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| 1 | Current status of high on-treatment platelet reactivity in patients with coronary or peripheral arterial disease:Mechanisms,evaluation and clinical implications显示文摘Antiplatelet therapy with aspirin or clopidogrel or both is the standard care for patients with proven coronary or peripheral arterial disease,especially those undergoing endovascular revascularization procedures. However,despite the administration of the antiplatelet regiments,some patients still experience recurrent cardiovascular ischemic events. So far,it is well documented by several studies that in vitro response of platelets may be extremely variable. Poor antiplatelet effect of clopidogrel or high on-treatment platelet reactivity(HTPR) is under investigation by numerous recent studies. This review article focuses on methods used for the ex vivo evaluation of HTPR,as well as on the possible underlying mechanisms and the clinical consequences of this entity. Alternative therapeutic options and future directions are also addressed. | Stavros Spiliopoulos Georgios Pastromas | 2015 | World Journal of Cardiology2015，7，12： | 13 |
| 2 | 硝苯地平控释片对氯吡格雷抗血小板功能的影响显示文摘目的观察合并高血压病的经皮冠状动脉支架植入(PCI)术后患者服用硝苯地平控释片降压对氯吡格雷抗血小板功能的影响。方法将600例合并有高血压病的PCI术后双联抗血小板患者分为治疗组283例和对照组317例,采用比浊法检测血小板最大聚集率(MPAR)。结果治疗组的MPAR显著高于对照组(P<0.01);但随访12个月后,两组患者的不良心脑血管事件(MACCE)发生率比较,差异无统计学意义(P>0.05)。结论硝苯地平控释片可降低氯吡格雷的抗血小板聚集作用,但不增加PCI术后患者的临床MACCE发生率。 | 朱茜 宁忠平 武英彪 李新明 | 2015 | 中国药业2015，24，22： | 2 |
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