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| 1 | A study of preoperative methionine-depleting parenteral nutrition plus chemotherapy in gastric cancer patients显示文摘AIM To investigate the interference ofmethionine.free parenteral nutrition plus 5-Fu(-MetTPN+5-Fu)in gastric cancer cell kineticsand the side effects of the regimen.METHODS Fifteen patients with advancedgastric cancer were randomly divided into twogroups,7 patients were given preoperatively aseven-day course of standard parenteralnutrition in combination with a five-day courseof chemotherapy(sTPN+5-Fu),while the other8 patients were given methionine-deprivedparenteral nutrition and 5-Fu(-MetTPN+5-Fu).Cell cycles of gastric cancer and normal mucosawere studied by flow cytometry(FCM).Bloodsamples were taken to measure the serumprotein,methionine(Met)and cysteine(Cys)levels,and liver and kidney functions.RESULTS As compared with the resultsobtained before the treatment,the percentage ofG0/G1 tumor cells increased and that of S phasedecreased in the-MetTPN+5-Fu group,while thecontrary was observed in the sTPN+5-Fu group.Except that the ALT,AST and AKP levels wereslightly increased in a few cases receiving-MetTPN+5-Fu,all the other biochemicalparameters were within normal limits.Serum Cys level decreased slightly after the treatmentin both groups.Serum Met level of patientsreceiving sTPN+5-Fu was somewhat higher aftertreatment than that before treatment;however,no significant change occurred in the -MetTPN+5-Fu group,nor operative complications in bothgroups.CONCLUSION -MetTPN+5-Fu exerted asuppressive effect on cancer cell proliferation,probably through a double mechanism ofcreating a state of'Met starvation'adverse tothe tumor cell cycle,and by allowing 5-Fu to killspecifically cells in S phase.Preoperative short-term administration of -MetTPN+5-Fu had littleundesirable effect on host metabolism. | Cao WX Cheng QM Fei XF Li SF Yin HR Lin YZ | 2000 | World Journal of Gastroenterology2000，6，2： | 22 |
| 2 | Four-dimensional echocardio graphy: methods and clinical application显示文摘 | Wang XF Li ZA Cheng TO | 1996 | Am Heart J1996，132，3： | 1 |
| 3 | Real-time 3-dimensional echocardiography in assessing atrial and ventricular septal defects: An echocardiographic-surgical correlative study 显示文摘 | Cheng TO Xie MX Wang XF | 2004 | American Heart Journal2004，148，： | 1 |
| 4 | Three dimensional morphometry of the knee to design the total knee arthroplasty for chinese population 显示文摘 | Cheng FB Ji XF Lai Y | 2009 | The Knee2009，16，5： | 1 |
| 5 | Real-time three-dimensional echocardiography in assessing atrial and ventricular septat defects: an echocardingraphic-surgical correlative study 显示文摘 | Cheng TO Xie MX Wang XF | 2004 | Am Heart J2004，148，6： | 1 |
| 6 | Three dimensional morphomet of the knee to design the total knee arthroplasty for Chinese population显示文摘 | Cheng FB Ji XF Lai Y | 2009 | Knee2009，16，： | 1 |
| 7 | Real-time 3-dimensional echocardiography:a review of the development of the technology and its clinical application显示文摘 | Xie MX Wang XF Cheng TO | 2005 | Prog Cardiovasc Dis2005，48，3： | 1 |
| 8 | Potential for soil carbonsequestration of eroded areas in subtropical china显示文摘 | Shi XZ Wang H J Yu DS Weindorf DC Cheng XF Pan XZ Sun WX Chen JM | 2009 | Soil and Tillage Research2009，105，： | 1 |
| 9 | Real-time 3-dimensional echocardiography:a review of the development of the technology and its clinical application显示文摘 | Xie MX Wang XF Cheng TO | 2005 | Prog Cardiovasc Dis2005，48，3： | 1 |
| 10 | EXagnosis of constrictive pericar-ditis by quantitative tissue Doppler imaging显示文摘 | Lu XF Wang XF Cheng TO | 2009 | Int J Cardiol2009，137，1： | 1 |
| 11 | Peratrial closure of atrial septal defects without cardiopulmonary bypass 显示文摘 | Zeng XJ Chen XF Cheng D | 2007 | J Asian Cardiovasc Thorac Ann2007，15，3： | 1 |
| 12 | Comparison of accuracy ofmitral valve area inmitral stenosis by real-time three-dimensionalechocardiography versus two-dimensional echocardiography versusdoppler pressure half-time 显示文摘 | Xie MX Wang XF Cheng TO | 2005 | Am J Cardiol2005，95，： | 1 |
| 13 | Growth inhibitory effect of Kruppel - like factor 6 on human prostatic carcinoma and renal carcinoma cell lines显示文摘 | Cheng XF Li D Zhuang M | 2008 | Tohoku J Exp Med2008，216，： | 1 |
| 14 | Correlation between atrial tbril- lation, scrum amyloid protein A mid other intlammalory cytokines 显示文摘 | Cheng T Wang XF Hou YT | 2012 | Mol Med Rep2012，6，3： | 1 |
| 15 | Intratumoral hepatic stellate cells as a poor prognostic marker and a new treatment target for hepatocellular carcinoma 显示文摘 | Sun B Zhang XF Cheng XS | 2013 | PLoS One2013，8，80： | 1 |
| 16 | Upregulation of microRNA-126 inHepatic StellateCells May Affect Pathogenesis of Liver FibrosisThrough the NF-kB Pathway 显示文摘 | Feng X Tan XF Cheng S | 2015 | DNA and Cell Biology 120152015，，： | 1 |
| 17 | Real-time 3-dimensional echocardiography:a review of the development of the technology and its clinical application显示文摘 | Xie MX Wang XF Cheng TO | 2005 | Prog Cardiovasc Dis2005，48，3： | 1 |
| 18 | Increased expression of HSP27 linked to vincristine resistance in human gastric cancer cell line显示文摘 | Yang YX Sun XF Cheng AL | 2009 | J Cancer Res Clin 0nlcol2009，135，2： | 1 |
| 19 | Hypermethylation of TET1 promoter is a new diagnosic marker for breast cancer metastasis显示文摘 | Sang Y Cheng C Tang XF | 2015 | Asian Pac J Cancer Prew2015，16，3： | 1 |
| 20 | Increased expression of HSP27 linked to vincristine resistance in human gastric cancer cell line 显示文摘 | Yang YX Sun XF Cheng AL | 2009 | J Cancer Res Clin Oncol2009，135，2： | 1 |
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