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| 1 | Efficacies of β-L-D4A against Hepatitis B virus in 2.2.15 cells显示文摘AIM:To investigate the antiviral effect of beta-L-enantiomer of 2',3'-didehydro-2',3'-dideoxyadenosine (β-L-D4A) on 2.2.15 cells transfected with the hepatitis B virus (HBV) genome. METHODS:Lamivudine (3TC) as a positive control. Then, HBV DNA in treated 2.2.15 cells and the Hepatitis B surface antigen (HBsAg) in the culture supernatants were detected to determine the inhibitory effect of β-L-D4A. At the same time, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) was used to detect the survival ratio of 2.2.15 cells. RESULTS:β-L-D4A has a dose-dependent inhibitory effect on HBV DNA replication;this effect was apparent when the concentration was above 1 mol/L. When β-L-D4A was at the highest concentration, 100 mol/L, the HBsAg inhibition ratio was above 50%. The Therapeutic index (TI) of β-L-D4A was above 2.1. CONCLUSION:β-L-D4A has a dose-dependent inhibitory effect on the replication of HBV DNA and the secretion of HBsAg at low toxicity. | Lin-Lin Gao, Xiao-Yan Wang, Ju-Sheng Lin, Ying-Hui Zhang, Yan Li, Institute of Liver Diseases, Tongji Hospital, Tongii Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China Author contributions:Gao LL and Wang XY contributed equally to this work Gao LL, Wang XY, Lin JS, Zhang YH, Li Y designed the research Gao LL and Wang XY performed the research Gao LL wrote the paper | 2008 | World Journal of Gastroenterology2008，14，8： | 7 |
| 2 | Numerical Modeling on Suspended Sediment Transportation in the Hangzhou Bay显示文摘In this paper the characteristics of tidal flow and seasonal variation of seidment content in theHangzhou Bay and their affecting factors are studied.Field investigations and data analysis indicate thatthe sediment movement is mainly influenced by the Yangtze estuary and the sediment of the Yangtze estua-ry is induced by wind wave and tidal flow.Owing to the variation of dynamic conditions,the instanta-neous sediment content is controlled by tidal flow,wind wave,depth of water and tidal range synthetically.A sediment content relationship formula is established with related factors.A non-equilibrium2-dimensional numerical model of suspended sediment transportation is set up,and the finite element meth-od is applied.The computation results of the model is in accordance with field data. | Zhang, JS Lu, PD Xu, M | 1998 | China Ocean Engineering1998，13，1： | 7 |
| 3 | Desorption corona beam ionization source for mass spectrometry显示文摘 | Wang H Sun WJ Zhang JS | | Analyst0，，： | 2 |
| 4 | A NEW TRITERPENOID FROM THE FUNGUS GANODERMA LUCIDUM显示文摘A NEW TRITERPENOID FROM THE FUNGUS GANODERMA LUCIDUMFangShengWANG;HuiCAI;ZaiXinJING(UniversityofAgricultureandAnimalScience.P... | Wang, FS Cai, H Jing, ZX Yang, JS Zhang, YM | 1995 | Chinese Chemical Letters1995，6，12： | 2 |
| 5 | Step Sintering of Microwave Heating and MicrowavePlasma Heating for Alumina Ceramics显示文摘The invention of microwave induced plasma during microwave heating makes it possible to confine plasma inside a crucible, in the pressure range of 1.33 Pa to 0.5 MPa, and above 900℃.In this study, the step sintering of microwave heating and microwave plasma heating (SSMP)was proposed. In this process, microwave heating and plasma heating was ingeniously combined in one chamber, and vacuum was unnecessary for microwave induced