|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | The relationship of Imp2 and DR3 genes with susceptibility to type Ⅰ diabetes mellitus in south China Han population显示文摘AIN To study the relationship of Imp2 and DR3genes with type Ⅰ diabetes mellitus.NETHODS Imp2 genotypes and DR3 wereidentified in 68 patients with type Ⅰ diabetesmellitus(Ⅰ-DM)and 71 healthy controls.Then,Ⅰ-DM patients and controls were respectivelyallocated into DR3-positive and DR3-negativegroups.The frequencies of Imp2 and DR3 genein random subjects,and Imp2 genotypes in DR3-matched subjects were compared between Ⅰ-DMpatients and controls.At the same time,Ⅰ-DMpatients were divided into 3 groups based on theonset age of diabetics:group A≤14 years,group B 15-30 years and group C≥31 years.RESULTS The frequency of DR3 in Ⅰ-DMpatients was significantly higher than that incontrols(47% vs 21%,P<0.005),and it wassignificantly higher in group A than that in groupB+C(70% vs 36%,x^2=7.07,P<0.01).Therewas a significant difference among groups withdifferent onset age of diabetics(x^2=8.19,rp=0.33,P<0.05).In random subjects,thefrequency of Imp2.R/R in Ⅰ-DM patients waslower(43% vs 61%,P<0.05)and Imp2.R/Hhigher(53% vs 28%,P<0.05)than that incontrols,and there was no significant differenceamong groups with different onset age ofdiabetics.In DR3-positive subjects,thefrequency of Imp2.R/R in Ⅰ-DM patients waslower(47% vs 87%,P<0.05)and Imp2-R/H higher(47% vs 13%,P<0.05)than that incontrols.In DR3-negative subjects,thefrequency of Imp2.R/H in Ⅰ-DM patients washigher than that in controls(58% vs 32%,P<0.01),but the frequency of Imp2-R/R and Imp2H/H was not significantly different betweenthese two groups.CONCLUSION DR3 gene may be one of thesusceptible genes of Ⅰ-DM,and significantlyrelated to the onset age of diabetics,and thepersons with DR3 may have an younger onsetage of diabeteS.The Imp2-R/R may be theprotective genotype of Ⅰ-DM,and Imp2-R/H thesusceptible genotype.These were not affectedby DR3 gene.Imp-2 genotypes were not relatedwith the onset age of diabetics. | Ding HL Cheng H Fu ZZ Deng QL Yan L Yan T | 2000 | World Journal of Gastroenterology2000，6，1： | 7 |
| 3 | Diabetes mellitus increases risk for colorectal adenomas in younger patients显示文摘AIM:To determine if diabetes mellitus(DM)is associated with increased risk of colorectal adenomas in younger subjects.METHODS:This was a retrospective cohort study of375 patients undergoing index colonoscopy at a single tertiary care center in the United States.Three cohorts of patients matched for exam date and gender were compared:(1)ages 40-49 years with DM;(2)ages40-49 years without DM;and(3)ages 50-59 years without DM.Data collected included demographics,co-morbidities,colonoscopy and pathology results.Adenoma detection rates(ADR)were calculated and compared.Conditional logistic regression analysis was performed to determine the association between each cohort and ADR.RESULTS:One hundred and twenty-five patients ages40-49 with DM met study eligibility criteria.Patients in the other two cohorts were randomly selected,match-ing for date of exam and gender.ADR was 14.4%in those ages 40-49 years without DM,30.4%in those ages 40-49 years with DM,and 32.0%in those ages50-59 years without DM.Compared to those ages40-49 years without DM,ADR was higher in those ages40-49 years with DM(OR=3.1;95%CI:1.5-6.4;P=0.002)and those ages 50-59 years without DM(OR=2.9;95%CI:1.5-5.6;P=0.002).There was no difference between the ADR in those ages 40-49 years with DM and those ages 50-59 years without DM(P=0.83).CONCLUSION:DM was associated with higher risk of colorectal adenomas in patients ages 40-49 years.These subjects harbored as many adenomas as those at the standard screening age of 50-59 years without DM. | Hongha T Vu Nneka Ufere Yan Yan Jean S Wang Dayna S Early Jill E Elwing | 2014 | World Journal of Gastroenterology2014，20，22： | 5 |
