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| 1 | Procalcitonin and intestinal ischemia:A review of the literature显示文摘Intestinal ischemia is common after emergency gastrointestinal or cardiovascular surgery.At present,there are no diagnostic tools for the early diagnosis of intestinal ischemia.In the last decade,procalcitonin(PCT)has been suggested as a marker of this condition.Here,we review the use of PCT as a diagnostic tool for intestinal ischemia.Two reviewers independently searched the Pub Med and EMBASE databases for articles on intestinal ischemia and PCT.They then considered(1)the criteria applicable to preclinical and clinicaldata;and(2)PCT’s predictive value in the diagnosis of intestinal ischemia.Article quality was rated according to the STAndards for Reporting of Diagnostic accuracy.Between 1993 and 2014,seven studies(including two preclinical studies and five clinical studies)dealt with the use of PCT to diagnose intestinal ischemia.Procalcitonin’s sensitivity,specificity,positive predictive value and negative predictive value ranged between 72%and 100%;68%and 91%;27%and 90%and 81%and 100%,respectively.The area under the receiver operating characteristic curve ranged from 0.77 to 0.92.In view of the preclinical and clinical data,we consider that PCT can be used in daily practice as a tool for diagnosing intestinal ischemia. | Cyril Cosse Charles Sabbagh Sad Kamel Antoine Galmiche Jean-Marc Regimbeau | 2014 | World Journal of Gastroenterology2014，20，47： | 9 |
| 2 | Restrictive model of compensated carbon tetrachloride-induced cirrhosis in rats显示文摘AIM: To develop a simplified and quick protocol to induce cirrhosis and standardize models of partial liver resection in rats.METHODS: In Fischer F344 rats two modified protocols of phenobarbital-carbon tetrachloride (CCl4) (dilution 50%) gavage to induce cirrhosis (frequency adjusted according to weight, but each subsequent dose was systematically administered) were tested, i.e. the rapid and slow protocols. Prothrombin time (PT) and total bili-rubin (TB) were also evaluated. Animals from the rapid group underwent 15% hepatectomy and animals from the slow group underwent 70% hepatectomy.RESULTS: Rapid protocol: This corresponded to 1 ga-vage/4 d over 6 wk (mortality 30%). Mean PT was 35.2 ± 2.8 s (normal: 14.5 s), and mean TB was 1.8 ± 0.2 mg/dL (normal: 0.1 mg/dL). Slow protocol: This cor-responded to 1 gavage/6 d over 9 wk (mortality 10%). Mean PT was 11.8 ± 0.2 s (normal: 14.5 s), and mean TB was 0.4 ± 0.04 mg/dL (normal: 0.1 mg/dL). Patho-logical analyses were performed in both protocols which showed persistent cirrhosis at 3 mo. Rat mortality in the rapid gavage group who underwent 15% hepatectomy and in the slow gavage group who underwent 70% hepatectomy was 50% and 70%, respectively.CONCLUSION: Our modified model is a simplified method to induce cirrhosis which is rapid (6 to 9 wk), efficient and stable up to 3 mo. Using this method, 'Child Pugh A' or 'Child Pugh BC' cirrhotic rats were obtained. Our models of cirrhosis and hepatectomy can be used in various situations focusing on postoperative survival. | Jean-Marc Regimbeau David Fuks Niaz Kohneh-Shahri Benot Terris Olivier Soubrane | 2008 | World Journal of Gastroenterology2008，14，45： | 8 |
