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| 1 | Recent Progress in Dual-Polarization Radar Research and Applications in China显示文摘Dual-polarization(dual-pol)radar can measure additional parameters that provide more microphysical information of precipitation systems than those provided by conventional Doppler radar.The dual-pol parameters have been successfully utilized to investigate precipitation microphysics and improve radar quantitative precipitation estimation(QPE).The recent progress in dual-pol radar research and applications in China is summarized in four aspects.Firstly,the characteristics of several representative dual-pol radars are reviewed.Various approaches have been developed for radar data quality control,including calibration,attenuation correction,calculation of specific differential phase shift,and identification and removal of non-meteorological echoes.Using dual-pol radar measurements,the microphysical characteristics derived from raindrop size distribution retrieval,hydrometeor classification,and QPE is better understood in China.The limited number of studies in China that have sought to use dual-pol radar data to validate the microphysical parameterization and initialization of numerical models and assimilate dual-pol data into numerical models are summarized.The challenges of applying dual-pol data in numerical models and emerging technologies that may make significant impacts on the field of radar meteorology are discussed. | Kun ZHAO Hao HUANG Mingjun WANG Wen-Chau LEE Gang CHEN Long WEN Jing WEN Guifu ZHANG Ming XUE Zhengwei YANG Liping LIU Chong WU Zhiqun HU Sheng CHEN | 2019 | Advances in Atmospheric Sciences2019，36，9： | 12 |
| 2 | Increased activity of MdFRK2, a high-affinity fructokinase, leads to upregulation of sorbitol metabolism and downregulation of sucrose metabolism in apple leaves显示文摘To investigate the functions of fructokinase(FRK)in apple(Malus domestica)carbohydrate metabolism,we cloned the coding sequences of MdFRK1 and MdFRK2 from the‘Royal Gala’apple.The results showed that MdFRK2 expression was extremely high in shoot tips and young fruit.Analyses of heterologously expressed proteins revealed that MdFRK2 had a higher affinity for fructose than did MdFRK1,with Km values of 0.1 and 0.62 mM for MdFRK2 and MdFRK1,respectively.The two proteins,however,exhibited similar Vmax values when their activities were significantly inhibited by high concentrations of fructose.MdFRK2 ectopic expression was associated with a general decrease in fructose concentration in transgenic lines.In leaves,increased FRK activity similarly resulted in reduced concentrations of glucose and sucrose but no alterations in sorbitol concentration.When compared with those in the untransformed control,genes involved in sorbitol synthesis(A6PR)and the degradation pathway(SDH1/2)were significantly upregulated in transgenic lines,whereas those involved in sucrose synthesis(SPS1)and other degradation processes(SUSY4,NINV1/2,and HxK2)were downregulated.The activity of enzymes participating in carbohydrate metabolism was proportional to the level of gene expression.However,the growth performance and photosynthetic efficiency did not differ between the transgenic and wild-type plants.These results provide new genetic evidence to support the view that FRK plays roles in regulating sugar and sorbitol metabolism in Rosaceae plants. | Jingjing Yang Lingcheng Zhu Weifang Cui Chen Zhang Dongxia Li Baiquan Ma Lailiang Cheng Yong-Ling Ruan Fengwang Ma Mingjun Li | 2018 | Horticulture Research2018，5，1： | 9 |
| 3 | Formation mechanism of a smooth, defectfree surface of fused silica optics using rapid CO2 laser polishing显示文摘Surface defects introduced by conventional mechanical processing methods can induce irreversible damage and reduce the service life of optics applied in high-power lasers.Compared to mechanical processing,laser polishing with moving beam spot is a noncontact processing method,which is able to form a defect-free surface.This work aims to explore the mechanism of forming a smooth,defect-free fused silica surface by high-power density laser polishing with coupled multiple beams.The underlying mechanisms of laser polishing was revealed by numerical simulations and the theoretical results were verified by experiments.The simulated polishing depth and machined surface morphology were in close agreement with the experimental results.To obtain the optimized polishing quality,the effects of laser polishing parameters(e.g.overlap rate,pulse width and polishing times)on the polishing quality were experimentally investigated.It was found that the processing efficiency of fused silica materials by carbon dioxide(CO2)laser polishing could reach 8.68 mm2 s−1,and the surface roughness(Ra)was better than 25 nm.Besides,the cracks on pristine fused silica surfaces introduced by initial grinding process were completely removed by laser polishing to achieve a defect-free surface.The maximum laser polishing rate can reach 3.88μm s−1,much higher than that of the traditional mechanical polishing methods.The rapid CO2 laser polishing can effectively achieve smooth,defect-free surface,which is of great significance to improve the surface quality of fused silica optics applied in high-power laser facilities. | Linjie Zhao Jian Cheng Mingjun Chen Xiaodong Yuan Wei Liao Qi Liu Hao Yang Haijun Wang | 2019 | International Journal of Extreme Manufacturing2019，1，3： | 8 |
