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| 1 | Discovery of ultrahigh-pressure magnesite-bearing garnet lherzolite (>3.8 GPa) in the Altyn Tagh, Northwest China显示文摘Magnesite-bearing garnet Iherzolite from the Altyn Tagh, associated with garnet pyroxenite, and garnet-bearing felsic gneiss, crops out as lenses in Proterozoic gneiss about 100 km east of the Jianggelasayi River. The garnet Iherzolite, together with the eclogite in western Jianggelasayi, composes a high-pressure to ultrahigh-pressure metamorphic belt in the southern margin of the Altyn Tagh. Parageneses of minerals from magnesite-bearing garnet Iherzolite indicate that the rock evolved a multi-stage metamorphism. The peak-stage metamorphism produces an assemblage of Grt+Ol+Opx+Cpx±Mgs, in which A12O3 content of Opxis very low (0.30-0.66wt%). The calculated P-T condition of the peak stage is 3.8-5.lGPa and 880-970°C, some exsolution rods of clinopyroxene and rutile occur in the Grt and magnesite is rimed by dolomite and orthopyroxene, all implying that the peak stage was a UHP metamorphic process. Together with regional geological studies, isotopic dating and the discovery of coesite inclusions in | LIU Liang, SUN Yong, XIAO Peixi, CHE Zicheng, LUO Jinhai, CHEN Danling, WANG Yan, ZHANG Anda, CHEN Liang & WANG YongheKey Laboratory of Continental Dynamics of the Ministry of Education, Northwest University, Xi’an 710069, China The Northwest Institute of | 2002 | Chinese Science Bulletin2002，47，11： | 69 |
| 2 | XA23 Is an Executor R Protein and Confers Broad-Spectrum Disease Resistance in Rice显示文摘 | Chunlian Wang Xiaoping Zhang Yinglun Fan Ying Gao Qinlong Zhu Chongke Zheng Tengfei Qin Yanqiang Li Jinying Che Mingwei Zhang Bing Yang Yaoguang Liu Kaijun Zhao | 2015 | Molecular Plant2015，8，2： | 55 |
| 3 | Enhanced secondary pollution offset reduction of primary emissions during COVID-19 lockdown in China显示文摘To control the spread of the 2019 novel coronavirus(COVID-19),China imposed nationwide restrictions on the movement of its population(lockdown)after the Chinese New Year of 2020,leading to large reductions in economic activities and associated emissions.Despite such large decreases in primary pollution,there were nonetheless several periods of heavy haze pollution in eastern China,raising questions about the well-established relationship between human activities and air quality.Here,using comprehensive measurements and modeling,we show that the haze during the COVID lockdown was driven by enhancements of secondary pollution.In particular,large decreases in NOx emissions from transportation increased ozone and nighttime NO_(3)radical formation,and these increases in atmospheric oxidizing capacity in turn facilitated the formation of secondary particulate matter.Our results,afforded by the tragic natural experiment of the COVID-19 pandemic,indicate that haze mitigation depends upon a coordinated and balanced strategy for controlling multiple pollutants. | Xin Huang Aijun Ding Jian Gao Bo Zheng Derong Zhou Ximeng Qi Rong Tang Jiaping Wang Chuanhua Ren Wei Nie Xuguang Chi Zheng Xu Liangduo Chen Yuanyuan Li Fei Che Nini Pang Haikun Wang Dan Tong Wei Qin Wei Cheng Weijing Liu Qingyan Fu Baoxian Liu Fahe Chai Steven JDavis Qiang Zhang Kebin He | 2021 | National Science Review2021，8，2： | 47 |
| 4 | Danshen: a phytochemical and pharmacological overview显示文摘Danshen, the dried root or rhizome of Salvia miltiorrhiza Bge., is a traditional and folk medicine in Asian countries, especially in China and Japan. In this review, we summarized the recent researches of Danshen in traditional uses and preparations, chemical constituents, pharmacological activities and side effects. A total of 201 compounds from Danshen have been reported, including lipophilic diterpenoids, water-soluble phenolic acids, and other constituents, which have showed various pharmacological activities, such as anti-inflammation, anti-oxidation, anti-tumor, anti-atherogenesis, and anti-diabetes. This article intends to provide novel insight information for further development of Danshen, which could be of great value to its improvement of utilization. | MEI Xiao-Dan CAO Yan-Feng CHE Yan-Yun LI Jing SHANG Zhan-Peng ZHAO Wen-Jing QIAO Yan-Jiang ZHANG Jia-Yu | 2019 | Chinese Journal of Natural Medicines2019，17，1： | 43 |
