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| 1 | The relationship of Imp2 and DR3 genes with susceptibility to type Ⅰ diabetes mellitus in south China Han population显示文摘AIN To study the relationship of Imp2 and DR3genes with type Ⅰ diabetes mellitus.NETHODS Imp2 genotypes and DR3 wereidentified in 68 patients with type Ⅰ diabetesmellitus(Ⅰ-DM)and 71 healthy controls.Then,Ⅰ-DM patients and controls were respectivelyallocated into DR3-positive and DR3-negativegroups.The frequencies of Imp2 and DR3 genein random subjects,and Imp2 genotypes in DR3-matched subjects were compared between Ⅰ-DMpatients and controls.At the same time,Ⅰ-DMpatients were divided into 3 groups based on theonset age of diabetics:group A≤14 years,group B 15-30 years and group C≥31 years.RESULTS The frequency of DR3 in Ⅰ-DMpatients was significantly higher than that incontrols(47% vs 21%,P<0.005),and it wassignificantly higher in group A than that in groupB+C(70% vs 36%,x^2=7.07,P<0.01).Therewas a significant difference among groups withdifferent onset age of diabetics(x^2=8.19,rp=0.33,P<0.05).In random subjects,thefrequency of Imp2.R/R in Ⅰ-DM patients waslower(43% vs 61%,P<0.05)and Imp2.R/Hhigher(53% vs 28%,P<0.05)than that incontrols,and there was no significant differenceamong groups with different onset age ofdiabetics.In DR3-positive subjects,thefrequency of Imp2.R/R in Ⅰ-DM patients waslower(47% vs 87%,P<0.05)and Imp2-R/H higher(47% vs 13%,P<0.05)than that incontrols.In DR3-negative subjects,thefrequency of Imp2.R/H in Ⅰ-DM patients washigher than that in controls(58% vs 32%,P<0.01),but the frequency of Imp2-R/R and Imp2H/H was not significantly different betweenthese two groups.CONCLUSION DR3 gene may be one of thesusceptible genes of Ⅰ-DM,and significantlyrelated to the onset age of diabetics,and thepersons with DR3 may have an younger onsetage of diabeteS.The Imp2-R/R may be theprotective genotype of Ⅰ-DM,and Imp2-R/H thesusceptible genotype.These were not affectedby DR3 gene.Imp-2 genotypes were not relatedwith the onset age of diabetics. | Ding HL Cheng H Fu ZZ Deng QL Yan L Yan T | 2000 | World Journal of Gastroenterology2000，6，1： | 7 |
| 2 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 3 | Famciclovir for the suppression of symptomatic and asymptomatic herpes simplex virus reactivation in HIV-infected persons, a double-blind, placebo-controlled trial 显示文摘 | Schacker T Hu HL Koelle DM | 1998 | Ann Intern Meal1998，128，1： | 1 |
| 4 | Caudatin induces cell cycle arrest and caspase-dependent apoptosis in HepG2 cell 显示文摘 | Fei HR Chen HL Xiao T | 2012 | Mol Biol Rep2012，39，1： | 1 |
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| 8 | Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma:a double-blind randomised phase 3 study显示文摘 | Kindler HL Ioka T Richel DJ | | 0，，03： | 1 |
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| 10 | Clinical learning environment and supervision:Testing a research instrument in an international comparative study显示文摘 | Saarikoski M Kilpi HL Warne T | 2002 | Nurse Education Today2002，22，： | 1 |
| 11 | Three protein cocktails mediate delayed-type hypersensitivity responses indistinguishable from thate licited by purified protein derivative in the guinea pig model of Mycobacterium tuberculosis infection显示文摘 | Yang HL Troudt J Grover A t t al | 2011 | Infect Immun2011，79，2： | 1 |
| 12 | Induction and inhibition of estradiol hydroxylase activities in MCF-7 human breast cancer cells in culture显示文摘 | Niwa T Bradlow HL Fishman J | 1990 | Steroids1990，55，7： | 1 |
| 13 | NEPTUNE Study: On-treatment HBsAg level analysis confirms prediction of response observed in phase 3 study of peginterferon alfa-2a in HBeAg-positive patients 显示文摘 | Gane E Jia J Han K Tanwandee T Chuang WL Marcellin P Chan HL Piratvisuth T Wat C Martins E Liaw YF | 2011 | J Hepatol2011，54，： | 1 |
| 14 | The interpretation(a): Overview of the Surviving Sepsis Campaign: international guide- lines for management of severe sepsis and septic shock: 2008显示文摘 | ZHAO HL SHEN LW CHENG T | 2008 | Clinical Focus2008，23，7： | 1 |
| 15 | Epi- thelial to mesenchymal transition in human breast cancer can provide a nonmalignant stroma 显示文摘 | PETERSEN OW NIELSEN HL GUDJONSSON T | 2003 | Am J Pathol2003，162，2： | 1 |
| 16 | In their own words: young people's mental health in drought-affected rural and re- mote NSW显示文摘 | Carnie T Berry HL Blinkhorn SA | 2011 | Aust J Rrual Health2011，19，5： | 1 |
| 17 | Isolation,immortalization, and characterization of a human breast epithelial cell line with stem cell properties显示文摘 | Gudjonsson T Villadsen R Nielsen HL | 2002 | Gene Dev2002，16，6： | 1 |
| 18 | Microbial leakage evaluation of the continuous wave of condensation显示文摘 | Jacobson HL Xia T Baumgartner JC | 2002 | J Endod2002，28，4： | 1 |
| 19 | Below-ground carbon in put to soil is control led by nutrient availability and fine root dynamics in loblolly pine显示文摘 | King JS Albaugh T J Allen HL | 2002 | New Phytologist2002，154，2： | 1 |
| 20 | ACDF with the PCB cage-plate system versus laminoplasty for multilevel cervical spondylotic myelopathy 显示文摘 | Liu T Yang HL Xu YZ | 2011 | J Spinal Disord Tech2011，24，4： | 1 |
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