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| 1 | Transjugular intrahepatic portosystemic shunt for the management of acute variceal hemorrhage显示文摘Acute variceal hemorrhage,a life-threatening condition that requires a multidisciplinary approach for effective therapy,is defined as visible bleeding from an esophageal or gastric varix at the time of endoscopy,the presence of large esophageal varices with recent stigmata of bleeding,or fresh blood visible in the stomach with no other source of bleeding identified.Transfusion of blood products,pharmacological treatments and early endoscopic therapy are often effective;however,if primary hemostasis cannot be obtained or if uncontrollable early rebleeding occurs,transjugular intrahepatic portosystemic shunt(TIPS)is recommended as rescue treatment.The TIPS represents a major advance in the treatment of complications of portal hypertension.Acute variceal hemorrhage that is poorly controlled with endoscopic therapy is generally well controlled with TIPS,which has a 90%to 100%success rate.However,TIPS is associated with a mortality of 30%to 50%in such a setting.Emergency TIPS should be considered early in patients with refractory variceal bleeding once medical treatment and endoscopic sclerotherapy failure,before the clinical condition worsens.Furthermore,admission to specialized centers is mandatory in such a setting and regional protocols are essential to be organized effectively.This review article discusses initial management and then focuses on the specific role of TIPS as a primary therapy to control acute variceal hemorrhage,particularly as a rescue therapy following failure of endoscopic approaches. | Romaric Loffroy Louis Estivalet Violaine Cherblanc Sylvain Favelier Pierre Pottecher Samia Hamza Anne Minello Patrick Hillon Pierre Thouant Pierre-Henri Lefevre Denis Krausé Jean-Pierre Cercueil | 2013 | World Journal of Gastroenterology2013，19，37： | 25 |
| 2 | BAS-ADAM:An ADAM Based Approach to Improve the Performance of Beetle Antennae Search Optimizer显示文摘In this paper,we propose enhancements to Beetle Antennae search(BAS)algorithm,called BAS-ADAIVL to smoothen the convergence behavior and avoid trapping in localminima for a highly noin-convex objective function.We achieve this by adaptively adjusting the step-size in each iteration using the adaptive moment estimation(ADAM)update rule.The proposed algorithm also increases the convergence rate in a narrow valley.A key feature of the ADAM update rule is the ability to adjust the step-size for each dimension separately instead of using the same step-size.Since ADAM is traditionally used with gradient-based optimization algorithms,therefore we first propose a gradient estimation model without the need to differentiate the objective function.Resultantly,it demonstrates excellent performance and fast convergence rate in searching for the optimum of noin-convex functions.The efficiency of the proposed algorithm was tested on three different benchmark problems,including the training of a high-dimensional neural network.The performance is compared with particle swarm optimizer(PSO)and the original BAS algorithm. | Ameer Hamza Khan Xinwei Cao Shuai Li Vasilios N.Katsikis Liefa Liao | 2020 | IEEE/CAA Journal of Automatica Sinica2020，7，2： | 20 |
| 3 | Micro RNAs in colorectal cancer:Role in metastasis and clinical perspectives显示文摘Colorectal cancer(CRC)is the third most common malignancy and the third leading cause of cancer related deaths in the United States.Almost 90%of the patients diagnosed with CRC die due to metastases.Micro RNAs(mi RNAs)are evolutionarily conserved molecules that modulate the expression of their target genes post-transcriptionally,and they may participate in various physiological and pathological processes including CRC metastasis by influencing various factors in the human body.Recently,the role mi RNAs play throughout the CRC metastatic cascade has gain attention.Many studies have been published to link them with CRC metastasis.In this