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| 1 | 5-Azacytidine induces changes in electrophysiological properties of human mesenchymal stem cells显示文摘以前,导出髓的干细胞(MSC ) 与不确定的脱氧核糖核酸甲基转移酶禁止者 5-azacytidine 对待的老鼠骨头被报导区分 intocardiomyocytes。现在的学习的目的是在从健康骨髓施主获得的人的单音的原子房间调查类似的区别策略的效率。After1-3 段落,文化为 24 h 暴露于到 6 星期进一步的文化跟随的 5-azacytidine (3 mciroM ) 。药处理没导致 myogenic 标记 MyoD 或心脏的 markersNkx2.5 和 GATA-4 的表示并且没在后续期间产出跳动的房间。在补丁夹钳实验,近似 10-15% 对待,未经治疗的房间展出了 L 类型 Ca (2+) 水流。几乎所有房间表面地出现了修正快速或慢的激活动力学的 K (+) 水流。在与匹配时间的控制相比在 6 星期处理以后加倍的 +60 mV 意味着当前的振幅。对待的房间的 Membranecapacitance 比在在处理以后的 controls2 星期内显著地大并且在 6 个星期以后仍然保持高。为 K (+) 隧道 Kv1.1, Kv1.5, Kv2.1, Kv4.3 和 KCNMA1 并且为 Ca (2+) 隧道 Ca (v) 的 mRNAs 的表示层次 1.2 没被 5-azacytidine 影响。在以前显示出禁止 hMSC 的快速或慢慢地激活的 K (+) 水流的集中的 Treatmentwith 钾隧道块 ers tetraethylammonium 和 clofilium 禁止了这些房间的增长。我们的结果建议尽管有进 cardiomyocytes 的 hMSC 的区别的缺席,有 5-azacytidine 的处理在当前的密度引起了深刻变化。 | Bartosz Balanal Cecilia Nicoletti Ihor Zahanich Eva M Graf Torsten Christ Sabine Boxberger Ursula Ravens | 2006 | Cell Research2006，16，12： | 20 |
| 2 | 在最后三扫描仪代的 CT 剂量和图象质量显示文摘 AIM: To compare the computed tomography(CT) dose and image quality with the filtered back projection against the iterative reconstruction and CT with a minimal electronic noise detector. METHODS: A lung phantom(Chest Phantom N1 by Kyoto Kagaku) was scanned with 3 different CT scanners: the Somatom Sensation, the Definition Flash and the Definition Edge(all from Siemens, Erlangen, Germany). The scan parameters were identical to the Siemens presetting for THORAX ROUTINE(scan length 35 cm and FOV 33 cm). Nine different exposition levels were examined(reference mAs/peek voltage): 100/120, 100/100, 100/80, 50/120, 50/100, 50/80, 25/120, 25/100 and 25 mAs/80 kVp. Images from the SOMATOM Sensation were reconstructed using classic filtered back projection. Iterative reconstruction(SAFIRE, level 3) was performed for the two other scanners. A Stellar detector was used with the Somatom Definition Edge. The CT doses were represented by the dose length products(DLPs)(mGycm) provided by the scanners. Signal, contrast, noise and subjective image quality were recorded by two different radiologists with 10 and 3 years of experience in chest CT radiology. To determine the average dose reduction between two scanners, the integral of the dose difference was calculated from the lowest to the highest noise level. RESULTS: When using iterative reconstruction(IR) instead of filtered back projection(FBP), the average dose reduction was 30%, 52% and 80% for bone, soft tissue and air, respectively, for the same image quality(P < 0.0001). The recently introduced Stellar detector(Sd) lowered the radiation dose by an additional 27%, 54% and 70% for bone, soft tissue and air, respectively(P < 0.0001). The benefit of dose reduction was larger at lower dose levels. With the same radiation dose, an average of 34%(22%-37%) and 25%(13%-46%) more contrast to noise was achieved by changing from FBP to IR and from IR to Sd, respectively. For the same contrast to noise level, an average of 59%(46%-71%) and 51%(38%-68%) dose reduction was produced for IR and Sd, respectively. For the same subjective image quality, the dose could be reduced by 25%(2%-42%) and 44%(33%-54%) using IR and Sd, respectively. CONCLUSION: This study showed an average dose reduction between 27% and 70% for the new Stellar detector, which is equivalent to using IR instead of FBP. | Andreas Christe Johannes Heverhagen Christoph Ozdoba Christian Weisstanner Stefan Ulzheimer Lukas Ebner | 2013 | World Journal of Radiology2013，5，11： | 10 |
