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| 1 | Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions显示文摘Brain tumors are dynamic complex ecosystems with multiple cell types.To model the brain tumor microenvironment in a reproducible and scalable system,we developed a rapid three-dimensional(3D)bioprinting method to construct clinically relevant biomimetic tissue models.In recurrent glioblastoma,macrophages/microglia prominently contribute to the tumor mass.To parse the function of macrophages in 3D,we compared the growth of glioblastoma stem cells(GSCs)alone or with astrocytes and neural precursor cells in a hyaluronic acid-rich hydrogel,with or without macrophage.Bioprinted constructs integrating macrophage recapitulate patient-derived transcriptional profiles predictive of patient survival,maintenance of stemness,invasion,and drug resistance.Whole-genome CRISPR screening with bioprinted complex systems identified unique molecular dependencies in GSCs,relative to sphere culture.Multicellular bioprinted models serve as a scalable and physiologic platform to interrogate drug sensitivity,cellular crosstalk,invasion,context-specific functional dependencies,as well as immunologic interactions in a species-matched neural environment. | Min Tang Qi Xie Ryan C.Gimple Zheng Zhong Trevor Tam Jing Tian Reilly L.Kidwell Qiulian Wu Briana C.Prager Zhixin Qiu Aaron Yu Zhe Zhu Pinar Mesci Hui Jing Jacob Schimelman Pengrui Wang Derrick Lee Michael H.Lorenzini Deobrat Dixit Linjie Zhao Shruti B.hargava Tyler E.Miller Xueyi Wan Jing Tang Bingjie Sun Benjamin F.Cravatt Alysson R.Muotri Shaochen Chen Jeremy N.Rich | 2020 | Cell Research2020，30，10： | 6 |
| 2 | Two-dimensional optical spatial differentiation and high-contrast imaging显示文摘Optical analog signal processing technology has been widely studied and applied in a variety of science and engineering fields, with the advantages of overcoming the low-speed and high-power consumption associated with its digital counterparts. Much attention has been given to emerging metasurface technology in the field of optical imaging and processing systems. Here, we demonstrate, for the first time, broadband two-dimensional spatial differentiation and high-contrast edge imaging based on a dielectric metasurface across the whole visible spectrum. This edge detection method works for both intensity and phase objects simply by inserting the metasurface into a commercial optical microscope. This highly efficient metasurface performing a basic optical differentiation operation opens up new opportunities in applications of fast,compactible and power-efficient ultrathin devices for data processing and biological imaging. | Junxiao Zhou Haoliang Qian Junxiang Zhao Min Tang Qianyi Wu Ming Lei Hailu Luo Shuangchun Wen Shaochen Chen Zhaowei Liu | 2021 | National Science Review2021，8，6： | 6 |
| 3 | A triboelectric/electromagnetic hybrid generator for efficient wind energy collection and power supply for electronic devices显示文摘Harvesting energy from ambient environment has been considered as a promising strategy for driving portable electronic devices in a sustainable way. A wind driven triboelectric-electromagnetic hybrid nanogenerator has been fabricated to convert wind energy into electricity. It is composed of an electromagnetic generator(EMG) and a triboelectric nanogenerator(TENG) with the output power of 35 and 0.32 mW, respectively when the wind speed is 5 m/s. Generally, TENG shows a low current output with a high voltage output characteristic, on the contrary the EMG shows a high current output and a low voltage output. This hybrid nanogenerator overcomes these problems and exhibits comprehensive and efficient performance on scavenging energy.Moreover, in view of the output performance and charging ability of the hybrid nanogenerator, it shows high stability, making it suitable for charging capacitors or batteries and driving portable electronics sustainably. A new structure of integrated TENG and EMG was designed to harvest wind energy, which shows potential applications in portable and small device power supply system, especially in the areas of remote mountains, deserts, islands, etc., as emergency power supply. | XU GuanPing ZHENG YouBin FENG YanGe MA ShaoChen LUO Ning FENG Min CHEN ShouGang WANG DaoAi | 2021 | Science China(Technological Sciences)2021，64，9： | 2 |