| 4 | Molecular dynamics simulations of thermal effects in nanometric cutting process显示文摘Understanding the basic action of how material removing in nanoscale is a critical issue of producing well-formed components.In order to clarify thermal effects on material removal at atomic level,molecular dynamics(MD)simulations of nanometric cutting of mono-crystalline copper are performed with Morse,EAM and Tersoff potential.The effects of cutting speed on temperature distribution are investigated.The simulation results demonstrate that the temperature distribution shows a roughly concentric shape around shear zone and a steep temperature gradient lies in diamond tool,a relative high temperature is located in shear zone and machined surface,but the highest temperature is found in chip.At a high cutting speed mode,the atoms in shear zone with high temperature implies a large stress is built up in a local region. | GUO YongBo,LIANG YingChun,CHEN MingJun,BAI QingShun&LU LiHua Precision Research Engineering Institute,Harbin Institute of Technology,Harbin 150001,China | 2010 | Science China(Technological Sciences)2010，53，3： | 7 |
| 5 | Tartrate-resistant acid phosphatase 5b is a potential biomarker for rheumatoid arthritis: a pilot study in Han Chinese显示文摘 | Cheng Tao Wang Mingjun Chen Zhiwei Robert A Eisenberg Zhang Yu Zou Yaohong Deng Yingsu Wang Mian Zhou Ling | 2014 | Chinese Medical Journal2014，，16： | 7 |
| 6 | Multiscale simulation of nanometric cutting of single crystal copper——effect of different cutting speeds显示文摘A multiscale simulation has been performed to determine the effect of the cutting speed on the deformation mechanism and cutting forces in nanometric cutting of single crystal copper.The multiscale simulation model,which links the finite element method and the molecular dynamics method,captures the atomistic mechanisms during nanometric cutting from the free surface without the computational cost of full atomistic simulations.Simulation results show the material deformation mechanism of single crystal copper greatly changes when the cutting speed exceeds the material static propagation speed of plastic wave.At such a high cutting speed,the average magnitudes of tangential and normal forces increase rapidly.In addition,the variation of strain energy of work material atoms in different cutting speeds is investigated. | Hongmin PEN Qingshun BAI Yingchun LIANG Mingjun CHEN | 2009 | Acta Metallurgica Sinica(English Letters)2009，22，6： | 6 |
| 7 | On-machine Precision Preparation and Dressing of Ball-headed Diamond Wheel for the Grinding of Fused Silica显示文摘In the grinding of high quality fused silica parts with complex surface or structure using ball-headed metal bonded diamond wheel with small diameter,the existing dressing methods are not suitable to dress the ball-headed diamond wheel precisely due to that they are either on-line in process dressing which may causes collision problem or without consideration for the effects of the tool setting error and electrode wear.An on-machine precision preparation and dressing method is proposed for ball-headed diamond wheel based on electrical discharge machining.By using this method the cylindrical diamond wheel with small diameter is manufactured to hemispherical-headed form.The obtained ball-headed diamond wheel is dressed after several grinding passes to recover geometrical accuracy and sharpness which is lost due to the wheel wear.A tool setting method based on high precision optical system is presented to reduce the wheel center setting error and dimension error.The effect of electrode tool wear is investigated by electrical dressing experiments,and the electrode tool wear compensation model is established based on the experimental results which show that the value of wear ratio coefficient K' tends to be constant with the increasing of the feed length of electrode and the mean value of K' is 0.156.Grinding experiments of fused silica are carried out on a test bench to evaluate the performance of the preparation and dressing method.The experimental results show that the surface roughness of the finished workpiece is 0.03 μm.The effect of the grinding parameter and dressing frequency on the surface roughness is investigated based on the measurement results of the surface roughness.This research provides an on-machine preparation and dressing method for ball-headed metal bonded diamond wheel used in the grinding of fused silica,which provides a solution to the tool setting method and the effect of electrode tool wear. | CHEN Mingjun LI Ziang YU Bo PENG Hui FANG Zhen | 2013 | Chinese Journal of Mechanical Engineering2013，26，5： | 5 |