review,we will briefly discuss metastatic steps in the light of mi RNAs,along with their target genes.We will discuss how the aberration in the expression of mi RNAs leads to the formation of CRC by effecting the regulation of their target genes.As mi RNAs are being exploited for diagnosis,prognosis,and monitoring of cancer and other diseases,their high tissue specificity and critical role in oncogenesis make them new biomarkers for the diagnosis and classification of cancer as well as for predicting patients’outcome.Mi RNA signatures have been identified for many human tumors including CRC,and mi RNA-based therapies to treat cancer have been emphasized lately.These will also be discussed in this review. | Shan Muhammad Kavanjit Kaur Rui Huang Qian Zhang Paviter Kaur Hamza Obaid Yazdani Muhammad Umar Bilal Jiang Zheng Liu Zheng Xi-Shan Wang | 2014 | World Journal of Gastroenterology2014，20，45： | 13 |
| 4 | 人血浆硫氧化还原蛋白80随着年龄增长而增加,并在载脂蛋白E基因敲除小鼠中诱导炎症、血管生成和动脉粥样硬化显示文摘硫氧化还原蛋白(thioredoxin,TRX)1是一种普遍存在的12kD的蛋白质,可产生抗氧化和抗炎作用。由巨噬细胞产生的截断形式称为TRX80,其可诱导促炎细胞因子的上调。TRX80还促进小鼠腹膜和人巨噬细胞向促炎M1表型的分化。方法:使用特异性酶联免疫吸附试验测定血浆TRX1和TRX80水平。 | 刘莉 叶鹏 Couchie D Vaisman B Abderrazak A Mahmood DFD Hamza MM Canesi F Diderot V El Hadri K Nègre-Salvayre AE Le Page A Fulop T Remaley AT Rouis M | 2017 | 中华高血压杂志2017，25，6： | 9 |
| 5 | FROM A SYSTEMIC APPROACH IN TEACHING AND LEARNING CHEMISTRY (SATLC) TO BENIGN ANALYSIS显示文摘 | A. F. M. Fahmy M. S. A. Hamza H. A. A. Medien W.G. Hanna M. Abdel-Sabour J. J. Lagowski | 2002 | 化学教育2002，23，12： | 9 |
| 6 | Pancreatic injury in patients with septic shock: A literature review显示文摘Sepsis and septic shock are life threatening condition associated with high mortality rate in critically-ill patients. This high mortality is mainly related to the inadequacy between oxygen delivery and cellular demand leading to the onset of multiorgan dysfunction. Whether this multiorgan failure affect the pancreas is not fully investigated. In fact, pancreatic injury may occur because of ischemia, overwhelming inflammatory response, oxidative stress, cellular apoptosis and/or metabolic derangement. Increased serum amylase and/or lipase levels are common in patients with septic shock. However, imaging test rarely reveal significant pancreatic damage. Whether pancreatic dysfunction does affect the prognosis of patients with septic shock or not is still a matter of debate. In fact, only few studies with limited sample size assessed the clinical relevance of the pancreatic injury in this group of patients. In this review, we aimed to describe the epidemiology and the physiopathology of pancreatic injury in septic shock patients, to clarify whether it requires specific management and to assess its prognostic value. Our main finding is that pancreatic injury does not significantly affect the outcome in septic shock patients. Hence, increased serum pancreatic enzymes without clinical features of acute pancreatitis do not require further imaging investigations and specific therapeutic intervention. | Anis Chaari Karim Abdel Hakim Kamel Bousselmi Mahmoud Etman Mohamed El Bahr Ahmed El Saka Eman Hamza Mohamed Ismail Elsayed Mahmoud Khalil Vipin Kauts William Francis Casey | 2016 | World Journal of Gastrointestinal Oncology2016，8，7： | 8 |
| 7 | miRNA-24 and miRNA-466i-5p controls inflammation in rat hepatocytes显示文摘 | Subramanian Saravanan Krishnaraj Thirugnanasambantham Hamza Hanieh Kulandaivelu Karikalan Durairaj Sekar Rukkumani Rajagopalan Villianur Ibrahim Hairul Islam | 2015 | Cellular & Molecular Immunology2015，12，1： | 7 |
| 8 | Prevalence of occult HBV infection in haemodialysis patients with chronic HCV显示文摘瞄准:与长期的 HCV 在血液透析病人学习流行和秘密 HBV 感染的临床的效果。方法:有否定 HbsAg 的五十个长期的牙齿过敏细胞溶解病人,和积极 anti-HCV 在学习被包括。这些病人被划分成二个组:积极的 HCV-RNA 和 HCV-RNA negative,基于 HCV-RNA PCR 的结果。HBV-DNA 在两个组用 PCR 方法被学习。结果:任何一个都没由 PCR 方法在浆液 22 个 HCV-RNA 积极病人和 28 个 HCV-RNA 否定病人揭示 HBV-DNA。平均年龄是 47.2 +/- 17.0 在 HCV-RNA 积极的组和 39.6 +/- , 15.6 在 HCV-RNA negative 组织。结论:秘密 HBV 感染的流行不在有在我们的区域的长期的 HCV 的血液透析病人高。我们的学习的这结果不得不在我们的区域在在 HBsAg 确实(8%-10%) 和 HBV 异种的频率之间的相互作用的考虑被评估。 | Vedat Goral Hamza Ozkul Selahattin Tekes Dede Sit Ali Kemal Kadiroglu | 2006 | World Journal of Gastroenterology2006，12，21： | 7 |