| 3 | Multidisciplinary management of Mirizzi syndrome with cholecystobiliary fistula: the value of minimally invasive endoscopic surgery显示文摘Mirizzi syndrome, a rare complication of gallstones, is defined by obstruction of the main bile duct. This obstruction may worsen and thus result in cholecystobiliary fistula. Surgical management of Mirizzi syndrome is complicated by the presence of inflamed tissue around the hepatic pedicle, making it impossible to distinguish between the main bile duct and the gallbladder. The surgeon's first task is to perform subtotal cholecystotomy(from the fundus of the gallbladder to the neck) without trying to locate the cystic duct. In a second step, the gallstones are extracted and the main bile duct is then repaired. In most cases, a T-tube is used to drain the main bile duct, and abdominal drainage is left in place(in case a bile fistula forms). This study concluded that preoperative drainage of the main bile duct in the treatment of Mirizzi syndrome types II and III is feasible and might help to decrease the postoperative complication rate. | Fabien Le Roux Charles Sabbagh Brice Robert Thierry Yzet Laurent Dugue Jean-Paul Joly Jean-Marc Regimbeau | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，5： | 6 |
| 4 | Frey procedure for the treatment of chronic pancreatitis associated with common bile duct stricture显示文摘BACKGROUND:The Frey procedure(FP)is the treatment of choice for symptomatic chronic pancreatitis(CP).In cases of biliary stricture,biliary derivation can be performed by choledochoduodenostomy,Roux-en-Y choledochojejunostomy or,more recently,reinsertion of the common bile duct(CBD)into the resection cavity.The objective of the present study was to evaluate the outcomes associated with each of these three types of biliary derivation.METHODS:We retrospectively analyzed demographic,CPrelated,surgical and follow-up data for patients having undergone FP for CP with biliary derivation between 2004and 2012 in our university medical center.The primary efficacy endpoint was the rate of CBD stricture recurrence.The secondary endpoints were surgical parameters,postoperative complications,postoperative follow-up and the presence of risk factors for secondary CBD stricture.RESULTS:Eighty patients underwent surgery for CP during the study period.Of these,15 patients received biliary derivation with the FP.Eight of the FPs(53.3%)were combined with choledochoduodenostomy,4(26.7%)with choledochojejunostomy and 3(20.0%)with reinsertion of the CBD into the resection cavity.The mean operating time was 390minutes.Eleven complications(73.3%)were recorded,including one major complication(6.7%)that necessitated radiologicallyguided drainage of an abdominal collection.The mean(range)length of stay was 17 days(8-28)and the median(range)follow-up time was 35.2 months(7.2-95.4).Two patients presented stricture after CBD reinsertion into the resection cavity;one was treated with radiologically-guided dilatation and the other underwent revisional Roux-en-Y choledochojejunostomy.Three patients presented alkaline reflux gastritis(37.5%),one(12.5%)cholangitis and one CBD stricture after FP with choledochoduodenostomy.No risk factors for secondary CBD stricture were identified.CONCLUSIONS:As part of a biliary derivation,the FP gave good results.We did not observe any complications specifically related to surgical treatment of the biliary tract.However,CBD reinsertion into the resection cavity appeared to be associated with a higher stricture recurrence rate.In our experience,choledochojejunostomy remains the'gold standard'for the surgical treatment for CBD strictures. | Lionel Rebibo Thierry Yzet Cyril Cosse Richard Delcenserie Eric Bartoli Jean-Marc Regimbeau | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，6： | 5 |
| 5 | Multicentre European study of preoperative biliary drainage for hilar cholangiocarcinoma显示文摘 | O. Farges J. M. Regimbeau D. Fuks Y. P. Le Treut D. Cherqui P. Bachellier J. Y. Mabrut M. Adham F. R. Pruvot J. F. Gigot | 2012 | Br J Surg2012，，2： | 2 |