| 5 | Development of a Chinese land data assimilation system:its progress and prospects显示文摘陆地数据吸收的目的是为改进陆地表面状态的评价把多来源观察合成陆地表面模型的动力学。我们为中国的陆地领土开发了一个陆地数据吸收系统。在这个系统,普通陆地模型和简单生物圈,模型 2 被用来模仿陆地表面过程。当转移的观察操作员为预言建模进估计的亮度温度,融化并且结冰的土壤,雪,湖,和植被的放射的转移模型被使用。一个 Monte-Carlo 顺序的过滤器,整体 Kalman 过滤器,作为数据吸收方法被实现集成当模特儿并且观察。系统能够遥远地吸收被动微波察觉到的数据象特殊传感器微波成像器那样(SSM 我) , TRMM 微波成像器(TMI ) ,和先进微波扫描辐射计为曙光女神(AMSRE ) 提高了并且在土壤和雪的 situmeasurements 常规。与 0.25 度的一个空间决定和一个小时的时间的分辨率,为土壤潮湿,土壤温度,雪和冻结的土壤的空间与时间地一致的吸收数据集被生产了。这篇论文介绍在数据吸收算法,陆地表面水文学变量的陆地表面建模微波遥感,和大气的强迫的数据的准备上做的中国陆地数据吸收系统和进步的开发。为未来开发开发陆地数据吸收系统和观点的不同特征和挑战也被讨论。 | Li Xin Huang Chunlin Che Tao Jin Rui Wang Shugong Wang Jiemin Gao Feng Zhang Shuwen Qiu Chongjian Wang Chenghai | 2007 | Progress in Natural Science:Materials International2007，17，8： | 30 |
| 6 | Therapeutic potential of siRNA-mediated combined knockdown of the lAP genes (Livin, XIAP, and Survivin) on human bladder cancer T24 cells显示文摘Livin, apoptosis (XIAP ) 的 X 连接禁止者,和 Survivin 几乎是 apoptosis 的三个著名禁止者在癌症房间只过去表示并且为癌症治疗被认为有势力目标。在现在的学习,我们发现 Livin, XIAP,和 Survivin 同时在膀胱癌症房间被表示。我们推测了那 Livin, XIAP,和 Survivin 可能在房间生长和 apoptosis 上有 synergistic 效果。我们的结果证实了联合那所有这三基因击倒能 synergistically 禁止增长和高级膀胱癌症 T24 房间的转变能力并且把房间 apoptotic 敏感提升到化疗。而且,联合了 Livin, XIAP,和 Survivin 罐头击倒显著地增加许多活跃 caspase-3,活跃 caspase-7,活跃 caspase-9,和 cytosolic Smac。我们的调查结果暗示 Livin, XIAP,和 Survivin 的那联合 silencing 可以是一个有势力为膀胱癌症的多指向的基因治疗。 | Deyong Yang Xishuang Song Jianing Zhang Lin Ye Shujing Wang Xiangyu Che Jianbo Wang Zhiwei Zhang Lina Wang Wei Shi | 2010 | Acta Biochimica et Biophysica Sinica2010，42，2： | 29 |
| 7 | Zircon U-Pb geochronological framework of Qitianling granite batholith, middle part of Nanling Range, South China显示文摘The Qitianling granite batholith (QGB) is located in the southern Hunan Province, middle part of the Nanling Range, South China. Its total exposure area is about 520 km2. Based on our 25 single grain zircon U-Pb age data and 7 published data as well as the geological, petrological, and space distribution characteristics, we conclude that QGB is an Early Yanshanian (Jurassic) multi-staged composite pluton. Its formation process can be subdivided into three major stages. The first stage, emplaced at 163―160 Ma with a peak at about 161 Ma, is mainly composed of hornblende-biotite monzonitic granites and locally biotite granites, and distributed in the eastern, northern, and western peripheral parts of the pluton. The second stage, emplaced at 157―153 Ma with a peak at 157―156 Ma, is mainly composed of biotite granites and locally containing hornblende, and distributed in the middle and southeastern parts of the pluton. The third stage, emplaced at 150―146 Ma with a peak at about 149 Ma, is mainly composed of fine-grained (locally porphyritic) biotite granites, and distributed in the middle-southern part of the pluton. Each stage can be further disintegrated into several granite bodies. The first two intrusive stages comprise the major phase of QGB, and the third intrusive stage comprises the additional phase. Many second stage fine-grained granite bosses and dykes intruded into the first stage host granites with clear chilling margin-baking phenomena at their intrusive contacts. They were emplaced in the open fracture space of the earlier stage consolidated rocks. Their isotopic ages are mostly 2―6 Ma younger than their hosts. Conceivably, the time interval from magma emplacement, through cooling, crystallization, solidification, up to fracturing of the earlier stage granites cannot exceed 2―6 Ma. During the Middle-Late Jurassic in the Qitianling area and neighboring Nanling Range, the coeval granitic and basic-intermediate magmatic activities were widely developed. It indicates that the Early Yanshanian period was the culmination time of magmatic activities in this region. The Nanling Range was under a post-orogenic, intracontinental geotectonic environment with an obvious lithospheric extension and thinning. The crust-mantle interaction played an important role in formation of granitic rocks in this region. | ZHU JinChu WANG RuCheng ZHANG PeiHua XIE CaiFu ZHANG WenLan ZHAO KuiDong XIE Lei YANG Ce CHE XuDong YU APeng WANG LuBin | 2009 | Science China Earth Sciences2009，52，9： | 27 |