| 3 | 转诊类型学和驱动力辨析显示文摘分析和讨论转诊的定义、内涵和相关因素是确定转诊行为的评价指标及确定转诊管理和政策的重要前提。本文把转诊行为根据行为的客体划分为使用者转诊和提供者转诊,并讨论了各种转诊行为的驱动力。任何医疗服务行为及其管理制度均建立在对激励行为的理解上。政府如欲推动双向转诊制度向健康的方向发展,应该对各种转诊行为的驱动力和阻力予以深刻的理解,并采用适宜的政策措施培育适宜转诊的驱动力,减少适宜转诊的阻力。 | 杨辉 Christ Anderson Shane Tomas | 2006 | 中国全科医学2006，9，22： | 10 |
| 4 | 一种亚稳β钛合金中疲劳短裂纹穿晶扩展晶体学特征的EBSD研究显示文摘简单介绍一种疲劳短裂纹扩展跨越晶界的晶体学模型和利用EBSD技术判定活动滑移系的简便方法.作为实际应用的示例,利用EBSD技术应用晶体学模型研究了一种亚稳β钛合金--TIMETAL LCB中疲劳短裂纹穿晶扩展的晶体学特征.实现了穿晶裂纹活动滑移系的判定.结果表明:除在试样表面晶粒两侧的裂纹走向偏折因素外,裂纹面(活动滑移面)间角是更重要的控制短裂纹穿晶扩展的晶体学因素. | 雷家峰 刘羽寅 杨锐 李东 Hans-Jūrgen Christ | 2002 | 金属学报2002，38，z1： | 10 |
| 5 | The lncRNA APOLO interacts with the transcription factor WRKY42 to trigger root hair cell expansion in response to cold显示文摘Plant long noncoding RNAs(lncRNAs)have emerged as important regulators of chromatin dynamics,impacting on transcriptional programs leading to different developmental outputs.The lncRNA AUXIN-REGULATED PROMOTER LOOP(APOLO)directly recognizes multiple independent loci across the Arabidopsis genome and modulates their three-dimensional chromatin conformation,leading to transcriptional shifts.Here,we show that APOLO recognizes the locus encoding the root hair(RH)master regulator ROOT HAIR DEFECTIVE 6(RHD6)and controls RHD6 transcriptional activity,leading to cold-enhanced RH elongation through the consequent activation of the transcription factor gene RHD6-like RSL4.Furthermore,we demonstrate that APOLO interacts with the transcription factor WRKY42 and modulates its binding to the RHD6 promoter.WRKY42 is required for the activation of RHD6 by low temperatures and WRKY42 deregulation impairs cold-induced RH expansion.Collectively,our results indicate that a novel ribonucleoprotein complex with APOLO and WRKY42 forms a regulatory hub to activate RHD6 by shaping its epigenetic environment and integrate signals governing RH growth and development. | Michael Moison Javier Martinez Pacheco Leandro Lucero Camille Fonouni-Farde Johan Rodriguez-Melo Natanael Mansilla Aurelie Christ Jeremie Bazin Moussa Benhamed Fernando Ibanez Martin Crespi Jose M.Estevez Federico Ariel | 2021 | Molecular Plant2021，14，6： | 8 |
| 6 | 急诊胸片诊断心力衰竭的准确性显示文摘本研究旨在明确心力衰竭(HE)胸片表现对因呼吸困难急诊住院病人诊断的准确性。运用BASEL次级分析,由2位放射学医师在不知确诊结果的情况下(56%最终诊断为HF),盲法分析227例急性呼吸困难病人的首诊胸片。使用预先定义的HF胸片诊断标准,统计方法包括受试者工作特征(ROC)曲线分析和logistic回归模型计算B型利钠肽(BNP)水平。阅片者的整体印象表明仰卧位及立位胸片诊断HF的ROC曲线下最大面积分别为0.855和0.857。在各种影像表现中, | U. Studler M. Kretzschmar M. Christ T. Breidthardt M. Noveanu A.Schoetzau 邢艳(译) 刘文亚(校) 唐光健(校) | 2008 | 国际医学放射学杂志2008，31，5： | 5 |
| 7 | The effects of gronth factors on the day13 CAM:a study of VEGF165 and PDGF-BB显示文摘 | Wilting J Christ B Weich HA | 1992 | Anat Embroy(Berl)1992，186，3： | 2 |