| 4 | Berry-Esseen bounds and Cramér type large deviations for eigenvalues of random matrices.显示文摘We establish Berry-Esseen bounds and Cramér type large deviations for the eigenvalues of Wigner Hermitian matrices in the bulk and at the edge cases. Similar results are also obtained for covariance matrices. | CHEN Lei GAO FuQing WANG ShaoChen | 2015 | Science China Mathematics2015，58，9： | 2 |
| 5 | A new component maps correction method using variable geometric parameters显示文摘Accurate engine performance models are important for model-based performance evaluation of aero engine.The accuracy of the model often depends on engine component maps,so there is a need for a method that can accurately correct the component maps of the model over a wide range.In this paper,a new method for modifying component maps is proposed,this method combines the correction of the scaling factors with the solution process of the off-design working point,and uses the adjustment of the variable geometric parameters of the engine to change the position of the working line,in order to obtain more correction results and guarantee high accuracy in a wider range.The method is validated by taking the main fan of the Adaptive Cycle Engine(ACE),an ideal power unit for a new generation of multi-purpose and ultra-wide working range aircraft,as an example.The results show that the maximum error between the corrected component maps and the target maps is less than 1%.New possibility for more precise component maps can be realized in this paper. | Shaochen LI Hailong TANG Min CHEN | 2021 | Chinese Journal of Aeronautics2021，34，4： | 1 |
| 6 | Glyphosate exposure deteriorates oocyte meiotic maturation via induction of organelle dysfunctions in pigs显示文摘Background:Recently,defects in mammalian oocytes maturation induced by environmental pollution results in the decreasing animal reproduction.Animal exposed to glyphosate is largely unavoidable because glyphosate is one of the most widely used herbicide worldwide due to its high-efficiency and broad-spectrum effects,which causes glyphosate an environmental contaminant found in soil,water and food.During the last few years,the growing and wider use of glyphosate has raised great concerns about its effects of reproductive toxicity.In this study,using porcine models,we investigated effects of glyphosate on organelle functions during oocyte meiosis.Results:The results showed glyphosate exposure disrupted porcine oocyte maturation.Expression levels of cumulus expansion-related genes were interfered,further indicating the meiotic defects.The damaging effects were mediated by destruction of mitochondrial distribution and functions,which induced ROS accumulation and oxidative stress,also indicated by the decreased mRNA expression of related antioxidant enzyme genes.We also found an interference of endoplasmic reticulum(ER)distribution,disturbance of Ca^(2+)homeostasis,as well as fluctuation of ER stress,showing with the reduced ER stress-related mRNA or protein expression,which could indicate the dysfunction of ER for protein processing and signal transduction in glyphosate-exposed oocytes.Moreover,glyphosate exposure induced the disruption of lysosome function for autophagy,showing with the decrease of LAMP2 expression and autophagy-related genes mRNA expression.Additionally,our data showed the distribution of Golgi apparatus and the functions of ribosome were disturbed after glyphosate exposure,which might affect protein synthesis and transport.Conclusions:Collectively,our study showed that exposed to glyphosate could affect animal reproduction by compromising the quality of oocytes through its wide toxic effects on organelle functions. | Chunhua Xing Shun Chen Yue Wang Zhennan Pan Yuanjing Zou Shaochen Sun Zili Ren Yu Zhang | 2022 | Journal of Animal Science and Biotechnology2022，13，6： | 1 |
| 7 | Microfabrication of complex porous tissue engineering scaffolds using 3D projection stereolithography显示文摘 | Robert Gauvin Ying-Chieh Chen Jin Woo Lee Pranav Soman Pinar Zorlutuna Jason W. Nichol Hojae Bae Shaochen Chen Ali Khademhosseini | 2012 | Biomaterials2012，，15： | 1 |
| 8 | Analytical Analysis of a Circular PZT Actuator for Valveless Micropumps显示文摘 | Li Shifeng Chen Shaochen | 2003 | Sensors and Actuators A2003，104，9： | 1 |
