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| 1 | Regenerative medicine based applications to combat stress urinary incontinence显示文摘Stress urinary incontinence(SUI), as an isolated symptom, is not a life threatening condition. However, the fear of unexpected urine leakage contributes to a significant decline in quality of life parameters for afflicted patients. Compared to other forms of incontinence, SUI cannot be easily treated with pharmacotherapy since it is inherently an anatomic problem. Treatment options include the use of bio-injectable materials to enhance closing pressures, and the placement of slings to bolster fascial support to the urethra. However, histologic findings of degeneration in the incontinent urethral sphincter invite the use of tissues engineering strategies to regenerate structures that aid in promoting continence. In this review, we will assess the role of stem cells in restoring multiple anatomic and physiological aspects of the sphincter. In particular, mesenchymal stem cells and CD34+cells have shown great promise to differentiate into muscular and vascular components,respectively. Evidence supporting the use of cytokines and growth factors such as hypoxia-inducible factor1-alpha, vascular endothelial growth factor, basic fi-broblast growth factor, hepatocyte growth factor and insulin-like growth factor further enhance the viability and direction of differentiation. Bridging the benefits of stem cells and growth factors involves the use of synthetic scaffolds like poly(1,8-octanediol-co-citrate)(POC) thin films. POC scaffolds are synthetic, elastomeric polymers that serve as substrates for cell growth,and upon degradation, release growth factors to the microenvironment in a controlled, predictable fashion.The combination of cellular, cytokine and scaffold elements aims to address the pathologic deficits to urinary incontinence, with a goal to improve patient symptoms and overall quality of life. | Hatim Thaker Arun K Sharma | 2013 | World Journal of Stem Cells2013，5，4： | 3 |
| 2 | 脂肪干细胞在治疗2型糖尿病膀胱功能障碍大鼠模型中的研究显示文摘目的制造2型糖尿病膀胱功能障碍的大鼠模型,探讨脂肪干细胞移植在糖尿病膀胱功能障碍中的治疗作用及治疗机制。方法制造2型糖尿病膀胱功能障碍大鼠模型,提取脂肪干细胞然后移植入大鼠体内,检测膀胱功能,并留取膀胱组织行组织学检测。结果脂肪干细胞可显著加快2型糖尿病膀胱功能障碍的修复,治疗组膀胱组织内血管数目显著增加。结论脂肪干细胞能够促进大鼠模型膀胱功能的恢复,促进血管形成是脂肪干细胞治疗过程中的重要的反应。 | 张海洋 王慕文 赵勇 李连军 陈友根 金讯波 | 2013 | 泌尿外科杂志(电子版)2013，5，1： | 1 |
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