind Pharm2001，27，5： | 1 |
| 12 | Isolation of aumiotic stem cell lines with potential for therapy显示文摘 | De Coppi P Bartsch G Jr Siddiqui MM | 2007 | Nat Biotechnol2007，25，1： | 1 |
| 13 | Outer Membrane c-Type Cytochromes Required for Fe (Ⅲ) and Mn ( IV ) Oxide Reduction in Geobacter sulfurreducens显示文摘 | Mehtal T Coppi M V Childers S E | 2005 | Applied and Enviromnental Microbiology2005，71，12： | 1 |
| 14 | Alginate/chitosan microparticles for tamoxifen delivery to the lymphatic system 显示文摘 | Coppi G Iannuccelli V | 2009 | Int J Pharm2009，367，12： | 1 |
| 15 | Protein immobilization in crosslinked alginate microparticle显示文摘 | COPPI G IANNUCCELLI V LEO E | 2002 | J Microencapsulation2002，19，： | 1 |
| 16 | Antenatal management of isolated congen- ital diaphragmatic hernia today and tomorrow : ongoing collabor-ative research and development 显示文摘 | Deprest J De Coppi P | 2012 | J Pediatr Surg2012，47，2： | 1 |
| 17 | Pidotimod stimulates natural killer cell activity and inhibits thymocyte cell death 显示文摘 | Migliorati G D'Adamio L Coppi G | 1992 | Imm u nopha rmacol Immunotoxicol1992，14，4： | 1 |
| 18 | Isolation of amniotic stem cell lines with potential for therapy显示文摘 | De Coppi P Bartsch G Jr Siddiqui MM | 2007 | Nat Biotechnol2007，25，1： | 1 |
| 19 | Hepa?ran sulfate proteoglycans provide a signal to Plasmo?dium sporozoites to stop migrating and productively invade cells显示文摘 | COPPI A TEWARI R BISHOPJ R | 2007 | Cell Host Microbe2007，2，5： | 1 |
| 20 | Experimental immunological screening tests on pidotimod 显示文摘 | Coppi G Manzardo S | 1994 | Arzneimittelforsch1994，44，12： | 1 |
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