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| 1 | Effects of partial portal vein arterialization on the hilar bile duct in a rat model显示文摘BACKGROUND: Liver revascularization is frequently required during the enlarged radical operation for hilar cholangio carcinoma involving the hepatic artery. Researchers have carried out a number of experiments applying partial porta vein arterialization (PVA) in clinical practice. In this study we aimed to establish a theoretical basis for clinical application o partial PVA and to investigate the effects of partial PVA on ra hilar bile duct and hepatic functions. METHODS: Thirty rats were randomly and equally assigned into 3 groups: control (group A), hepatic artery ligation+bile duct recanalization (group B), and partial PVA+bile duc recanalization (group C). Proliferation and apoptosis o rat hilar bile duct epithelial cells, arteriolar counts of the peribiliary plexus (PBP) of the bile duct wall, changes in serum biochemistry, and pathologic changes in the bile duc were assessed 1 month after operation. RESULTS: The proliferation of hilar bile duct epithelial cells in group B was greater than in groups A and C (P<0.01). No apoptotic hilar bile duct epithelial cells were detected in any of the groups. The PBP arteriolar counts of the hilar bile duc wall were similar in groups A and C (P>0.05), but the coun was lower in group B than in group A (P<0.01). No statistically significant differences in alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and albumin were found in the 3 groups. The gamma-glutamyltransferase value was higher in group B than in groups A and C (P<0.01) The hepatic tissues of groups A and C showed no significan abnormality. Chronic inflammatory changes in the hilar bile duct walls were observed only in group B. CONCLUSION: Partial PVA can restore the arterial blood supply of the hilar bile duct and significantly extenuate the injury to hilar bile duct epithelial cells resulting from hepatic artery ligation. | Shao-Hua Guo, Chong-Hui Li,Yong-Liang Chen, Jian-Ning Song,Ai-Qun Zhang and Cheng Zhou Department of Hepatobiliary Surgery (Guo SH, Li CH, Chen YL, Song JN, Zhang AQ and Zhou C) and Department of Surgical Oncology (Guo SH), General Hospital of PLA, Beijing 100853, China | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，5： | 8 |
| 2 | The effects of Ginkgo biloba extracts on the memory and motor funct/ons of rats with chronic cerebral insufi%iency 显示文摘 | Lin CC Cheng WL Hsu SH | 2003 | Neuropsychobiology2003，47，1： | 1 |
| 3 | Local radiotherapy with or without transcathere arteriale chemoembolization for patients with unresectable hepatocellular carcinoma 显示文摘 | Chuang VP Cheng SH | 2000 | Int J Radiat Oncol Biol Phys2000，47，： | 1 |
| 4 | A combined sEMG and accelerometer system for monitoring functional activity in stroke显示文摘 | Roy SH Cheng MS Chang SS | 2009 | IEEE Trans Neural Syst Rehabil Eng2009，17，6： | 1 |
| 5 | Examining prognostic factors and patterns of failure in nasopharyngeal carcinoma following concomitant radiotherapy and chemotherapy: impact on future clinical trials显示文摘 | Cheng SH Yen KL Jian JJ | 2001 | Int J Radiat Oncol Biol Phys2001，50，： | 1 |
| 6 | MRI findings of prostatic synovial sarcoma显示文摘 | Cheng YC WangJ H Shen SH | 2007 | Br J Radiol2007，80，： | 1 |
| 7 | ECRG2 regulates ECM degradation and uPAR/FPRL1 pathway contributing cell invasion/migration 显示文摘 | Cheng X Lu SH Cui Y | 2010 | Cancer Lett2010，290，1： | 1 |
| 8 | Char-acteristics and biocompatibility of a biodegradable genipin-crosslinked gelatin/β-tricalcium phosphate reinforced nerve guide conduit显示文摘 | Yang YC Shen CC Huang TB Chang SH Cheng HC Liu BS | | 0，，： | 1 |
| 9 | Preparative isolation of triterpenoids from Ganoderma lucidum by counter-current chromatography combined with pH-zone-refining 显示文摘 | Cheng CR Li YF Xu PP Feng RH Yang M Guan SH Guo DA | 2012 | Food Chem2012，130，： | 1 |
| 10 | Association of polymorphism of human leukocyte antigen aleles with development of hepatocellular carcinoma in Hong Kong Chinese显示文摘 | Ng MH Cheng SH Lai PB | 2012 | Hong Kong Med J2012，18，6： | 1 |
| 11 | Local radiotherapy with or without transcatheter arterial chemoembolization for patients with unresectable hepatocellular carcinoma 显示文摘 | Cheng JC Chuang VP Cheng SH | 2000 | Int J Radia Oncol Biol Phys2000，47，： | 1 |
| 12 | Prognostic features and treatment outcome in locoregionally advanced nasopharyngeal carcinoma following concurrent chemotherapy and radiotherapy 显示文摘 | Jian JJ Tsai Sy | 1998 | Int J Radiat Biol Phys1998，41，4： | 1 |
| 13 | A pilot study of threedimensional conformal radiotherapy in unresectabl hepatocellular carcinsioma显示文摘 | Lin YM Chuang VP | 1999 | J Gastroenterol Hepatol1999，14，： | 1 |
| 14 | Long-term survival of nasopharyngeal carcinoma following concomitant radiotherapy and chemotherapy显示文摘 | Jian J J Tsai SY | 2000 | Int J Radiat Oncol Biol Phys2000，48，5： | 1 |
| 15 | A combined sEMGand accelerometer system for monitoring functional activityin stroke显示文摘 | Roy SH Cheng MS Chang SS | 2009 | IEEE Trans Neural Syst Rehabil Eng2009，17，6： | 1 |
| 16 | Mechanism of concentration - dependent induction of heme oxygenase - 1 by resveratrol in human aortic smooth muscle cells 显示文摘 | Juan SH Cheng TH Lin HC | 2005 | Biochem Pharmacol2005，69，1： | 1 |
| 17 | Concomitant chemotherapy and radiotherapy for locally advaneed nasophatyngeal carcinoma显示文摘 | CHENG SH LIU TW JIAN JJ | 1997 | Cancer J Sei Am1997，3，： | 1 |
| 18 | MRI findings of prostatic synovial sarcoma显示文摘 | Cheng YC Wang JH Shen SH | 2007 | Br J Radiol2007，80，949： | 1 |
| 19 | Gene expression predictors of breast cancer outcomes显示文摘 | Huang E Cheng SH Dressman H | 2003 | Lancet2003，361，9369： | 1 |
| 20 | Ascending migration of endophytic rhizobia,from roots to leaves,inside rice plants and assessment of benefits to rice growth physiology显示文摘 | Chi F Shen SH Cheng HP Jing YX Yanni YG Dazzo FB | | 0，，11： | 1 |
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