| 9 | Hypoxia inducible factor-1 alpha stabilization for regenerative therapy in traumatic brain injury显示文摘Mild traumatic brain injury(TBI), also called concussion, initiates sequelae leading to motor deficits, cognitive impairments and subtly compromised neurobehaviors. While the acute phase of TBI is associated with neuroinflammation and nitroxidative burst, the chronic phase shows a lack of stimulation of the neurorepair process and regeneration. The deficiency of nitric oxide(NO), the consequent disturbed NO metabolome, and imbalanced mechanisms of S-nitrosylation are implicated in blocking the mechanisms of neurorepair processes and functional recovery in the both phases. Hypoxia inducible factor-1 alpha(HIF-1α), a master regulator of hypoxia/ischemia, stimulates the process of neurorepair and thus aids in functional recovery after brain trauma. The activity of HIF-1α is regulated by NO via the mechanism of S-nitrosylation of HIF-1α. S-nitrosylation is dynamically regulated by NO metabolites such as S-nitrosoglutathione(GSNO) and peroxynitrite. GSNO stabilizes, and peroxynitrite destabilizes HIF-1α. Exogenously administered GSNO was found not only to stabilize HIF-1α and to induce HIF-1α-dependent genes but also to stimulate the regeneration process and to aid in functional recovery in TBI animals. | Mushfiquddin Khan Hamza Khan Inderjit Singh Avtar K.Singh | 2017 | Neural Regeneration Research2017，12，5： | 7 |
| 10 | Is there any link between homocysteine and atherosclerosis?显示文摘 | Hamza Duygu | 2017 | Journal of Geriatric Cardiology2017，14，3： | 7 |
| 11 | Tracking control of redundant manipulator under active remote center-of-motion constraints: an RNN-based metaheuristic approach显示文摘In this paper, we propose a recurrent neural network(RNN) for the tracking control of surgical robots while satisfying remote center-of-motion(RCM) constraints. RCM constraints enforce rules suggesting that the surgical tip should not go beyond the region of incision while tracking the commands of the surgeon.Violations of RCM constraints can result in serious injury to the patient. We unify the RCM constraints with the tracing control by formulating a single constrained optimization problem using a penalty-term approach.The penalty-term actively rewards the optimizer for satisfying the RCM constraints. We then propose an RNN-based metaheuristic optimization algorithm called 'Beetle Antennae Olfactory Recurrent Neural Network(BAORNN)' for solving the formulated optimization problem in real time. The proposed control framework can track the surgeon’s commands and satisfy the RCM constraints simultaneously. Theoretical analysis is performed to demonstrate the stability and convergence of the BAORNN algorithm. Simulations using LBR IIWA14, a 7-degree-of-freedom robotic arm, are performed to analyze the performance of the proposed framework. | Ameer Hamza KHAN Shuai LI Xinwei CAO | 2021 | Science China(Information Sciences)2021，64，3： | 5 |
| 12 | Trends in incidence and management of cancer of the ampulla of Vater显示文摘AIM:To provide trends in incidence,management and survival of cancer of the ampulla of Vater in a welldefined French population.METHODS:Data were obtained from the populationbased digestive cancer registry of Burgundy over a34-year period.Age-standardized incidence rates were computed using the world standard population.Average annual variations in incidence rates were estimated using a poisson regression.A univariate and multivariate relative survival analysis was performed.RESULTS:Age-standardized incidence rates were0.46 and 0.30 per 100000 inhabitants for men and women,respectively.Incidence rate increased from0.26(1976-1984)to 0.58(2003-2009)for men and remained stable for women.Resection for cure was performed in 48.3%of cases.This proportion was stable over the study period.Among cases with curative