| 4 | PROBLEMS AND COUNTERMEASURES OF WATER RESOURCES FOR SUSTAINABLE UTILIZATION IN CHINA显示文摘According to the theory of sustainable development,the current situation and existent problems of the expl oita-tion of water resources were analyze d in this paper.The results show that the contradiction between supply an d demand of water resources is continually aggravating,water pollution is incre asingly serious,water environment is worse,the over-extraction area of the underground water is expanding and water crisis stands out gradually,so it is imp erative under the situation to actualize the susta inable exploitation strategies of water resources.It is necessary for s ustainable utilizing water resources to introduce the mod el of sustainable utilization of water resources-the model of wealth transferring be-tween the generations of water resou rces,establish water-saving socie ty system and water market,form tech nology sys-tems,management systems and evaluation systems for many sorts of water r esources,improve the utilization r atio of water resources,transform waste water in to resources and maintain and restore the water space of water environmen t. | DENG Wei,BAI Jun-hong,YAN Min-hua(Changchun Institute of Geography,t he Chinese Academy of Sciences,Changchun 130012,P.R.China) | 2002 | Chinese Geographical Science2002，12，4： | 3 |
| 5 | Adipocyte iron regulates adiponectin and insulin sensitivity显示文摘 | Gabrielsen J Scott Gao Yan Simcox Judith A Huang Jingyu Thorup David Jones Deborah Cooksey Robert C Gabrielsen David Adams Ted D Hunt Steven C Hopkins Paul N Cefalu William T McClain Donald A | 2012 | EN2012，，10： | 2 |
| 6 | An Asian emission inventory of anthropogenic emission sources for the period 1980–2020显示文摘 | Ohara T. Akimoto H. Kurokawa J. Horii N. Yamaji K. Yan X. Hayasaka T | 2007 | Atmospheric Chemistry and Physics2007，，100： | 2 |
| 7 | Towards better coordination of the supply chain显示文摘 | Xu Kefeng Dong Yan Evers P T | 2001 | Transportation ResearchPart E2001，37，2： | 1 |
| 8 | A 2-V 900MHz Monolithic CMOS Dual-Loop Frequency Synthesizer for GSM Receivers显示文摘 | Yan W S T Luong H C | 2001 | IEEE J of Solid-State Circuit2001，36，2： | 1 |
| 9 | Water-repelleney and surface free energy of a-C: H films prepared by heat-treatment of polymer precursor 显示文摘 | YAN X B XU T YUE S S | 2005 | Diamond & Related Mat2005，14，： | 1 |
| 10 | Fragmentation Behavior of Pyrite and Calcite During High-Temperature Processing and Mathematical Simulation 显示文摘 | Yan L Gupta R P Wall T F | 2001 | Energy and Fuels2001，15，2： | 1 |
| 11 | Commutators of BMO functions and singular integral operators with non-smooth kernels 显示文摘 | Duong X T Yan L X | 2003 | Bull Austral Math Soc2003，67，： | 1 |
| 12 | Comparison of efficacy of selamectin, ivermectin and mebendazole for the control of gastrointestinal nematodes in rhesus macaques, China显示文摘 | WANG T YANG G Y YAN H J | 2008 | Vet Parasitol2008，153，12： | 1 |
| 13 | Seasonal variations in clinical and laboratory variables among chronic hemodialysis patients显示文摘 | Cheung AK Yan G Greene T | 2002 | J Am Soc Nephrol2002，13，： | 1 |
| 14 | On commutators of fractional integrals显示文摘 | Duong X T Yan L X | 2004 | Proc Amer Math Soc2004，132，： | 1 |
| 15 | Hydrothermally stable aluminosilicate mesostructures prepared from zeolite ZSM-5显示文摘 | WANG S DOU T LI Y DOU Z ZHANG Y LI X YAN Z | 2007 | J Mater Sci2007，42，1： | 1 |
| 16 | Stochastic spline ritz method based on stochastic variational principle 显示文摘 | Yang L F Leung A Y T Yan L B | 2005 | Engineering Structures2005，27，3： | 1 |
| 17 | Estimating water retention characteristic from soil particle-size distribution using a nonsimilar media concept 显示文摘 | Zhuang J Yan J Miyazaki T | 2001 | Soil Science2001，166，： | 1 |
| 18 | Surface modification and electrochemical studies of spherical nickel hydroxide 显示文摘 | WANG X Y YAN J YUAN H T | 1998 | J Power Sources1998，72，： | 1 |
| 19 | Topology of Magnetic Field and Coronal Heating in Solar Active Regions显示文摘 | Wang H N Yan Y Sakurai T | 2001 | Solar Phys2001，201，2： | 1 |
| 20 | In-situ density modification of DNAPL by using polyaphrons显示文摘 | YAN L THOMPSON K VALSARAJ K T | 2003 | Environ Sci Technol2003，37，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员