| 8 | Relative Contributions of Boundary-Layer Meteorological Factors to the Explosive Growth of PM2.5 during the Red-Alert Heavy Pollution Episodes in Beijing in December 2016显示文摘Based on observations of urban mass concentration of fine particulate matter smaller than 2.5 μm in diameter(PM_(2.5)), ground meteorological data, vertical measurements of winds, temperature, and relative humidity(RH), and ECMWF reanalysis data, the major changes in the vertical structures of meteorological factors in the boundary layer(BL) during the heavy aerosol pollution episodes(HPEs) that occurred in winter 2016 in the urban Beijing area were analyzed. The HPEs are divided into two stages: the transport of pollutants under prevailing southerly winds, known as the transport stage(TS), and the PM_(2.5) explosive growth and pollution accumulation period characterized by a temperature inversion with low winds and high RH in the lower BL, known as the cumulative stage(CS). During the TS, a surface high lies south of Beijing, and pollutants are transported northwards. During the CS, a stable BL forms and is characterized by weak winds, temperature inversion, and moisture accumulation. Stable atmospheric stratification featured with light/calm winds and accumulated moisture(RH > 80%) below 250 m at the beginning of the CS is closely associated with the inversion, which is strengthened by the considerable decrease in near-surface air temperature due to the interaction between aerosols and radiation after the aerosol pollution occurs. A significant increase in the PLAM(Parameter Linking Aerosol Pollution and Meteorological Elements) index is found, which is linearly related to PM mass change. During the first 10 h of the CS, the more stable BL contributes approximately 84% of the explosive growth of PM_(2.5) mass. Additional accumulated near-surface moisture caused by the ground temperature decrease, weak turbulent diffusion, low BL height, and inhibited vertical mixing of water vapor is conducive to the secondary aerosol formation through chemical reactions, including liquid phase and heterogeneous reactions, which further increases the PM_(2.5) concentration levels. The contribution of these reaction mechanisms to the explosive growth of PM_(2.5) mass during the early CS and subsequent pollution accumulation requires further investigation. | junting zhong xiaoye zhang yaqiang wang junying sun yangmei zhang jizhi wang kaiyan tan xiaojing shen haochi che lu zhang zhouxiang zhang xuefei qi huarong zhao sanxue ren yang li | 2017 | Journal of Meteorological Research2017，31，5： | 25 |
| 9 | Zircon U-Pb dating confirms existence of a Caledonian scheelite-bearing aplitic vein in the Penggongmiao granite batholith, South Hunan显示文摘Granite at Penggongmiao is a large batholith in the Nanling Range, with an outcrop area of over 900 km 2 . There are many scheelite-quartz veins around the granite. LA-ICP-MS U-Pb dating was carried out for zircons from the granite. The middlecoarse-grained biotite granite has U-Pb ages of 435 to 436 Ma. Ages of 426.5±2.5 Ma were obtained for aplitic dyke cross-cutting the granite. The scheelite of magmatic origin in the aplite dyke was identified from petrographic investigation. This demonstrates that W-bearing granites of Early Paleozoic (corresponding to the Caledonian orogensis in the traditional sense) occur in the Nanling Range. This finding has important implications for the ore-forming potential of Paleozoic granites and on the extent of Mesozoic mineralization. Thus it merits performing an intensive study of Paleozoic granites in South China. The occurrences of aplite or microgranite may be an indicative of the Caledonian tungsten granites and associated W mineralization. | ZHANG WenLan WANG RuCheng LEI ZeHeng HUA RenMin ZHU JinChu LU JianJun XIE Lei CHE XueDong ZHANG RongQing YAO Yuan CHEN Jun | 2011 | Chinese Science Bulletin2011，56，19： | 23 |
