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| 1 | 曹雪涛院士科研团队论文荣膺中国百篇最具影响国际学术论文--长链非编码RNA1nc-DC通过STAT3调控人DC的分化和功能显示文摘树突状细胞(DC)是免疫系统中重要的抗原提呈细胞,其成熟和功能状态决定着免疫应答的走向和强度。哺乳动物基因组能够转录产生大量的长链非编码RNA(long noncoding RNA,IncRNA),其在免疫系统中的功能还知之甚少。
曹雪涛院十科研团队王品副教授课题组采用了转录组芯片二代测序高通量筛选方法、RNA-pulldown、ChIP-seq等技术展开了对IncRNA在DC分化和功能中作用的研究,发现并鉴定了特异性高表达于DC的1ncRNA,命名为1nc-DC,其可通过抑制STAT3去磷酸化,从而促进DC分化和功能。该研究成果发表于Science杂志[2014,344(6181):310-313],并于2015年12月被评为“中国百篇最具影响国际学术论文”。 | wang p xue y han y lin l wu c xu s jiang z xu j liu q cao x | 2016 | 中国肿瘤生物治疗杂志2016，23，1： | 10 |
| 2 | 用防老剂及并用防老剂提高轮胎胶料的耐屈挠疲劳和动态臭氧龟裂性能显示文摘为了延长轮胎使用寿命 ,轮胎公司一直在试图研究改进轮胎各部件的屈挠疲劳性能和轮胎外部件如胎侧、胎面及三角胶在动态臭氧条件下的耐龟裂性能。本文研究了用各种防老剂及其并用来改进轮胎内部件的屈挠疲劳性能 ,还评价了通过防老剂并用来改进外部件的动态臭氧龟裂性能 ,并进而推荐了适宜的防老剂及防老剂并用。此外 ,本文还根据实验室的试验结果 ,讨论了防老剂如何防止氧化破坏及臭氧如何与防老剂发生反应的假设机理。 | Hong S W Lin C Y | 2002 | 轮胎工业2002，22，3： | 7 |
| 3 | Urban China in Transformation:Hybrid Economy,Juxtaposed Space,and New Testing Ground for Geographical Enquiries显示文摘History has brought us into a significant moment when the majority of the human kind has taken up resi-dence in urban settlements. The focus of global urbanization has shifted to the developing world and the center of manufacturing is no longer confined to the Global North. This paper provides a periodical assessment of the current status of China's urban transformation in the global context of a shifting emphasis of industrialization and urbaniza-tion. China's phenomenal urban transformation deserves a special attention not only because of its unparalleled scale and speed but also because of its distinct trajectory of growth that does not conform to normal theoretical ex-pectations. The results of assessment revealed an urban economy with remarkable hybridity, a society that is in-creasingly stratified, polarized, and segregated, and a juxtaposed urban space undergoing restless and pervasive transformation. A decentering world should entail a decentering knowledge production. A critical reflection upon the Chinese patterns and processes of urban transformation has identified 4 main issues with great potentials for inno-vative knowledge production, namely: 1) privatization and economic development; 2) state, society, and space; 3) urbanization of capital, labor, and land; and 4) the environment and Chinese political ecology. The paper closes with the remark that a rapidly transforming urban China has presented itself as a fertile and resourceful testing ground for critical and innovative geographic enquiries. | George C S LIN | 2011 | Chinese Geographical Science2011，21，1： | 4 |
| 4 | 欧洲和中国的心脏与肾脏远程缺血预适应研究:一项随机对照试验显示文摘远程缺血预适应(remote ischemic preconditioning,RIPC)对经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)术后造影剂肾病(contrast-induced nephropathy,CIN)的潜在保护作用尚待确定。该研究为双盲、随机、安慰剂对照的多中心研究,纳入年龄〈85岁,肾清除率为30~60mL/(min·1.73m^2)的有临床适应证的患者,除了直接PCI外均按1∶1给予RIPC或标准治疗。主要终点是CIN的发生率。次要终点是围手术期心肌梗死(peri-procedural myocardial infarction,PMI)的发生率。 | 刘青 叶鹏 Moretti C Cerrato E Cavallero E Lin S Rossi ML Picchi A Sanguineti F Ugo F Palazzuoli A Bertaina M Presbitero P Shao-Liang C Pozzi R Giammaria M Limbruno U Lefèvre T Gasparetto V Garbo R OmedèP Sheiban I Escaned J Biondi-Zoccai G Gaita F Perl L D'Ascenzo F | 2018 | 中华高血压杂志2018，26，4： | 3 |
| 5 | Adult metaplastic hutch diverticulum with robotic-assisted diverticulectomy and reconstruction:A case report显示文摘BACKGROUND Hutch diverticulum arises from the compromised muscular development at the ureteral orifice.It is a congenital disease and extremely rare in adult,only accounting for about 3%occurrence worldwide.It can be either symptomatic or asymptomatic,and relies on image tools for diagnosis and preoperative planning.Indications for surgery are dependent on the complications from the diverticulum.Metaplasia is about 10%among those with hutch diverticulum,and it still has chances turning into malignancy,especially urothelial cell carcinoma.CASE SUMMARY A 27-year-old man was presented with frequently recurrent urinary tract infection for one year,and had suffered from intermittent right flank pain for 3 mo.No past medical histories