| 8 | Bioprinting of novel 3D tumor array chip for drug screening显示文摘Biomedical field has been seeking a feasible standard drug screening system consisting of 3D tumor model array for drug researching due to providing sufficient samples and simulating actual in vivo tumor growth situation,which is still a challenge to rapidly and uniformly establish though.Here,we propose a novel drug screening system,namely 3D tumor array chip with“layer cake”structure,for drug screening.Accurate gelatin methacryloyl hydrogel droplets(~0.1μL)containing tumor cells can be automatically deposited on demand with electrohydrodynamic 3D printing.Transparent conductive membrane is introduced as a chip basement for preventing charges accumulation during fabricating and convenient observing during screening.Culturing chambers formed by stainless steel and silicon interlayer is convenient to be assembled and recycled.As this chip is compatible with the existing 96-well culturing plate,the drug screening protocols could keep the same as convention.Important properties of this chip,namely printing stability,customizability,accuracy,microenvironment,tumor functionalization,are detailly examined.As a demonstration,it is applied for screening of epirubicin and paclitaxel with breast tumor cells to confirm the compatibility of the proposed screening system with the traditional screening methods.We believe this chip will potentially play a significant role in drug evaluation in the future. | Mingjun Xie Qing Gao Jianzhong Fu Zichen Chen Yong He | 2020 | Bio-Design and Manufacturing2020，3，3： | 3 |
| 9 | Urban-rural disparities in mild cognitive impairment and its functional subtypes among community- dwelling older residents in central China显示文摘background Substantial variations in the prevalence of mild cognitive impairment(MCI)and its subtypes have been reported,although mostly in geographically defined developed countries and regions.Less is known about MCI and its subtypes in rural areas of less developed central China.Aims The study aimed to compare the prevalence of MCI and its subtypes in residents aged 65 years or older in urban and rural areas of Hubei Province,China.Methods Participants aged 65 years or older were recruited between 2018 and 2019.Inperson structured interviews and clinical and neuropsychological assessments were performed at city health community centres and township hospitals.results Among 2644 participants without dementia,735 had MCI,resulting in a prevalence of 27.8%for total MCI,20.9%for amnestic MCI(aMCI)and 6.9%for non-amnestic MCI(naMCI).The prevalence of MCI in urban and rural areas was 20.2%and 44.1%,respectively.After adjusting for demographic factors,the prevalence of total MCI,aMCI and naMCI differed significantly between rural and urban areas(adjusted odds ratio(OR)2.10,1.44 and 3.76,respectively).Subgroup analysis revealed an association between rural socioeconomic and lifestyle disadvantage and MCI and its subtypes.Conclusions Our findings suggest that the prevalence of MCI among urban residents in central China is consistent with that in other metropolis areas,such as Shanghai,but the prevalence in rural areas is twice that in urban areas.Prospective studies and dementia prevention in China should focus on rural areas. | Dan Liu Lin Li Lina An Guirong Cheng Cong Chen Mingjun Zou Bo Zhang Xuguang Gan Lang Xu Yangming Ou Qingming Wu Ru Wang Yan Zeng | 2021 | General Psychiatry2021，34，5： | 3 |
| 10 | Theoretical and Experimental Research on Error Analysis and Optimization of Tool Path in Fabricating Aspheric Compound Eyes by Precision Micro Milling显示文摘Structure design and fabricating methods of three-dimensional(3D)artificial spherical compound eyes have been researched by many scholars.Micro-nano optical manufacturing is mostly used to process 3D artificial compound eyes.However,spherical optical compound eyes are less at optical performance than the eyes of insects,and it is difficult to further improve the imaging quality of compound eyes by means of micro-nano optical manufacturing.In this research,nonhomogeneous aspheric compound eyes(ACEs)are designed and fabricated.The nonhomogeneous aspheric structure is applied to calibrate the spherical aberration.Micro milling with advantages in processing three-dimensional micro structures is adopted to manufacture ACEs.In order to obtain ACEs with high imaging quality,the tool paths are optimized by analyzing the influence factors consisting of interpolation allowable error,scallop height and tool path pattern.In the experiments,two kinds of ACEs are manufactured by micro-milling with different too path patterns and cutting parameter on the miniature precision five-axis milling machine tool.The experimental results indicate that the ACEs of high surface quality can be achieved by circularly milling small micro-lens individually with changeable cutting depth.A prototype of the aspheric compound eye(ACE)with surface roughness(Ra)below 0.12?m is obtained with good imaging performance.This research ameliorates the imaging quality of 3D artificial compound eyes,and the proposed method of micro-milling can improve surface processing quality of compound eyes. | CHEN Mingjun XIAO Yong TIAN Wenlan WU Chunya CHU Xin | 2014 | Chinese Journal of Mechanical Engineering2014，27，3： | 3 |