resection,pancreatico-duodenectomy was performed in94.0%of cases and ampullectomy in 6.0%of cases.A total of 50.8%of cancers of the ampulla of Vater were diagnosed at an advanced stage.Their proportion remained stable throughout the study period.The overall1-and 5-year relative survival rates were 60.2%and27.7%,respectively.Relative survival did not vary over time.Treatment and stage at diagnosis were the most important determinants of survival.The 5-year relative survival rate was 41.5%after resection for cure,9.5%after palliative surgery and 6.7%after symptomatic treatment.In multivariate analysis,only stage at diagnosis significantly influenced the risk of death.CONCLUSION:Cancer of the ampulla of Vater is still uncommon,but its incidence increased for men in Burgundy.Diagnosis is often made at an advanced stage,dramatically worsening the prognosis. | Florian Rostain Samia Hamza Antoine Drouillard Jean Faivre Anne-Marie Bouvier C?me Lepage | 2014 | World Journal of Gastroenterology2014，20，29： | 5 |
| 13 | Nickel ferrite spinel as catalyst precursor in the dry reforming of methane:Synthesis,characterization and catalytic properties显示文摘Dry reforming of methane by CO2 using nickel ferrite as precursor of catalysts was investigated.Nickel ferrite crystalline particles were prepared by coprecipitation of nitrates with NaOH or ammonia followed by calcination,or by hydrothermal synthesis without calcination step.The textural and structural properties were determined by a number of analysis methods,including X-ray diffraction (XRD),Raman spectroscopy and X-ray photoelectron spectroscopy (XPS),among which X-ray diffraction (XRD) was at room and variable temperatures.All synthesized oxides showed the presence of micro or nanoparticles of NiFe2O4 inverse spinel,but Fe2O3 (hematite) was also present when ammonia was used for coprecipitation.The reducibility by hydrogen was studied by temperature-programmed reduction (TPR) and in situ XRD,which showed the influence of the preparation method.The surface area (BET),particle size (Rietveld refinement),as well as surface Ni/Fe atomic ratio (XPS) and the behavior upon reduction varied according to the synthesis method.The catalytic reactivity was investigated using isopropanol decomposition to determine the acid/base properties.The catalytic performance of methane reforming with CO2 was measured with and without the pre-treatment of catalysts under H2 in 650-800 C range.The catalytic conversions of methane and CO2 were quite low but they increased when the catalysts were pre-reduced.A significant contribution of reverse water gas shift reaction accounted for the low values of H2 /CO ratio.No coking was observed as shown by the reoxidation step performed after the catalytic reactions.The possible formation of nickel-iron alloy observed during the study of reducibility by hydrogen was invoked to account for the catalytic behavior. | Rafik Benrabaa Hamza Boukhlouf Axel Lfberg Annick Rubbens Rose-Nelle Vannier Elisabeth Bordes-Richard Akila Barama | 2012 | Journal of Natural Gas Chemistry2012，21，5： | 5 |
| 14 | Molecular principles of metastasis: a hallmark of cancer revisited显示文摘Metastasis is the hallmark of cancer that is responsible for the greatest number of cancer-related deaths.Yet,it remains poorly understood.The continuous evolution of cancer biology research and the emergence of new paradigms in the study of metastasis have revealed some of the molecular underpinnings of this dissemination process.The invading tumor cell,on its way to the target site,interacts with other proteins and cells.Recognition of these interactions improved the understanding of some of the biological principles of the metastatic cell that govern its mobility and plasticity.Communication with the tumor microenvironment allows invading cancer cells to overcome stromal challenges,settle,and colonize.These characteristics of cancer cells are driven by genetic and epigenetic modifications within the tumor cell itself and its microenvironment.Establishing the biological mechanisms of the metastatic process is crucial in finding open therapeutic windows for successful interventions.In this review,the authors explore the recent advancements in the field of metastasis and highlight the latest insights that contribute to shaping this hallmark of cancer. | Jawad Fares Mohamad Y.Fares Hussein H.Khachfe Hamza A.Salhab Youssef Fares | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 15 | Gauss-Seidel最小二乘渐进迭代逼近显示文摘几何迭代法,即渐进迭代逼近(progressive-iterativeapproximation,PIA),作为一种有效的数据拟合方法,吸引了众多研究者的关注,并获得广泛的应用.