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| 1 | Hepatic arterial infusion of gemcitabine-oxaliplatin in a large metastasis from colon cancer显示文摘Hepatic arterial infusion (HAI) of chemotherapy can be performed in cases of liver-confined metastatic disease,resulting in increased local drug concentrations.Here we report the case of a 61-year-old man who presented with an isolated large unresectable liver metastasis of colon cancer after failure of surgery and multiple administration of systemic chemotherapy.The patient was treated with a combination of gemcitabine and oxaliplatin using HAI.The tolerance was excellent and a radiological complete response was obtained after 8 cycles of HAI.The rationale for the use of gemcitabine and oxaliplatin as well as that for the combination of the 2 drugs is discussed in this paper.HAI of gemcitabine-oxaliplatin should be evaluated in further clinical trials. | Boris Guiu Julie Vincent Séverine Guiu Sylvain Ladoire Pablo Ortega-Deballon Jean-Pierre Cercueil Bruno Chauffert Franois Ghiringhelli | 2010 | World Journal of Gastroenterology2010，16，9： | 4 |
| 2 | Sirolimus,bevacizumab,5-Fluorouracil and irinotecan for advanced colorectal cancer:A pilot study显示文摘AIM:To evaluate the efficacy and the safety of combined 5-Fluorouracil,irinotecan,bevacizumab and sirolimus in refractory advanced colorectal carcinoma. METHODS:We initiated a regimen with at day 1 an injection(iv)of bevacizumab at 5 mg/kg,followed by 180 mg/m 2 irinotecan,followed by Leucovorin 400 mg/m 2 ,followed by a 5-Fluorouracil bolus 400 mg/m 2 and a 46-h infusion 2400 mg/m 2 .Sirolimus was given orally as continuous administration of 2 mg twice a day every days.This treatment was repeated every 14 d. RESULTS:A total of 12 patients were enrolled. All patients presented with metastatic disease that had failed at least three lines of chemotherapy that contained oxaliplatin,irinotecan and bevacizumab. Cetuximab failure was also observed in all K-Ras wildtype patients.The median number of cycles was 8.5 (range 2-20)and clinical benefit was observed in eight patients.The median time to progression was 5 mo and the median survival was 8 mo.Grade 3 neutropenia developed in four patients,and grade 3 diarrhea and stomatitis in two. CONCLUSION:The combination regimen of 5-Fluorouracil,irinotecan,bevacizumab and sirolimus in advanced colorectal carcinoma after failure of classical treatment is feasible and promising.Further evaluation of this combination is required. | Francois Ghiringhelli Boris Guiu Bruno Chauffert Sylvain Ladoire | 2009 | World Journal of Gastroenterology2009，15，34： | 2 |
| 3 | Phase III trial comparing intensive induction chemoradiotherapy (60 Gy, infusional 5-FU and intermittent cisplatin) followed hy maintenance gemcitabine with gemcitabine alone for locally advanced unresectable pancreatic cancer显示文摘 | Chauffert B Momex F Bonnetain F | 2008 | Ann On- col2008，19，9： | 1 |
| 4 | Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients显示文摘 | Fran?ois Ghiringhelli Cedric Menard Pierre Emmanuel Puig Sylvain Ladoire Stephan Roux Fran?ois Martin Eric Solary Axel Le Cesne Laurence Zitvogel Bruno Chauffert | 2007 | Cancer Immunology Immunotherapy2007，，5： | 1 |
| 5 | Phase Ⅲ trial com- paring intensive induction chemoradiotherapy (60 Gy, infusion- al 5-FU and intermittent cisplatin) followed by maintenance gemeitabine with gemcitabine alone for loeally advanced unre- sectable pancreatic cancer: definitive results of the 2000-01FFCD/SFRO study显示文摘 | Chauffert B Mornex F Bonnetaln F | 2008 | Ann Oncol2008，19，9： | 1 |