were recorded before.No obvious abnormalities on laboratory data and urine examination were found.Under ultrasound,right hydronephrosis was seen and an anatomical abnormality was observed on intravenous pyelography.Further computed tomography urogram showed one diverticulum seated at superolateral side of right ureteral orifice.Cystoscopy was done and biopsy results showed focal metaplasia.After discussing with him,roboticassisted diverticulectomy with reconstruction was performed.Right hydronephrosis was greatly improved after surgery.He has completed his 1.5-year follow-ups,and no malignancies were seen from urine cytology and image of intravenous pyelography.CONCLUSION Robotic-assisted diverticulectomy and reconstruction to hutch diverticulum is a safe and efficient operation,providing several advantages over open and laparoscopic ones. | Che H Yang Yi S Lin Yen C Ou Wei C Weng Li H Huang Chin H Lu Chao Y Hsu Min C Tung | 2020 | World Journal of Clinical Cases2020，8，20： | 2 |
| 6 | Continuous room-temperature operation of optically pumped LnGaAs/InGaAsP microdisk lasers显示文摘 | Thiyagarajan S M K Levi A F J Lin C K | | Electronics Letters0，，： | 2 |
| 7 | Novel cytotoxic principles of formosan Ganodema lucidum显示文摘 | Lin C N Tome W P Won S J | 1991 | J Nat Prod1991，54，4： | 2 |
| 8 | Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor显示文摘 | Anne Brunet Azad Bonni Michael J Zigmond Michael Z Lin Peter Juo Linda S Hu Michael J Anderson Karen C Arden John Blenis Michael E Greenberg | 1999 | Cell1999，，6： | 2 |
| 9 | Combined contrast-enhanced power Doppler and real-time sonoelastography performed during EUS, used in the differential diagnosis of focal pancreatic masses (with videos)显示文摘 | Adrian S?ftoiu Sevasti?a Iordache Dan Ionu? Gheonea Carmen Popescu Anca Malo? Florin Gorunescu Tudorel Ciurea Alexandru Iordache Gabriel Lucian Popescu Cǎtǎlin Manea | 2010 | Gastrointestinal Endoscopy2010，，4： | 2 |
| 10 | A toxicity testing protocol using a bioluminescent reporter bacterium from activated sludge显示文摘 | Lajoie C A Lin S C Nguyen H | 2002 | Journal of Microbiological Methods2002，50，3： | 2 |
| 11 | Screw Dislocation Dipole Near an Internal Crack显示文摘 | Lin K M Hu C T Lee S B | 1993 | Engineering Fracture Mechanics1993，45，： | 1 |
| 12 | Hospital lift system simulator: A performance Evaluator Predictor显示文摘 | Sydney C K Chu Lin C K Y Lam S S | 2003 | European Journal of Operational Research2003，146，1： | 1 |
| 13 | Suppression of lipopolysaccharide- induced nuclear factor- kappaB activity by theaflavin-3,3'-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages 显示文摘 | Pan M H Lin-shiau S Y Ho C T Lin J H Lin J K | 2000 | Biochem Pharm2000，59，： | 1 |
| 14 | Preparation,morphology and properties of acid and amine modified multiwalled carbon nanotube/polyimide composite显示文摘 | Yuen S M Ma C C M Lin Y Y | 2007 | Comps SciTechn2007，67，1112： | 1 |
| 15 | Effect of substrate temperature and annealing treatment on the electrical and optical properties of silver-based multilayer coating electrodes 显示文摘 | SAHU D R CHEN C Y LIN S Y | 2006 | Thin Solid Films2006，515，： | 1 |
| 16 | Capsaicin induced cell cycle arrest and apoptosis in human esophagus epidermoid carcinoma CE81T/VGH cells through the elevation of intracellular reactive oxygen species and Ca^2+ productions and caspase-3 activation 显示文摘 | WU C C LIN J P YANG J S | 2006 | Mutat Res2006，601，12： | 1 |
| 17 | Evaluation of early-stage Parkinson's disease with ^99mTc-TRODAT-1 imaging显示文摘 | Huang W S Lin S Z Lin J C | 2001 | Journal of Nuclear Medicine2001，42，9： | 1 |
| 18 | Laterai response evaluation of single piles using inclinometer data显示文摘 | LIN S S LIAO J C | 2006 | Journal of Geotechnical and Geoenviromental Engineering2006，132，12： | 1 |
| 19 | Rainbow trout has two genes for growth hormone显示文摘 | Agellon L B Davies S L Lin C M | 1988 | Mol Rep Develop1988，1，： | 1 |
| 20 | Reversible watermarking: current status and key issues 显示文摘 | FENG J B LIN I C TSAI C S | 2006 | International Journal of Network Security2006，2，3： | 1 |
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