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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations显示文摘 | Thompson MC Fuller C Hogg TL Dalton J Finkelstein D Lau CC Chintagumpala M Adesina A Ashley DM KeUie SJ Taylor MD Curran T Gajjar A Gilbertson RJ | 2006 | 中国神经肿瘤杂志2006，4，1： | 17 |
| 3 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 4 | Condensed chromatin and cell inactivation by single-hit kinetics显示文摘 | Chapman JD Stobbe CC Gales T | 1999 | Radiat Res1999，151，4： | 1 |
| 5 | Regional variations in the glial influence on synapse development in the mouse CNS显示文摘 | Steinmetz CC Buard I Claudepierre T | 2006 | J Physiol2006，577，1： | 1 |
| 6 | A method for inflorescence proliferation显示文摘 | Lin C S Chen C T Lin CC | 2003 | Plant Cell Rep2003，21，9： | 1 |
| 7 | Therapeutic window for use of hyperbaric oxygenation in focal transient ischemia in rats显示文摘 | Lou M Eschenfelder CC Herdegen T | 2004 | Stroke2004，35，2： | 1 |
| 8 | Autoantibody from women with preeclampsia induces soluble Fms -like tyrosine kinase -1 production via angiotensin type 1 receptor and calcineurinlnuclear factor of activated T -cells signaling显示文摘 | Zhou CC Ahmad 5 Mi T | 2008 | Hypertension2008，51，4： | 1 |
| 9 | Consensus guidelines for managing postoperative nausea and vomiting 显示文摘 | GAN TJ MEYER T APFEL CC | 2003 | Anesth Analg2003，97，1： | 1 |
| 10 | Persistent bilateral ureteral obstruc- tion secondary to endometriosis despite treatment with an aroma- tase inhibitor 显示文摘 | Bohrer J Chen CC Falcone T | 2008 | Fertil Steril2008，90，： | 1 |
| 11 | Lin-Telaranta classification: he impor tance of different procedures for different indication in sympa thetic surgery显示文摘 | Lin CC Telaranta T | 2001 | Ann Chit Gyn2001，90，： | 1 |
| 12 | Robotie gynecologic surgery: past, present, and future 显示文摘 | Chen CC Falcone T | 2009 | Clin Obster Gynecol2009，52，3： | 1 |
| 13 | Kidney injury molecule-1 :a tissue and urinary biomarker for nephrotoxicant induced renal injury显示文摘 | Ichimura T Hung CC Yang SA | 2004 | Am J Physiol Renal Physiol2004，286，3： | 1 |
| 14 | Surgical treatment of a sacral nerve root with intermittent claudication in an 85-year-old patient: case report显示文摘 | Su CC Shirane R Okubo T | 1996 | Surg Neurol1996，45，： | 1 |
| 15 | Gene expres- sion changes in response to E2F1 activition显示文摘 | Stanelle J Stiewe T Theseling CC | 2002 | Nucleic Acids Res2002，30，8： | 1 |
| 16 | Role of crosstalk between phosphatidylinositol 3-kinase and extracellular signal-regu- lated kinase/mitogen-activated protein kinase pathways in artery-vein specification 显示文摘 | Hong CC Kume T Peterson RT | 2008 | Circ Res2008，103，6： | 1 |
| 17 | Screening of Taiwanese curde drugs for antibacterial activity against Streptococcus mutans显示文摘 | Chen CP Lin CC Namba T | 1989 | Journal of Ethnopharmacology1989，27，3： | 1 |
| 18 | Gap junctions and neurological disorders of the central nervous system 显示文摘 | Nakase T Naus CC | 2004 | Biochim Biophys Acta2004，1662，12： | 1 |
| 19 | Osmotic demyelination syndrome after correction of chronic hyponatremia with norm Saline 显示文摘 | Lin SH Chau T Wu CC | 2002 | Am J Med Sci2002，323，： | 1 |
| 20 | BDNF induction with mild exercise in the rat hippocampus显示文摘 | Soya H Nakamura T Deocaris CC | 2007 | Biochem Biophys Res Commun2007，358，4： | 1 |
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