| 8 | Epidermal growth factor receptor and HER-3 restrict cell response to sorafenib in hepatocellular carcinoma cells显示文摘 | Marie-José Blivet-Van Eggelpo?l Hamza Chettouh Laetitia Fartoux Lynda Aoudjehane Véronique Barbu Colette Rey Sabrina Priam Chantal Housset Olivier Rosmorduc Christèle Desbois-Mouthon | 2012 | Journal of Hepatology2012，，1： | 2 |
| 9 | Calcium-Channel Blockers Reduce the Antiplatelet Effect of Clopidogrel显示文摘 | Jolanta M. Siller-Matula Irene Lang Guenter Christ Bernd Jilma | 2008 | Journal of the American College of Cardiology2008，，19： | 2 |
| 10 | Incremental Value of Copeptin for Rapid Rule Out of Acute Myocardial Infarction显示文摘 | Tobias Reichlin Willibald Hochholzer Claudia Stelzig Kirsten Laule Heike Freidank Nils G. Morgenthaler Andreas Bergmann Mihael Potocki Markus Noveanu Tobias Breidthardt Andreas Christ Tujana Boldanova Ramona Merki Nora Schaub Roland Bingisser Michael Chri | 2009 | Journal of the American College of Cardiology2009，，1： | 2 |
| 11 | American College of Rheumatology Guidelines for Screening, Treatment, and Management of Lupus Nephritis显示文摘 | Bevra H.Hahn Maureen A.McMahon W. DeanWallace David I.Daikh John D.Fitzgerald George A.Karpouzas Joan T.Merrill Daniel J.Wallace JinoosYazdany RosalindRamsey‐Goldman KarandeepSingh MazdakKhalighi Soo‐InChoi ManeeshGogia SuzanneKafaja MohammadKamgar Christ | 2012 | Arthritis Care Res2012，，： | 2 |
| 12 | Isolation and Hepatocyte Differentiation of Mesenchymal Stem Cells From Porcine Bone Marrow—“Surgical Waste” as a Novel MSC Source显示文摘 | S. Brückner H.-M. Tautenhahn S. Winkler P. Stock S. Jonas M. Dollinger B. Christ | 2013 | Transplantation Proceedings2013，，5： | 2 |
| 13 | Improvement of Left Ventricular Remodeling and Function by Hydroxymethylglutaryl Coenzyme A Reductase Inhibition With Cerivastatin in Rats With Heart Failure After Myocardial Infarction显示文摘 | Johann Bauersachs Paolo Galuppo Daniela Fraccarollo Michael Christ Georg Ertl | 2001 | Circulation: Journal of the American Heart Association2001，，9： | 2 |
| 14 | Analysis the presence and physiological relevance of subcanducting states of connexin 43-derived gap junction channels in cultured human corporal vascular smooth muscle cells 显示文摘 | Christ GJ Brink PR | 1999 | Circ Res1999，84，7： | 1 |
| 15 | CD13 :Waving the flag for a novel cancer stem cell target显示文摘 | Christ B Stock P Dollinger MM | 2011 | Hepatology2011，53，4： | 1 |
| 16 | The transcription factor Proxl is a marker for lymphatic endothelial cells in normal and diseased human tissues显示文摘 | Wilting J Papoutsi M Christ B | 2002 | FASEB J2002，16，10： | 1 |
| 17 | Regulation of Epha4 expression in paraxial and lateral plate mesoderm by ectodermderived signals 显示文摘 | Schmidt C Christ B Maden M | 2001 | Dev Dyn2001，，： | 1 |
| 18 | Thermodynamic investigation of the magnesium-hydrogen system显示文摘 | Bogdanovíc B Bohmhammel K Christ B | 1999 | J Alloys Compd1999，282，： | 1 |
| 19 | Plasminogen activator inhibitor-1:physiological and pathophysiological roles显示文摘 | Bernd BR Christ G Gruber F | 2002 | News Physiol Sci2002，17，： | 1 |
| 20 | Transient MR changes and symptomatic epilepsy following gamma knife treatment of a residual GH-secreting pituitary adenoma in the cavernous sinus显示文摘 | Schindler K Christ ER Mindermann T | 2006 | Acta Neurochir (Wien)2006，148，8： | 1 |
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