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| 1 | Clinical observation of salvianolic acid B in treatment of liver fibrosis in chronic hepatitis B显示文摘AIM: To evaluate the clinical efficacy of salvianolic acidB (SA-B) on liver fibrosis in chronic hepatitis B.METHODS: Sixty patients with definite diagnosis of liverfibrosis with hepatitis B were included in the trial.Interferon-γ (IFN-γ) was used as control drug. Thepatients took orally SA-B tablets or received muscularinjection of IFN-γ in the double blind randomized test,The complete course lasted 6 months. The histologicalchanges of liver biopsy specimen before and after thetreatment were the main evidence in evaluation, incombination with the results of contents of serum HA,LN, Ⅳ-C, P-Ⅲ-P, liver ultrasound imaging, andsymptoms and signs.RESULTS: Reverse rate of fibrotic stage was 36.67 % inSA-B group and 30.0 % in IFN-γgroup. Inflammatoryalleviating rate was 40.0 % in SA-B group and 36.67 %in IFN-γ group. The average content of HA and Ⅳ-Cwas significantly lower than that before treatment. Theabnormal rate also decreased remarkably. Overallanalysis of 4 serological fibrotic markers showedsignificant improvement in SA-B group as comparedwith the IFN-γgroup. Score of liver ultrasound imagingwas lower in SA-B group than in IFN-γgroup (HA 36.7 %vs80 %,Ⅳ-C 3.3 % vs23.2 %). Before the treatment,ALT AST activity and total bilirubin content of patientswho had regression of fibrosis after oral administrationof SA-B, were significantly lower than those of patientswho had aggravation of fibrosis after oraladministration of SA-B. IFN-γ showed certain sideeffects (fever and transient decrease of leukocytes,occurrence rates were 50 % and 3.23 %), but SA-Bshowed no side effects.CONCLUSION: SA-B could effectively reverse liverfibrosis in chronic hepatitis B. SA-B was better than IFN-γ in reduction of serum HA content, overall decrease of4 serum fibrotic markers, and decrease of ultrasoundimaging score. Liver fibrosis in chronic hepatitis B withslight liver injury was more suitable to SA-B in anti-fibrotic treatment. SA-B showed no obvious side effects. | Ping Liu Yi-Yang Hu Cheng Liu Hui-Ming Xue Zhi-Qiang Xu Lie-Ming Xu Cheng-Hai Liu Hong-Tu Gu Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China Da-Yuan Zhu Shanghai Institute of Metaria Medica,Chinese Academy of Sciences,Shanghai 200031,China Zhi-Qing Zhang the 4~(th) Hualyin City Hospital,Hualan City,223000,JiangSu Province,China | 2002 | World Journal of Gastroenterology2002，8，4： | 85 |
| 2 | Pulmonary infection control window in treatment of severe respiratory failure of chronic obstructive pulmonary diseases: a prospective, randomized controlled, multi-centred study显示文摘Background Early withdraw from invasive mechanical ventilation (MV) followed by noninvasive MV is a new strategy for changing modes of treatment. This study was conducted to estimate the feasibility and the efficacy of early extubation and sequential noninvasive MV commenced at beginning of pulmonary infection control window in patients with exacerbated hypercapnic respiratory failure caused by chronic obstructive pulmonary diseases (COPD). Methods A prospective, randomized controlled study was conducted in eleven teaching hospitals' respiratory or medical intensive care units in China. Ninety intubated COPD patients with severe hypercapnic respiratory failure triggered by pulmonary infection (pneumonia or purulent bronchitis) were involved in the study. When the pulmonary infection had been controlled by antibiotics and comprehensive therapy, the 'pulmonary infection control window (PIC window)' has been reached. Each case was randomly assigned to study group (extubation and noninvasive MV via facial mask immediately) or control group (invasive MV was received continuously after PIC window by using conventional weaning technique).Results Study group (n=47) and control group (n=43) had similar clinical characteristics initially and at the time of PIC window. Compared with control group, study group had shorter duration of invasive MV [(6.4±4.4) days vs (11.3±6.2) days, P=0.000], lower rate of ventilator associated pneumonia (VAP) (3/47 vs 12/43, P=0.014), fewer days in ICU [(12±8) days vs (16±11) days, P=0.047] and lower hospital mortality (1/47 vs 7/43, P=0.025).Conclusions In COPD patients requiring intubation and invasive MV for hypercapnic respiratory failure, which is exacerbated by pulmonary infection, early extubation followed by noninvasive MV initiated at the start of PIC window may decrease significantly the duration of invasive MV, the risk of VAP and hospital mortality. | Wang, C Zhan, QY Cao, ZX Wei, LQ Cheng, ZZ Liu, S Zhang, JL Chen, RC Luo, Q Niu, SF Zhu, L Wu, DW Fang, BM Wu, TH Wang, CZ Liu, YN | 2005 | Chinese Medical Journal2005，，19： | 6 |