| 11 | Research on the influence of machining introduced sub-surface defects and residue stress upon the mechanical properties of single crystal copper显示文摘Large scale molecular dynamics simulations of nanomachining and stretching of single crystal copper are performed to analyze the machining process’ influence on the material’s mechanical properties. The simulation results show that the machining process will introduce interfacial defects inside the specimen and enhance the compressive stress beneath the surface. Gener- ally speaking, interfacial defects lead to the decrease of the strength limit, while residue compressive stress can enhance the elastic limit and even the strength limit. Various machining parameters are adopted to investigate their influence on the me- chanical behavior of machined specimen. Lower cutting speed and smaller cutting depth lead to less defects and greater residue compressive stress, which brings about better mechanical properties. The elastic limit increases by 36.8% under the cutting depth of 0.73 nm and decreases by 21.1% under the cutting depth of 1.46 nm. The strength limit increases by 7.7% under the cutting speed of 100 m/s and decreases by 28.2% under the cutting speed of 300 m/s. | CHEN MingJun, XIAO GaoBo, CHEN JiaXuan & WU ChunYa Harbin Institute of Technology, Harbin 150001, China | 2010 | Science China(Technological Sciences)2010，53，12： | 3 |
| 12 | Short-channel effects on the static noise margin of 6T SRAM composed of 2D semiconductor MOSFETs显示文摘This paper investigates the influence of the short-channel effects(SCEs) on the static noise margin(SNM) of 6 T(6 transistors) SRAM composed of 2 D MOSFETs. An analytical all-region I-V model for short-channel complementary 2 D MOSFETs has been developed, and a simulation model has been built to calculate SNM with the consideration of SCEs and velocity saturation. The results show that there exists an optimal value of channel length(L_(opt)) where SNM reaches a maximum, and Lopt is approximately three times the scale length. In the region where L>L_(opt), SNM increases slightly as L decreases because of velocity saturation, while in the region where L | Qian XIE Chen CHEN Mingjun LIU Shuang XIA Zheng WANG | 2019 | Science China(Information Sciences)2019，62，6： | 3 |
| 13 | Positional Electronic Effects in Iminopyridine-N-oxide Nickel Catalyzed Ethylene Polymerization显示文摘A series of dibenzhydryl-based iminopyridine-N-oxide ligands bearing a range of electron-donating or-withdrawing substituents(OMe,H;and NO_(2))and corresponding nickel pre-catalysts are prepared and characterized.The substituents are installed at different positions on the ligand structure,including 4-position of the pyridine-N-oxide moiety(position X)and 4-position of the aniline moiety(position Y).These nickel pre-catalysts are highly active in ethylene polymerization with the addition of very little amount of aluminum cocatalysts,leading to the formation of polyethylenes with molecular weights of well above one million.Electron-donating substituents make the catalysts sensitive to polymerization temperature.In contrast,the catalysts bearing electron-withdrawing NO_(2) substituents show relatively steady performances at different temperatures.Most importantly,we demonstrate that different substituents and different positions both play important roles in determining the properties of nickel catalysts.This provides an alternative strategy for the future design of high-performance polymerization catalyst. | Mingjun Chi Ao Chen Wenmin Pang Chen Tan Changle Chen | 2021 | Chinese Journal of Chemistry2021，39，6： | 2 |
| 14 | All-optical controlled-NOT logic gate achieving directional asymmetric transmission based on metasurface doublet显示文摘Optical logic gates play important roles in all-optical logic circuits,which lie at the heart of the next-generation optical computing technology.However,the intrinsic contradiction between compactness and robustness hinders the development in this field.Here,we propose a simple design principle that can possess multiple-input-output states according to the incident circular polarization and direction based on the metasurface doublet,which enables controlled-NOT logic gates in infrared region.Therefore,the directional asymmetric electromagnetic transmission can be achieved.As a proof of concept,a spin-dependent Janus metasurface is designed and experimentally verified that four distinct images corresponding to four input states can be captured in the far-field.In addition,since the design method is derived from geometric optics,it can be easily applied to other spectra.We believe that the proposed metasurface doublet may empower many potential applications in chiral imaging,chiroptical spectroscopy and optical computing. | Yijia Huang Tianxiao Xiao Shuai Chen Zhengwei Xie Jie Zheng Jianqi Zhu Yarong Su Weidong Chen Ke Liu Mingjun Tang Peter Müller-Buschbaum Ling Li | 2023 | Opto-Electronic Advances2023，6，7： | 2 |
