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| 1 | Multivariate statistical analysis of clinicopathologic factors influencing survival of patients with bile duct carcinoma显示文摘AIM: To evaluate the influence of various clinicopathologicfactors on survival of patients with bile duct carcinoma aftercurative resection.METHODS: A retrospective analysis was made for 86 casesof bile duct carcinoma treated from January 1981 toSeptember 1995. Fifteen clinicopathologic factors possiblyinfluencing survival were selected. Independent variableswere first analyzed by univariate methods. Survival forvariable was estimated by the method of Kaplan and Meier.The variables that were statistically significant by univarlateanalysis were included in a multivariate analysis, which wereconfirmed using the Cox stepwise proportion hazard modelwith the help of SPSS 10.0 for Windows software.RESULTS: The overall cumulative survival rate was 72.6 %at 1 year, 32.4 % at 3 years, and 18.7 % at 5 years. Theresults of univariate analysis showed that the majorsignificant prognostic factors influencing survival of thesepatients were histological type of lesion, lymph nodemetastasis, pancreatic invasion, duodenal invasion, pedneuralinvasion, macroscopic vessel involvement, resected surgicalmargin and depth of cancer invasion (P=0.02, 0.02, 0.004,0.005, 0.01, 0.43, 0.03 and 0.04). Age, sex, location of tumor,size of tumor, macroscopic type of lesions, hepaticmetastasis, and hepatic invasion were not significantlyassociated with prognosis (P>0.05). Pancreatic invasion,perineural invasion and lymph node metastases were thethree most important prognostic factors by multivariateanalysis using the Cox proportional hazards model.CONCLUSION: Pancreatic invasion, pedneural invasion andlymph node metastases are the most important prognosticfactors for bile duct carcinoma after curative resection. | He, P Shi, JS Chen, WK Wang, ZR Ren, H Li, H | 2002 | World Journal of Gastroenterology2002，8，5： | 10 |
| 2 | 小胶质细胞对星形胶质细胞的免疫和神经保护功能的调节作用(英文)显示文摘在中枢神经系统中,小胶质细胞和星形胶质细胞对神经元的发育、功能维持及细胞存活具有重要的作用。但在炎症反应过程中,星形胶质细胞增生的作用及其对神经元的影响目前并不十分清楚。因此,本研究对不同种类的细胞进行培养,给予细菌脂多糖(lipopolysaccharide,LPS)刺激,观察各种细胞的反应。结果显示,星形胶质细胞可以减轻炎症反应的神经元毒性,提示星形胶质细胞增生主要具有神经保护作用。如果去掉上清液中由星形胶质细胞分泌的胶质细胞源性神经营养因子(glial cell line-derived neurotrophic factor,GDNF),这种神经保护作用显著降低。为了研究星形胶质细胞的免疫功能,本研究培养了高浓度的星形胶质细胞,并发现LPS不能诱导肿瘤坏死因子(tumor necrosis factor,TNF)-α及诱导型一氧化氮合酶(inducible nitric oxide synthase,iN OS)/一氧化氮(nitric oxide,NO)(iN OS/NO)释放。但如果在培养的高浓度星形胶质细胞中增加0.5%~1%的小胶质细胞,则可以诱导TNF-α及iN OS/NO的释放。这提示小胶质细胞和星形胶质细胞间的相互作用对于LPS诱导星形胶质细胞释放前炎症因子及GDNF是必须的。我们还发现,小胶质细胞释放的TNF-α可以通过旁分泌作用调节星形胶质细胞的神经保护功能。综上所述,本研究结果提示星形胶质细胞可能不会直接被LPS激活,而是通过与小胶质细胞相互作用被激活,释放神经营养因子,减少因炎症反应激活的小胶质细胞释放的毒性物质对神经元的损害作用。 | Chen SH Oyarzabal EA Sung YF Chu CH Wang Q Chen SL Lu RB Hong JS 唐颖馨 | 2015 | 神经损伤与功能重建2015，10，1： | 9 |
| 3 | 儿童期肥胖、成年期肥胖和心血管风险因子显示文摘过去30年,儿童超重或肥胖的发生率明显增加[1]。儿童期肥胖是死亡率增加的预测因子,这主要是由于儿童期肥胖可导致心血管疾病发生率增加。相关的预测研究提示"肥胖流行症"可能改变目前心血管疾病死亡率下降的趋势,使现今儿童的寿命缩短。 | Juonala M Magnussen CG Berenson GS Venn A Burns TL Sabin MA Srinivasan SR Daniels SR Davis PH Chen W Sun C Cheung M Viikari JS Dwyer T Raitakari OT 叶鹏 | 2012 | 中华高血压杂志2012，20，1： | 6 |