| 6 | Is Stenting as “a Bridge to Surgery” an Oncologically Safe Strategy for the Management of Acute, Left-Sided, Malignant, Colonic Obstruction? A Comparative Study With a Propensity Score Analysis显示文摘 | Charles Sabbagh Fran?ois Browet Momar Diouf Cyril Cosse Olivier Brehant Eric Bartoli Fran?ois Mauvais Bruno Chauffert Jean-Louis Dupas Eric Nguyen-Khac Jean-Marc Regimbeau | 2013 | Annals of Surgery2013，，1： | 1 |
| 7 | Raltitrexed and oxaliplatin hepatic arterial infusion for advanced colorectal cancer: a retrospective study显示文摘 | Cedric Khouri Boris Guiu Jean Pierre Cercueil Bruno Chauffert Sylvain Ladoire Francois Ghiringhelli | 2010 | Anti-Cancer Drugs2010，，6： | 1 |
| 8 | Screening of anticancer drugs for chemoembolization of hepatocellular carcinoma显示文摘 | Boulin M Guiu S Chauffert B | | 0，，08： | 1 |
| 9 | Feasibility of using quinine,a potential multidrug resistance-reversing agent,in combination with mitoxantrone and cytarabine for the treatment of acute leukemia显示文摘 | Solary E Caillot D Chauffert B | 1992 | J Clin Oncol1992，10，11： | 1 |
| 10 | Brain natriuretic peptide variations are linked to volume status in hemodial- ysis patients显示文摘 | Roueff S Martin E Chauffert ML | 2008 | Clin Nephrol2008，70，6： | 1 |
| 11 | HSP27 as a mediator of confluence-dependent resistance to cell death induced by anticancer drugs显示文摘 | Garrido C Chauffert B Mehlen P | 1997 | Cancer Res1997，57，13： | 1 |
| 12 | New biological perspectives for the improvement of the efficacy of sorafenib in hepatocellular carcinoma显示文摘 | Galmiche A Chauffert B Barbare JC | 2014 | Cancer Lett2014，346，2： | 1 |
| 13 | New biological perspectives for the improvement of the efficacy of Sorafenib in Hepatocellular Carcinoma显示文摘 | Antoine Galmiche Bruno Chauffert Jean-Claude Barbare | 2013 | Cancer Letters2013，，： | 1 |
| 14 | Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients显示文摘 | Fran?ois Ghiringhelli Cedric Menard Pierre Emmanuel Puig Sylvain Ladoire Stephan Roux Fran?ois Martin Eric Solary Axel Le Cesne Laurence Zitvogel Bruno Chauffert | 2007 | Cancer Immunology Immunotherapy2007，，5： | 1 |
| 15 | Reduction of the inflammatory response following coronary bypass grafting with total minimal extracorporeal circulation显示文摘 | Yves Fromes Didier Gaillard Olivier Ponzio Maryline Chauffert Marie-Fran?oise Gerhardt Philippe Deleuze Olivier M. Bical | 2002 | European Journal of Cardio-Thoracic Surgery2002，，4： | 1 |
| 16 | Screening of anticancer drugs for chemoembolization of hepatocellular carcinoma 显示文摘 | Boulin M Guiu S Chauffert B | 2011 | Anticancer Drugs2011，22，8： | 1 |
| 17 | Rationale supporting the use of vasoconstrictors for intraperitoneal chemotherapy with platinum derivatives显示文摘 | Chauffert B Favoulet P Polycarpe E | 2003 | Surg Oncol Clin N Am2003，12，3： | 1 |
| 18 | Brain natriuretic peptide -ariations are linked to -olume status in hemodialysis patients 显示文摘 | Roueff S Martin E Chauffert M | 2008 | Clin Nephrol2008，70，6： | 1 |
| 19 | Anticancer chemotherapy prevention of toxicity 显示文摘 | Bonnotte B Chauffert B | 1998 | Press Med1998，27，39： | 1 |
| 20 | Distribution of HLADQA1 and -DQB1 alleles and DQA1-DQB1 genotypes among Senegalese patients with insulin-dependent diabetes mellitus 显示文摘 | Cisse A Chauffert M Chevenne D | 1996 | Tissue Antigens1996，47，4： | 1 |
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