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| 1 | Rhubarb extract partially improves mucosal integrity in chemotherapy-induced intestinal mucositis显示文摘AIM To investigate the effects of orally gavaged aqueous rhubarb extract(RE) on 5-fluorouracil(5-FU)-induced intestinal mucositis in rats. METHODS Female Dark Agouti rats(n = 8/group) were gavaged daily(1 mL) with water, high-dose RE(HDR; 200 mg/kg) or low-dose RE(LDR; 20mg/kg) for eight days. Intestinal mucositis was induced(day 5) with 5-FU(150 mg/kg) via intraperitoneal injection. Intestinal tissue samples were collected for myeloperoxidase(MPO) activity and histological examination. Xenopus oocytes expressing aquaporin 4 water channels were prepared to examine the effect of aqueous RE on cell volume, indicating a potential mechanism responsible for modulating net fluid absorption and secretion in the gastrointestinal tract. Statistical significance was assumed at P < 0.05 by one-way ANOVA. RESULTS B o d y w e i g h t w a s s i g n i f i c a n t l y r e d u c e d i n r a t s administered 5-FU compared to healthy controls(P < 0.01). Rats administered 5-FU significantly increased intestinal MPO levels(≥ 307%; P < 0.001), compared to healthy controls. However, LDR attenuated this effect in 5-FU treated rats, significantly decreasing ileal MPO activity(by 45%; P < 0.05), as compared to 5-FU controls. 5-FU significantly reduced intestinal mucosal thickness(by ≥ 29% P < 0.001) as compared to healthy controls. LDR significantly increased ileal mucosal thickness in 5-FU treated rats(19%; P < 0.05) relative to 5-FU controls. In xenopus oocytes expressing AQP4 water channels, RE selectively blocked water influx into the cell, induced by a decrease in external osmotic pressure. As water efflux was unaltered by the presence of extracellular RE, the directional flow of water across the epithelial barrier, in the presence of extracellular RE, indicated that RE may alleviate water loss across the epithelial barrier and promote intestinal health in chemotherapy-induced intestinal mucositis.CONCLUSION In summary, low dose RE improves selected parameters of mucosal integrity and reduces ileal inflammation, manifesting from 5-FU-induced intestinal mucositis. | Juliana E Bajic Georgina L Eden Lorrinne S Lampton Ker Y Cheah Kerry A Lymn Jinxin V Pei Andrea J Yool Gordon S Howarth | 2016 | World Journal of Gastroenterology2016，22，37： | 3 |
| 2 | GInK, a PII-homologue: structure reveals ATP binding site and indicates how the T-loops may be involved in molecular recognition显示文摘 | Xu Y Cheah E Can' PD | 1998 | J Mol Biol1998，282，1： | 1 |
| 3 | The a/t3 hydrolase fold显示文摘 | Ollis D L Cheah E Cygler M | 1992 | Protein Eng1992，5，： | 1 |
| 4 | Regeneration of banana via secondary somatic embryogenesis显示文摘 | Khalil S M Cheah K T Perez E A | 2002 | Plant Cell Reports2002，20，12： | 1 |
| 5 | The alpha/beta hydrolase fold显示文摘 | Ollis DL Cheah E Cygler M | 1992 | Protein Engineering1992，5，： | 1 |
| 6 | The α/β hydrolase fold显示文摘 | Ollis DL Cheah E Cygler M | 1992 | Pro- tein Eng1992，5，3： | 1 |
| 7 | Depletion of annexin A5, annexin A6, and collagen X causes no gross changes in matrix vesicle–mediated mineralization, but lack of collagen X affects hematopoiesis and the Th1/Th2 response显示文摘 | Ivan Grskovic Anna Kutsch Christian Frie Gergely Groma Jacek Stermann Ursula Schl?tzer‐Schrehardt Anja Niehoff Stephen E Moss Sabrina Rosenbaum Ernst P?schl Markus Chmielewski Gunter Rappl Hinrich Abken John F Bateman Kathryn SE Cheah Mats Paulsson Bent B | 2012 | J Bone Miner Res2012，，11： | 1 |
| 8 | Respiration and ethylene Production in kiwifruit following hot water dips显示文摘 | IRVING D E PALLESEN J C CHEAH L H | 1991 | Postharvest Biology Technology1991，1，： | 1 |
| 9 | Epidemiology of prostatitis: new evidence for a world-wide problem 显示文摘 | Krieger J N Riley D E Cheah P Y | 2003 | World J Urol2003，21，2： | 1 |
| 10 | Can localization studies be used to direct focused parathyroid operations 显示文摘 | Arici C Cheah WK ltuarte PHG e t a l | 2001 | Surgery2001，129，6： | 1 |
| 11 | The alpha/beta hydrolase fold 显示文摘 | Ollis D L Cheah E Cygler M | 1992 | ProteinEng1992，5，3： | 1 |
| 12 | Biomedical applications of accelerator mass spectrometry显示文摘 | CHEAH E L C KOH H L | 2008 | Current Anal Chem2008，4，： | 1 |
| 13 | Adaptive Jaeobian vision based control for robots with uncertain depth information显示文摘 | Cheah C C Liu C Slotine J J E | 2010 | Automatiea2010，46，12： | 1 |
| 14 | XAFS study of Cu model compounds and Cu^2+ sorption products on amorphous SiO2,γ-Al203,and anatase显示文摘 | Cheah S F Brown G E Parks G A | 2000 | American Mineralogist2000，85，： | 1 |
| 15 | Adaptive Jacobian tracking control of robots with uncertainties in kinematic, dynamic and actuator models显示文摘 | CHEAH C C LIU C SLOTINE J J E | 2006 | IEEE Transactions on Automatic Control2006，51，6： | 1 |
| 16 | The alpha/beta hydrolase fold 显示文摘 | Ollis D L Cheah E Cygler M | 1992 | Protein Eng1992，，5： | 1 |
| 17 | Epidemiology of prostatitis:new evidence for a world-wide problem显示文摘 | Krieger J N Riley D E Cheah P Y | | 0，，02： | 1 |
| 18 | The alpha/beta hydrolase fold显示文摘 | Olis D L Cheah E Cygler M | 1992 | Protein Engineering1992，5，： | 1 |
| 19 | Adaptive tracking control for robots with unknown kinematic and dynamic properties显示文摘 | CHEAH C C LID C SLOTINE J J E | 2006 | The International Journal of Robotics Research2006，25，3： | 1 |
| 20 | Adaptive tracking control for robots with unknown kinematic and dynamic properties 显示文摘 | Cheah C C Liu C Slotine J J E | 2006 | The International of Robotics Research2006，25，3： | 1 |
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