plasma. In the first step, the microwave energy directly heated alumina ceramics to a given temperature. above which microwave will mainly ionize the gas and sustain a plasma. Then the plasma further heated alumina ceramics to the final temperature to finish sintering. Maintaining the advantages of microwave heating and plasma heating, this step sintering approach will overcome the limitation of both processes for processing ceramics. and it will be suitable for sintering all kinds of ceramics in | Zhang, JS Cao, L Yang, YJ Diao, YX Shen, XX | 1999 | Journal of Materials Science & Technology1999，15，5： | 2 |
| 6 | EPIMEDOKOREANONE A FROM THE AERIAL PARTS O FEPIMEDIUM KOREANUM NAKAI显示文摘EPIMEDOKOREANONEAFROMTHEAERIALPARTSOFEPIMEDIUMKOREANUMNAKAIWenKuiLI;JunShanYANG;PeiGenXIAO(InstituteofMedicinalPlantDevelopme... | Li, WK Yang, JS Xiao, PG Pan, JQ Lu, MJ Zhang, RY | 1996 | Chinese Chemical Letters1996，7，1： | 2 |
| 7 | Two-kidney,two clip renovascular hypertensive rats can be used as stroke-prone rats显示文摘 | Zeng JS Zhang YQ Mo JW | 1998 | Stroke1998，29，8： | 2 |
| 8 | Chronic morphine treatment and withdrawal induce up - regulation of c - Jun N - terminal kinase 3 gene expression in rat brain 显示文摘 | Fan XL Zhang JS Zhang XQ | 2003 | Neuroscience2003，122，： | 1 |
| 9 | Primary study of attenuated live hepatitis A vaccine(H2 strain)in humans显示文摘 | Dong DX Zhang HY | 1989 | J Infect Dis1989，159，4： | 1 |
| 10 | Structural elucidation of a neutral fucogalactan from the mycelium of Coprinus comatus显示文摘 | FAN JM ZHANG JS TANG QJ | 2006 | Carbohydr Res2006，341，9： | 1 |
| 11 | Effects of environmental conditions on the VOC sorption by building materials--Part I:experimental results显示文摘 | Zhang J Zhang JS Chen Q | 2002 | ASHRAE Transactions2002，108，2： | 1 |
| 12 | Preliminary application of pyramidaltractography in evaluating prognosis of patients with hypertensive in-tracerebral hemorrhage显示文摘 | QIN TM ZHANG Y WU JS | 2008 | Acta Neurochir Suppl2008，105，： | 1 |
| 13 | Synthesis and antitumour activity of novel diterpenequinone salvicine and the analogs显示文摘 | Zhang JS Ding J Tang QM | 1999 | Bioorganic & Medicinal Chemistry Letters1999，9，18： | 1 |
| 14 | X chromosome polymorphism in Koreans on DXS7132 and DXS6800显示文摘 | Lee SD Ahn JS Zhang YJ | 2002 | Forensic Sci Int2002，126，： | 1 |
| 15 | Heat shock Protein 27 interacts with vimentin and Prevents insolubilization of vimentin subunits induced by Cadmium 显示文摘 | Lee JS Zhang MH Yun EK | 2005 | ExP Mol Med2005，37，5： | 1 |
| 16 | Similarity analysis of DNA sequences based on EMD method显示文摘 | BAI FL ZHANG JH ZHENG JS | | 0，，02： | 1 |
| 17 | Chemical modification of an acidic polysaceharide (TAPA1) from Tremella au- rantialba and potential biological activities 显示文摘 | Du X J Zhang JS Lv ZW | 2014 | Food Chem2014，143，： | 1 |
| 18 | Role of delivery and trafficking of delta-opioid peptide receptors in opioid analgesia and toler- ance 显示文摘 | Zhang X Bao L Guan JS | 2006 | Trends Pharmacol Sci2006，27，6： | 1 |
| 19 | Causes of deaths in children younger than 5 years in China in 28显示文摘 | Rudan I Chan KY Zhang JS | 2010 | Lancet2010，，375： | 1 |
| 20 | The use of posterior vertebral column resection in the management of severe posttuberculous kyphosis:a retrospective study and literature review显示文摘 | Zhang HQ Li JS Liu SH | 2013 | Arch Orthop Trauma Surg2013，133，9： | 1 |
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