| 3 | 广州队列研究生物库中条形码技术应用与评价显示文摘目的建立大规模人群的分子流行病学队列研究生物库,确保快速、准确地识别每一份生物样本,并保持其活性,以便长时间跟踪研究。方法采用条形码识别技术对血液样品的采集、处理及存储、查询过程进行全程管理。结果创建成功以条形码自动识别技术为核心的新型运作管理模式,建立起10 000人份的生物样品库。大型生物样本库实施条形码管理系统可缩短每份样品的处理时间,提高工作效率1.5倍。结论条形码技术的应用可有效地避免样品间的相互混淆,使实验室每一项工作准确、可靠、高效,实现医学研究工作全面信息化,提高基因队列研究的质量。 | 朱彤 李成毅 江朝强 TH Lam K K Cheng | 2006 | 中国公共卫生2006，22，9： | 6 |
| 4 | The sweet potato sporamin promoter confers high- level phytase expression and improves organic phosphorus acquisition and tuber yield of transgenic potato 显示文摘 | Hong YF Liu CY Cheng KJ Hour AL Chan MT Tseng TH Chert KY Shaw JF Yu SM | 2008 | Plant Mol Biol2008，67，： | 1 |
| 5 | Functionalized temperature-sensitive copolymer for tissue engineering of articular cartilage and meniscus显示文摘 | Chen JP Cheng TH | | 0，，313： | 1 |
| 6 | General cone-beam reconstruction algorithm显示文摘 | Wang G Lin TH Cheng PC | 1993 | IEEE Transactions on Medical Imaging1993，12，3： | 1 |
| 7 | Paeonol reduced cerebral infarction involving the superoxide anion and microglia activation in ischemia-reperfusion injured rats 显示文摘 | Hsieh CL Cheng CY Tsai TH | 2006 | Joumal of Ethnopharmacology Volume 106 Issue 2 30 June 20062006，，： | 1 |
| 8 | Paeonol attenuates H202-induced NF-KB-associated arnyloid precursor protein expression显示文摘 | Su sY Cheng CY Tsai TH | 2010 | Am J Chin Meal2010，38，6： | 1 |
| 9 | Mechanism of concentration - dependent induction of heme oxygenase - 1 by resveratrol in human aortic smooth muscle cells 显示文摘 | Juan SH Cheng TH Lin HC | 2005 | Biochem Pharmacol2005，69，1： | 1 |
| 10 | Increased skeletal: renal uptake ratio: etiology and characteristics显示文摘 | Cheng TH Holman BL | 1980 | Radiology1980，136，2： | 1 |
| 11 | Role of mitogen activated protein kinase pathway in reactive oxygen species-mediated endothelin-l-in- duced beta-myosin heavy chain gene expression and cardiomyocyte hy- pertrophy显示文摘 | Cheng TH Shih NL Chen CH et 81 | 2005 | J Biomed Sei2005，12，2： | 1 |
| 12 | Enhanced nuclear factor-kappa B-associated Wnt-1 expression in hepatitis B-and C-related hepatocarcinogenesis:identification by functional proteomics显示文摘 | Lee TH Tai DI Cheng CJ | 2006 | J Biomed Sci2006，13，1： | 1 |
| 13 | Error analysis on the generalized FeldKamp cone-beam algorithm 显示文摘 | Wang G Lin TH Cheng PC | 1995 | Journal of Scanning Microcopy1995，17，： | 1 |
| 14 | A-tomatine suppresses invasion and migration of human non-small cell lung cancer NCI-H460 cells through inactivating FAK/PI3K/Akt signaling pathway and reducing binding activity of NF-jB 显示文摘 | Shieh JM Cheng TH Shi MD | 2011 | Cell Biochem Biophys2011，60，1： | 1 |
| 15 | Effects ofpropofol on cyclic strain-induced endothelin-1 expression in hu- man umbilical vein endothelial cells显示文摘 | Cheng TH Chen JJ Chen CH | 2009 | Anesthesiolo gy2009，110，1： | 1 |
| 16 | Hydroxyl radical in living'systems and its separation methods 显示文摘 | Cheng FC Jen JF Tsai TH | 2002 | J Chromatogr Br2002，781，： | 1 |
| 17 | p16 INK4 and p15 INK4B alterations in primary gynecologic malignancy显示文摘 | F Wong MD Cheng TKH Cheng TH | 1997 | Gynecologic Oncology1997，65，： | 1 |
| 18 | Resveratrol inhibits angiotensin Ⅱ -induced endothelin-1 gene expression and subsequent proliferation in rat aortic smooth muscle cells显示文摘 | Chao HH Juan SH Liu JC Yang HY Yang E Cheng TH | 2005 | Eur J Pharmacol2005，515，13： | 1 |
| 19 | Functionalized temperature-sensitive copolymer for tissue engineering of articular cartilage and meniscus 显示文摘 | Chen JP Cheng TH | 2008 | Colloids Surf A Physicoehem Eng Aspects2008，，313314： | 1 |
| 20 | Coronary normograms and the coronary-aorta index: objective determinants of coronary artery dilatation 显示文摘 | Tan TH Wong KY Cheng TK | 2003 | Pediatr Cardiol2003，24，4： | 1 |
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