|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A study of preoperative methionine-depleting parenteral nutrition plus chemotherapy in gastric cancer patients显示文摘AIM To investigate the interference ofmethionine.free parenteral nutrition plus 5-Fu(-MetTPN+5-Fu)in gastric cancer cell kineticsand the side effects of the regimen.METHODS Fifteen patients with advancedgastric cancer were randomly divided into twogroups,7 patients were given preoperatively aseven-day course of standard parenteralnutrition in combination with a five-day courseof chemotherapy(sTPN+5-Fu),while the other8 patients were given methionine-deprivedparenteral nutrition and 5-Fu(-MetTPN+5-Fu).Cell cycles of gastric cancer and normal mucosawere studied by flow cytometry(FCM).Bloodsamples were taken to measure the serumprotein,methionine(Met)and cysteine(Cys)levels,and liver and kidney functions.RESULTS As compared with the resultsobtained before the treatment,the percentage ofG0/G1 tumor cells increased and that of S phasedecreased in the-MetTPN+5-Fu group,while thecontrary was observed in the sTPN+5-Fu group.Except that the ALT,AST and AKP levels wereslightly increased in a few cases receiving-MetTPN+5-Fu,all the other biochemicalparameters were within normal limits.Serum Cys level decreased slightly after the treatmentin both groups.Serum Met level of patientsreceiving sTPN+5-Fu was somewhat higher aftertreatment than that before treatment;however,no significant change occurred in the -MetTPN+5-Fu group,nor operative complications in bothgroups.CONCLUSION -MetTPN+5-Fu exerted asuppressive effect on cancer cell proliferation,probably through a double mechanism ofcreating a state of'Met starvation'adverse tothe tumor cell cycle,and by allowing 5-Fu to killspecifically cells in S phase.Preoperative short-term administration of -MetTPN+5-Fu had littleundesirable effect on host metabolism. | Cao WX Cheng QM Fei XF Li SF Yin HR Lin YZ | 2000 | World Journal of Gastroenterology2000，6，2： | 22 |
| 2 | Rhizosphere priming effects on the decomposition of soil organic matter in C4 and C3 grassland soils显示文摘 | Fu SL Cheng WX | 2002 | Plant and Soil2002，238，2： | 1 |
| 3 | Rhizosphere priming effect:its functional relationships with microbial tumover,evapotranspiration,and C-N budgets显示文摘 | Cheng WX | | 0，，： | 1 |
| 4 | Rhizosphere effects on decomposition:controls of plant species,phenology,and fertilization显示文摘 | Cheng WX Johnson DW Fu SL | | 0，，： | 1 |
| 5 | Differential gene expression proles in the hippocampus of senescence - accelerated mouse 显示文摘 | Cheng XR Zhou WX Zhang YX | 2007 | Neurobiol Aging2007，28，4： | 1 |
| 6 | The effects of Liuwei Dihuang decoction on the gene expression in the hippocampus of senescence-accelerated mouse显示文摘 | Cheng XR Zhou WX Zhang YX | 2007 | Fitoterapia2007，78，3： | 1 |
| 7 | Viral agents associated with a- cute gastroenteritis in children hospitalized with diarrhea in Lanzhou, China显示文摘 | Jin Y Cheng WX Yang XM | 2009 | J Clin Virol2009，44，3： | 1 |
| 8 | Synthesis and modeling perspectives ofrhizosphere priming显示文摘 | Cheng WX Parton WJ Gonzalez-Meler MA Phillips R Asao S McNickle GG Brzostek E Jastrow JD | | 0，，： | 1 |
| 9 | Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death显示文摘 | Wei MC Zong WX Cheng EH | 2001 | Science2001，292，5517： | 1 |
| 10 | Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death 显示文摘 | Wei MC Zong WX Cheng EH | 2001 | Science2001，292，5517： | 1 |
| 11 | Proapoptotic BAX and BAK:a requisite gateway to mitochondrial dysfunction and death显示文摘 | Wei MC Zong WX Cheng EH | 2001 | Science2001，292，5517： | 1 |
| 12 | Viral agents associated with acute gastrocnteritis in children hospitalized with diarrhea in Lanzhou,China显示文摘 | Jin Y Cheng WX Yang XM | 2009 | J Clin Virol2009，44，： | 1 |
| 13 | Gene expression patterns of hippocampus and cerebral cortex of senescence-accelerated mouse treated with Huang-Lian-Jie-Du decoction显示文摘 | Zheng Y Cheng XR Zhou WX | 2008 | Neurosci Lett2008，439，2： | 1 |
| 14 | Potential for soil carbonsequestration of eroded areas in subtropical china显示文摘 | Shi XZ Wang H J Yu DS Weindorf DC Cheng XF Pan XZ Sun WX Chen JM | 2009 | Soil and Tillage Research2009，105，： | 1 |
| 15 | Viral agents associated with acute gastroenteritis in children hospitalized with diarrhea in Lanzhou, China 显示文摘 | Jin Y Cheng WX Yang XM | 2009 | J Clin Virol2009，44，3： | 1 |
| 16 | Proapoptotic BAX and BAK:a requisite gateway to mitochondrial dysfunction and death显示文摘 | Wei MC Zong WX Cheng EH | 2001 | Science2001，292，5517： | 1 |
| 17 | Proapoptotic BAX and BAK:a requisite gateway to mitochondrial dysfunction and death显示文摘 | ZONG WX CHENG EH | 2001 | Science2001，292，5517： | 1 |
| 18 | Viral agents associated with a- cute gastroenteritis in children hospitalized with diarrhea in Lanzhou, China显示文摘 | Jin Y Cheng WX Yang XM | 2009 | J Clin Viral2009，44，： | 1 |
| 19 | Viral agents as- sociated with acute gastroenteritis in children hospitalized with diarrhea in Lanzhou, China 显示文摘 | Jin Y Cheng WX Yang XM | 2009 | J Clin Virol2009，44，3： | 1 |
| 20 | Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death 显示文摘 | Wei MC Zong WX Cheng EH | 2001 | Sci- ence2001，292，5517： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员