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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病痴呆诊断标准的推荐显示文摘由美国国立老化研究所(NIA)和阿尔茨海默病(AD)协会组织了一个工作组,负责修订1984年版AD痴呆的诊断标准。旨在确保修订后的标准具有足够的灵活性,既可供缺乏神经心理学测验、先进的影像技术和脑脊液检查措施的普通医务人员使用,也可供具备上述措施的科研、临床试验的专业研究者使用。新的标准广泛适用于各种原因的痴呆以及专门针对AD痴呆的标准,保留了1984年版标准中的“很可能的AD痴呆”的总体框架。在过去27年的经验基础上,工作组对临床诊断标准做了一些修改,保留了“可能的AD痴呆”的术语,但对其进行了更有针对性的重新定义。在科研用的“很可能的和可能的AD痴呆”的诊断标准中纳入了生物标志物证据。AD痴呆的核心临床标准仍将是临床实践中诊断的基础,但用生物标志物证据来提高AD痴呆诊断的病理生理学特异性也被人们寄予厚望。要实现AD痴呆的生物标志物诊断,还有许多工作摆在面前。 | McKhann GM Knopman DS Chertkow H Hyman BT Jack CR Jr Kawas CH Klunk WE Koroshetz WJ Manly J J Mayeux R Mohs RC Morris JC Rossor MN Scheltens P Carrillo MC Thies B Weintraub S Phelps CH 贾建平(译) 陆璐(译) 张逸驰(译) 黄丽(译) 韩阅(译) | 2012 | 中华神经科杂志2012，45，5： | 52 |
| 2 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 3 | Tumor size as a prognostic factor in patients with advanced gastric cancer in the lower third of the stomach显示文摘AIM: To explore the impact of tumor size on outcomes in patients with advanced gastric cancer in the lower third of the stomach. METHODS: We retrospectively analyzed the clinical records of 430 patients with advanced gastric cancer in the lower third of the stomach who underwent distal subtotal gastrectomy and D2 lymphadenectomy in our hospital from January 1998 to June 2004. Receiver-operating characteristic (ROC) curve analysis was used to determine the appropriate cutoff value for tumor size, which was measured as maximum tumor diameter. Based on this cutoff value, patients were divided into two groups: those with large-sized tumors (LSTs) and those with small-sized tumors (SSTs). The correlations between other clinicopathologic factors and tumor size were investigated, and the 5-year overall survival (OS) rate was compared between the two groups. Potential prognostic factors were evaluated by univariate KaplanMeier survival analysis and multivariate Cox's propor-tional hazard model analysis. The 5-year OS rates in the two groups were compared according to pT stage and pN stage. RESULTS: The 5-year OS rate in the 430 patients with advanced gastric cancer in the lower third of the stomach was 53.7%. The mean ± SD tumor size was 4.9 ± 1.9 cm, and the median tumor size was 5.0 cm. ROC analysis indicated that the sensitivity and specificity results for the appropriate tumor size cutoff value of 4.8 cm were 80.0% and 68.2%, respectively (AUC=0.795, 95%CI: 0.751-0.839, P=0.000). Using this cutoff value, 222 patients (51.6%) had LSTs (tumor size ≥ 4.8 cm) and 208 (48.4%) had SSTs (tumor size<4.8 cm). Tumor size was significantly correlated with histological type (P=0.039), Borrmann type (P=0.000), depth of tumor invasion (P=0.000), lymph node metastasis (P=0.000), tumor-nodes metastasis stage (P=0.000), mean number of metastatic lymph nodes (P=0.000) and metastatic lymph node ratio (P=0.000). Patients with LSTs had a significantly lower 5-year OS rate than those with SSTs (37.1% vs 63.3%, P=0.000). Univariate analysis showed that depth of tumor invasion (c 2=69.581, P=0.000), lymph node metastasis (c 2=138.815, P=0.000), tumor size (c 2=78.184, P=0.000) and metastatic lymph node ratio (c 2=139.034, P=0.000) were significantly associated with 5-year OS rate. Multivariate analysis revealed that depth of tumor invasion (P=0.000), lymph node metastasis (P=0.019) and tumor size (P=0.000) were independent prognostic factors. Gastric cancers were divided into 12 subgroups: pT2N0; pT2N1; pT2N2; pT2N3; pT3N0; pT3N1; pT3N2; pT3N3; pT4aN0; pT4aN1; pT4aN2; and pT4aN3. In patients with pT2-3N3 stage tumors and patients with pT4a stage tumors, 5-year OS rates were significantly lower for LSTs than for SSTs (P<0.05 each), but there were no significant differences in the 5-year OS rates in LST and SST patients with pT23N0-2 stage tumors (P > 0.05). CONCLUSION: Using a tumor size cutoff value of 4.8cm, tumor size is a prognostic factor in patients with pN3 stage or pT4a stage advanced gastric cancer located in the lower third of the stomach. | Hong-Mei Wang, Chang-Ming Huang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Department of Gastric Surgery, Affiliated Union Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China Author contributions: Wang HM and Huang CM conceived of the study, analyzed the data, and drafted the manuscript Zheng CH, Li P and Xie JW helped revise the manuscript critically for important intellectual content Wang JB, Lin JX and Lu J helped collect data and design the study and all authors read and approved the final manuscript. | 2012 | World Journal of Gastroenterology2012，18，38： | 15 |