| 4 | 急性缺血性脑卒中后低脉压与不良预后相关显示文摘众所周知,脉压与心脏功能、动脉僵硬度、体液状态和血管事件有关。该研究旨在探讨基于中国台湾地区脑卒中登记资料的急性缺血性脑卒中(acute ischemic stroke,AIS)患者入院时脉压的预后作用。 | 刘莉 叶鹏 Tang SC Yin JH Liu CH Sun MH Lee JT Sun Y Hsu CS Sun MC Lin CH Chen CH Lien LM Muo CH Jeng JS Hsu CY | 2017 | 中华高血压杂志2017，25，7： | 5 |
| 5 | A New Anthraquinone from Clinopodium polycephalum Glyceroyl-1,6,8-trihydroxy-3-methyl-9,10-dioxo-2-anthracene Carboxylate显示文摘A new anthraquinone, Glyceroyl-l, 6, 8 -trihydroxy-3 -methyl-9, 10-dioxo-2 -anthracenecarboxylate 1, was isolated from Clinopodium polycephalum. The chemical structure was determined by spectroscopic methods. | Chen, JY Chen, JM Wan, CL Yang, JS Xiao, PG | 1998 | Chinese Chemical Letters1998，9，2： | 5 |
| 6 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 7 | A human vascular endothelial cell model to study angiogenesis and tumorigenesis.显示文摘 | Rhim JS Tsai WP Chen ZQ | | 0，，： | 2 |
| 8 | Direct effects of caffeine on osteoblastic cells metabolism:the possible causal effect of caffeine on the formation of osteoporosis显示文摘 | Tsuang YH Sun JS Chen LT | 2006 | J Orthop Surg Res2006，1，： | 1 |
| 9 | Effects of environmental conditions on the VOC sorption by building materials--Part I:experimental results显示文摘 | Zhang J Zhang JS Chen Q | 2002 | ASHRAE Transactions2002，108，2： | 1 |
| 10 | Recent advances in the chemistry and biology of naturally occurring antibiotics显示文摘 | Nicolaou KC Chen JS Edmonds DJ | 2009 | Angew Chem lnt Ed Engl2009，48，： | 1 |
| 11 | Visualization of the transport pathways of low density lipoproteins across the endothelial cells in the branched regions of rat arteries显示文摘 | Kao CH Chen JK Kuo JS | 1995 | Atherosclerosis1995，116，1： | 1 |
| 12 | Phase Ⅱ study of gemcitabine in patients with advanced hepatocellular carcinoma显示文摘 | Yang TS Lin YC Chen JS | 2000 | Cancer2000，89，4： | 1 |
| 13 | Statistical analysis of re- al-time PCR data 显示文摘 | Yuan JS Reed A Chen F | 2006 | BMC Bioinformatics2006，7，： | 1 |
| 14 | Brain stem cavernous mal- formations显示文摘 | Huang AP Chen JS Yang CC | 2010 | J Clin Neurosci2010，17，1： | 1 |
| 15 | Folate receptor-positive circulatingtumor cells as a novel diagnostic biomarker in non-small cell lungcancer显示文摘 | Yu Y Chen ZL Dong JS | 2013 | Transl Oncol2013，6，6： | 1 |
| 16 | A 12-month Tai Chi train- ing in the elderly: its effect on health fitness 显示文摘 | Lan C Lzti JS Chen SY etal | 1998 | Med Sci Sports Exerc1998，30，3： | 1 |
| 17 | Serum uric acid plays a protective role for bone loss inperi-and postmenopausal womcn:A longitudinal study显示文摘 | Makovey J Maeara M Chen JS | 2013 | Bone2013，52，： | 1 |
| 18 | Emergency departmentneurologic deterioration in patients with spontaneous intracerebralhemorrhage:incidence,predictors,and prognostic significance显示文摘 | Fan JS Huang HH Chen YC | 2012 | Acad Emerg Med2012，19，2： | 1 |
| 19 | Functional roles of charged residues in the putative voltage sensor of the HCN2 pacemaker channel显示文摘 | CHEN J MITCHESON JS LIN M | 2000 | J Biol Chem2000，275，36： | 1 |
| 20 | Anti-Herpes simplex virus activity of Bidens pilosa and Houttuynia cordata 显示文摘 | Chiang LC Chang JS Chen CC | 2003 | Am J Chin Med2003，31，3： | 1 |
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