针对经典LSPIA算法收敛速度较慢的问题,提出一种基于Gauss-Seidel迭代方法的快速PIA算法,称为GS-LSPIA.首先,从给定的数据点中选取拟合曲线的控制点;然后,采用累加弦长法参数化给定数据点;最后,GS-LSPIA通过迭代地调整控制点来生成一系列拟合曲线(曲面),并且保证了生成的曲线(曲面)的极限是对于给定数据点的最小二乘拟合结果.在多个曲线曲面拟合上的实验结果表明,为达到相同的拟合精度,GS-LSPIA算法比LSPIA算法需要更少的步骤和更短的运算时间.因此,GS-LSPIA是有效的,而且具有比LSPIA算法更快的收敛速度. | Yusuf Fatihu Hamza 蒋旖旎 蔺宏伟 | 2021 | 计算机辅助设计与图形学学报2021，33，1： | 4 |
| 16 | Surface Flood and Underground Flood in Xiangxi River Karst Basin: Characteristics, Models, and Comparisons显示文摘Xiangxi River Basin, located in western Hubei Province in central China, is a karst ridge-trough area with an inhomogeneous and complicated distribution of water resources. This paper compares the characteristics of surface and subsurface floods in this karst basin, utilizing a one-parameter Darcian model and the traditional exponential model. The observed hydrographs and inferred water components are strikingly similar for surface and subsurface floods. The Darcian model and the exponential model are based on different views of the flood generation process, with the former fitting the entire hydrograph with a single time constant, and the latter fitting only the recession limb with multiple time constants. Due to the anisotropy and heterogeneity of karst media, a combination of physical and chemical techniques including the use of 3S(remote sensing, geographical information system, global positioning system) method is proposed for an enhanced hydrological investigation to assess and characterize karst water resources in mountainous areas. | Mingming Luo Zhihua Chen Dechao Yin Hamza Jakada He Huang Hong Zhou Tao Wang | 2016 | Journal of Earth Science2016，27，1： | 4 |
| 17 | Weed detection in canola fields using maximum likelihood classification and deep convolutional neural network显示文摘Herbicide use is rising globally to enhance food production,causing harm to environment and the ecosystem.Precision agriculture suggests variable-rate herbicide application based on weed densities to mitigate adverse effects of herbicides.Accurate weed density estimation using advanced computer vision techniques like deep learning requires large labelled agriculture data.Labelling large agriculture data at pixel level is a time-consuming and tedious job.In this paper,a methodology is developed to accelerate manual labelling of pixels using a two-step procedure.In the first step,the background and foreground are segmented using maximum likelihood classification,and in the second step,the weed pixels are manually labelled.Such labelled data is used to train semantic segmentation models,which classify crop and background pixels as one class,and all other vegetation as the second class.This paper evaluates the proposed methodology on high-resolution colour images of canola fields and makes performance comparison of deep learning meta-architectures like SegNet and UNET and encoder blocks like VGG16 and ResNet-50.ResNet-50 based SegNet model has shown the best results with mean intersection over union value of 0.8288 and frequency weighted intersection over union value of 0.9869. | Muhammad Hamza Asad Abdul Bais | 2020 | Information Processing in Agriculture2020，7，4： | 3 |
