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| 1 | From Golden Rice to aSTARice:Bioengineering Astaxanthin Biosynthesis in Rice Endosperm显示文摘Carotenoids are important phytonutrients with antioxidant properties,and are widely used in foods and feedstuffs as Supplements.Astaxanthin,a red-colored ketocarotenoid,has strong antioxidant activity and thus can benefit human health.However,astaxanthin is not produced in most higher plants.Here we report the bioengineering of astaxanthin biosynthesis in rice endosperm by introducing four synthetic genes,sZmPSY1,sPaCrtl,sCrBKT,and sHpBHY,which encode the enzymes phytoene synthase,phytoene desaturase,β-carotene ketolase,and β-carotene hydroxylase,respectively.Transgneic overexpression of two (sZmPSY1 and sPaCrtl),three (sZmPSY1,sPaCrtl and sCrBKT),and all these four genes driven by rice endosperm-specific promoters established the Carotenoid/ketocarotenoid/astaxanthin biosynthetic pathways in the endosperm and thus resulted in various types of germplasm,from the yellow-grained β-caro- tene-enriched Golden Rice to orange-red-grained Canthaxanthin Rice and Astaxanthin Rice,respectively. Grains Of Astaxanthin Rice were enriched with astaxanthin in the endosperm and had higher antioxidant activity.These results proved that introduction of a minimal set of four transgenes enables de novo biosynthesis of astaxanthin in therice endosperm.This work provides a Successful example for synthetic biology in plants and biofortification in crops;the biofortified rice products generated by this study could be consumed as health-promoting foods and processed tO produce dietary supplements. | Qinlong Zhu Dongchang Zeng Suize Yu Chaojun Cui Jiamin Li Heying Li Junyu Chen Runzhao Zhang Xiucai Zhao Letian Chen Yao-Guang Liu | 2018 | Molecular Plant2018，11，12： | 35 |
| 2 | Comparative Proteome Analysis of Human Lung Squamous Carcinoma Tissue显示文摘客观:与高分辨率建立二维的电气泳动侧面;从人的肺的重制度有鳞的癌织物;配对的正常肿瘤邻近的支气管的上皮,;识别微分表示由使用 proteome 分析的联系肿瘤的蛋白质。方法:有 20 人的肺的比较 proteome 分析有鳞的癌纸巾;邻近肿瘤的配对的正常支气管的上皮被执行。人的肺的全部的蛋白质有鳞的癌织物;配对的正常肿瘤邻近的支气管的上皮借助于使不能调动的 pH 被分开基于坡度的二维的胶化电气泳动(2-DE ) ;染色的银。微分表示蛋白质被分析;然后到飞行团分光术(MALDI-TOF-MS ) 的帮助矩阵的激光解吸附作用 / 电离时间识别了。结果:(1 ) 人的肺的解决得好的、可再现的 2-DE 模式有鳞的癌;邻近的正常支气管的上皮被获得。为肿瘤织物, 3 胶化的平均的点是 1567 ± 4 6,;4 看到的 1436 ± 5 与 91.6% 的平均匹配率被匹配。为控制, 3 胶化的平均的点是 1349 ± 5 8,;5 看到的 1228 ± 3 与 91.03% 的平均匹配率被匹配。匹配的点的平均位置偏差是在 IEF 的 0.924 ± 0 .128 公里方向,;在 SDS 页方向的 1.022 ± 0 .205 公里;(2 ) 6 看到的 1178 ± 5 的一个总数在 20 人的肺的电泳地图之间被匹配有鳞的癌纸巾;配对正常肿瘤邻近的支气管的上皮。76 差别表示了蛋白质被屏蔽;(3 ) 68 微分蛋白质被 PMF 识别,一些蛋白质是 oncogenes 的产品,;涉及房间的规定的其它骑车;信号转导变异;(4 ) 以便验证识别结果的可靠性, 3 蛋白质 mdm2 的表示, c-jun;EGFR,它与肺被相关有鳞的癌,被免疫检测组织化学的染色;西方的污点分析。结果揭示了那 mdm2, c-jun;EGFR 在肺是起来调整的有鳞的癌而他们在邻近的正常支气管的上皮是下面调整的,正常的肺纸巾;煽动性的假肿瘤,它与我们的 proteome 分析一致结果。结论:人的肺的解决得好的、可再现的 2-DE 模式有鳞的癌;邻近的正常支气管的上皮被建立;68 微分蛋白质被成功地使用比较 proteome 分析描绘。这些结果将为屏蔽使用到 diagnose 的分子的简历标记提供科学基础;对待肺有鳞的癌,以及改进病人的预后;为肺的研究提供新线索有鳞的致癌机制。 | LI Cui TANG Can'e DUAN Chaojun YI Hong XIAO Zhiqiang CHEN Zhuchu | 2006 | The Chinese-German Journal of Clinical Oncology2006，5，4： | 11 |
| 3 | Scientific challenges of research on natural hazards and disaster risk显示文摘As a discipline,the science of natural hazards and disaster risk aims to explain the spatial-temporal pattern,process and mechanism,emergency response and risk mitigation of natural hazards,which requires a multidisci-plinary and interdisciplinary approach.With the support of Natural Science Finance of China(NSFC)and Chinese Academy of Sciences(CAS),in-depth research and systematic analysis on natural hazards and disaster risk were conducted.In this paper,the state of the art in research on natural hazards is summarized from seven aspects:formation process,mechanism and dynamic of natural hazards,disaster risk assessment,forecast,monitoring and early warning,disaster mitigation,emergency treatment and rescue,risk management and post-disaster re-construction.The trends within the natural hazards and disaster risk as a discipline were identified,along with existing shortcomings and significant gaps that need to be addressed.This paper highlighted:1)the scientific challenges including the frontier scientific issues and technological gaps on natural hazards and disaster risk dis-cipline from 2025 to 2035 in China,and 2)the proposal to develop a systemic and holistic natural hazards and disaster risk discipline. | Peng Cui Jianbing Peng Peijun Shi Huiming Tang Chaojun Ouyang Qiang Zou Lianyou Liu Changdong Li Yu Lei | 2021 | Geography and Sustainability2021，2，3： | 3 |
| 4 | New Subclasses of Biholomorphic Mappings and the Modified Roper-Suffridge Operator显示文摘The authors propose a new approach to construct subclasses of biholomorphic mappings with special geometric properties in several complex variables. The RoperSuffridge operator on the unit ball B^n in C^n is modified. By the analytical characteristics and the growth theorems of subclasses of spirallike mappings, it is proved that the modified Roper-Suffridge operator [Φ_(G,γ)(f)](z) preserves the properties of S_Ω~*(A, B), as well as strong and almost spirallikeness of type β and order α on B^n. Thus, the mappings in S_Ω~*(A, B), as well as strong and almost spirallike mappings, can be constructed through the corresponding functions in one complex variable. The conclusions follow some special cases and contain the elementary results. | Chaojun WANG Yanyan CUI Hao LIU | 2016 | Chinese Annals of Mathematics,Series B2016，37，5： | 1 |
| 5 | Synthesis and electrochemical performance of lithium vanadium ox- ide nanotubes as cathodes for rechargeable lithium-ion batteries 显示文摘 | Cui Chaojun Wu Guangming Shen Jun | 2010 | Electrochimica Acta2010，55，： | 1 |
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