|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The Effects of Prior Spending on Future Spending Decisions: The Role of Acquisition Liabilities and Payments显示文摘 | Dilip Soman Vivian M. W. Lam | | Marketing Letters0，，： | 2 |
| 2 | 颗粒性过敏原对致敏小鼠肥大细胞生成干扰素的影响研究显示文摘目的研究颗粒过敏原诱导过敏性哮喘反应中重要的效应细胞肥大细胞生成干扰素IFN-γ的能力以及可能的作用机制。方法为模拟环境中附着有过敏原成分的可吸入性颗粒物,将模式过敏原蛋白三硝基苯基结合的卵清蛋白(OVA-TNP)共价偶联于大小均一的微球上形成颗粒状过敏原。肥大细胞首先用识别TNP的IgE致敏,然后用颗粒过敏原进行刺激。以Real-time PCR方法测定肥大细胞活化后IFN-γ的基因表达水平。采用同等剂量的以可溶形式存在的OVA/TNP作为可溶过敏原,比较颗粒过敏原刺激肥大细胞生成干扰素的能力。采用三种骨架蛋白抑制剂(Latrunculin B,cytochalasin D和Jasplakinolinde)观察阻断Actin的功能。结果与可溶过敏原相比,颗粒过敏原刺激IgE致敏的肥大细胞的IFN-γ的基因表达水平上升。肥大细胞IFN-γ基因表达的峰值出现在过敏原刺激后1 h。骨架蛋白抑制剂降低过敏原刺激肥大细胞IFN-γ的基因表达水平。结论当过敏原以颗粒形式存在时可以刺激致敏的肥大细胞生成更高水平的Th1型细胞因子干扰素IFN-γ,但作用机制与已知颗粒过敏原增强肥大细胞生成Th2型细胞因子的机制不同。 | 金聪 宁钧宇 Soman A | 2011 | 环境与健康杂志2011，28，4： | 2 |
| 3 | Significance of serum carcinoembryonic antigen in metastatic breast cancer patients:A prospective study显示文摘BACKGROUND Carcinoembryonic antigen(CEA)is an important serum tumour marker with a substantial role in diagnosis and monitoring of various solid tumours.About 36%-70%of breast cancers have elevated serum CEA.And the available studies show discrepancy in addressing the prognostic significance of CEA in advanced breast cancer.AIM To estimate the serum CEA level in our metastatic breast cancer patients and correlate it with response to treatment and clinical outcome.METHODS This was a prospective clinical study conducted on 50 metastatic breast cancer patients treated at breast clinic,with newly diagnosed metastatic breast cancer planned for palliative chemotherapy,targeted therapy,and hormonal treatment.We estimated the proportion of patients with elevated serum CEA level at baseline and after palliative treatment and also studied the association of serum CEA levels with known prognostic factors.The response to treatment was correlated with the serum CEA levels in the context of responders and nonresponders.RESULTS The median pre-treatment and post-treatment CEA levels were 7.9(1.8-40.7)ng/mL and 4.39(1.4-12.15)ng/mL,respectively,in the whole study population(P=0.032).No statistically significant difference was seen in baseline serum CEA between responders and non-responders.Even in the luminal group,pretreatment serum CEA was not a predictor of response,but post-treatment CEA was a significant predictor of tumour progression.In patients with liver and lung metastases,post-treatment CEA level difference was not statistically significant in both responders and non-responders though the values were higher in nonresponders.Among those with bone metastases,69.5%had elevated post-treatment serum CEA,and only 37.5%had elevated serum CEA in those with no bone metastases.CONCLUSION Elevated post-treatment serum CEA levels are associated with disease progression and poor response to therapy.Persistently elevated post-treatment serum CEA levels are significantly associated with bone metastases.Elevated serum CEA and hormonal status are significant predictors of treatment response. | Thattungal Manoharan Anoop Rona Joseph P Saikumar Soman Steffi Chacko Mintu Mathew | 2022 | World Journal of Clinical Oncology2022，13，6： | 2 |
| 4 | Least square estimation of three parameters of a weibull estimation显示文摘 | SOMAN K P MISRA K B | 1992 | Microelectronics and Reliability1992，32，3： | 1 |
| 5 | Lead salt of 2,4 N-trinitroanilinoacetic acid-an energetic bullistic modifier for double base propellants 显示文摘 | Soman R R Mukundan T Bhat V K | 2000 | Journal of Energetic Materials2000，，18： | 1 |
| 6 | Use of Substituted (Benzylidinearnino) guanidines in the Study of Guanidino Group Specific ADP-ribosyltransferase 显示文摘 | Soman G Narayanan J Martin L N | 1986 | Biochemistry1986，25，： | 1 |
| 7 | Three-dimensional solution structure of a single zinc finger DNA-binding domain显示文摘 | LEE M S GIPPERT G P SOMAN K V | 1989 | Science1989，245，4918： | 1 |
| 8 | YidC/Alb3/Oxal family of insertases显示文摘 | Hennon SW Soman R Zhu L | 2015 | The Journal of Biological Chemistry2015，290，14： | 1 |
| 9 | Diffrentia1 protein expression profiles of gastric epithelia1 cells following Helicobacter pylori infection using protein chips显示文摘 | Das S Sierra J C Soman K V | 2005 | J Proteome Res2005，，3： | 1 |
| 10 | The onset of the southwest monsoon over Kerala: 1901-1980显示文摘 | ANANTHAKRISHNAN R SOMAN M K | 1988 | J Climatol1988，8，3： | 1 |
| 11 | Combined make-to-order and make-to-stock in a food production system 显示文摘 | SOMAN C A VAN DONK D P GAALMAN G | 2004 | International Journal of Production Economics2004，90，2： | 1 |
| 12 | Least Square Estimation of Three Parame-ters of a Weibull Estimation显示文摘 | Soman K P Misra K B | 1992 | Microelectronics and Reliability1992，32，3： | 1 |
| 13 | Power Doppler har- monicimaging:afeasibility study of a new technique for the as- sessment of myocardial perfusion 显示文摘 | SENIOR R KAUL S SOMAN P | 2000 | Am Heart2000，139，21： | 1 |
| 14 | Environmental radiation and cancer in India显示文摘 | NAMBIK S SOMAN S D | 1987 | Health Phys1987，52，5： | 1 |
| 15 | Paroxysmal non-epilepticevents resembling seizures in children with otitis media显示文摘 | Soman TB Krishnamoorthy KS | 2005 | Clin Pediatr2005，44，5： | 1 |
| 16 | Contrast - induced nephropathy显示文摘 | McCullough PA Soman SS | 2005 | Crit Care Clin2005，21，2： | 1 |
| 17 | Space-time evolution of meteorological features associated with the onset of Indian summer monsoon显示文摘 | SOMAN M K KRISHNAR K K | 1993 | Mon Wea Rev1993，121，4： | 1 |
| 18 | Textural kinetics: A novel dynamic contrast-enhanced-MRI feature for breast lesion classifi- cation显示文摘 | Agner SC Soman S Libfeld E | 2011 | J Digit [maging2011，24，3： | 1 |
| 19 | Discovery of Anasplatyrhynchos avian β-defensin 2 (Apl_AvBD2) with antibacterialand chemotactic functions 显示文摘 | Soman S S Arathy D S Sreekumar E | 2009 | Molecular Immunology2009，46，： | 1 |
| 20 | Contrast-induced nephropathy显示文摘 | McCullough PA Soman SS | 2005 | Crit Clin2005，21，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员