| 6 | Is Hepatic Resection for Large or Multinodular Hepatocellular Carcinoma Justified? Results From a Multi-Institutional Database显示文摘 | Kelvin K. Ng Jean-Nicolas Vauthey Timothy M. Pawlik Gregory Y. Lauwers Jean-Marc Regimbeau Jacques Belghiti Iwao Ikai Yoshio Yamaoka Steven A. Curley David M. Nagorney Irene O. Ng Sheung Tat Fan Ronnie T. Poon | 2005 | Annals of Surgical Oncology2005，，5： | 2 |
| 7 | Portal Vein Embolization Before Right Hepatectomy: Prospective Clinical Trial显示文摘 | Olivier Farges Jacques Belghiti Reza Kianmanesh Jean Marc Regimbeau Roberto Santoro Valérie Vilgrain Alban Denys Alain Sauvanet | 2003 | Annals of Surgery2003，，2： | 2 |
| 8 | Prise en charge chirurgicale de la pancréatite chronique显示文摘 | Jean-Marc Regimbeau Frédéric Dumont Thierry Yzet Denis Chatelain éric Bartoli Franck Brazier Olivier Bréhant Jean-Louis Dupas Fran?ois Mauvais Richard Delcenserie | 2007 | Gastroenterologie Clinique et Biologique2007，，8： | 2 |
| 9 | Meta-analysis of smooth muscle relaxants in the treatment of irritable bowel syndrome显示文摘 | Regimbeau C Benhamou Y | 2001 | Aliment Pharmacol Ther2001，15，3： | 1 |
| 10 | Operative and long term results after surgery for chronic radiation enteritis显示文摘 | Regimbeau JM Pan is Y Gouzi JL | 2001 | Am J Surg2001，182，7： | 1 |
| 11 | Prognostic value of jaundice in patients with gallbladder cancer by the AFC-GBC- 2009 study group 显示文摘 | Regimbeau JM Fuks D Bachellier P | 2011 | Eur J Surg Oncol2011，37，6： | 1 |
| 12 | A comparative study of surgery and endoscopy for the treatment of bile duct stricture in patients with chronic pancreatitis显示文摘 | Jean-Marc Regimbeau David Fuks Eric Bartoli Mathurin Fumery Adina Hanes Thierry Yzet Richard Delcenserie | 2012 | Surgical Endoscopy2012，，10： | 1 |
| 13 | Operative and long term results after surgery for chronic radiation enteritis显示文摘 | Regimbeau JM Panis Y Gouzi JL | 2001 | Am J Surgery2001，182，： | 1 |
| 14 | Aggressive management of recurrence following surgical resection of hepatocellular carcinoma 显示文摘 | Farges O Regimbeau JM Belghiti J | 1998 | Hepatogastroenterology1998，453，： | 1 |
| 15 | Intrahepatic cholangiocarcinoma and hepatolithiasis: an unusual in westem countries显示文摘 | Lesutel M Regimbeau JM Farges O | 2002 | Eur J Gastroenterol Hepatol2002，14，9： | 1 |
| 16 | Hypoder- minA, a new inhibitor of human complement for the prevention of xenogeneic hyperacute rejection 显示文摘 | MALASSAGNE B REGIMBEAU J M TABOIT F | 2003 | Xenotransplantation2003，10，3： | 1 |
| 17 | Metaanalysis of smooth muscle relaxants in the treatment of irritable boul syndrome显示文摘 | POYNARD T REGIMBEAU C BENHAMOU Y | 2001 | Aliment Pharmacol Ther2001，15，： | 1 |
| 18 | Is Stenting as “a Bridge to Surgery” an Oncologically Safe Strategy for the Management of Acute, Left-Sided, Malignant, Colonic Obstruction? A Comparative Study With a Propensity Score Analysis显示文摘 | Charles Sabbagh Fran?ois Browet Momar Diouf Cyril Cosse Olivier Brehant Eric Bartoli Fran?ois Mauvais Bruno Chauffert Jean-Louis Dupas Eric Nguyen-Khac Jean-Marc Regimbeau | 2013 | Annals of Surgery2013，，1： | 1 |
| 19 | Endoscopic treatment of chronic pancreatitis显示文摘 | Eric Bartoli Richard Delcenserie Thierry Yzet Franck Brazier Guillaume Geslin Jean-Marc Regimbeau Jean-Louis Dupas | 2005 | Gastroenterologie Clinique et Biologique2005，，5： | 1 |
| 20 | Risk factors for early due to recurrence after liver resection for hepatocarcinoma : resuits of a multieenter study显示文摘 | Regimbeau JM Abdalla EK Vauthek JN | 2004 | J Surg Oncol2004，85，1： | 1 |
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