| 10 | Side population cells isolated from KATO Ⅲ human gastric cancer cell line have cancer stem cell-like characteristics显示文摘AIM: To investigate whether the side population (SP) cells possess cancer stem cell-like characteristics in vitro and the role of SP cells in tumorigenic process in gastric cancer. METHODS: We analyzed the presence of SP cells indifferent human gastric carcinoma cell lines, and then isolated and identified the SP cells from the KATO Ⅲ human gastric cancer cell line by flow cytometry. The clonogenic ability and self-renewal were evaluated by clone and sphere formation assays. The related genes were determined by reverse transcription polymerase chain reaction. To compare tumorigenic ability, SP and non-side population (NSP) cells from the KATO Ⅲ human gastric cancer cell line were subcutaneously injected into nude mice. RESULTS: SP cells from the total population accounted for 0.57% in KATO Ⅲ, 1.04% in Hs-746T, and 0.02% in AGS (CRL-1739). SP cells could grow clonally and have self-renewal capability in conditioned media. The expression of ABCG2, MDRI, Bmi-1 and Oct-4 was different between SP and NSP cells. However, there was no apparent difference between SP and NSP cells when they were injected into nude mice. CONCLUSION: SP cells have some cancer stem celllike characteristics in vitro and can be used for studying the tumorigenic process in gastric cancer. | Jun-Jun She Peng-Ge Zhang Xuan Wang Xiang-Ming Che Zi-Ming Wang | 2012 | World Journal of Gastroenterology2012，18，33： | 20 |
| 11 | Sodium humate accelerates cutaneous wound healing by activating TGF-β/Smads signaling pathway in rats显示文摘Sodium humate(HA-Na) has been topically used as a wound healing and anti-inflammatory agent in folk medicine. In the present study, HA-Na was investigated for cutaneous wound healing in Sprague–Dawley rats. HA-Na solution(1.0%, w/v) was topically administered to rats undergoing excision wound models. Healing was assessed with a recombinant bovine basic fibroblast growth factor for external use as positive control. Wound healing rates were calculated on Day 3, 6, 9, 14 and 21 after injury, and tissues were also harvested after the same intervals for histological analysis. In addition, tissue hydroxyproline levels were measured. Furthermore, m RNA levels and protein expressions of transforming growth factor-β1, 2, 3(TGF-β1, 2, 3) were determined by RT-PCR and western blot. Protein expression levels of Smad-2,-3,-4 and-7 were also detected by western blot. Our study demonstrates that HA-Na has the capacity to promote wound healing in rats via accelerated wound contraction and increased hydroxyproline content. More importantly, these wound healing effects of HA-Na might be mediated through the TGF-β/Smad signaling pathway. HA-Na may be an effective agent for enhanced wound healing. | Yuanyuan Ji Aijun Zhang Xiaobin Chen Xiaoxia Che Kai Zhou Zhidong Wang | 2016 | Acta Pharmaceutica Sinica B2016，6，2： | 17 |
| 12 | Observation and analysis of near-surface atmospheric aerosol optical properties in urban Beijing显示文摘Year-round measurements of the mass concentration and optical properties of fine aerosols(PM_(2.5)) from June 2009 to May 2010 at an urban site in Beijing were analyzed.The annual mean values of the PM_(2.5) mass concentration,absorption coefficient(Ab),scattering coefficient(Sc) and single scattering albedo(SSA)at 525 nm were 67±66μg/m^3,64 ±62 Mm^(-1),360 ±405 Mm^(-1) and 0.82 ±0.09,respectively.The bulk mass absorption efficiency and scattering efficiency of the PM_(2.5) at 525 nm were 0.78 m^2/g and 5.55 m^2/g,respectively.The Ab and Sc showed a similar diurnal variation with a maximum at night and a minimum in the afternoon,whereas SSA displayed an opposite diurnal pattern.Significant increases in the Ab and Sc were observed in pollution episodes caused by the accumulation of pollutants from both local and regional sources under unfavorable weather conditions.Aerosol loadings in dust events increased by several times in the spring,which had limited effects on the Ab and Sc due to the low absorption and scattering efficiency of dust particles.The frequency of haze days was the highest in autumn because of the high aerosol absorption and scattering under unfavorable weather conditions.The daily PM_(2.5)concentration should be controlled to a level lower than 64 μg/m^3 to prevent the occurrence of haze days according to its exponentially decreased relationship with visibility. | Junshan Jing Yunfei Wu Jun Tao Huizheng Che Xiangao Xia Xiaochun Zhang Peng Yan Deming Zhao Leiming Zhang | 2015 | Particuology2015，13，1： | 16 |