| 15 | Analysis of molecular variation in porcine reproductive and respiratory syndrome virus in China between 2007 and 2012显示文摘In the present study, 89 porcine reproductive and respiratory syndrome virus(PRRSV) isolates in China during 2007 to 2012 were randomly selected from the GenBank genetic sequence database. Evolutionary characteristics of these isolates were analyzed based on the sequences of non-struc-tural protein 2(Nsp2) and glycoprotein 5(GP5). The genetic variations of the isolates were also compared with six representative strains. The results showed that a high degree of genetic diversity exists among the PRRSV population in China. Highly pathogenic PRRSV isolates, with a discon-tinuous deletion of a 30 amino acid residue in the Nsp2 region, remained the most dominant virus throughout 2007–2012 in China. Owing to the extensive use of representative vaccine strains, natu-ral recombination events occurred between strains. Three isolates – HH08, DY, and YN-2011 – were more closely related to vaccine strains than the other isolates. Both YN-2011 and DY were the evolu-tionary products of recombination events between strains SP and CH-1R. The results of the present study provide useful information for the epidemiology of PRRSV as well as for vaccine development. | Yuhang Cao Hongsheng Ouyang Mingjun Zhang Fuwang Chen Xin Yang Daxing Pang Linzhu Ren | 2014 | Virologica Sinica2014，29，3： | 2 |
| 16 | Magnetorheological finishing of an irregular-shaped small-bore complex component using a small ball-end permanent-magnet polishing head显示文摘A novel magnetorheological finishing(MRF)process using a small ball-end permanent-magnet polishing head is proposed,and a four-axes linkage dedicated MRF machine tool is fabricated to achieve the nanofinishing of an irregularψ-shaped small-bore complex component with concave surfaces of a curvature radius less than3 mm.The processing method of the complex component is introduced.Magnetostatic simulation during the entire finishing path is carried out to analyze the material removal characteristics.A typicalψ-shaped small-bore complex component is polished on the developed device,and a fine surface quality is obtained with surface roughness Raof 0.0107μm and surface accuracy of the finished spherical surfaces of 0.3320μm(PV).These findings indicate that the proposed MRF process can perform the nanofinishing of a kind of small-bore complex component with small-curvature-radius concave surfaces. | Henan Liu Jian Cheng Tingzhang Wang Mingjun Chen | 2019 | Nanotechnology and Precision Engineering2019，2，3： | 2 |
| 17 | An atlas of CNV maps in cattle, goat and sheep显示文摘Copy number variation(CNV)is the most prevalent type of genetic structural variation that has been recognized as an important source of phenotypic variation in humans,animals and plants.However,the mechanisms underlying the evolution of CNVs and their function in natural or artificial selection remain unknown.Here,we generated CNV region(CNVR)datasets which were diverged or shared among cattle,goat,and sheep,including 886 individuals from 171 diverse populations.Using 9 environmental factors for genome-wide association study(GWAS),we identified a series of candidate CNVRs,including genes relating to immunity,tick resistance,multi-drug resistance,and muscle development.The number of CNVRs shared between species is significantly higher than expected(P<0.00001),and these CNVRs may be more persist than the single nucleotide polymorphisms(SNPs)shared between species.We also identified genomic regions under long-term balancing selection and uncovered the potential diversity of the selected CNVRs close to the important functional genes.This study provides the evidence that balancing selection might be more common in mammals than previously considered,and might play an important role in the daily activities of these ruminant species. | Yongzhen Huang Yunjia Li Xihong Wang Jiantao Yu Yudong Cai Zhuqing Zheng Ran Li Shunjin Zhang Ningbo Chen Hojjat Asadollahpour Nanaei Quratulain Hanif Qiuming Chen Weiwei Fu Chao Li Xiukai Cao Guangxian Zhou Shudong Liu Sangang He Wenrong Li Yulin Chen Hong Chen Chuzhao Lei Mingjun Liu Yu Jiang | 2021 | Science China(Life Sciences)2021，64，10： | 2 |
| 18 | Analysis of 3D microtopography in machined KDP crystal surfaces based on fractal and wavelet methods显示文摘 | Mingjun Chen Qilong Pang Jinghe Wang Kai Cheng | 2007 | International Journal of Machine Tools and Manufacture2007，，7： | 1 |
| 19 | Oligo-microarray analysis reveals the role of cyclophilin A in drug resistance显示文摘 | Shuai Chen Mingjun Zhang Honghui Ma Hexige Saiyin Suqin Shen Jiajie Xi Bo Wan Long Yu | 2008 | Cancer Chemotherapy and Pharmacology2008，，： | 1 |
| 20 | An ultra-low frequency parallel connection nonlinear isolator for precision instruments 显示文摘 | Li Dan Chen Mingjun | 2004 | Key Engineering Materials2004，57，258： | 1 |
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