| 18 | Synthesis, Characterization and X-ray Structure of N-(4-bromobutanoyl-N'-(2-3-and 4-methylphenyl)thiourea显示文摘N-4-(bromobutanoyl)-N'-(o-, m- and p-tolyl)thioureas 3a, 3b and 3c respectively, were synthesized by the reaction of 4-bromobutanoylisothiocyanate with p-, m- and o-toludine. The products were characterized by IR, and NMR spectroscopic techniques. The two carbonoylthiourea isomers N-(4-bromobutanoyl)-N'-(3-methylphenyl)thiourea(3b) and N-(4-bromobutanoyl)-N'-(4-methylphenyl)thiourea(3c) were obtained in crystalline form by recrystallization from DMSO. Xray crystallographic studies showed that both compounds 3b and 3c crystallize in triclinic system with space group of P1. The molecules adopt trans-cis configuration with respect to the positions of 4-bromobutanoyl and tolyl groups respectively, against the thiono C=S bond across their C–N bonds. The configuration is attributed by the intrahydrogen bond between the carbonyl oxygen and amide hydrogen atoms. Both crystal structures are stabilized by N–H···S intermolecular hydrogen bonds to form dimers and arranged along the b axis. | Hamza M Abosadiya Siti Aishah Hasbullah Bohari M Yamin | 2015 | Chinese Journal of Structural Chemistry2015，34，3： | 3 |
| 19 | Concealing arbitrary objects remotely with multi-folded transformation optics显示文摘An invisibility cloak that can hide an arbitrary object external to the cloak itself has not been devised before.In this Letter,we introduce a novel way to design a remote cloaking device that makes any object located at a certain distance invisible.This is accomplished using multi-folded transformation optics to remotely generate a hidden region around the object that no field can penetrate and that does not disturb the far-field scattering electromagnetic field.As a result,any object in the hidden region can stay in position or move freely within that region and remain invisible.Our idea is further extended in order to design a remote illusion optics that can transform any arbitrary object into another one.Unlike other cloaking methods,this method would require no knowledge of the details of the object itself.The proposed multi-folded transformation optics will be crucial in the design of remote devices in a variety of contexts. | Bin Zheng Hamza Ahmad Madni Ran Hao Xianmin Zhang Xu Liu Erping Li Hongsheng Chen | 2016 | Light(Science & Applications)2016，5，1： | 3 |
| 20 | Visual outcomes in patients with open globe injuries compared to predicted outcomes using the Ocular Trauma Scoring system显示文摘AIM: To determine the visual outcomes in adult patients who sustained open globe injuries and to determine whether the visual prognosis following an eye injury in an African setting differs from the predicted outcomes according to the Ocular Trauma Score(OTS)study. A secondary aim was to establish the evisceration rate for these injuries and assess how this form of intervention affected outcomes in comparison to the OTS.·METHODS: A prospective case series of all patients admitted with open globe injuries over a two-year(July2009 to June 2011) period. Injuries were scored using the OTS and the surgical intervention was recorded. The best corrected visual acuity at three months was regarded as visual outcome.· RESULTS: There were 249 open globe injuries, of which 169 patients(169 eyes) completed the 3-month follow-up. All patients underwent primary surgery, 175(70.3%) repairs, 61(24.5%) eviscerations and 13(5.2%)other procedures. Globe eviscerations were mainly done on OTS Category 1 cases, but outcomes in this category were not found to be different from OTS outcomes.Outcomes were significantly worse in Category 2, but when the entire distribution was tested, the differences were not statistically significant. The overall association between OTS outcomes and the final visual outcomes in this study was found to be a strong(P <0.005).· CONCLUSION: Reliable information regarding the expected outcomes of eye injuries will influence management decisions and patient expectations. The OTS is a valuable tool, the use of which has been validated in many parts of the world-it may also be a valid predictor in an African setting. | Nagib du Toit Hamza Mustak Colin Cook | 2015 | International Journal of Ophthalmology(English edition)2015，8，6： | 2 |
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