| 13 | Groundwater arsenic removal by coagulation using ferric(Ⅲ)sulfate and polyferric sulfate: A comparative and mechanistic study显示文摘Elevated arsenic(As) in groundwater poses a great threat to human health. Coagulation using mono- and poly-Fe salts is becoming one of the most cost-effective processes for groundwater As removal. However, a limitation comes from insufficient understanding of the As removal mechanism from groundwater matrices in the coagulation process, which is critical for groundwater treatment and residual solid disposal. Here, we overcame this hurdle by utilizing microscopic techniques to explore molecular As surface complexes on the freshly formed Fe flocs and compared ferric(III) sulfate(FS) and polyferric sulfate(PFS)performance, and finally provided a practical solution in As-geogenic areas. FS and PFS exhibited a similar As removal efficiency in coagulation and coagulation/filtration in a two-bucket system using 5 mg/L Ca(ClO)_2. By using the two-bucket system combining coagulation and sand filtration, 500 L of As-safe water(< 10 μg/L) was achieved during five treatment cycles by washing the sand layer after each cycle. Fe k-edge X-ray absorption near-edge structure(XANES) and As k-edge extended X-ray absorption fine structure(EXAFS) analysis of the solid residue indicated that As formed a bidentate binuclear complex on ferrihydrite, with no observation of scorodite or poorly-crystalline ferric arsenate. Such a stable surface complex is beneficial for As immobilization in the solid residue, as confirmed by the achievement of much lower leachate As(0.9 μg/L–0.487 mg/L)than the US EPA regulatory limit(5 mg/L). Finally, PFS is superior to FS because of its lower dose, much lower solid residue, and lower cost for As-safe drinking water. | Jinli Cui Chuanyong Jing Dongsheng Che Jianfeng Zhang Shuxuan Duan | 2015 | Journal of Environmental Sciences2015，27，6： | 16 |
| 14 | Discrepancy in Response of Rice Yield and Soil Fertility to Long-Term Chemical Fertilization and Organic Amendments in Paddy Soils Cultivated from Infertile Upland in Subtropical China显示文摘From 1990,over 17 years field experiment was carried out in paddy field cultivated from infertile upland to evaluate the response of rice productivity,soil organic carbon(SOC),and total N to long-term NPK fertilization or NPK combined with organic amendments.The field trials included NPK(N,P,K fertilizer),NPKRS(NPK combined with rice straw),NPK2RS(NPK combined with double amount of rice straw),NPKPM(NPK combined with pig manure) and NPKGM(NPK combined with green manure) and the cropping system was rice-rice(Oryza sativa L.) rotation.Annual rice yield,straw biomass,and harvesting index increased steadily with cultivation time in all treatments.Average annual rice yield from 1991 to 2006 was ranged from 7 795 to 8 572 kg ha-1 among treatments.Rice yields in treatments with organic amendments were usually higher than that in treatment with NPK.Contents of SOC and total N also increased gradually in the cultivation years and reached the level of 7.82 to 9.45 and 0.85 to 1.03 g kg-1,respectively,in 2006.Soil fertilities in treatments with chemical fertilization combined with organic amendments were relatively appropriate than those in treatment with NPK.There was obvious discrepancy between cumulative characters of rice yield and soil organic fertility in newly formed paddy field.Compared with relatively high rate of crop productivity improvement,cumulative rates of SOC and total N were much lower in our study.SOC and total N contents were still less than half of those in local highly productive paddy soils after 17 years cultivation in subtropical China.Present work helps to better understand the development of infertile paddy soils and to estimate the potential of yield improvement in this region. | LIU Ming LI Zhong-pei ZHANG Tao-lin JIANG Chun-yu CHE Yu-ping | 2011 | Agricultural Sciences in China2011，10，2： | 12 |