| 4 | Photonic gas sensors exploiting directly the optical properties of hybrid carbon nanotube localized surface plasmon structures显示文摘Weinvestigate the modification of the optical properties of carbon nanotubes(CNTs)resulting from a chemical reaction triggered by the presence of a specific compound(gaseous carbon dioxide(CO_(2)))and show this mechanism has important consequences for chemical sensing.CNTs have attracted significant research interest because they can be functionalized for a particular chemical,yielding a specific physical response which suggests many potential applications in the fields of nanotechnology and sensing.So far,however,utilizing their optical properties for this purpose has proven to be challenging.We demonstrate the use of localized surface plasmons generated on a nanostructured thin film,resembling a large array of nano-wires,to detect changes in the optical properties of the CNTs.Chemical selectivity is demonstrated using CO_(2) in gaseous form at room temperature.The demonstrated methodology results additionally in a new,electrically passive,optical sensing configuration that opens up the possibilities of using CNTs as sensors in hazardous/explosive environments. | Thomas Allsop Raz Arif Ron Neal Kyriacos Kalli Vojtěch Kundrát Aleksey Rozhin Phil Culverhouse David J Webb | 2016 | Light(Science & Applications)2016，5，1： | 3 |
| 5 | Acute mesenteric ischemia: value of computerized tomography diagnosis显示文摘 | Huisman TA Benoit CH Traber J | 2000 | Schweiz Rundsch Med Prax2000，89，23： | 2 |
| 6 | Polymorphism of stress protein HSP70-2 gene in Tunisians: susceptibility implications in type 2 diabetes and obesity显示文摘 | K Zouari Bouassida L Chouchane K Jellouli S Chérif S Haddad S Gabbouj J Danguir | 2004 | Diabetes and Metabolism2004，，2： | 2 |
| 7 | 体位性低血压的危险因素:老年男女存在差异显示文摘体位性低血压(orthostatic hypotension,OH)一般发生在站立后调节血压水平的机制发生变化以后。目前尚不清楚不同性别间OH的发生率和危险因素有何不同。本文旨在调查老年人OH患病率和危险因素的性别差异。方法:纳入来自委内瑞拉马拉开波老龄化研究的882名参与者。从仰卧位到站立位3 min后,收缩压持续下降≥20和(或)舒张压持续下降≥10 mm Hg(1 mm Hg=0.133 kPa)定义为OH。考虑到性别的交互作用和性别分层,研究者采用多因素Logistic回归模型评估男、女OH危险因素的相关性。 | Méndez AS Melgarejo JD Mena LJ Chávez CA González AC Boggia J Terwilliger JD Lee JH Maestre GE 陈云 叶鹏 | 2019 | 中华高血压杂志2019，27，6： | 2 |
| 8 | Effect of brain-derived neurotrophic factor, nerve growth factor, and neurotrophin-3 on functional recovery and regeneration after spinal cord injury in adult rats显示文摘 | Namiki J Kojima A Tator CH | | 0，，： | 2 |
| 9 | Efficient detection of temporally impulsive dirt impairments in archived films 显示文摘 | J Ch Ren and T Vlachos | 2007 | Signal Processing2007，87，3： | 1 |
| 10 | Power density distribution simulation and relevant heat effect calculation of a high-power CO2 laser with low order modes显示文摘 | MA K FAN Z B | 2002 | Chinese Journal of Laser2002，11，5： | 1 |
| 11 | Chaos behavior of crude copper composition time series from the copper convertor and the predicable time scale显示文摘 | WANG Y N MEI Ch | 2006 | Nonlinear Analysis:Real World Applications2006，7，4： | 1 |
| 12 | The effect of excess Zn on mineral nutrition and antioxidative response in rapeseed seedlings显示文摘 | WANG CH ZHANG S H WANG P F HOU J ZHANG W J LI W LIN ZH P | 2009 | Chemosphere2009，75，： | 1 |
| 13 | Cellular senescence is an important mechanism of tumor regression upon c-myc inactivation显示文摘 | WU CH Riggelen J Yetil A | 2007 | PNAS2007，104，13： | 1 |
| 14 | Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX显示文摘 | Bassing CH Chua KF Sekiguchi J | 2002 | Proc Natl Acad Sci USA2002，99，12： | 1 |
| 15 | Ultrasound stimulates NF-kappaB activation and iNOS expression via the Ras/Raf/ MEK/ERK signaling pathway in cultured preosteoblasts 显示文摘 | Hou CH Lin J Huang SC | 2009 | J Cell Physiol2009，220，1： | 1 |
| 16 | Topotecan in the treatment of rcplased small cell lung cancer patients with poor pcrfommnce status 显示文摘 | Treat J Huang CH Lane SiR | 2004 | Oncolgist2004，9，： | 1 |
| 17 | Phase Ⅲ study of weekly highdose infusional fluorouracil plus folinic acid with or without irinotecan in patients with metastatic colorectal cancer: European Organisation for Research and Treatment of Cancer Gastrointestinal Group study 40986 显示文摘 | Kohne CH van Cutsem E Wils J | 2005 | J Clin Oncol2005，23，8： | 1 |
| 18 | Modification of flavonoid biosynthesis in crop plants显示文摘 | Schijlen E G Ric de Vos CH van Tunen A J | 2004 | Phytochemistry2004，65，19： | 1 |
| 19 | Duloxetine: A new treatment for the emotional and physical symptoms of depression 显示文摘 | Mallinckrodt CH Golddtein D J Detke M J | 2003 | Prin Care Companion J Clin Psychiatry2003，5，1： | 1 |
| 20 | Combined anterior and pos- terior surgeries in the treatment of spinal tuberculous Spondylitis 显示文摘 | Chen W J Wu CC Jtmg CH el al | 2002 | Clin Orthop Relat Res2002，39，8： | 1 |
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