| 9 | Compressive Behavior of Wood-based 2-D Lattice Structure under Multivariable Analysis显示文摘In order to optimize the out-of-plane compression performance of the wood structure,wood-based 2-D lattice structures were designed and manufactured with oriented strand board as the panel and birch round stick as the core by using a simple insert-glue method.In this experiment,the different thicknesses of the upper and lower panels,the different shavings arrangement directions of the upper and lower panels and the different configurations of the specimens were used to analyze the compression performance of the specimens under multivariable conditions.Through the combination of experimental test and theoretical analysis,we analyzed and compared different failure types of the structure and multiple compression parameters.The results showed that the shavings arrangement direction of the panel has a more important influence on the whole specimen than the thickness of the panel,especially the transverse shavings of the panel can withstand greater shear stress than the longitudinal shavings for a specimen. | Yanxia FENG Mengyuan WANG Shaochen HU Lili JIA Jihe CHEN Tianshi FENG Yingcheng HU | 2019 | Journal of Bioresources and Bioproducts2019，4，2： | 0 |
| 10 | Experimental investigation of flame propagation characteristics in the in-line crimped-ribbon flame arrester显示文摘An experimental system that consisted was of gas mixing equipment,a sensor detection flame system,a data and acquisition quenching device,and an electric spark ignition device set in up to investigate fuel/air deflagration propagation suppression processes through when a crimped-ribbon concentration flame arrester an was enclosed close horizontal the pipe.Deflagration ratio,experiments showed that the the four of and flammable ethylene-air combustion,gas to stoichiometric pipe the evolution processes of and explosion could pressure divided for propane-air stages:premixed slow gases in the diameter(DN32–DN400)and were similar be into isobaric pressure was rise,quick pressure and rise,pressure oscillation.However,high.the explosion duration quickly of the the hydrogen-air premixed gas stage.relatively short,the peak be explosion pressure three was The pipe pressure diameter rose after isobaric combustion speed Therefore,the the process can divided into stages increased in the and(DN15–DN150).Deflagration increases results indicated that propane-air flame speed initially eventually decreased along with in the pipe diameter(DN32–DN400);however,the of ethylene-air flame speed gradually flame increased with the increase the of the pipe diameter(DN80–DN400).No notable pattern change speed in the hydrogen-air at speed was observed in pipe diameter(DN15–DN150).The maximum happened propane-air when flame occurred 5%concentration.The the maximum conditions flame of speed same for size ethylene-air of and hydrogen-air tube the mixture ignition was close to but stoichiometric different ratio.Under or the experimental configuration experimental and the same distance flame pipe lengths,stopped the same flames pipe length high but different ignition low distances,results showed that the arrester successfully the at flame speed and explosion pressure,but failed at low flame speed and high explosion pressure. | SUN ShaoChen DING ChunHui HU XiYu LIU Gang YE Chen BI MingShu | 2017 | Science China(Technological Sciences)2017，60，5： | 0 |
| 11 | Two distinct roles of Al_(2)Sm and Al_(11)Sm_(3) phases on the corrosion behavior of the magnesium alloy Mg-5Sm-xAl显示文摘The roles of Al11Sm3 and Al_(2)Sm phases on microstructure evolution,mechanical properties and corrosion behavior of the Mg-5Sm-x Al system was investigated.The results showed that adding Al to Mg–5Sm binary alloy brought two Al–Sm phases,Al11Sm3 and Al_(2)Sm,which had two distinct roles regarding the microstructure evolution,mechanical properties and corrosion behavior of the Mg-Sm-Al alloy.Al11Sm3 produced a strong galvanic couple with the Mg matrix,and significantly accelerated the corrosion.The Al_(2)Sm particles promoted heterogeneous nucleation and refined the grains,which increased the tensile strength and ductility.Both types of Al–Sm particles provided strengthening effect for the alloy.With higher Al contents,Al2Sm formed an Al oxide protective surface layer and increased corrosion resistance. | Xingrui Chen Qi Zou Qichi Le Shaochen Ning Chenglu Hu Xiaoqiang Li Anrej Atrens | 2021 | Progress in Natural Science:Materials International2021，31，4： | 0 |
| 12 | Structures and Nonlinear Optical Properties of Lithium-adsorbed Polycyclic π-Conjugated Pentacene Systems显示文摘 | LI Shaochen YU Guangtao CHEN Wei HUANG Xuri | 2015 | Chemical Research in Chinese Universities2015，31，2： | 0 |
| 13 | Moderate deviations and central limittheorem for small perturbationWishart processes显示文摘 | Lei CHEN Fuqing GAO Shaochen WANG | 2014 | Frontiers of Mathematics in China2014，9，1： | 0 |
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