| 15 | Numerical study on scanning radiation acoustic field in formations generated from a borehole显示文摘Numerical study on scanning radiation acoustic field in formations generated by linear phased array transmitters in a fluid-filled borehole is carried out using a real axis integration (RAI) method. The main lobe width of the acoustic beams and the incident angle on the borehole wall can be controlled by means of adjusting parameters, such as the element number and the delay time between the neighboring array elements of linear phased array transmitter. The steered angle of longitudinal waves generated in the formation satisfies the Snell’s law for plane waves when the incident angle on the borehole wall is less than the first critical angle. When the lobe width of the acoustic beams is narrow and the steered angle is less than the first critical angle, the acoustic field in the formation can be approximately calculated given that the linear phased array is put in the formation without borehole. The technique of scanning radiation acoustic field can be applied to enhancing investigation resolution and signal-to-noise ratio in crosswell seismic survey and borehole acoustic reflection imaging. | CHE Xiaohua1, ZHANG Hailan1, QIAO Wenxiao2 & JU Xiaodong2 1. Institute of Acoustics, Chinese Academy of Sciences, Beijing 100080, China 2. Faculty of Natural Resources & Information Technology, University of Petroleum, Beijing 102249, China | 2005 | Science China(Physics,Mechanics & Astronomy)2005，48，2： | 11 |
| 16 | A study on the Dushiling tungsten-copper deposit in the Miao'ershan-Yuechengling area, Northern Guangxi, China:Implications for variations in the mineralization of multi-aged composite granite plutons显示文摘The polymetallic Dushiling W-Cu deposit is a large, altered, skarn-type deposit, located in the northeastern part of the Miao'ershan-Yuechengling pluton, China. Two types of granite have been identified in the deposit: a medium-grained porphyritic biotite granite, and a medium- to fine-grained biotite granite. Both are spatially and temporally related to ore bodies, suggesting they may be the source of mineralization in the deposit. A medium- to fine-grained porphyritic biotite granite is exposed at the surface in the region of mineralization. U-Pb dating of zircons yielded magmatic ages of 423 Ma for the medium-grained porphyritic biotite granite and 421 Ma for the medium- to fine-grained porphyritic biotite granite, while a younger age(217 Ma) obtained for surface samples indicates later diagenesis. Thus, magmatism occurred during the Caledonian and Indosinian, respectively. The petrological and geochemical characteristics of the two Caledonian granites show that both are calc-alkaline and peraluminous.They are moderately enriched in Cs, Rb, U, and REE, and strongly depleted in Sr,Ba,P,and Ti; they show similar REE behavior,including negative Eu anomalies. These geochemical similarities suggest that the two granites were derived from the same source,although they were emplaced during different stages of the evolution of the magma. Furthermore, the granites are associated with mineralization, suggesting they were the source of mineralization in the Dushiling W-Cu deposit. Sm-Nd ages of scheelite from the Dushiling W-Cu deposit indicate that metallogenesis occurred at 417±35 Ma, while the two types of titanite, intergrown with scheelite, yield U-Pb ages of 423–425 Ma(in altered granite sample) and 218 Ma(in skarn sample). These ages place the main mineralization event in the late Caledonian, and later magmatic-hydrothermal activity occurred in the Indosinian. The ages obtained for the Dushiling W-Cu deposit in the western Nanling Range, northern Yuechengling, together with the occurrence and ages of the Niutangjie W deposit in southern Yuechengling, provide insight into the process of ore concentration during the Caledonian and Indosinian. | CHEN WenDi ZHANG WenLan WANG RuCheng CHU ZhuYin XIAO Rong ZHANG Di CHE XuDong | 2016 | Science China Earth Sciences2016，59，11： | 10 |
