维普期刊资源整合服务平台（V6.5）

171篇 您的检索式：作者名="Chitty"

选中清除导出查看参考文献查看引证文献引用追踪共9页首页上一页第1页下一页末页 /9 跳转

	题名	作者	年代	出处	被引量
1	H-NS family protein MvaU downregulates phenazine-1-carboxylic acid(PCA)biosynthesis via binding to an AT-rich region within the promoter of the phz2 gene cluster in the rhizobacterium Pseudomonas strain PA1201显示文摘Histone-like nucleoid-structuring(H-NS)proteins are key regulators in gene expression silencing and in nucleoid compaction.The H-NS family member proteins MvaU in Pseudomonas aeruginosa are thought to bind the same AT-rich regions of chromosomes and function to coordinate the control of a common set of genes.Here,we explored the molecular mechanism by which MvaU controls PCA biosynthesis in P.aeruginosa PA1201.We present evidence suggesting that MvaU is self-regulated.Deletion of mvaU significantly increased PCA production,and PCA production sharply decreased when mvaU was over-expressed.MvaU transcriptionally repressed phz2 cluster expression and consequently reduced PCA biosynthesis.β-galactosidase assays confirmed that base pairing near the35 box is required when MvaU regulates PCA production in PA1201.Electrophoretic mobility shift assays(EMSA)and additional point mutation analysis demonstrated that MvaU directly bound to an AT-rich motif within the promoter of the phz2 cluster.Chromatin immunoprecipitation(ChIP)analysis also indicated that MvaU directly bound to the P5 region of the phz2 cluster promoter.MvaU repression of PCA biosynthesis was independent of QscR and OxyR in PA1201 and neither PCA or H2O2 were the environmental signals that induced mvaU expression.These findings detail a new MvaU-dependent regulatory pathway of PCA biosynthesis in PA1201 and provide a foundation to increase PCA fermentation titer by genetic engineering.	Yun-Ling Fang Ying Cui Lian Zhou Chitti Thawai Tatheer Alam Naqvi Hong-Yan Zhang Ya-Wen He	2021	Synthetic and Systems Biotechnology2021，6，4：	2
2	Inter-observer agreement for Crohn’s disease sub-phenotypes using the Montreal Classification: How good are we? A multi-centre Australasian study显示文摘	Krupa Krishnaprasad Jane M. Andrews Ian C. Lawrance Timothy Florin Richard B. Gearry Rupert W.L. Leong Gillian Mahy Peter Bampton Ruth Prosser Peta Leach Laurie Chitti Charles Cock Rachel Grafton Anthony R. Croft Sharon Cooke James D. Doecke Graham L. Rad	2011	Journal of Crohn’s and Colitis2011，，3：	2
3	Practical issues drawn from the implementation of the integrated test for Down syndrome screening into routine clinical practice 显示文摘	Weisz B Pandya P Chitty L	2007	B JOG2007，114，4：	1
4	Effectiveness of routine ultrasonography in detecting fetal structural abnormalities in a low risk population显示文摘	Chitty LS Hunt GH Moore J		0，，6811：	1
5	Ultrasound screening for fetal abnormalities in the first trimester显示文摘	Chitty L S Pandya P P	1997	Prenat Diagn1997，17，13：	1
6	Genetic tnmsformation of the C4 plant, F/ateda b/den/s显示文摘	Chitty JA Furbank RT Marshall JS	1994	The Plant Journal1994，6，6：	1
7	Multiplex ligation-de- pendent probe amplification (MLPA) : a reliable alternative for fetal chromosome analysis? 显示文摘	Chitty LS Kistler J Akolekar R	2011	J Matern Fetal Neonatal Med2011，，：	1
8	Continuous renal replacementtherapy after cardiac surgery显示文摘	Lugones F Chitti G Carrier M	2010	Blood Pu2010，22，3：	1
9	Sex selection: triumph or tyranny? 显示文摘	Marteau TM Chitty LS	2006	Prenat Diagn2006，26，：	1
10	Will the introduction of non-invasive prenatal diagnostic testing erode informed choices?An experimental study of health care professionals显示文摘	van den Heuvel A Chitty L Dormandy E	2010	Patient Educ Couns2010，78，1：	1
11	New aids for the non-inva- sive prenatal diagnosis of aehondroplasia: dysmorphic features, charts of fetal size and molecular confirmation using cell-free fetal DNA in maternal plasma 显示文摘	Chitty LS Griffin DR Meaney C	2011	Ultrasound Obstet Gynecol2011，37，3：	1
12	Prenatal diagnosis by rapidaneuploidy detection and karyotyping: a prospective study ofthe role of ultrasound in 1589 second-trimester amniocente-sis显示文摘	Leung W C Waters J J Chitty L	2004	Prenat Diagn2004，24，10：	1
13	Non-invasive fetal sex determination: Impact on clinical practice 显示文摘	Finning K M Chitty L S	2008	Semin Fetal Neonatal Med2008，13，：	1
14	Noninvasive prenatal diagnosis: current practice and future perspectives 显示文摘	Hahn S Chitty LS	2008	Curr Opin Obstet Gynecol2008，20，2：	1
15	RNAi-mediated replacement of morphine with the nonnarcotic alkaloid reticuline in opium poppy 显示文摘	Allen R S Millgate A G Chitty J A	2004	Nat Biotechnol2004，22，12：	1
16	An analytical model for local heat transfer coefficients for forced convective condensation inside smooth horizontal tubes显示文摘	Chitti M S Anand N K	1995	Int J Heat Mass Transfer1995，38，4：	1
17	The future of prenatal diag- nosis: rapid testing or full karyotype? An audit of chromosome abnor- malities and pregnancy outcomes for women referred for Down's sy'n- drome testing显示文摘	Ogilvie C M Lashwood A Chitty L	2005	BJOG2005，112，10：	1
18	A study of the deterministic properties of unbounded fire plume显示文摘	CHITTY R	1980	Combust Flame1980，，39：	1
19	A heat transfer correlation for condensation inside horizontal smooth tubes using the population balance approach显示文摘	Chitti M S Anand N K	1996	International Journal of Heat and Mass Transfer1996，39，：	1
20	The Role and Status of LEAs:post-war pride and finde siecle uncertainty 显示文摘	Clyde Chitty	2002	Oxford Review of Education2002，，2：	1

返回顶部每页显示：

共9页首页上一页第1页下一页末页 /9 跳转

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

用户提示