| 17 | Changes in air temperature over China in response to the recent global warming hiatus显示文摘The 1998-2012 global wanning hiatus has aroused great public interest over the past several years.Based on the air temperature measurements from 622 meteorological stations in China,the temperature response to the global warming hiatus was analyzed at national and regional scales.We found that air temperature changed-0.221°C/10a during 1998-2012,which was lower than the long-term trend for 1960-1998 by 0.427°C/10a.Therefore,the warming hiatus in China was more pronounced than the global mean.Winter played a domi nant role in the nati on wide warming hiatus,con tributi ng 74.13%,while summer contributed the least among the four seasons.Furthermore,the warming hiatus was spatial heterogeneous across different climate conditions in China.Comparing the three geographic zones,the monsoon region of eastern China,arid region of northwestern China,and high frigid region of the Tibetan Plateau,there was significant cooling in eastern and northwestern China.In eastern China,which contributed 53.79%,the trend magnitudes were 0.896°C/10a in winter and 0.134°C/10a in summer.In the Tibeta n Plateau,air temperature in creased by 0.204°C/10a,indicating a lack of a significant warming hiatus.More broadly,the warming hiatus in China may have been associated with the negative phase of PDO and reduction in sunspot numbers and total solar radiation.Finally,although a warming hiatus occurred in China from 1998 to 2012,air temperature rapidly increased after 2012 and will likely to continuously warm in the next few years. | DU Qinqin ZHANG Mingjun WANG Shengjie CHE Cunwei MA Rong MA Zhuanzhuan | 2019 | Journal of Geographical Sciences2019，29，4： | 9 |
| 18 | A transgene-free method for rapid and efficient generation of precisely edited pigs without monoclonal selection显示文摘Gene-edited pigs for agricultural and biomedical applications are typically generated using somatic cell nuclear transfer(SCNT).However, SCNT requires the use of monoclonal cells as donors, and the time-consuming and laborious monoclonal selection process limits the production of large populations of gene-edited animals. Here, we developed a rapid and efficient method named RE-DSRNP(reporter RNA enriched dual-sg RNA/CRISPR-Cas9 ribonucleoproteins) for generating gene-edited donor cells. RE-DSRNP takes advantage of the precise and efficient editing features of dual-sg RNA and the high editing efficiency, low off-target effects, transgene-free nature, and low cytotoxic characteristics of reporter RNA enriched RNPs(CRISPR-Cas9ribonucleoproteins), thus eliminating the need for the selection of monoclonal cells and thereby greatly reducing the generation time of donor cells from 3–4 weeks to 1 week, while also reducing the extent of apoptosis and chromosomal aneuploidy of donor cells. We applied RE-DSRNP to produce cloned pigs bearing a deletion edit of the wild-type p53-induced phosphatase 1(WIP1)gene: among 32 weaned cloned pigs, 31(97%) carried WIP1 edits, and 15(47%) were homozygous for the designed fragment deletion, and no off-target event was detected. The WIP1 knockout(KO) pigs exhibited male reproductive disorders, illustrating the utility of RE-DSRNP for rapidly generating precisely edited animals for functional genomics and disease research. REDSRNP's strong editing performance in a large animal and its marked reduction in the required time for producing SCNT donor cells support its application prospects for rapidly generating populations of transgene-free cloned animals. | Kui Xu Xiuling Zhang Zhiguo Liu Jinxue Ruan Changjiang Xu Jingjing Che Ziyao Fan Yulian Mu Kui Li | 2022 | Science China(Life Sciences)2022，65，8： | 9 |
| 19 | β-elemene enhances the radiosensitivity of gastric cancer cells by inhibiting Pak1 activation显示文摘AIM:To explore the potential of β-elemene as a radiosensitizer for gastric cancer cells and the underlying mechanisms.METHODS:SGC7901,MKN45,MKN28,N87,and AGS human gastric cancer cell lines were used to screen for radioresistant gastric cancer cell lines. A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium(MTT) assay was used to determine the effects of β-elemene and IPA-3 on cell viability in MKN45 and SGC7901 gastric cancer cell lines. A clonogenic survival assay and annexin V-FITC/PI apoptosis detection assay were used to evaluate cellular radiosensitivity and radiation-induced cell death,respectively. A proteomic method,isobaric tags for relative and absolute quantitation(i TRAQ),was employed to screen the proteins regulated by β-elemene pretreatment prior to ionizing radiation(IR) in SGC7901 gastric cancer cell line. IPA-3 was used as a specific small molecule inhibitor of p21-activated protein kinase 1(Pak1) to target Pak1 signaling. Protein levels of PAK1IP1(p21-activated protein kinase-interacting protein 1),total Pak1(t-Pak1),phospho-Pak1(T423),phospho-ERK1/2( Thr202/Tyr204),and cleaved caspase-3(17 k Da) were assessed by western blotting.RESULTS:MKN45 and SGC7901 gastric cancer cell lines were relatively more resistant to IR. β-elemene pretreatment decreased clonogenic survival following IR in MKN45 and SGC7901 gastric cancer cell lines. Additionally,β-elemene pretreatment prior to IR increased radiation-induced cell death compared with IR alone in MKN45(10.4% ± 0.9% vs 34.8% ± 2.8%,P < 0.05) and SGC7901(11.6% ± 0.9% vs 46.7% ± 5.2%,P < 0.05) human gastric cancer cell lines,respectively,consistent with the level of cleaved caspase-3(17 k Da). Through i TRAQ analysis and western blot validation,we found that β-elemene upregulated PAK1IP1 and downregulated phospho-Pak1(T423) and phosphoERK1/2 in SGC7901 gastric cancer cells. IR increased the level of phospho-Pak1(T423). Pretreatment with β-elemene decreased radiation-induced Pak1 and ERK1/2 phosphorylation. Inhibition of Pak1 using IPA-3 decreased clonogenic survival following IR. In addition,IPA-3 increased radiation-induced cell death in MKN45(13.4% ± 0.3% vs 26.6% ± 1.0%,P < 0.05) and SGC7901(16.0% ± 0.6% vs 37.3% ± 1.7%,P < 0.05) gastric cancer cell lines,respectively,consistent with the level of cleaved caspase-3(17 k Da). Western blotting showed that IPA-3 decreased radiation-induced Pak1 and ERK1/2 phosphorylation.CONCLUSION:This is the first demonstration that β-elemene enhances radiosensitivity of gastric cancer cells,and that the mechanism involves inhibition of Pak1 signaling. | Jun-Song Liu Xiang-Ming Che Shuai Chang Guang-Lin Qiu Shi-Cai He Lin Fan Wei Zhao Zheng-Liang Zhang Shu-Feng Wang | 2015 | World Journal of Gastroenterology2015，21，34： | 9 |
| 20 | Comparative Analysis of Nutrient Composition of Caulerpa lentillifera from Different Regions显示文摘This study investigated the difference of nutrient composition in Caulerpa lentillifera collected from different regions.The nutrient compositions of C.lentillifera from China's Hainan and Shandong provinces were determined and compared with those from Semporna(Malaysia),Sabah(Malaysia),Petchburi(Thailand),and two other species of seaweeds(Malaysia).The results showed that the polysaccharide and protein contents of C.lentillifera from Hainan(44.82%±0.98%and 12.5%±0.70%),Shandong(43.22%±1.42%and 14.7%±0.72%),Petchburi(59.27%±2.31%and 12.49%±0.30%),and Sabah(44.02%±2.01%and 19.38%±1.48%)were higher than those of Eucheuma cottonii(26.49%±3.01%and 9.76%±1.33%)and Sargassum polycystum(33.49%±1.70%and 5.40%±0.07%),respectively.The polyunsaturated fatty acid contents in C.lentillifera from Hainan(29.98%)and Shandong(22.11%)were higher than that in Semporna(16.76%±0.27%),Sabah(9.49%),and S.polycystum(20.34%±0.43%),but lower than that in E.cottonii(51.55%±0.57%).In Caulerpa lentillifera of Hainan and Shandong provinces,the essential amino acid(EAA)/total amino acid(TAA)ratios were 35.22%and 38.78%,respectively;and the EAA/ETAA ratios were 54.36%and 63.35%,respectively.The EAA composition of C.lentillifera was close to the ideal model of Food and Agriculture Organization/World Health Organization.C.lentillifera was rich in mineral elements,including calcium((3315.85±127.55)mg(100 g)^-1 and(3728.35±92.38)mg(100 g)^-1),magnesium((6715.74±82.58)mg(100 g)^-1 and(8128.59±242.72)mg(100 g)^-1),and trace elements,including iron((510.65±5.47)mg(100 g)^-1 and(1972.97±183.35)mg(100 g)^-1),selenium((1.04±0.08)mg(100 g)^-1 and(0.83±0.15)mg(100 g)^-1),and zinc((33.90±0.13)mg(100 g)^-1 and(11.75±2.05)mg(100 g)^-1).These results showed that C.lentillifera was more nutritious than S.polycystum or E.cottonii in terms of polysaccharide,protein,and fatty acid contents.Furthermore,both C.lentillifera species collected from Hainan and Shandong provinces show more basic nutrients.Therefore,C.lentillifera has important development and application prospects. | ZHANG Meijian MA Yurong CHE Xinyi HUANG Zumei CHEN Peng XIA Guanghua ZHAO Meihui | 2020 | Journal of Ocean University of China2020，19，2： | 8 |
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